Adiposity, reproductive and metabolic health, and activity levels in zoo Asian elephant (Elephas maximus)

Acknowledgements The authors thank Dr Barbara Gower, Maryellen Williams, Heather Hunter and Cindy Zeng at the UAB NORC's Metabolism Core for their assistance with hormone assays and mass spectroscopy, and Dr Katie Edwards, Steve Paris and Niki Boisseau at SCBI for inflammatory and estradiol analyses. The authors thank African Lion Safari, Cincinnati Zoo & Botanical Garden, Columbus Zoo & Aquarium, Fort Worth Zoo, Little Rock Zoo, Oklahoma City Zoo, Oregon Zoo, Santa Barbara Zoo and Saint Louis Zoo for their participation in this study. Specifically, a very big thank you to the zoos' elephant keepers and elephants, who made this study possible and enjoyable. A special thank you to the Birmingham Zoo and Pat Flora and his elephant team for their continued support, help and input with method improvement. Funding This work was supported in part by the Smithsonian Institution, the UAB Nutrition Obesity Research Center (P30DK056336), the Diabetes Research Center (P30DK079626), the Nathan Shock Center on Aging (P30AG050886), and the National Heart, Lung, and Blood Institute (T32HL105349 to D.E.C.). Deposited in PMC for release after 12 months.Peer reviewedPublisher PD

Synthesis and pharmacological investigation of new N-hydroxyalkyl-2-aminophenothiazines exhibiting marked MDR inhibitory effect

Novel N-hydroxyalkyl-2-aminophenothiazines implying a tetrazole moiety at the alkyl chain have been synthesized by hydroboration-oxidation of dienes followed by Buchwald-Hartwig cross-coupling reaction. Also, some sulfoxide and sulfone derivatives have been prepared by selective oxidations. MDR inhibition studies on rat hepatocyte cell culture revealed that some derivatives exhibit marked biological efficacy exceeding that of the standard verapamil (e.g. 3h, 4h, 16). Selected derivatives were subjected to chemical resolution to provide both enantiomers which were shown of similar activity on P-gp interaction measurements. The new compounds exhibited no toxicit

Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation

In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According to the mechanical measurements, the tensile strength of the membranes is comparable to those of soft the connective tissues and visceral tissues. Furthermore, the suture retention test suggests, that the membranes would withstand surgical handling and in vivo fixation. The in vivo biocompatibility study demonstrates how membranes undergo in vivo hydrolysis and by the 3rd day they become poly(aspartic acid) fibrous membranes, which can be then enzymatically degraded. After one week, the disulfide crosslinked membranes almost completely degrade, while the alkyl-chain crosslinked ones mildly lose their integrity as the surrounding tissue invades them. Histopathology revealed mild acute inflammation, which diminished to a minimal level after seven days

Sorösszegzés regularizációi

Szakdolgozatomban a divergens sorok összegzésével foglalkozunk. Az elején tisztázzuk a regularizáció axiómáit. A dolgozat folyamán négy féle összegzési eljárást hasonlítunk össze: A szokásos értelemben vett összegzést,a Cesàro-, az Abel- és a Borel-féle összegzést, majd megállapítunk egy erőviszonyt. Ezekre az eljárásokra mutatunk 1-1 példát, majd ellenőrízzük, hogy valóban teljesülnek-e a regularizációra megismert axiómák. Végül a Cesàro-összegzésre nézünk egy alkalmazást, melyben ismertetjük Fejér Lipót híres tételét.BSc/BAMatematikag