The Remains of Friendship and the Ethics of Misreading: Melville, Emerson, Thoreau

A deconstructive approach to the philosophy of friendship that draws on works by Melville, Emerson and Thoreau

"Is There a Space of Maternal Ethics? Emma Donoghue's Room"

Emma Donoghue's 2010 novel, Room, is read as an allegory of parenting and as a brilliant account of the profoundly relational and ethical structure of subjecthood. This chapter draws on the work of Jessica Benjamin, D.W. Winnicott and Lisa Guenther

Introduction: Risking Feeling: Alice Munro’s Fiction of “Exquisite Shame”

This introduction places the volume in the context of previous scholarship on Munro and anchors the collection in the wealth of affect and ethical theory that has informed recent cultural studies. We argue that these new essays, taken together, offer us an Alice Munro who is not the kindly Canadian icon reinforcing small-town verities who was celebrated and perpetuated in acts of national teaching with her Nobel Prize win; they ponder, instead, an edgier, messier Munro whose fictions of affective and ethical perplexities disturb rather than comfort

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

A Jewish Rose by Any Other Name: Thoughts on the Regulation of Jewish Women’s Personal Names

Even as individuals are granted the right to name and be named, they are acting in the context of a given society, each with its own cultural and political designs. It follows that societies are wont to regulate the area of personal names. They do so by means, such as fashion and social pressure. In addition, as this article argues, the institution of law is intimately, if not always obviously, tied up with personal names and naming. Here the argument is made in conjunction with the naming of Jewish girls. In this regard, centuries of Jewish history have produced exceedingly similar findings: compared to men’s names, which tend to line-up in long, ongoing patrilineal formation, women’s names are somewhat fickle, changing from time to time, from place to place, discontinuing each other, if they are lucky enough to receive a mention at all. This article suggest that one of the reasons for the aforementioned “nominal” gender discrepancy is that the law has consistently considered only men’s names to be of importance, hence the dispensing of the shaping of women’s names to the more fleeting forces of fashion and so on, rather than the more enduring forces of tradition and inter-generational continuity, for example. In other words, it could be suggested that would the law had attributed more to Jewish women’s names, there might have been more to them.

Emergence des premiers mots

National audienc

Emergence des premiers mots

National audienc

Émergence des premiers mots

Extrait 2-1 – Chat ! Madeleine 1;01,10 à 10 min 50 s Extrait http://ct3.ortolang.fr/devlang/2-1-madeleine-chat-1-01-10.mp4 OBSERVATEUR là tu attaques le plastique Madeleine ! sit la mère de Madeleine est en train de lui donner un yaourt. MADELEINE chat ! xpnt montre la fenêtre de l’index MÈRE t(u) as vu un chat ? MÈRE mais non. MÈRE mais non y en a pas là. MADELEINE yyy ! pho [aja] xpnt Madeleine garde le doigt pointé vers la fenêtre MADELEINE chat ! MÈRE oui on en voit souvent mais là y en ..

Emergence des premiers mots

National audienc