575 research outputs found
Isothermal life prediction of composite lamina using a damage mechanics approach
A method for predicting isothermal plastic fatigue life of a composite lamina is presented in which both fibers and matrix are isotropic materials. In general, the fatigue resistances of the matrix, fibers, and interfacial material must be known in order to predict composite fatigue life. Composite fatigue life is predicted using only the matrix fatigue resistance due to inelasticity micromechanisms. The effect of the fiber orientation on loading direction is accounted for while predicting composite life. The application is currently limited to isothermal cases where the internal thermal stresses that might arise from thermal strain mismatch between fibers and matrix are negligible. The theory is formulated to predict the fatigue life of a composite lamina under either load or strain control. It is applied currently to predict the life of tungsten-copper composite lamina at 260 C under tension-tension load control. The calculated life of the lamina is in good agreement with available composite low cycle fatigue data
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Super-Efficient Cross-Correlation (SEC-C): A Fast Matched Filtering Code Suitable for Desktop Computers
Super-Earths: A New Class of Planetary Bodies
Super-Earths, a class of planetary bodies with masses ranging from a few
Earth-masses to slightly smaller than Uranus, have recently found a special
place in the exoplanetary science. Being slightly larger than a typical
terrestrial planet, super-Earths may have physical and dynamical
characteristics similar to those of Earth whereas unlike terrestrial planets,
they are relatively easier to detect. Because of their sizes, super-Earths can
maintain moderate atmospheres and possibly dynamic interiors with plate
tectonics. They also seem to be more common around low-mass stars where the
habitable zone is in closer distances. This article presents a review of the
current state of research on super-Earths, and discusses the models of the
formation, dynamical evolution, and possible habitability of these objects.
Given the recent advances in detection techniques, the detectability of
super-Earths is also discussed, and a review of the prospects of their
detection in the habitable zones of low-mass stars is presented.Comment: A (non-technical) review of the literature on the current state
ofresearch on super-Earths. The topics include observation, formation,
dynamical evolution, habitability, composition, interior dynamics, magnetic
field, atmosphere, and propsect of detection. The article has 44 pages, 27
figures, and 203 references. It has been accepted for publication in the
journal Contemporary Physics (2011
Probing Polarization and Dielectric Function of Molecules with Higher Order Harmonics in Scattering-near-field Scanning Optical Microscopy
The idealized system of an atomically flat metallic surface [highly oriented pyrolytic graphite (HOPG)] and an organic monolayer (porphyrin) was used to determine whether the dielectric function and associated properties of thin films can be accessed with scanning–near-field scanning optical microscopy (s-NSOM). Here, we demonstrate the use of harmonics up to fourth order and the polarization dependence of incident light to probe dielectric properties on idealized samples of monolayers of organic molecules on atomically smooth substrates. An analytical treatment of light/ sample interaction using the s-NSOM tip was developed in order to quantify the dielectric properties. The theoretical analysis and numerical modeling, as well as experimental data, demonstrate that higher order harmonic scattering can be used to extract the dielectric properties of materials with tens of nanometer spatial resolution. To date, the third harmonic provides the best lateral resolution(~50 nm) and dielectric constant contrast for a porphyrin film on HOPG
A novel secreted protein, MYR1, is central to Toxoplasma’s manipulation of host cells
The intracellular protozoan Toxoplasma gondii dramatically reprograms the transcriptome of host cells it infects, including substantially up-regulating the host oncogene c-myc. By applying a flow cytometry-based selection to infected mouse cells expressing green fluorescent protein fused to c-Myc (c-Myc–GFP), we isolated mutant tachyzoites defective in this host c-Myc up-regulation. Whole-genome sequencing of three such mutants led to the identification of MYR1 (Myc regulation 1; TGGT1_254470) as essential for c-Myc induction. MYR1 is a secreted protein that requires TgASP5 to be cleaved into two stable portions, both of which are ultimately found within the parasitophorous vacuole and at the parasitophorous vacuole membrane. Deletion of MYR1 revealed that in addition to its requirement for c-Myc up-regulation, the MYR1 protein is needed for the ability of Toxoplasma tachyzoites to modulate several other important host pathways, including those mediated by the dense granule effectors GRA16 and GRA24. This result, combined with its location at the parasitophorous vacuole membrane, suggested that MYR1 might be a component of the machinery that translocates Toxoplasma effectors from the parasitophorous vacuole into the host cytosol. Support for this possibility was obtained by showing that transit of GRA24 to the host nucleus is indeed MYR1-dependent. As predicted by this pleiotropic phenotype, parasites deficient in MYR1 were found to be severely attenuated in a mouse model of infection. We conclude, therefore, that MYR1 is a novel protein that plays a critical role in how Toxoplasma delivers effector proteins to the infected host cell and that this is crucial to virulence
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