Decision to delivery interval in emergency LSCS and its impact on fetal outcome

Background: Emergency LSCS can be categorized based on RCOG guidelines into category I and II which indicates maternal or fetal compromise. Here an urgent delivery and the DDI (decision to delivery interval) within 30 and 45 minutes respectively is needed.Methods: This is a retrospective cross-sectional analysis conducted on a sample of 630 patients who underwent caesarean section over a year, from June 2016 to June 2017. The DDI were further classified into ≤30 and >30 minutes for category I, ≤45 and >45 minutes for category II LSCS. The primary objective is to determine whether DDI in Category I and II emergency LSCS has an impact on fetal outcome and secondary objective is to ensure that DDI is within the standard criterion as per RCOG protocol.Results: Out of 630 samples of caesareans, it was found that 173 falls in Category I and 189 falls in Category II. Out of 87 (50.29%) patients delivered within 30 minutes in Category I, 29 babies required NICU admission. DDI was more than 30 minutes in 86 (49.71%) cases in Category I out of which 38 babies got admitted in NICU with low APGAR scores. Out of 176 (93.12%) patients who delivered within 45 minutes in Category II, 56 babies required NICU admission. DDI was more than 45 minutes in 13 (6.88%) cases in Category II and all these babies got admitted in NICU.Conclusions: Decision -delivery interval has a significant impact on fetal outcome

An encounter with alobar holoprosencephaly: a case report

Alobar holopresencephaly is a rare embryonic condition where there is anomalous fusion of cerebral hemispheres. The key features include neurological impairment and facial dysmorphism like cyclopia, ocular hypertelorism with divided orbits and a proboscis. Obstetric ultrasound and foetal MRI are the diagnostic modalities. Majority of cases are sporadic in origin while a genetic association is also described. A small recurrence risk is noted in cases with sporadic origin. Early diagnosis and pregnancy termination are advisable for the condition since the survival rate is very low

Amaranthus deflexus L. (Amaranthaceae), a new addition to Indian Flora

Few populations of Amaranthus deflexus L. were observed in Kerala region (SE-India), contributing the first record of this species to the national Flora. A morphological (macro and micro) description of the species, as well as ecological data are given. A note on the phenotypic plasticity exhibited by the taxon is also provided

Amaranthus powellii (Amaranthaceae), a new addition for the flora of India and a preliminary list of the Indian Amaranthus species

Three populations of Amaranthus powellii were discovered in Kerala region (SE-India), representing the first record of this species for the national flora. A morphological description based on the Indian plants, as well as ecological data are given. A preliminary list of all the Amaranthus species occurring in India, which was never published during the last 135 years, is also provided

Asystasia dalzelliana var. alba (Acanthaceae), a new variety from southern Western Ghats of Kerala, India

Asystasia dalzelliana var. alba, a new variety of the family Acanthaceae is described and illustrated from the southern Western Ghats of Kerala, India. The new variety differs from the typical variety with respect to color of flowers and lack of black blue bands on the anthers. Critical notes along with conservation status of the new variety are provided

A rare case of endometriosis to clear cell ovarian carcinoma: a case report

Clear cell carcinoma of ovary is a rare tumour with a very low incidence in pregnancy. It is attributed to develop from an existing background of endometriosis. There are very few case reports of the above combination tumours in pregnancy. It is a very aggressive tumour with a worse prognosis and low survival rate because of its peculiar chemo resistant nature. Early detection and effective treatment are the best approach. The treatment options for advanced stages are still under research

Optimization of Interior Spacing in Car with Help of Air Inflatable Seat

Automobile plays an inevitable role in the present world for transportation of people and goods. Much advancement has done in automobiles to increase various aspects like aesthetics, safety, comfort and engine performance etc., among this, one of the major requirements of modern automobiles is to increase fuel economy. Every design modification that has been made in automobile will need to meet with requirement of increase in fuel economy and engine performance. On considering Indian consumers, their usage and requirements are multipurpose. Their requirement is about having comfortable seating and also having additional space for goods, if the need arise. To comply with above requirement of Indian consumers with improved fuel economy, various concepts are discussed. One among the factor was seat weight. This can be modified by implanting inflatable seats in automobile

In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment

Tractable experimental model that accounts for inter-tumor molecular heterogeneity is a key element of anti-cancer drug development. Hepatocellular carcinoma is known to exhibit highly heterogeneous molecular aberrations across the tumors, including somatic genetic and epigenetic alterations. Previous studies showed that molecular tumor subtypes determined by transcriptome, as a comprehensive functional readout, are reproducibly observed across global patient populations irrespective of geographic and etiological variations. Here we demonstrate that transcriptomic hepatocellular carcinoma subtypes, S1 and S2, determined by our previous transcriptome meta-analysis of multiple clinical hepatocellular carcinoma cohorts, are presented in a panel of hepatoma cell lines widely used by the research community. Interestingly, cell line that resembles gene expression pattern of S3 subtype, representing less aggressive tumors, was not identified in the panel. MYC pathway-activated S2-like cell lines showed higher sensitivity to a small molecule BET bromodomain inhibitor, (+)-JQ1, which has anti-MYC activity. These results support the use of hepatoma cell lines as models to evaluate molecular subtype-specific drug response, which is expected to lead to development of tailored, precision care of the patients with hepatocellular carcinoma

Molecular liver cancer prevention in cirrhosis by organ transcriptome analysis and lysophosphatidic acid pathway inhibition

Cirrhosis is a milieu that develops hepatocellular carcinoma (HCC), the second most lethal cancer worldwide. HCC prediction and prevention in cirrhosis are key unmet medical needs. Here we have established an HCC risk gene signature applicable to all major HCC etiologies: hepatitis B/C, alcohol, and non-alcoholic steatohepatitis. A transcriptome meta-analysis of >500 human cirrhotics revealed global regulatory gene modules driving HCC risk and the lysophosphatidic acid pathway as a central chemoprevention target. Pharmacological inhibition of the pathway in vivo reduced tumors and reversed the gene signature, which was verified in organotypic ex vivo culture of patient-derived fibrotic liver tissues. These results demonstrate the utility of clinical organ transcriptome to enable a strategy, namely, reverse-engineering precision cancer prevention