blue-c Räumlich-immersive Projektions- und 3D Video-Portale für Telepräsenz. Teil 1: Konzept, Hardware und Videoverarbeitung

Zusammenfassung: Der folgende Beitrag beschreibt das Design und die Architektur von blue-c, einem Polyprojekt der ETH Zürich, an dem über einen Zeitraum von 4 Jahren bis zu 20 wissenschaftliche Mitarbeiter mitgewirkt haben und insgesamt 9 Doktorarbeiten entstanden sin

Visualising an Amusement Park - A Case Study

This paper presents a real-time visualisation of an early architectural design for an amusement park. This commercial project, aimed at generating political support and investor interest for the proposed development, was implemented to strict budgets and deadlines and provides the case study to analyse the limitations of current content creation tools and formulate requirements for further research and development. The architectural design of the amusement park was in its early stages at the beginning of the project. The visualisation team received a series of hand drawings from the architect representing the top-down view of the site including its immediate surroundings and a rough CAD model including building outlines. The development covers an area of roughly 1 km square, which is typical for many similar projects, although the team has previously handled real-time urban visualisations for larger regions of approximately 5 by 3 km. The amusement park is a parkland setting including green zones, transportation, pedestrian areas, large artificial ponds and a range of buildings representing different geographic regions and industries. The modelling team was tasked to visually enhance a basic block model provided by the architect to move away from the abstract look towards a "realistic" experience. This required a degree of guess-work and artistic freedom as the details of the architecture had not been specified at that point. This was a rather unusual project brief, as it required the modellers to make decisions usually left to the architect about the look of buildings. At the same time, it allowed the modellers to take a "game development" approach where design decisions were influenced by the polygon budget. Normally, the modellers are presented with fully specified CAD models that may need optimisation for real-time display. A rendering of the resulting model is shown in Figure 1

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome.

Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is therefore highly relevant in the context of circadian biology, but its characterization on the proteome-wide scale and its circadian clock dependence are still poorly described. Here, we provide a comprehensive and rhythmic acetylome map of the mouse liver. Rhythmic acetylated proteins showed subcellular localization-specific phases that correlated with the related metabolites in the regulated pathways. Mitochondrial proteins were over-represented among the rhythmically acetylated proteins and were highly correlated with SIRT3-dependent deacetylation. SIRT3 activity being nicotinamide adenine dinucleotide (NAD) <sup>+</sup> level-dependent, we show that NAD <sup>+</sup> is orchestrated by both feeding rhythms and the circadian clock through the NAD <sup>+</sup> salvage pathway but also via the nicotinamide riboside pathway. Hence, the diurnal acetylome relies on a functional circadian clock and affects important diurnal metabolic pathways in the mouse liver

Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver.

Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulation at the transcriptional level, much less is known about temporally controlled functions within the nucleus and their regulation at the protein level. Here, we quantified the temporal nuclear accumulation of proteins and phosphoproteins from mouse liver by SILAC proteomics. We identified around 5,000 nuclear proteins, over 500 of which showed a diurnal accumulation. Parallel analysis of the nuclear phosphoproteome enabled the inference of the temporal activity of kinases accounting for rhythmic phosphorylation. Many identified rhythmic proteins were parts of nuclear complexes involved in transcriptional regulation, ribosome biogenesis, DNA repair, and the cell cycle and its potentially associated diurnal rhythm of hepatocyte polyploidy. Taken together, these findings provide unprecedented insights into the diurnal regulatory landscape of the mouse liver nucleus

Perceived sounds and their reported level of disturbance in intensive care units: A multinational survey among healthcare professionals

