810 research outputs found
The Kolmogorov-Smirnov test for the CMB
We investigate the statistics of the cosmic microwave background using the
Kolmogorov-Smirnov test. We show that, when we correctly de-correlate the data,
the partition function of the Kolmogorov stochasticity parameter is compatible
with the Kolmogorov distribution and, contrary to previous claims, the CMB data
are compatible with Gaussian fluctuations with the correlation function given
by standard Lambda-CDM. We then use the Kolmogorov-Smirnov test to derive upper
bounds on residual point source power in the CMB, and indicate the promise of
this statistics for further datasets, especially Planck, to search for
deviations from Gaussianity and for detecting point sources and Galactic
foregrounds.Comment: Improved significance of the results (which remain unchanged) by
using patches instead of ring segments in the analysis. Added sky maps of the
Kolmogorov-parameter for original and de-correlated CMB ma
A systematic review investigating fatigue, psychological and cognitive impairment following TIA and minor stroke:protocol paper
Approximately 20,000 people have a transient ischemic attack (TIA) and 23,375 have a minor stroke in England each year. Fatigue, psychological and cognitive impairments are well documented post-stroke. Evidence suggests that TIA and minor stroke patients also experience these impairments; however, they are not routinely offered relevant treatment. This systematic review aims to: (1) establish the prevalence of fatigue, anxiety, depression, post-traumatic stress disorder (PTSD) and cognitive impairment following TIA and minor stroke and to investigate the temporal course of these impairments; (2) explore impact on quality of life (QoL), change in emotions and return to work; (3) identify where further research is required and to potentially inform an intervention study
Fast and precise map-making for massively multi-detector CMB experiments
Future cosmic microwave background (CMB) polarisation experiments aim to
measure an unprecedentedly small signal - the primordial gravity wave component
of the polarisation field B-mode. To achieve this, they will analyse huge
datasets, involving years worth of time-ordered data (TOD) from massively
multi-detector focal planes. This creates the need for fast and precise methods
to complement the M-L approach in analysis pipelines. In this paper, we
investigate fast map-making methods as applied to long duration, massively
multi-detector, ground-based experiments, in the context of the search for
B-modes. We focus on two alternative map-making approaches: destriping and TOD
filtering, comparing their performance on simulated multi-detector polarisation
data. We have written an optimised, parallel destriping code, the DEStriping
CARTographer DESCART, that is generalised for massive focal planes, including
the potential effect of cross-correlated TOD 1/f noise. We also determine the
scaling of computing time for destriping as applied to a simulated full-season
data-set for a realistic experiment. We find that destriping can out-perform
filtering in estimating both the large-scale E and B-mode angular power
spectra. In particular, filtering can produce significant spurious B-mode power
via EB mixing. Whilst this can be removed, it contributes to the variance of
B-mode bandpower estimates at scales near the primordial B-mode peak. For the
experimental configuration we simulate, this has an effect on the possible
detection significance for primordial B-modes. Destriping is a viable
alternative fast method to the full M-L approach that does not cause the
problems associated with filtering, and is flexible enough to fit into both M-L
and Monte-Carlo pseudo-Cl pipelines.Comment: 16 pages, 14 figures. MNRAS accepted. Typos corrected and computing
time/memory requirement orders-of-magnitude numbers in section 4 replaced by
precise number
Survey strategy optimization for the Atacama Cosmology Telescope
In recent years there have been significant improvements in the sensitivity
and the angular resolution of the instruments dedicated to the observation of
the Cosmic Microwave Background (CMB). ACTPol is the first polarization
receiver for the Atacama Cosmology Telescope (ACT) and is observing the CMB sky
with arcmin resolution over about 2000 sq. deg. Its upgrade, Advanced ACTPol
(AdvACT), will observe the CMB in five frequency bands and over a larger area
of the sky. We describe the optimization and implementation of the ACTPol and
AdvACT surveys. The selection of the observed fields is driven mainly by the
science goals, that is, small angular scale CMB measurements, B-mode
measurements and cross-correlation studies. For the ACTPol survey we have
observed patches of the southern galactic sky with low galactic foreground
emissions which were also chosen to maximize the overlap with several galaxy
surveys to allow unique cross-correlation studies. A wider field in the
northern galactic cap ensured significant additional overlap with the BOSS
spectroscopic survey. The exact shapes and footprints of the fields were
optimized to achieve uniform coverage and to obtain cross-linked maps by
observing the fields with different scan directions. We have maximized the
efficiency of the survey by implementing a close to 24 hour observing strategy,
switching between daytime and nighttime observing plans and minimizing the
telescope idle time. We describe the challenges represented by the survey
optimization for the significantly wider area observed by AdvACT, which will
observe roughly half of the low-foreground sky. The survey strategies described
here may prove useful for planning future ground-based CMB surveys, such as the
Simons Observatory and CMB Stage IV surveys.Comment: 14 Pages, 9 Figures, 4 Table
CMBPol Mission Concept Study: Prospects for polarized foreground removal
In this report we discuss the impact of polarized foregrounds on a future
CMBPol satellite mission. We review our current knowledge of Galactic polarized
emission at microwave frequencies, including synchrotron and thermal dust
emission. We use existing data and our understanding of the physical behavior
