The Iowa Homemaker vol.33, no.2

Tomorrow?, Salli Hearst, page 7 Where Will You Live, Jacquie Edwards and Mary Kay Pitzer, page 8 From Campus to Career Clothes, Jane Hammerly, page 10 Your Paycheck… It’s All Yours, Prof. Edna Douglas, page 11 Your Career Days, Nancy Butler, page 12 From Bathroom to Ballroom – Terry Cloth, Ruth Anderson, page 13 Alums in the News, Margaret Cole and Kay Scholten, page 14 Career Antics, Mary Jean Stoddard, page 16 Live While You Work, Beth Bailey McLean, page 18 Today – Freezer Magic, Pat Stiff, page 20 Tomorrow – 70-Second Dinners, Mary Ann Thorsen, page 20 Seniors Decide, Ruth Anderson, page 22 Be On Your Toes About Hose, Karla Baur, page 23 What’s New, Ann Lindemeyer and Dee Mingus, page 24 Scholarships Abroad, Doris Jirsa, page 26 Marriage or Career… Here’s Your Future, Dorothy Thompson, page 28 Information Please, Rachel Bernau and Margaret Mattison, page 29 Trends, Gwen Olson, page 3

The Iowa Homemaker vol.33, no.2

Tomorrow?, Salli Hearst, page 7 Where Will You Live, Jacquie Edwards and Mary Kay Pitzer, page 8 From Campus to Career Clothes, Jane Hammerly, page 10 Your Paycheck… It’s All Yours, Prof. Edna Douglas, page 11 Your Career Days, Nancy Butler, page 12 From Bathroom to Ballroom – Terry Cloth, Ruth Anderson, page 13 Alums in the News, Margaret Cole and Kay Scholten, page 14 Career Antics, Mary Jean Stoddard, page 16 Live While You Work, Beth Bailey McLean, page 18 Today – Freezer Magic, Pat Stiff, page 20 Tomorrow – 70-Second Dinners, Mary Ann Thorsen, page 20 Seniors Decide, Ruth Anderson, page 22 Be On Your Toes About Hose, Karla Baur, page 23 What’s New, Ann Lindemeyer and Dee Mingus, page 24 Scholarships Abroad, Doris Jirsa, page 26 Marriage or Career… Here’s Your Future, Dorothy Thompson, page 28 Information Please, Rachel Bernau and Margaret Mattison, page 29 Trends, Gwen Olson, page 30</p

Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a Myc/p53-Dependent Bottleneck in Lymphomagenesis

Retroviral insertional mutagenesis (RIM) is a powerful tool for cancer genomics that was combined in this study with deep sequencing (RIM/DS) to facilitate a comprehensive analysis of lymphoma progression. Transgenic mice expressing two potent collaborating oncogenes in the germ line (CD2-MYC, -Runx2) develop rapid onset tumours that can be accelerated and rendered polyclonal by neonatal Moloney murine leukaemia virus (MoMLV) infection. RIM/DS analysis of 28 polyclonal lymphomas identified 771 common insertion sites (CISs) defining a ‘progression network’ that encompassed a remarkably large fraction of known MoMLV target genes, with further strong indications of oncogenic selection above the background of MoMLV integration preference. Progression driven by RIM was characterised as a Darwinian process of clonal competition engaging proliferation control networks downstream of cytokine and T-cell receptor signalling. Enhancer mode activation accounted for the most efficiently selected CIS target genes, including Ccr7 as the most prominent of a set of chemokine receptors driving paracrine growth stimulation and lymphoma dissemination. Another large target gene subset including candidate tumour suppressors was disrupted by intragenic insertions. A second RIM/DS screen comparing lymphomas of wild-type and parental transgenics showed that CD2-MYC tumours are virtually dependent on activation of Runx family genes in strong preference to other potent Myc collaborating genes (Gfi1, Notch1). Ikzf1 was identified as a novel collaborating gene for Runx2 and illustrated the interface between integration preference and oncogenic selection. Lymphoma target genes for MoMLV can be classified into (a) a small set of master regulators that confer self-renewal; overcoming p53 and other failsafe pathways and (b) a large group of progression genes that control autonomous proliferation in transformed cells. These findings provide insights into retroviral biology, human cancer genetics and the safety of vector-mediated gene therapy.Computer Science & EngineeringElectrical Engineering, Mathematics and Computer Scienc

Enhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States

Coronavirus disease 2019 (COVID-19), the respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China and has since become pandemic. In response to the first cases identified in the United States, close contacts of confirmed COVID-19 cases were investigated to enable early identification and isolation of additional cases and to learn more about risk factors for transmission. Close contacts of nine early travel-related cases in the United States were identified and monitored daily for development of symptoms (active monitoring). Selected close contacts (including those with exposures categorized as higher risk) were targeted for collection of additional exposure information and respiratory samples. Respiratory samples were tested for SARS-CoV-2 by real-time reverse transcription polymerase chain reaction at the Centers for Disease Control and Prevention. Four hundred four close contacts were actively monitored in the jurisdictions that managed the travel-related cases. Three hundred thirty-eight of the 404 close contacts provided at least basic exposure information, of whom 159 close contacts had ≥1 set of respiratory samples collected and tested. Across all actively monitored close contacts, two additional symptomatic COVID-19 cases (i.e., secondary cases) were identified; both secondary cases were in spouses of travel-associated case patients. When considering only household members, all of whom had ≥1 respiratory sample tested for SARS-CoV-2, the secondary attack rate (i.e., the number of secondary cases as a proportion of total close contacts) was 13% (95% CI: 4–38%). The results from these contact tracing investigations suggest that household members, especially significant others, of COVID-19 cases are at highest risk of becoming infected. The importance of personal protective equipment for healthcare workers is also underlined. Isolation of persons with COVID-19, in combination with quarantine of exposed close contacts and practice of everyday preventive behaviors, is important to mitigate spread of COVID-19