Dengue and dengue haemorrhagic fever: implications of host genetics

Little is known of the role of human leucocyte antigen (HLA) alleles or non-HLA alleles in determining resistance, susceptibility or the severity of acute viral infections. Dengue fever (DF) and dengue haemorrhagic fever (DHF) are suitable models for immunogenetic studies, yet only superficial efforts have been made to study dengue disease to date. DF and DHF can be caused by both primary and secondary infection by any of the four serotypes of the dengue virus. Differences in host susceptibility to infectious disease and disease severity cannot be attributed solely to the virus virulence. Variations in immune response, often associated with polymorphism in the human genome, can now be detected. Data on the influence of human genes in DF and DHF are discussed here in relation to (1) associations between HLA polymorphism and dengue disease susceptibility or resistance, (2) protective alleles influencing progression to severe disease, (3) alleles restricting CD4+ and CD8+ T lymphocytes, and (4) non-HLA genetic factors that may contribute to DHF evolution. Recent discoveries regarding genetic associations in other viral infections may provide clues to understanding the development of end-stage complications in dengue disease. The scanty positive data presented here indicate a need for detailed genetic studies in different ethnic groups in different countries during the acute phase of DF and DHF on a larger number of patients

Performing Embodied Translations: Decolonizing Methodologies of Knowing and Being

This performance and transcript emerge from a collaborative journey that grapples with what it might mean to agitate dominant pedagogical and methodological conventions of Eurocentric Angophone academia. Together, we perform an argument and a search: for multiple entry points into decolonizing feminisms; for multiple modes of knowing and being that can interrupt and challenge the epistemes that are rooted in thoughts and practices of colonialism and coloniality; for interrogating the dominant politics of citation that often operate in academic practices in disembodied ways. We search for a politics of knowing that is firmly rooted in relationalities where power and authority can be shared across uneven and unequal locations and languages. We invite you to step into the spaces that we have started imagining here and push all of our collective conversations and imaginations further, beyond the silos that cage us in our disciplined modes of thinking, writing, arguing, and dreaming

Dengue virus-specific suppressor T cells: current perspectives

Dengue virus was the first microorganism that was shown to induce generation of antigen-specific suppressor T (TS) cells in mice. The cascade of the three generations of TS cells (TS1, TS2, TS3) and their secretary products, the suppressor factors (SF1, SF2), was delineated. The TS pathway was proposed to be protective through inhibition of the production of enhancing antibody, which may enhance the severity of dengue disease. The currently second most favoured mechanism of severe dengue disease is the 'cytokine tsunami'. During the last decade, suppressor/regulatory T cells have been studied in greater detail using modern techniques in various diseases, including viral infections. This brief review discusses the role of dengue-specific suppressor T cells in protection and/or induction of severe dengue disease in view of our current understanding of suppressor/regulatory T cells

Effect of air pollutants on physiological parameters and yield attributes of paddy and wheat crops in Faridabad region, India

Air pollution is one of the major problems in the Delhi NCR region due to industrial emissions, traffic congestion, population growth and rapid development. Air pollutants deteriorate the environment, human health, plants and crops. This study focuses on the physiological parameters and yield attributes of paddy and wheat crops in the vicinity of a gas-based national thermal power plant (NTPC) located in Faridabad. Ten sites were selected, including the control site within a 10 km aerial distance from the exhaust chimney stack of the power plant. Major air pollutants, such as NOx, SOx, O3, and PM10, were monitored using Central Pollution Control Board (CPCB) guidelines. The air quality index (AQI) was moderately polluted at the sampling site, while good air quality was observed at the control site. The results showed that the photosynthetic rates were reduced to 46% in paddies and 48% in wheat crops. In the vegetative growth stage of paddies and wheat crops, the stomatal conductance of paddies decreased to 0.11 mmol m-2s-1 compared to 0.19 mmol m-2s-1 at the control site. The transpiration rate ranged from 0.6 to 7.7 μmol/m2/s in paddies and 1.2 to 9.8 μmol/m2/s in wheat crops. The R2 value ranged from 0.702 to 0.985, which shows a strong impact of the air quality index on the physiological parameters of crops. The yield reduction due to air pollution in paddies was 11.6%, and in wheat crops, it was 14.8%. This study also provides an inventory of air pollutants in Faridabad region and their subsequent impacts on crops

