Geospatial approach for assessment of groundwater quality

The increasing population, erratic distribution of rainfall, and their rising demand for water in domestic and irrigation are fulfilled by groundwater resources. Due to overexploitation, there is the deterioration of groundwater quality, and hence to evaluate the groundwater quality, a study was undertaken to understand the water suitability for drinking as well as for irrigation purposes. For this study, five villages, namely Kumulur, Tachankurunchi, Pudurutamanur, Pandaravadai and Poovalur, were selected from Trichy District, Tamil Nadu, India, with an aerial extent of 45.1 km2. For the water quality assessment, samples were drawn from 53 locations from the sources like open wells, bore wells and hand pumps, etc. Parameters of pH, EC, TDS, Anions—CO3-2, CO3 2−, HCO3−, Cl−, SO42-, Cations—Ca2+, Mg2+, B3+, Na+ and potassium (K+) were estimated using the standard analytical procedure in three different seasons, viz., S-I (September 2019), S-II (December 2019) and S-III (March 2020). The WQI was computed for drinking water quality and found that 25% of samples in S-I, 80% samples in S-II and 83% samples in S-III were above the permissible limit for drinking purposes. Indices like Sodium Percentage, Sodium Adsorption Ratio, Permeability Index, Kelly’s Ratio, Magnesium Hazard Ratio, Potential Salinity, USSL Diagram, Wilcox Plot, Piper Diagram and Gibbs plot were evaluated for examining irrigation water quality. The results revealed that in 90% of the area, the water is suitable for irrigation purposes and a few locations (10%) wherein the salt content of water is relatively higher than the entire study area.</p

Reflection confocal nanoscopy using a super-oscillatory lens

A Superoscillatory lens (SOL) is known to produce a sub-diffraction hotspot which is useful for high-resolution imaging. However, high-energy rings called sidelobes coexist with the central hotspot. Additionally, SOLs have not yet been directly used to image reflective objects due to low efficiency and poor imaging properties. We propose a novel reflection confocal nanoscope which mitigates these issues by relaying the SOL intensity pattern onto the object and use conventional optics for detection. We experimentally demonstrate super-resolution by imaging double bars with 330 nm separation using a 632.8 nm excitation and a 0.95 NA objective. We also discuss the enhanced contrast properties of the SOL nanoscope against a laser confocal microscope, and the degradation of performance while imaging large objects.Comment: 17 pages, 15 figures, supplementary include

Reflection confocal nanoscopy using a super-oscillatory lens

A superoscillatory lens (SOL) is known to produce a sub-diffraction hotspot that is useful for high-resolution imaging. SOLs have not yet been directly used in a confocal reflection setup, as the SOL suffers from poor imaging properties. Additionally, the illuminating intensity distribution of the SOL still has high-intensity rings called sidelobes coexisting with the central hotspot. By means of a reflection setup, which does not have the SOL in the detection chain, thereby mitigating the poor imaging properties, we assessed the resolution capabilities of a SOL. This was done for different objects, whose dimensions were both above and below the SOL field-of-view (FOV). We found that the sidelobe illumination degrades the imaging properties in the case of extended objects, limiting the applicability of a SOL system

