Optical afterglow luminosities in the Swift epoch: confirming clustering and bimodality

We show that Gamma Ray Bursts (GRBs) of known redshift and rest frame optical extinction detected by the Swift satellite fully confirm earlier results concerning the distribution of the optical afterglow luminosity at 12 hours after trigger (rest frame time). This distribution is bimodal and relatively narrow, especially for the high luminosity branch. This is intriguing, given that Swift GRBs have, on average, a redshift larger than pre-Swift ones, and is unexpected in the common scenario explaining the GRB afterglow. We investigate if the observed distribution can be the result of selection effects affecting a unimodal parent luminosity distribution, and find that either the distribution is intrinsically bimodal, or most (60 per cent) of the bursts are absorbed by a substantial amount of grey dust. In both cases we suggest that most dark bursts should belong to the underluminous optical family.Comment: 5 pages 3 figures, minor revision, added reference, accepted for publication in MNRAS Letter

A scalable data-plane architecture for one-to-one device-to-device communications in LTE-Advanced

One-to-one device-to-device (D2D) communications are expected to play a major role in future releases of LTE-A, as well as in future 5G networks. Despite the abundance of works on resource allocation for D2D communications, few works, if any, discuss how D2D should be realized within the LTE-A protocol stack. While it is generally understood that D2D endpoints should be able to communicate both on the direct path or sidelink (SL) and on the relayed path (RP) through the eNB, little has been said on how this can be achieved in practice. In this paper we present a comprehensive proposal for a data-plane architecture for D2D communication: we define how communications should occur on the SL and the RP, and propose a solution for the challenges associated with mode switching between the SL and the RP. In particular, we argue that two different communication modes on the RP are required to allow D2D connections to be kept alive across cell borders in a multicell environment. Our proposal is scalable, since it does not require any signaling, and is guaranteed to not introduce losses. We evaluate our proposal through detailed system-level simulations, also focusing on its interplay with transport-layer protocols

Short term X-ray spectral variability of the quasar PDS 456 observed in a low flux state

We present an analysis of the 2013 Suzaku campaign on the nearby luminous quasar PDS 456, covering a total duration of ~1 Ms and a net exposure of 455 ks. During these observations, the X-ray flux was suppressed by a factor of >10 in the soft X-ray band when compared to other epochs. We investigated the broadband continuum by constructing a spectral energy distribution, making use of the optical/UV photometry and hard X-ray spectra from the later XMM-Newton/NuSTAR campaign in 2014. The high energy part of this low flux state cannot be accounted for by self-consistent accretion disc and corona models without attenuation by absorbing gas, which partially covers a substantial fraction of the line of sight towards the X-ray source. Two absorption layers are required, of column density $\log (N_{\rm{H,low}}/{\rm cm^{-2}})=22.3\pm0.1$ and $\log (N_{\rm{H,high}}/{\rm cm^{-2}})=23.2\pm0.1$, with average covering factors of ~80% (with typical 5% variations) and 60% ($\pm$10-15%), respectively. In these observations PDS 456 displays significant short term X-ray spectral variability, on timescales of ~100 ks, which can be accounted for by variable covering of the absorbing gas. The partial covering absorber prefers an outflow velocity of $v_{\rm pc} = 0.25^{+0.01}_{-0.05}c$ at the >99.9% confidence level over the case where $v_{\rm pc}=0$. This is consistent with the velocity of the highly ionised outflow responsible for the blueshifted iron K absorption profile. We therefore suggest that the partial covering clouds could be the denser, or clumpy part of an inhomogeneous accretion disc wind. Finally we estimate the size-scale of the X-ray source from its variability. The radial extent of the X-ray emitter is found to be of the order ~15-20 $R_{\rm g}$, although the hard X-ray (>2 keV) emission may originate from a more compact or patchy corona of hot electrons, which is ~6-8 $R_{\rm g}$ in size.Comment: 38 pages, 13 figures, accepted for publication in MNRA

Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites

Background: During epithelial-to-mesenchymal transition, cancer cells lose adhesion capacity gaining migratory properties. The role of the process on prognosis has been evaluated in 50 cases of laryngeal carcinoma. Methods: E-cadherin, N-cadherin, β-catenin, α-catenin, γ-catenin, caveolin-1, and vimentin immunohistochemical expression were evaluated using a double score based on staining intensity and cellular localization. Results: Cytoplasmic E-cadherin and α/γ catenin staining were associated with a decrease in survival, cytoplasmic β-catenin was associated with advanced stage, and N-cadherin and vimentin expression were associated with poor differentiation and tumor relapse. On the basis of cancer cells, epithelial or mesenchymal morphological and immunophenotypic similarity we identified 4 main subgroups correlated with a transition to a more undifferentiated phenotype, which have a different pattern of relapse and survival. Conclusion: The negative prognostic role of epithelial-to-mesenchymal transition has been confirmed and a predictive role in glottic tumors has been suggested, leading us to propose epithelial-to-mesenchymal transition as an additional adverse feature in laryngeal carcinoma

