Ferroelectricity in ultra-thin perovskite films

We report studies of ferroelectricity in ultra-thin perovskite films with realistic electrodes. The results reveal stable ferroelectric states in thin films less than 10 \AA thick with polarization normal to the surface. Under short-circuit boundary conditions, the screening effect of realistic electrodes and the influence of real metal/oxide interfaces on thin film polarization are investigated. Our studies indicate that metallic screening from the electrodes is affected by the difference in work functions at oxide surfaces. We demonstrate this effect in ferroelectric PbTiO$_3$ and BaTiO$_3$ films.Comment: 4 pages in REVTEX4, 4 epsf figure

Work domain analysis and intelligent transport systems: Implications for vehicle design

This article presents a Work Domain Analysis (WDA) of the road transport system in Victoria, Australia. A series of driver information requirements and tasks that could potentially be supported through the use of Intelligent Transport Systems (ITS) are then extracted from the WDA. The potential use of ITS technologies to circumvent these information gaps and provide additional support to drivers is discussed. It is concluded that driver information requirements are currently not entirely satisfied by contemporary vehicle design and also that there are a number of driving tasks that could be further supported through the provision of supplementary systems within vehicles

Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition

Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps necessary step in the pathogenesis of Alzheimer's disease (AD). Aβ accumulation leads to the formation of Aβ aggregates, which may directly and indirectly lead to eventual neurodegeneration. While Aβ production is accelerated in many familial forms of early-onset AD, increasing evidence indicates that impaired clearance of Aβ is more evident in late-onset AD. To uncover the mechanisms underlying impaired Aβ clearance in AD, we examined the role of low-density lipoprotein receptor-related protein 1 (LRP1) in astrocytes. Although LRP1 has been shown to play critical roles in brain Aβ metabolism in neurons and vascular mural cells, its role in astrocytes, the most abundant cell type in the brain responsible for maintaining neuronal homeostasis, remains unclear. Here, we show that astrocytic LRP1 plays a critical role in brain Aβ clearance. LRP1 knockdown in primary astrocytes resulted in decreased cellular Aβ uptake and degradation. In addition, silencing of LRP1 in astrocytes led to downregulation of several major Aβ-degrading enzymes, including matrix metalloproteases MMP2, MMP9, and insulin-degrading enzyme. More important, conditional knock-out of theLrp1gene in astrocytes in the background of APP/PS1 mice impaired brain Aβ clearance, exacerbated Aβ accumulation, and accelerated amyloid plaque deposition without affecting its production. Together, our results demonstrate that astrocytic LRP1 plays an important role in Aβ metabolism and that restoring LRP1 expression and function in the brain could be an effective strategy to facilitate Aβ clearance and counter amyloid pathology in AD.SIGNIFICANCE STATEMENTAstrocytes represent a major cell type regulating brain homeostasis; however, their roles in brain clearance of amyloid-β (Aβ) and underlying mechanism are not clear. In this study, we used both cellular models and conditional knock-out mouse models to address the role of a critical Aβ receptor, the low-density lipoprotein receptor-related protein 1 (LRP1) in astrocytes. We found that LRP1 in astrocytes plays a critical role in brain Aβ clearance by modulating several Aβ-degrading enzymes and cellular degradation pathways. Our results establish a critical role of astrocytic LRP1 in brain Aβ clearance and shed light on specific Aβ clearance pathways that may help to establish new targets for AD prevention and therapy.</jats:p

Continuum Theory for Piezoelectricity in Nanotubes and Nanowires

We develop and solve a continuum theory for the piezoelectric response of one dimensional nanotubes and nanowires, and apply the theory to study electromechanical effects in BN nanotubes. We find that the polarization of a nanotube depends on its aspect ratio, and a dimensionless constant specifying the ratio of the strengths of the elastic and electrostatic interactions. The solutions of the model as these two parameters are varied are discussed. The theory is applied to estimate the electric potential induced along the length of a BN nanotube in response to a uniaxial stress.Comment: 4 pages in RevTex4, 2 epsf figure

B→Dlν form factors at nonzero recoil and extraction of |Vcb|

We present a lattice QCD calculation of the B→Dlν semileptonic decay form factors f+(q2) and f0(q2) for the entire physical q2 range. Nonrelativistic QCD bottom quarks and highly improved staggered quark charm and light quarks are employed together with Nf=2+1 MILC gauge configurations. A joint fit to our lattice and BABAR experimental data allows an extraction of the Cabibbo-Kobayashi-Maskawa matrix element |Vcb|. We also determine the phenomenologically interesting ratio R(D)=B(B→Dτντ)/B(B→Dlνl) (l=e,μ). We find |Vcb|B→Dexcl=0.0402(17)(13), where the first error consists of the lattice simulation errors and the experimental statistical error and the second error is the experimental systematic error. For the branching fraction ratio we find R(D)=0.300(8)

Stagnating trends in complementary feeding practices in Bangladesh: An analysis of national surveys from 2004-2014.