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attributable burden of disease for 88 risk factors in 204 countries and territories and 811 subnational locations, from 1990 to 2021. Methods: The GBD 2021 risk factor analysis used data from 54 561 total distinct sources to produce epidemiological estimates for 88 risk factors and their associated health outcomes for a total of 631 risk–outcome pairs. Pairs were included on the basis of data-driven determination of a risk–outcome association. Age-sex-location-year-specific estimates were generated at global, regional, and national levels. Our approach followed the comparative risk assessment framework predicated on a causal web of hierarchically organised, potentially combinative, modifiable risks. Relative risks (RRs) of a given outcome occurring as a function of risk factor exposure were estimated separately for each risk–outcome pair, and summary exposure values (SEVs), representing risk-weighted exposure prevalence, and theoretical minimum risk exposure levels (TMRELs) were estimated for each risk factor. These estimates were used to calculate the population attributable fraction (PAF; ie, the proportional change in health risk that would occur if exposure to a risk factor were reduced to the TMREL). The product of PAFs and disease burden associated with a given outcome, measured in disability-adjusted life-years (DALYs), yielded measures of attributable burden (ie, the proportion of total disease burden attributable to a particular risk factor or combination of risk factors). Adjustments for mediation were applied to account for relationships involving risk factors that act indirectly on outcomes via intermediate risks. Attributable burden estimates were stratified by Socio-demographic Index (SDI) quintile and presented as counts, age-standardised rates, and rankings. To complement estimates of RR and attributable burden, newly developed burden of proof risk function (BPRF) methods were applied to yield supplementary, conservative interpretations of risk–outcome associations based on the consistency of underlying evidence, accounting for unexplained heterogeneity between input data from different studies. Estimates reported represent the mean value across 500 draws from the estimate's distribution, with 95% uncertainty intervals (UIs) calculated as the 2·5th and 97·5th percentile values across the draws. Findings: Among the specific risk factors analysed for this study, particulate matter air pollution was the leading contributor to the global disease burden in 2021, contributing 8·0% (95% UI 6·7–9·4) of total DALYs, followed by high systolic blood pressure (SBP; 7·8% [6·4–9·2]), smoking (5·7% [4·7–6·8]), low birthweight and short gestation (5·6% [4·8–6·3]), and high fasting plasma glucose (FPG; 5·4% [4·8–6·0]). For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. Age-standardised global DALY rates attributable to high BMI and high FPG rose considerably (15·7% [9·9–21·7] for high BMI and 7·9% [3·3–12·9] for high FPG) over this period, with exposure to these risks increasing annually at rates of 1·8% (1·6–1·9) for high BMI and 1·3% (1·1–1·5) for high FPG. By contrast, the global risk-attributable burden and exposure to many other risk factors declined, notably for risks such as child growth failure and unsafe water source, with age-standardised attributable DALYs decreasing by 71·5% (64·4–78·8) for child growth failure and 66·3% (60·2–72·0) for unsafe water source. We separated risk factors into three groups according to trajectory over time: those with a decreasing attributable burden, due largely to declining risk exposure (eg, diet high in trans-fat and household air pollution) but also to proportionally smaller child and youth populations (eg, child and maternal malnutrition); those for which the burden increased moderately in spite of declining risk exposure, due largely to population ageing (eg, smoking); and those for which the burden increased considerably due to both increasing risk exposure and population ageing (eg, ambient particulate matter air pollution, high BMI, high FPG, and high SBP). Interpretation: Substantial progress has been made in reducing the global disease burden attributable to a range of risk factors, particularly those related to maternal and child health, WaSH, and household air pollution. Maintaining efforts to minimise the impact of these risk factors, especially in low SDI locations, is necessary to sustain progress. Successes in moderating the smoking-related burden by reducing risk exposure highlight the need to advance policies that reduce exposure to other leading risk factors such as ambient particulate matter air pollution and high SBP. Troubling increases in high FPG, high BMI, and other risk factors related to obesity and metabolic syndrome indicate an urgent need to identify and implement interventions

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

Advances in physical organic chemistry

Abstract. A critical component in the design of secure processors is memory encryption which provides protection for the privacy of code and data stored in off-chip memory. The overhead of the decryption operation that must precede a load requiring an off-chip memory access, decryption being on the critical path, can significantly degrade performance. Recently hardware counter-based one-time pad encryption techniques [11, 13, 9] have been proposed to reduce this overhead. For highend processors the performance impact of decryption has been successfully limited due to: presence of fairly large on-chip L1 and L2 caches that reduce off-chip accesses; and additional hardware support proposed in [13, 9] to reduce decryption latency. However, for low- to medium-end embedded processors the performance degradation is high because first they only support small (if any) on-chip L1 caches thus leading to significant off-chip accesses and second the hardware cost of decryption latency reduction solutions in [13, 9] is too high making them unattractive for embedded processors. In this paper we present a compiler-assisted strategy that uses minimal hardware support to reduce the overhead of memory encryption in low- to medium-end embedded processors. Our experiments show that the proposed technique reduces average execution time overhead of memory encryption for low-end (medium-end) embedded processor with 0 KB (32 KB) L1 cache from 60 % (13.1%), with single counter, to 12.5 % (2.1%) by additionally using only 8 hardware counter-registers.