CTGA: the database for genetic disorders in Arab populations

The Arabs comprise a genetically heterogeneous group that resulted from the admixture of different populations throughout history. They share many common characteristics responsible for a considerable proportion of perinatal and neonatal mortalities. To this end, the Centre for Arab Genomic Studies (CAGS) launched a pilot project to construct the ‘Catalogue of Transmission Genetics in Arabs’ (CTGA) database for genetic disorders in Arabs. Information in CTGA is drawn from published research and mined hospital records. The database offers web-based basic and advanced search approaches. In either case, the final search result is a detailed HTML record that includes text-, URL- and graphic-based fields. At present, CTGA hosts entries for 692 phenotypes and 235 related genes described in Arab individuals. Of these, 213 phenotypic descriptions and 22 related genes were observed in the Arab population of the United Arab Emirates (UAE). These results emphasize the role of CTGA as an essential tool to promote scientific research on genetic disorders in the region. The priority of CTGA is to provide timely information on the occurrence of genetic disorders in Arab individuals. It is anticipated that data from Arab countries other than the UAE will be exhaustively searched and incorporated in CTGA ()

Consanguinity and reproductive health among Arabs

Consanguineous marriages have been practiced since the early existence of modern humans. Until now consanguinity is widely practiced in several global communities with variable rates depending on religion, culture, and geography. Arab populations have a long tradition of consanguinity due to socio-cultural factors. Many Arab countries display some of the highest rates of consanguineous marriages in the world, and specifically first cousin marriages which may reach 25-30% of all marriages. In some countries like Qatar, Yemen, and UAE, consanguinity rates are increasing in the current generation. Research among Arabs and worldwide has indicated that consanguinity could have an effect on some reproductive health parameters such as postnatal mortality and rates of congenital malformations. The association of consanguinity with other reproductive health parameters, such as fertility and fetal wastage, is controversial. The main impact of consanguinity, however, is an increase in the rate of homozygotes for autosomal recessive genetic disorders. Worldwide, known dominant disorders are more numerous than known recessive disorders. However, data on genetic disorders in Arab populations as extracted from the Catalogue of Transmission Genetics in Arabs (CTGA) database indicate a relative abundance of recessive disorders in the region that is clearly associated with the practice of consanguinity

Genomics into Healthcare: the 5th Pan Arab Human Genetics Conference and 2013 Golden Helix Symposium.

The joint 5th Pan Arab Human Genetics conference and 2013 Golden Helix Symposium, \u22Genomics into Healthcare\u22 was coorganized by the Center for Arab Genomic Studies (http://www.cags.org.ae) in collaboration with the Golden Helix Foundation (http://www.goldenhelix.org) in Dubai, United Arab Emirates from 17 to 19 November, 2013. The meeting was attended by over 900 participants, doctors and biomedical students from over 50 countries and was organized into a series of nine themed sessions that covered cancer genomics and epigenetics, genomic and epigenetic studies, genomics of blood and metabolic disorders, cytogenetic diagnosis and molecular profiling, next-generation sequencing, consanguinity and hereditary diseases, clinical genomics, clinical applications of pharmacogenomics, and genomics in public health

Constraints on primordial gravitational waves from the cosmic microwave background

Searches for primordial gravitational waves have resulted in constraints in a large frequency range from a variety of sources. The standard Cosmic Microwave Background (CMB) technique is to parameterise the tensor power spectrum in terms of the tensor-to-scalar ratio, r, and spectral index, nt, and constrain these using measurements of the temperature and polarization power spectra. Another method, applicable to modes well inside the cosmological horizon at recombination, uses the shortwave approximation, under which gravitational waves behave as an effective neutrino species. In this paper we give model-independent CMB constraints on the energy density of gravitational waves, Ωgw h2, for the entire range of observable frequencies. On large scales, f 10−16 Hz, we reconstruct the initial tensor power spectrum in logarithmic frequency bins, finding maximal sensitivity for scales close to the horizon size at recombination. On small scales, f 10−15 Hz, we use the shortwave approximation, finding Ωgw h2 < 1.7 ×10−6 for adiabatic initial conditions and Ωgw h2 < 2.9 ×10−7 for homogeneous initial conditions (both 2σ upper limits). For scales close to the horizon size at recombination, we use second-order perturbation theory to calculate the back-reaction from gravitational waves, finding Ωgw h2 < 8.4 ×10−7, in the absence of neutrino anisotropic stress and Ωgw h2 < 8.6 ×10−7 when including neutrino anisotropic stress. These constraints are valid for 10−15 Hz f 3 × 10−16 Hz