Myelodysplastic syndrome accompanied by basophilia and eosinophilia with t(5;12)(q31;p13)

The t(5;12)(q31not, vert, similar35;p12not, vert, similar13) is rare among cytogenetically categorized myeloid diseases. Here we describe a case of myelodysplastic syndrome (MDS) with basophilia followed by leukocytosis, basophilia, and eosinophilia with t(5;12)(q31;p13).A 44-year-old man was referred to Tsukuba University Hospital in August 2005, due to severe anemia and thrombocytopenia. Peripheral blood examination showed hemoglobin 4.5 g/dL, with mean corpuscular volume 109 fL, platelets 73 × 109/L, and white blood cells 4.9 × 109/L with 23% basophils, 3% eosinophils, and 0% blasts. Bone marrow was slightly hypocellular, with trilineage dysplasia. Cytogenetic examination of the bone marrow cells revealed a normal karyotype, 46,XY. A diagnosis of myelodysplastic syndrome–refractory anemia with excess blasts type 2 (MDS-RAEB2) was made according to the WHO classification

綿チップ押しつぶし課題の舌圧測定への応用と嚥下課題教示手段としての効果

研究報告Original articles　本研究では，“綿チップ押しつぶし” 課題の有用性について検討した．第１実験では，嚥下障害者を含む102 名を対象に“綿チップ押しつぶし” 課題後の綿球のつぶれ具合とJMS 舌圧測定器の最大舌圧の相関分析，回帰分析を行い，綿球のつぶれ具合で舌圧を推測できるかを調べた．第２実験では，健常若年者20 名を対象に，綿チップ押しつぶしを教示に用いた嚥下（MS），Effortful swallow（ES），普通嚥下の舌圧発現様相を比較し，嚥下課題の教示に用いることの有効性を調べた．その結果，第１実験では，舌圧=12.117 ＋ 67.961 ×綿球水分変化量の回帰式が得られ（R2 =0.568），第２実験では，MS はES とほぼ同等に舌圧持続時間と舌圧最大値が高値を示し，さらに，MS では綿チップの押しつぶし課題でターゲットとした部位の舌前方部（Ch1）の舌圧発現が他測定点より有意に早く，Ch1の舌圧持続時間はES より有意に延長した．以上のことから，“綿チップ押しつぶし” 課題は，嚥下訓練において多彩な訓練ツールとして用いることができることが示された．The present study investigated the usefulness of a “cotton swab squashing” task to patients with dysphagia. The first experiment involved 102 subjects, including dysphagia patients. To determine whether the post-task state of the cotton swab could be used to measure tongue pressure, the state of the cotton swab after the squashing task was evaluated, and a correlational analysis with maximum tongue pressure measured with a JMS tongue pressuremeasurement device as well as regression analysis were conducted. To investigate the efficacyof the squashing task for use in swallowing task instructions, a second experiment, involving 20 young healthy volunteers, compared tongue pressure during swallowing, using cotton swab squashing （CS）, effortful swallowing （ES）, and normal swallowing. The results of the firstexperiment indicated a regression equation of maximum tongue pressure: 12.117 ＋ 67.961 ×the amount of change in the cotton tip moisture content （R2 ＝ 0.568）. The second experiment indicated high values for tongue pressure duration and maximum tongue pressure, which were roughly identical for both CS and ES. Furthermore, tongue pressure expression in CS at the tongue anterior site（ Ch1）, which was targeted in the cotton swab squashing task, was significantly faster than at other measurement sites, and the tongue pressure duration, at Ch1 in CS, was significantly longer than in the ES. The above findings demonstrate that the cotton swab squashing task can be used in diverse ways for dysphagia training