of the sources of foreground emission to generate sky templates, and start to
assess how well primordial gravitational wave signals can be separated from
foreground contaminants for a CMBPol mission. At the estimated foreground
minimum of ~100 GHz, the polarized foregrounds are expected to be lower than a
primordial polarization signal with tensor-to-scalar ratio r=0.01, in a small
patch (~1%) of the sky known to have low Galactic emission. Over 75% of the sky
we expect the foreground amplitude to exceed the primordial signal by about a
factor of eight at the foreground minimum and on scales of two degrees. Only on
the largest scales does the polarized foreground amplitude exceed the
primordial signal by a larger factor of about 20. The prospects for detecting
an r=0.01 signal including degree-scale measurements appear promising, with 5
sigma_r ~0.003 forecast from multiple methods. A mission that observes a range
of scales offers better prospects from the foregrounds perspective than one
targeting only the lowest few multipoles. We begin to explore how optimizing
the composition of frequency channels in the focal plane can maximize our
ability to perform component separation, with a range of typically 40 < nu <
300 GHz preferred for ten channels. Foreground cleaning methods are already in
place to tackle a CMBPol mission data set, and further investigation of the
optimization and detectability of the primordial signal will be useful for
mission design.Comment: 42 pages, 14 figures, Foreground Removal Working Group contribution
to the CMBPol Mission Concept Study, v2, matches AIP versio
Determinants of Fatigue after First-Ever Ischemic Stroke during Acute Phase
© 2014 The Authors. Published by PLOS. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1371/journal.pone.0110037
A correction to the article was made on 19/12/2012: https://doi.org/10.1371/journal.pone.011646
A multicenter study on Leigh syndrome: Disease course and predictors of survival
Background: Leigh syndrome is a progressive neurodegenerative disorder, associated with primary or secondary dysfunction of the mitochondrial oxidative phosphorylation. Despite the fact that Leigh syndrome is the most common phenotype of mitochondrial disorders in children, longitudinal natural history data is missing. This study was undertaken to assess the phenotypic and genotypic spectrum of patients with Leigh syndrome, characterise the clinical course and identify predictors of survival in a large cohort of patients. Methods. This is a retrospective study of patients with Leigh syndrome that have been followed at eight centers specialising in mitochondrial diseases in Europe; Gothenburg, Rotterdam, Helsinki, Copenhagen, Stockholm, Brussels, Bergen and Oulu. Results: A total of 130 patients were included (78 males; 52 females), of whom 77 patients had identified pathogenic mutations. The median age of disease onset was 7 months, w
Simplifying the clinical classification of polymerase gamma (POLG) disease based on age of onset; studies using a cohort of 155 cases
Background: Variants in POLG are one of the most common causes of inherited mitochondrial disease. Phenotypic classification of POLG disease has evolved haphazardly making it complicated and difficult to implement in everyday clinical practise. The aim of our study was to simplify the classification and facilitate better clinical recognition. /
Methods: A multinational, retrospective study using data from 155 patients with POLG variants recruited from seven European countries. /
Results: We describe the spectrum of clinical features associated with POLG variants in the largest known cohort of patients. While clinical features clearly form a continuum, stratifying patients simply according to age of onset—onset prior to age 12 years; onset between 12 and 40 years and onset after the age of 40 years, permitted us to identify clear phenotypic and prognostic differences. Prior to 12 years of age, liver involvement (87%), seizures (84%), and feeding difficulties (84%) were the major features. For those with onset between 12 and 40 years, ataxia (90%), peripheral neuropathy (84%), and seizures (71%) predominated, while for those with onset over 40 years, ptosis (95%), progressive external ophthalmoplegia (89%), and ataxia (58%) were the major clinical features. The earlier the onset the worse the prognosis. Patients with epilepsy and those with compound heterozygous variants carried significantly worse prognosis. /
Conclusion: Based on our data, we propose a simplified POLG disease classification, which can be used to guide diagnostic investigations and predict disease course
The impact of gender, puberty, and pregnancy in patients with POLG disease
OBJECTIVE: To study the impact of gender, puberty, and pregnancy on the expression of POLG disease, one of the most common mitochondrial diseases known. METHODS: Clinical, laboratory, and genetic data were collected retrospectively from 155 patients with genetically confirmed POLG disease recruited from seven European countries. We used the available data to study the impact of gender, puberty, and pregnancy on disease onset and deterioration. RESULTS: We found that disease onset early in life was common in both sexes but there was also a second peak in females around the time of puberty. Further, pregnancy had a negative impact with 10 of 14 women (71%) experiencing disease onset or deterioration during pregnancy. INTERPRETATION: Gender clearly influences the expression of POLG disease. While onset very early in life was common in both males and females, puberty in females appeared associated both with disease onset and increased disease activity. Further, both disease onset and deterioration, including seizure aggravation and status epilepticus, appeared to be associated with pregnancy. Thus, whereas disease activity appears maximal early in life with no subsequent peaks in males, both menarche and pregnancy appear associated with disease onset or worsening in females. This suggests that hormonal changes may be a modulating factor
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