How Tradeoffs Shrink Attribute Hierarchy

Why do people sometimes struggle with decisions that once seemed relatively simple? This research suggests that comparing options leads people to lose sight of which decision attributes are important. Although the difference between important and unimportant attributes is often clear in the abstract, the act of making tradeoffs highlights what people must forgo on one attribute in exchange for a gain on another, which increases the perceived importance of trivial attributes in particular. This causes the variance in perceived importance across attributes to shrink, blurring the distinction between important and unimportant attributes. Four experiments demonstrate this phenomenon, explore the underlying mechanism, and show how it leads to increased choice difficulty and dissatisfaction with the choice experience

Structural determinants for NF-Y/DNA interaction at the CCAAT box

The recently determined crystal structures of the sequence-specific transcription factor NF-Y have illuminated the structural mechanism underlying transcription at the CCAAT box. NF-Y is a trimeric protein complex composed by the NF-YA, NF-YB, and NF-YC subunits. NF-YB and NF-YC contain a histone-like domain and assemble on a head-to-tail fashion to form a dimer, which provides the structural scaffold for the DNA sugar-phosphate backbone binding (mimicking the nucleosome H2A/H2B\ue2\u80\u93DNA assembly) and for the interaction with NF-YA. The NF-YA subunit hosts two structurally extended \uce\ub1-helices; one is involved in NF-YB/NF-YC binding and the other inserts deeply into the DNA minor groove, providing exquisite sequence-specificity for recognition and binding of the CCAAT box. The analysis of these structural data is expected to serve as a powerful guide for future experiments aimed at understanding the role of post-translational modification at NF-Y regulation sites and to unravel the three-dimensional architecture of higher order complexes formed between NF-Y and other transcription factors that act synergistically for transcription activation. Moreover, these structures represent an excellent starting point to challenge the formation of a stable hybrid nucleosome between NF-Y and core histone proteins, and to rationalize the fine molecular details associated with the wide combinatorial association of plant NF-Y subunits

The environment of the SN-less GRB 111005A at z = 0.0133

The collapsar model has proved highly successful in explaining the properties of long gamma-ray bursts (GRBs), with the most direct confirmation being the detection of a supernova (SN) coincident with the majority of nearby long GRBs. Within this model, a long GRB is produced by the core-collapse of a metal-poor, rapidly rotating, massive star. The detection of some long GRBs in metal-rich environments, and more fundamentally the three examples of long GRBs (GRB 060505, GRB 060614 and GRB 111005A) with no coincident SN detection down to very deep limits is in strong contention with theoretical expectations. In this paper we present MUSE observations of the host galaxy of GRB 111005A, which is the most recent and compelling example yet of a SN-less, long GRB. At z=0.01326, GRB 111005A is the third closest GRB ever detected, and second closest long duration GRB, enabling the nearby environment to be studied at a resolution of 270 pc. From the analysis of the MUSE data cube, we find GRB 111005A to have occurred within a metal-rich environment with little signs of ongoing star formation. Spectral analysis at the position of the GRB indicates the presence of an old stellar population (tau > 10 Myr), which limits the mass of the GRB progenitor to M_ZAMS<15 Msolar, in direct conflict with the collapsar model. Our deep limits on the presence of any SN emission combined with the environmental conditions at the position of GRB 111005A necessitate the exploration of a novel long GRB formation mechanism that is unrelated to massive stars.Comment: Now accepted by A&A. Manuscript replaced to match accepted version. Some additional discussion added, and velocity map of the host galaxy now include

Numerical solution of the two-dimensional Helmholtz equation with variable coefficients by the radial integration boundary integral and integro-differential equation methods

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2012 Taylor & Francis.This paper presents new formulations of the boundary–domain integral equation (BDIE) and the boundary–domain integro-differential equation (BDIDE) methods for the numerical solution of the two-dimensional Helmholtz equation with variable coefficients. When the material parameters are variable (with constant or variable wave number), a parametrix is adopted to reduce the Helmholtz equation to a BDIE or BDIDE. However, when material parameters are constant (with variable wave number), the standard fundamental solution for the Laplace equation is used in the formulation. The radial integration method is then employed to convert the domain integrals arising in both BDIE and BDIDE methods into equivalent boundary integrals. The resulting formulations lead to pure boundary integral and integro-differential equations with no domain integrals. Numerical examples are presented for several simple problems, for which exact solutions are available, to demonstrate the efficiency of the proposed methods