Homogeneous bubble nucleation limit of mercury under the normal working conditions of the planned European Spallation Source

In spallation neutron sources, liquid mercury is the subject of big thermal and pressure shocks, upon adsorbing the proton beam. These changes can cause unstable bubbles in the liquid, which can damage the structural material. While there are methods to deal with the pressure shock, the local temperature shock cannot be avoided. In our paper we calculated the work of the critical cluster formation (i.e. for mercury micro-bubbles) together with the rate of their formation (nucleation rate). It is shown that the homogeneous nucleation rates are very low even after adsorbing several proton pulses, therefore the probability of temperature induced homogeneous bubble nucleation is negligible.Comment: 22 Pages, 11 figures, one of them is colour, we plan to publish it in Eur. Phys. J.

Histopathology of cryptococcosis and other fungal infections in patients with acquired immunodeficiency syndrome

AbstractObjective: To gain insight into the histopathologic characteristics of fungal infection in acquired immunodeficiency syndrome (AIDS).Methods: A review was conducted of the histopathology for 162 patients with evident fungal infection.Results: The microscopic appearance of esophageal candidiasis that was common in patients with single organ involvement revealed necrotic debris containing proliferating hyphae at the site of mucosal erosions without fungal invasion of underlying tissue. The incidence of oral and esophageal candidiasis was followed by that of pulmonary aspergillosis and Candida infection. Eighteen patients had generalized cryptococcosis, representing the commonest generalized fungal disease. The essential histologic features of the disease consisted of yeast cell proliferation with a histiocytic response, but only minor lymphocytic and neutrophilic components. This was different from the manifestations of both Candida and Aspergillus infections. The two histologic patterns recognized in the pulmonary cryptococcal lesions could be graded with respect to the degree and type of inflammatory reaction. The milder one consisted of small scattered foci of intra-alveolar cryptococcal proliferation with a histiocytic response. Another pattern involved massive cryptococcal infection, which might be simply more extensive than that in the former. Capillary involvement of alveolar septa was an important common finding in all 18 patients.Conclusions: The absence of T cells and decreasing function of antigen-presenting activity in histiocytes were confirmed by immunohistologic examination. These findings suggest that the lungs in AIDS patients provide little resistance to blood stream dissemination by cryptococci

Prognostic factors influencing clinical outcome of allogeneic hematopoietic stem cell transplantation following imatinib-based therapy in BCR–ABL-positive ALL

We investigated prognostic factors for the clinical outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) following imatinib-based therapy. Among 100 adult patients who were prospectively enrolled in the JALSG Ph+ALL202 study, 97 patients obtained complete remission (CR) by imatinib-combined chemotherapy, among whom 60 underwent allo-HSCT in their first CR. The probabilities of overall survival (OS) and disease-free survival (DFS) at 3 years after HSCT were 64% (95% CI, 49–76) and 58% (95% CI, 43–70), respectively. Prognostic factor analysis revealed that the major BCR–ABL transcript was the only unfavorable predictor for OS and DFS after HSCT by both univariate (HR, 3.67 (95% CI 1.49–9.08); P=0.005 and HR, 6.25 (95% CI, 1.88–20.8); P=0.003, respectively) and multivariate analyses (HR, 3.20 (95% CI, 1.21–8.50); P=0.019 and HR, 6.92 (95% CI, 2.09–22.9); P=0.002, respectively). Minimal residual disease status at the time of HSCT had a significant influence on relapse rate (P=0.015). Further study of the BCR–ABL subtype for the clinical impact on outcome of allo-HSCT in Ph+ALL is warranted

Runx proteins regulate Foxp3 expression

Runx proteins are essential for hematopoiesis and play an important role in T cell development by regulating key target genes, such as CD4 and CD8 as well as lymphokine genes, during the specialization of naive CD4 T cells into distinct T helper subsets. In regulatory T (T reg) cells, the signature transcription factor Foxp3 interacts with and modulates the function of several other DNA binding proteins, including Runx family members, at the protein level. We show that Runx proteins also regulate the initiation and the maintenance of Foxp3 gene expression in CD4 T cells. Full-length Runx promoted the de novo expression of Foxp3 during inducible T reg cell differentiation, whereas the isolated dominant-negative Runt DNA binding domain antagonized de novo Foxp3 expression. Foxp3 expression in natural T reg cells remained dependent on Runx proteins and correlated with the binding of Runx/core-binding factor β to regulatory elements within the Foxp3 locus. Our data show that Runx and Foxp3 are components of a feed-forward loop in which Runx proteins contribute to the expression of Foxp3 and cooperate with Foxp3 proteins to regulate the expression of downstream target genes

Evaluation of the Quasi‐Biennial Oscillation in global climate models for the SPARC QBO‐initiative

The Quasi‐Biennial Oscillation initiative (QBOi) is a model intercomparison programme that specifically targets simulation of the QBO in current global climate models. Eleven of the models or model versions that participated in a QBOi intercomparison study have upper boundaries in or above the mesosphere and therefore simulate the region where the stratopause semiannual oscillation (SAO) is the dominant mode of variability of zonal winds in the tropical upper stratosphere. Comparisons of the SAO simulations in these models are presented here. These show that the model simulations of the amplitudes and phases of the SAO in zonal‐mean zonal wind near the stratopause agree well with the information derived from available observations. However, most of the models simulate time‐average zonal winds that are more westward than determined from observations, in some cases by several tens of m·s$^{–1}$. Validation of wave activity in the models is hampered by the limited observations of tropical waves in the upper stratosphere but suggests a deficit of eastward forcing either by large‐scale waves, such as Kelvin waves, or by gravity waves

Comparison between non‐orographic gravity‐wave parameterizations used in QBOi models and Strateole 2 constant‐level balloons

Gravity‐wave (GW) parameterizations from 12 general circulation models (GCMs) participating in the Quasi‐Biennial Oscillation initiative (QBOi) are compared with Strateole 2 balloon observations made in the tropical lower stratosphere from November 2019–February 2020 (phase 1) and from October 2021–January 2022 (phase 2). The parameterizations employ the three standard techniques used in GCMs to represent subgrid‐scale non‐orographic GWs, namely the two globally spectral techniques developed by Warner and McIntyre (1999) and Hines (1997), as well as the “multiwaves” approaches following the work of Lindzen (1981). The input meteorological fields necessary to run the parameterizations offline are extracted from the ERA5 reanalysis and correspond to the meteorological conditions found underneath the balloons. In general, there is fair agreement between amplitudes derived from measurements for waves with periods less than 1 $$1$$ h and parameterizations. The correlation between the daily observations and the corresponding results of the parameterization can be around 0.4, which is 99 % $$99\%$$ significant, since 1200 days of observations are used. Given that the parameterizations have only been tuned to produce a quasi‐biennial oscillation (QBO) in the models, the 0.4 correlation coefficient of the GW momentum fluxes is surprisingly good. These correlations nevertheless vary between schemes and depend little on their formulation (globally spectral versus multiwaves for instance). We therefore attribute these correlations to dynamical filtering, which all schemes take into account, whereas only a few relate the gravity waves to their sources. Statistically significant correlations are mostly found for eastward‐propagating waves, which may be due to the fact that during both Strateole 2 phases the QBO is easterly at the altitude of the balloon flights. We also found that the probability density functions (pdfs) of the momentum fluxes are represented better in spectral schemes with constant sources than in schemes (“spectral” or “multiwaves”) that relate GWs only to their convective sources