First Data Release of the Hyper Suprime-Cam Subaru Strategic Program

The Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) is a three-layered imaging survey aimed at addressing some of the most outstanding questions in astronomy today, including the nature of dark matter and dark energy. The survey has been awarded 300 nights of observing time at the Subaru Telescope and it started in March 2014. This paper presents the first public data release of HSC-SSP. This release includes data taken in the first 1.7 years of observations (61.5 nights) and each of the Wide, Deep, and UltraDeep layers covers about 108, 26, and 4 square degrees down to depths of i~26.4, ~26.5, and ~27.0 mag, respectively (5sigma for point sources). All the layers are observed in five broad bands (grizy), and the Deep and UltraDeep layers are observed in narrow bands as well. We achieve an impressive image quality of 0.6 arcsec in the i-band in the Wide layer. We show that we achieve 1-2 per cent PSF photometry (rms) both internally and externally (against Pan-STARRS1), and ~10 mas and 40 mas internal and external astrometric accuracy, respectively. Both the calibrated images and catalogs are made available to the community through dedicated user interfaces and database servers. In addition to the pipeline products, we also provide value-added products such as photometric redshifts and a collection of public spectroscopic redshifts. Detailed descriptions of all the data can be found online. The data release website is https://hsc-release.mtk.nao.ac.jp/.Comment: 34 pages, 20 figures, 7 tables, moderate revision, accepted for publication in PAS

The Japanese space gravitational wave antenna; DECIGO

DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. DECIGO is expected to open a new window of observation for gravitational wave astronomy especially between 0.1 Hz and 10 Hz, revealing various mysteries of the universe such as dark energy, formation mechanism of supermassive black holes, and inflation of the universe. The pre-conceptual design of DECIGO consists of three drag-free spacecraft, whose relative displacements are measured by a differential Fabry– Perot Michelson interferometer. We plan to launch two missions, DECIGO pathfinder and pre- DECIGO first and finally DECIGO in 2024

DECIGO pathfinder

DECIGO pathfinder (DPF) is a milestone satellite mission for DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) which is a future space gravitational wave antenna. DECIGO is expected to provide us fruitful insights into the universe, in particular about dark energy, a formation mechanism of supermassive black holes, and the inflation of the universe. Since DECIGO will be an extremely large mission which will formed by three drag-free spacecraft with 1000m separation, it is significant to gain the technical feasibility of DECIGO before its planned launch in 2024. Thus, we are planning to launch two milestone missions: DPF and pre-DECIGO. The conceptual design and current status of the first milestone mission, DPF, are reviewed in this article

The status of DECIGO

DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) is the planned Japanese space gravitational wave antenna, aiming to detect gravitational waves from astrophysically and cosmologically significant sources mainly between 0.1 Hz and 10 Hz and thus to open a new window for gravitational wave astronomy and for the universe. DECIGO will consists of three drag-free spacecraft arranged in an equilateral triangle with 1000 km arm lengths whose relative displacements are measured by a differential Fabry-Perot interferometer, and four units of triangular Fabry-Perot interferometers are arranged on heliocentric orbit around the sun. DECIGO is vary ambitious mission, we plan to launch DECIGO in era of 2030s after precursor satellite mission, B-DECIGO. B-DECIGO is essentially smaller version of DECIGO: B-DECIGO consists of three spacecraft arranged in an triangle with 100 km arm lengths orbiting 2000 km above the surface of the earth. It is hoped that the launch date will be late 2020s for the present

The Hyper Suprime-Cam SSP survey: Overview and survey design

Hyper Suprime-Cam (HSC) is a wide-field imaging camera on the prime focus of the 8.2-m Subaru telescope on the summit of Mauna Kea in Hawaii. A team of scientists from Japan, Taiwan, and Princeton University is using HSC to carry out a 300-night multi-band imaging survey of the high-latitude sky. The survey includes three layers: the Wide layer will cover 1400 deg2 in five broad bands (grizy), with a 5 σ point-source depth of r ≈ 26. The Deep layer covers a total of 26 deg2 in four fields, going roughly a magnitude fainter, while the UltraDeep layer goes almost a magnitude fainter still in two pointings of HSC (a total of 3.5 deg2). Here we describe the instrument, the science goals of the survey, and the survey strategy and data processing. This paper serves as an introduction to a special issue of the Publications of the Astronomical Society of Japan, which includes a large number of technical and scientific papers describing results from the early phases of this survey