The noise levels in intensive care units have been repeatedly reported to exceed the recommended guidelines and yield negative health outcomes among healthcare professionals. However, it is unclear which sound sources within this environment are perceived as disturbing. Therefore, this study aimed to evaluate how healthcare professionals in Germany, Switzerland, and Austria perceive the sound levels and the associated sound sources within their work environment and explore sound reduction strategies.; An online survey was conducted among 350 healthcare professionals working in intensive care units. The survey consisted of items on demographic and hospital data and questions about the perception of the sound levels [1 (strongly disagree) to 5 (strongly agree)], disturbance from sound sources [1 (not disturbing at all) to 5 (very disturbing)], and implementation potential, feasibility, and motivation to reduce sound reduction measures [1 (not high at all) to 5 (very high)].; Approximately 69.3% of the healthcare professionals perceived the sound levels in the ICUs as too high. Short-lasting human sounds (e.g. moans or laughs) [mean (M) ± standard deviation (SD) = 3.30 ± 0.81], devices and alarms (M ± SD = 2.67 ± 0.59), and short-lasting object sounds (M ± SD = 2.55 ± 0.68) were perceived as the most disturbing sounds. Reducing medical equipment alarms was considered to have greater implementation potential [M ± SD = 3.62 ± 0.92, t(334) = -7.30, p < 0.001], feasibility [M ± SD = 3.19 ± 0.93, t(334) = -11.02, p < 0.001], and motivation [M ± SD = 3.85 ± 0.89, t(334) = -10.10, p < 0.001] for reducing the sound levels.; This study showed that healthcare professionals perceive short-lasting human sounds as most disturbing and rated reducing medical equipment alarms as the best approach to reduce the sound levels in terms of potential, feasibility, and motivation for implementation

The Top Ten solar analogs in the ELODIE library

Several solar analogs have been identified in the library of high resolution stellar spectra taken with the echelle spectrograph ELODIE. A purely differential method has been used, based on the chi2 comparison of a large number of G dwarf spectra to 8 spectra of the Sun, taken on the Moon and Ceres. HD 146233 keeps its status of closest ever solar twin (Porto de Mello & da Silva 1997). Some other spectroscopic analogs have never been studied before, while the two planet-host stars HD095128 and HD186427 are also part of the selection. The fundamental parameters found in the literature for these stars show a surprising dispersion, partly due to the uncertainties which affect them. We discuss the advantages and drawbacks of photometric and spectroscopic methods to search for solar analogs and conclude that they have to be used jointly to find real solar twins.Comment: 12 pages, accepted in A&

Stability of Terrestrial Planets in the Habitable Zone of Gl 777 A, HD 72659, Gl 614, 47 Uma and HD 4208

We have undertaken a thorough dynamical investigation of five extrasolar planetary systems using extensive numerical experiments. The systems Gl 777 A, HD 72659, Gl 614, 47 Uma and HD 4208 were examined concerning the question of whether they could host terrestrial like planets in their habitable zones (=HZ). First we investigated the mean motion resonances between fictitious terrestrial planets and the existing gas giants in these five extrasolar systems. Then a fine grid of initial conditions for a potential terrestrial planet within the HZ was chosen for each system, from which the stability of orbits was then assessed by direct integrations over a time interval of 1 million years. The computations were carried out using a Lie-series integration method with an adaptive step size control. This integration method achieves machine precision accuracy in a highly efficient and robust way, requiring no special adjustments when the orbits have large eccentricities. The stability of orbits was examined with a determination of the Renyi entropy, estimated from recurrence plots, and with a more straight forward method based on the maximum eccentricity achieved by the planet over the 1 million year integration. Additionally, the eccentricity is an indication of the habitability of a terrestrial planet in the HZ; any value of e>0.2 produces a significant temperature difference on a planet's surface between apoapse and periapse. The results for possible stable orbits for terrestrial planets in habitable zones for the five systems are summarized as follows: for Gl 777 A nearly the entire HZ is stable, for 47 Uma, HD 72659 and HD 4208 terrestrial planets can survive for a sufficiently long time, while for Gl 614 our results exclude terrestrial planets moving in stable orbits within the HZ.Comment: 14 pages, 18 figures submitted to A&