Effect of pretreatment with chromium picolinate on haematological parameters during dengue virus infection in mice

Background & objectives: Dengue virus (DV) has caused severe epidemics of dengue fever (DF) and dengue haemorrhagic fever (DHF) and is endemic all over India. We have earlier reported that exposure of mice to hexavalent chromium [Cr(VI)] compounds increased the severity of dengue virus infection. Trivalent chromium picolinate (CrP) is used worldwide as micronutrient and nutritional supplement. The present study was therefore, carried out to investigate the effects of CrP on various haematological parameters during DV infection of mice. Methods: The Swiss Albino smice were inoculated with dengue virus (1000 LD50, intracerebrally) and fed with chromium picolinate (CrP) in drinking water (100 and 250 mg/l) for 24 wk. Peripheral blood leucocytes and other haematological parameters, and spleens were studied on days 4 and 8 after virus inoculations and the findings were compared with those given only CrP and the normal control age matched mice. Results: CrP in drinking water for 24 wk had no significant effects on peripheral blood cells of mice. On the other hand, there was significant decrease in different haematological parameters following inoculation of normal mice with DV. In CrP fed mice the effects of DV infection were abolished on most of the haematological parameters. Interpretation & conclusions: The findings of present study showed that the adverse effects of DV infection, specially on platelets and leucocytes, were abrogated by pretreatment of mice with CrP. The therapeutic utility of CrP in viral infections including dengue needs to be studied in depth

Escaping a migrant metropolis: Post-Soviet urbanization through the art project Nasreddin in Russia

This article narrates the politics of escape from borders and labour discipline in a post-Soviet migrant metropolis drawing on the art-activism project Nasreddin in Russia. It explores the relation between control and autonomy in urban migrations through a trans-aesthetics: a set of visual and verbal stories weaving together experiences and outcomes of the art project with academic debates on late capitalist urbanization. The encounter of artistic practices and migrants’ embodied, everyday struggles to inhabit the city, it is suggested, has potential for disrupting the disciplinary and exclusionary effects of capitalist transformations and migration enforcement. This is made visible through transient spaces of escape in which the everyday lives and social worlds of migrants, constrained by the precarization of labour and by the multiplication and diversification of bordering practices, are reclaimed through laughter, mobility and care. This point is illustrated by focusing on three such spaces and practices: trickster politics in the housing market, acts of disidentification and care work on the city ‘as a body.’ The article offers a methodologically innovative contribution to ongoing debates on aesthetic political economy, cities and borders and artistic and activist interventions in global cities.Peer reviewe

Refusals, radical vulnerability, and hungry translations – a conversation with Richa Nagar

Richa Nagar is Professor of Gender, Women, and Sexuality Studies and holds the title of Professor of the College at the University of Minnesota. Her multilingual and multi-genre work blends scholarship, creative writing, theatre, and activism to build alliances with people’s struggles and to engage questions of ethics, responsibility, and justice. We contacted Richa in December 2021 with a request to contribute to our special issue. Richa kindly agreed to engage in a written conversation on questions of refusal as they emerge in her intellectual and political journey and in her trilogy, Playing with Fire: Feminist Thought and Activism through Seven Lives in India (2006), Muddying the Waters: Coauthoring Feminisms Across Scholarship and Activism (2014), and Hungry Translations: Relearning the World Through Radical Vulnerability (2019). We present that conversation in this article

Macrophage and dengue virus: friend or foe?

The cells of monocyte-macrophage (Mφ) lineage play important roles both in innate and adaptive immune responses. They are the first line of defence in body and their job is to phagocytose a foreign invader, the pathogen, digest it and remove it. Mφ help body in mounting the antigenspecific immune response by presenting the digested pathogen antigen in conjunction with major histocompatibility complex (MHC) class II molecules to recruit B and T lymphocytes response. Usually Mφ succeed in their job of eliminating most pathogens from the body but sometimes the pathogen strikes a "friendship" with them and starts using them for its benefit. A number of pathogens, including dengue virus (DV), subvert Mφ and use them for their replication, increasing the severity of damage to the body. This duality may be related to the fact that Mφ serve as efficient host cell for DV replication, in addition to being responsible for innate immunity and for initiating adaptive immune responses. This review gives a brief overview of the various roles of Mφ (enmity and friendship) during dengue virus infection