A New Block S-Random Interleaver for Shorter Length Frames for Turbo Codes

In this paper, we have proposed a new design of interleaver based on S-random and block interleaver. The characteristics of both block and S-random interleaver are used by this proposed interleaver. There is a large influence of free distance in turbo codes due to interleaving as it lowers the error floor. The free distance of turbo codes can be increased by designing interleaver with high spread. In this case, the overall spreading factor is increased significantly for smaller length frames also. The simulations results are compared with full S-random interleavers. The bit error rate performance of proposed interleaver for Turbo codes is much better than full s-random interleaver at the cost of small delay

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei

TbPARG in Trypanosoma brucei. A) TbPARG localization in untreated (control) and in procyclic cultures exposed to 500 μM H2O2 for 10 min. IFI was carried out as reported in our previous work [33]. TbPARG was identified with our home-made antibody against TcPARG [33]; and PAR was identified with a commercial antibody against PAR (BD). White bar represents 50 μm. B) Western blot analysis of 40 μg protein per lane revealed with a commercial anti-PARG antibody (Antibody Verify) in T. brucei procyclic (PC) and bloodstream (BST) forms. The arrow indicates the band with the expected molecular weight (approximately 60 kDa). The membrane stained with Red Ponceau was used as a loading control. (TIF 4272 kb

Stability indicating method development and validation for simultaneous estimation of atorvastatin calcium and celecoxib in bulk and niosomal formulation by RP-HPLC

The present work describes development and validation of a specific, sensitive, precise and stability-indicating high-performance liquid chromatographic method of analysis of atorvastatin calcium and celecoxib, both as a bulk drug and in niosomal formulation. The analysis has been performed by using Cosmosil-C18 column (4.6 mm´250 mm, 5 m) at 25 °C using acetonitrile: ammonium acetate buffer pH 5.0: methanol (50:25:25 v/v/v) as mobile phase. The detection was carried out at 277nm with a flow rate of 1.0mL/min. The retention times of Atorvastatin calcium and Celecoxib were 6.195 and 3.989min, respectively. The method was validated according to ICH guidelines, for specificity, precision, linearity, accuracy and robustness. Atorvastatin calcium and Celecoxib were subjected to stress conditions of hydrolysis, oxidation, photolysis and thermal degradation. The degradation was observed in oxidation and acid hydrolysis. The linearity for atorvastatin calcium and celecoxib were in the range of 100-500 µg/mL. The recovery study of atorvastatin and celecoxib were found to be in the range of 98.96 - 99.92% and 98.90-100%, respectively. The proposed method was validated and successfully applied to the estimation of Atorvastatin calcium and Celecoxib in combined in-house niosomal formulation.O presente trabalho descreve o desenvolvimento e a validação de método de análise por cromatografia de alta eficiência específico, sensível, preciso e indicador de estabilidade de atorvastatina cálcica e celecoxibe, ambos como fármaco e como formulação niosômica. A análise foi realizada utilizando coluna Cosmosil-C18 (4,6 mm´250 mm, 5 m) a 25 °C, e acetonitrila: tampão acetato de amônio pH 5,0: metanol (50:25:25 v/v/v) como fase móvel. A detecção foi realizada a 277 nm, com fluxo de 1,0 mL/min. Os tempos de retenção de atorvastatina cálcica e de celecoxibe foram 6,195 e 3,989 min, respectivamente. O método foi validado de acordo com as regras da ICH para especificidade, precisão, exatidão e robustez. A atorvastatina cálcica e o celecoxibe foram submetidos a condições de estresse por hidrólise, oxidação, fotólise e degradação térmica. A degradação foi observada por oxidação e hidrólise ácida. Observou-se a linearidade da atorvastatina cálcica e do celecoxibe na faixa de 100-500 µg/mL. A recuperação da atorvastatina e do celecoxibe foi observada na faixa de 98,96-99,92% e 98,90-100%, respectivamente. O método proposto foi validado e aplicado com sucesso para a determinação de atorvastatina cálcica e celecoxibe em formulação niosômica caseira combinada