Bangladesh has experienced steady socio-economic development. However, improvements in child growth have not kept pace. It is important to document complementary feeding (CF) practices-a key determinant of children's growth-and their trends over time. The study aims to examine trends in CF practices in children aged 6-23 months using data from Bangladesh Demographic and Health Surveys conducted in 2004, 2007, 2011, and 2014. Multilevel logistic regression models were applied to identify independent predictors of four CF practice indicators among children 6-23 months, namely, timely introduction of complementary foods, minimum meal frequency, minimum dietary diversity, and minimum acceptable diet. Introduction of complementary foods was achieved among 64-71% of children between 2004 and 2014. The proportion meeting minimum meal frequency increased from 2004 to 2007 (71-81%) and declined and held steady at 65% from 2011 to 2014. The proportion meeting minimum dietary diversity in 2011 and 2014 was low (25% and 28%), and so was minimum acceptable diet (19% and 20%). From 2007 to 2014, child dietary diversity decreased and the most decline was in the consumption of legumes and nuts (29% to 8%), vitamin A-rich fruits and vegetables (54% to 41%), and other fruits and vegetables (47% to 20%). Young child age (6-11 months), poor parental education, household poverty, and residence in the Chittagong and Sylhet independently predicted poorer feeding practices. Dietary diversity and overall diet in Bangladeshi children are strikingly poor. Stagnation or worsening of feeding practices in the past decade are concerning and call for decisive policy and programme action to address inappropriate child feeding practices

Bs→KℓνB_s \to K \ell \nu form factors from lattice QCD

We report the first lattice QCD calculation of the form factors for the standard model tree-level decay $B_s\to K \ell\nu$. In combination with future measurement, this calculation will provide an alternative exclusive semileptonic determination of $|V_{ub}|$. We compare our results with previous model calculations, make predictions for differential decay rates and branching fractions, and predict the ratio of differential branching fractions between $B_s\to K\tau\nu$ and $B_s\to K\mu\nu$. We also present standard model predictions for differential decay rate forward-backward asymmetries, polarization fractions, and calculate potentially useful ratios of $B_s\to K$ form factors with those of the fictitious $B_s\to\eta_s$ decay. Our lattice simulations utilize NRQCD $b$ and HISQ light quarks on a subset of the MILC Collaboration's $2+1$ asqtad gauge configurations, including two lattice spacings and a range of light quark masses.Comment: 24 pages, 21 figures; Ver. 2 matches published versio

Bs→DsℓνB_s \to D_s \ell \nu Form Factors and the Fragmentation Fraction Ratio fs/fdf_s/f_d

We present a lattice quantum chromodynamics determination of the scalar and vector form factors for the $B_s \rightarrow D_s \ell \nu$ decay over the full physical range of momentum transfer. In conjunction with future experimental data, our results will provide a new method to extract $|V_{cb}|$, which may elucidate the current tension between exclusive and inclusive determinations of this parameter. Combining the form factor results at non-zero recoil with recent HPQCD results for the $B \rightarrow D \ell \nu$ form factors, we determine the ratios $f^{B_s \rightarrow D_s}_0(M_\pi^2) / f^{B \rightarrow D}_0(M_K^2) = 1.000(62)$ and $f^{B_s \rightarrow D_s}_0(M_\pi^2) / f^{B \rightarrow D}_0(M_\pi^2) = 1.006(62)$. These results give the fragmentation fraction ratios $f_s/f_d = 0.310(30)_{\mathrm{stat.}}(21)_{\mathrm{syst.}}(6)_{\mathrm{theor.}}(38)_{\mathrm{latt.}}$ and $f_s/f_d = 0.307(16)_{\mathrm{stat.}}(21)_{\mathrm{syst.}}(23)_{\mathrm{theor.}}(44)_{\mathrm{latt.}}$, respectively. The fragmentation fraction ratio is an important ingredient in experimental determinations of $B_s$ meson branching fractions at hadron colliders, in particular for the rare decay ${\cal B}(B_s \rightarrow \mu^+ \mu^-)$. In addition to the form factor results, we make the first prediction of the branching fraction ratio $R(D_s) = {\cal B}(B_s\to D_s\tau\nu)/{\cal B}(B_s\to D_s\ell\nu) = 0.301(6)$, where $\ell$ is an electron or muon. Current experimental measurements of the corresponding ratio for the semileptonic decays of $B$ mesons disagree with Standard Model expectations at the level of nearly four standard deviations. Future experimental measurements of $R(D_s)$ may help understand this discrepancy.Comment: 21 pages, 15 figure

Intractable policy failure: the case of bovine TB and badgers

The failure to eliminate bovine TB from the English and Welsh cattle herd represents a long-term intractable policy failure. Cattle-to-cattle transmission of the disease has been underemphasised in the debate compared with transmission from badgers despite a contested evidence base. Archival evidence shows that mythical constructions of the badger have shaped the policy debate. Relevant evidence was incomplete and contested; alternative framings of the policy problem were polarised and difficult to reconcile; and this rendered normal techniques of stakeholder management through co-option and mediation of little assistance

Form factors for B and B_s semileptonic decays with NRQCD/HISQ quarks

We discuss preliminaries of a calculation of the form factors for the semileptonic decays B -> pi lv, B_s -> K lv, and B -> K ll. We simulate with NRQCD heavy and HISQ light valence quarks on the MILC 2+1 dynamical asqtad configurations. The form factors are calculated over a range of momentum transfer to allow determination of their shape and the extraction of |V_ub|. Additionally, we are calculating ratios of these form factors to those for the unphysical decay B_s -> eta_s. We are studying the possibility of combining these precisely determined ratios with future calculations of B_s ->eta_s using HISQ b-quarks to generate form factors with significantly reduced errors.Comment: 7 pages, 5 figures. Proceedings of the 30th International Symposium on Lattice Field Theory - Lattice 2012; June 24-29, 2012; Cairns, Australi