Bioavailability in soils

The consumption of locally-produced vegetables by humans may be an important exposure pathway for soil contaminants in many urban settings and for agricultural land use. Hence, prediction of metal and metalloid uptake by vegetables from contaminated soils is an important part of the Human Health Risk Assessment procedure. The behaviour of metals (cadmium, chromium, cobalt, copper, mercury, molybdenum, nickel, lead and zinc) and metalloids (arsenic, boron and selenium) in contaminated soils depends to a large extent on the intrinsic charge, valence and speciation of the contaminant ion, and soil properties such as pH, redox status and contents of clay and/or organic matter. However, chemistry and behaviour of the contaminant in soil alone cannot predict soil-to-plant transfer. Root uptake, root selectivity, ion interactions, rhizosphere processes, leaf uptake from the atmosphere, and plant partitioning are important processes that ultimately govern the accumulation ofmetals and metalloids in edible vegetable tissues. Mechanistic models to accurately describe all these processes have not yet been developed, let alone validated under field conditions. Hence, to estimate risks by vegetable consumption, empirical models have been used to correlate concentrations of metals and metalloids in contaminated soils, soil physico-chemical characteristics, and concentrations of elements in vegetable tissues. These models should only be used within the bounds of their calibration, and often need to be re-calibrated or validated using local soil and environmental conditions on a regional or site-specific basis.Mike J. McLaughlin, Erik Smolders, Fien Degryse, and Rene Rietr

Residual effects of natural Zn chelates on navy bean response, Zn leaching and soil status

greenhouse experiment was conducted on weakly acidic and calcareous soils to evaluate the aging and residual effects of three natural organic Zn chelates [Zn-ethylenediaminedisuccinate (Zn-EDDS), Zn-polyhydroxyphenylcarboxylate and Zn-aminelignosulfonate] each administered in a single application to a first navy bean (Phaseolus vulgaris L.) crop at several different Zn application rates. In a second navy bean crop, we determined the following parameters: the extent of Zn leaching, the amount of available Zn remaining in soils, the amount of easily leachable Zn, the size of Zn fractions in soils, the pH and redox potential, the dry matter yield, and the soluble and total Zn concentrations in plants. The residual effect after 2 years of Zn fertilization mainly depended on the aging effect of Zn chelates and losses due to Zn leaching. The data relating to the evolution from the first to the second crop showed that the aging effect was noticeable in the calcareous soil. In the latter soil, the Zn-S,S-EDDS treatments showed greater decreases in the Zn uptake by plants than the other Zn treatments and the greatest Zn uptake by plants occurred when Zn was applied as Zn-aminelignosulfonate (10 mg Zn kg−1 rate, 6.85 mg Zn per lysimeter; 5 mg Zn kg−1 rate, 3.36 mg Zn per lysimeter). In contrast, in the calcareous soil, the maximum amount of Zn uptake, for the three chelates was 0.82 mg Zn per lysimeter. Consequently, a further application of Zn would be needed to prevent Zn deficiencies in the plants of a subsequent crop. The behaviour of the pH and Eh parameters in the soils and leachates did not depend on the natural Zn sources applied. In this study, the easily leachable Zn estimated by BaCl2 extraction was not adequate to predict Zn leaching from the soils in subsequent crops

Measurement of Angular Coefficients of Bˉ→D∗ℓνˉℓ\bar{B} \to D^* \ell \bar{\nu}_\ell: Implications for ∣Vcb∣|V_{cb}| and Tests of Lepton Flavor Universality

We measure the complete set of angular coefficients $J_i$ for exclusive $\bar{B} \to D^* \ell \bar{\nu}_\ell$ decays ($\ell = e, \mu$). Our analysis uses the full $711\,\mathrm{fb}^{-1}$ Belle data set with hadronic tag-side reconstruction. The results allow us to extract the form factors describing the $B \to D^*$ transition and the Cabibbo-Kobayashi-Maskawa matrix element $|V_{\rm cb}|$. Using recent lattice QCD calculations for the hadronic form factors, we find $|V_{\rm cb}| = (41.0 \pm 0.7) \times 10^3$ using the BGL parameterization, compatible with determinations from inclusive semileptonic decays. We search for lepton flavor universality violation as a function of the hadronic recoil parameter $w$, and investigate the differences of the electron and muon angular distributions. We find no deviation from Standard Model expectations

Observation of charmed strange meson pair production in Υ(2S)\Upsilon(2S) decays and in e+e−e^{+}e^{-} annihilation at s=10.52 GeV\sqrt{s} = 10.52~ \rm{GeV}

We observe the process $\Upsilon(2S)\to D_s^{(*)+} D_{sJ}^{-}$ and continuum production $e^+e^- \to D_s^{(*)+} D_{sJ}^-$ at $\sqrt{s} = 10.52$ GeV (and their charge conjugates) using the data samples collected by the Belle detector at KEKB, where $D_{sJ}^-$ is $D_{s1}(2536)^-$ or $D^{*}_{s2}(2573)^-$. Both $D_{sJ}^-$ states are identified through their decay into $\bar{K}\bar{D}^{(*)}$. We measure the products of branching fractions ${\cal B}(\Upsilon(2S) \to D_{s}^{(*)+} D_{sJ}^-) {\cal B}(D_{sJ}^-\to \bar{K} \bar{D}^{(*)})$ and the Born cross sections $\sigma^{\rm Born}(e^+e^- \to D_{s}^{(*)+} D_{sJ}^-) {\cal B}(D_{sJ}^-\to \bar{K} \bar{D}^{(*)})$, and then compare the ratios $R_1 \equiv {\cal B}(\Upsilon(2S)\to D_{s}^{(*)+} D_{sJ}^-)/{\cal B}(\Upsilon(2S)\to\mu^{+}\mu^-)$ for $\Upsilon(2S)$ decays and $R_2 \equiv \sigma^{\rm Born}(e^+e^-\to D_{s}^{(*)+}D_{sJ}^-)/\sigma^{\rm Born}(e^+e^-\to \mu^{+}\mu^-)$ for continuum production. We obtain $R_1/R_2 = 9.7\pm 2.3 \pm 1.1$, $6.8 \pm 2.1 \pm 0.8$, $10.2 \pm 3.3 \pm 2.5$, and $3.4 \pm 2.1 \pm 0.5$ for the $D_s^+ D_{s1}(2536)^-$, $D_s^{*+} D_{s1}(2536)^-$, $D_s^+ D_{s2}^{*}(2573)^{-}$, and $D_s^{*+} D_{s2}^{*}(2573)^{-}$ final states in the $D_{sJ}^-\to K^{-} \bar{D}^{(*)0}$ modes, respectively. Therefore, the strong decay is expected to dominate in the $\Upsilon(2S)\to D_{s}^{(*)+}D_{sJ}^-$ processes. We also measure the ratios of branching fractions ${\cal B}(D_{s1}(2536)^-\to K_S^0 D^{*}(2010)^{-})/{\cal B}(D_{s1}(2536)^-\to K^{-} D^{*}(2007)^0) = 0.48 \pm 0.07 \pm 0.02$ and ${\cal B}(D_{s2}^{*}(2573)^- \to K_S^0 D^-)/{\cal B}(D_{s2}^{*}(2573)^- \to K^{-}D^0) = 0.49 \pm 0.10 \pm 0.02$, which are consistent with isospin symmetry. The second ratio is the first measurement of this quantity. Here, the first uncertainties are statistical and the second are systematic

First test of lepton flavor universality in the charmed baryon decays Ω0^{0}c_{c} → Ω−^{-}ℓ+^{+}νℓ_{ℓ} using data of the Belle experiment

We present the first observation of the Ω0c→Ω−μ+νμ decay and present measurements of the branching fraction ratios of the Ω0c→Ω−ℓ+νℓ decays compared to the reference mode Ω0c→Ω−π+, (ℓ=e or μ). This analysis is based on 89.5  fb−1, 711  fb−1, and 121.1  fb−1 data samples collected with the Belle detector at the KEKB asymmetric-energy e+e− collider at the center-of-mass energies of 10.52 GeV, 10.58 GeV, and 10.86 GeV, respectively. The Ω0c signal yields are extracted by fitting MΩℓ and MΩπ spectra. The branching fraction ratios B(Ω0c→Ω−e+νe)/B(Ω0c→Ω−π+) and B(Ω0c→Ω−μ+νμ)/B(Ω0c→Ω−π+) are measured to be 1.98±0.13(stat)±0.08(syst) and 1.94±0.18(stat)±0.10(syst), respectively. The ratio of B(Ω0c→Ω−e+νe)/B(Ω0c→Ω−μ+νμ) is measured to be 1.02±0.10(stat)±0.02(syst), which is consistent with the expectation of lepton flavor universality