Document image classification combining textual and visual features.

This research contributes to the problem of classifying document images. The main addition of this thesis is the exploitation of textual and visual features through an approach that uses Convolutional Neural Networks. The study uses a combination of Optical Character Recognition and Natural Language Processing algorithms to extract and manipulate relevant text concepts from document images. Such content information are embedded within document images, with the aim of adding elements which help to improve the classification results of a Convolutional Neural Network. The experimental phase proves that the overall document classification accuracy of a Convolutional Neural Network trained using these text-augmented document images, is considerably higher than the one achieved by a similar model trained solely on classic document images, especially when different classes of documents share similar visual characteristics. The comparison between our method and state-of-the-art approaches demonstrates the effectiveness of combining visual and textual features. Although this thesis is about document image classification, the idea of using textual and visual features is not restricted to this context and comes from the observation that textual and visual information are complementary and synergetic in many aspects

The Importance of Human Mental Workload in Web Design

The focus of this study is the introduction of the construct of Human Mental Workload (HMW) in Web design, aimed at supporting current interaction design practices. An experiment has been conducted using the original Wikipedia and Google web-interfaces, and using two slightly different versions. Three subjective psychological mental workload assessment techniques (NASA-TLX, Workload Profile and SWAT) with a well-established assessments usability tool (SUS) have been adopted. T-tests have been performed to study the statistical significance of the original and modified web-pages, in terms of workload required by typical tasks and perceived usability. Preliminary results show that, in one ideal case, increments of usability correspond to decrements of generated workload, confirming the negative impact of the structural changes on the interface. In another case, changes are significant in terms of usability but not in terms of generated workloads, thus raising research questions and underlying the importance of Human Mental Workload in Interaction Design

HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal

Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in a variety of conditions including peritoneal dialysis (PD), post-surgery adhesions and peritoneal metastases. The acquisition of invasive and pro-fibrotic abilities by mesothelial cells (MCs) through induction of MMT, a cell-specific form of EMT, plays a main role in this process. Aim of this study was to evaluate possible effects of histone deacetylase (HDAC) inhibitors, key components of the epigenetic machinery, in counteracting MMT observed in MCs isolated from effluent of PD patients. HDAC inhibitors with different class/isoform selectivity have been used for pharmacological inhibition. While the effect of other inhibitors was limited to a partial E-cadherin re-expression, MS-275, a HDAC1-3 inhibitor, promoted: (i) downregulation of mesenchymal markers (MMP2, Col1A1, PAI-1, TGFβ1, TGFβRI) (ii) upregulation of epithelial markers (E-cadherin, Occludin), (iii) reacquisition of an epithelial-like morphology and (iv) marked reduction of cellular invasiveness. Results were confirmed by HDAC1 genetic silencing. Mechanistically, MS-275 causes: (i) increase of nuclear histone H3 acetylation (ii) rescue of the acetylation profile on E-cadherin promoter, (iii) Snail functional impairment. Overall, our study, pinpointing a role for HDAC1, revealed a new player in the regulation of peritoneal fibrosis, providing the rationale for future therapeutic opportunities

Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity

As regioisomers/bioisosteres of 1a, a 4-phenylbenzamide tranylcypromine (TCP) derivative previously disclosed by us, we report here the synthesis and biological evaluation of some (hetero)arylbenzoylamino TCP derivatives 1b-6, in which the 4-phenyl moiety of 1a was shifted at the benzamide C3 position or replaced by 2- or 3-furyl, 2- or 3-thienyl, or 4-pyridyl group, all at the benzamide C4 or C3 position. In anti-LSD1-CoREST assay, all the meta derivatives were more effective than the para analogues, with the meta thienyl analogs 4b and 5b being the most potent (IC50 values ¼ 0.015 and 0.005 lM) and the most selective over MAO-B (selectivity indexes: 24.4 and 164). When tested in U937 AML and prostate cancer LNCaP cells, selected compounds 1a,b, 2b, 3b, 4b, and 5a,b displayed cell growth arrest mainly in LNCaP cells. Western blot analyses showed increased levels of H3K4me2 and/or H3K9me2 confirming the involvement of LSD1 inhibition in these assays

RELACIONAMENTO INTERPESSOAL: IDENTIFICAÇÃO DE COMPORTAMENTOS PARA TRABALHO EM EQUIPE EM UNIDADE CORONARIANA

RESUMO Objetivo: identificar, na equipe multiprofissional da unidade coronariana, comportamentos facilitadores e dificultadores, para o trabalho em equipe, na perspectiva do relacionamento interprofissional. Metodologia: pesquisa descritiva/ abordagem qualitativa, utilizando-se técnica do incidente crítico, desenvolvida em unidade coronariana de um hospital público de Minas Gerais, Brasil. Coleta realizada em 2014, por meio de entrevista semiestruturada. Participaram 45 profissionais da equipe multiprofissional. Critério de inclusão: trabalhar na referida unidade há, no mínimo, 12 meses; critério de exclusão: estar afastado do trabalho à época da coleta definitiva dos dados e não ser localizado após três tentativas para agendamento/realização da entrevista. Análise de dados pautada na análise de conteúdo e na técnica do incidente crítico. Resultados: ocorrência de 218 comportamentos, sendo 113 positivos e 105 negativos, relacionados ao trabalho em equipe, quanto ao relacionamento interprofissional, emergindo três categorias: colaborar com o colega, trocar informações com outro agente e interagir com colega. Predomínio de comportamentos facilitadores para trabalho em equipe, destacando-se a comunicação entre os agentes. Conclusões: evidenciaram-se investimento e esforço dos profissionais para transpor obstáculos, na tentativa de implementar o trabalho em equipe como potência para atuar sobre o objeto de trabalho e atingir, com êxito, a finalidade do trabalho em saúde

Different abnormalities of electroencephalographic (EEG) markers in quiet wakefulness are related to motor visual hallucinations in patients with Parkinson's and Lewy body diseases

AbstractBackgroundParkinson's disease (PD) is the second‐most common neurodegenerative disorder that affects 2–3% of the population ≥ 65 years of age and may belong to cognitive deficits and dementia in 50% of cases. Disease with Lewy Bodies (DLB) is emerging as another important cause of dementia in pathological aging. PD and DLB are both due to intra‐neuronal Lewy bodies and are characterized not only by motor dysfunctions but also by cognitive and/or psychiatric symptoms. An open issue is the extent to which these diseases are distinct entities. In this respect, here we compared cortical sources of resting state eyes‐closed electroencephalographic (rsEEG) rhythms in PD and DLB patients having visual hallucinations.MethodClinical and rsEEG rhythms in demographic matched PD (N = 93), DLB (N = 46), Alzheimer's disease dementia (AD, N= 70) and healthy elderly (Nold, N = 60) subjects were available from an international archive. Pathological groups were matched for cognitive status. Individual alpha frequency peak was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were considered. The eLORETA freeware estimated rsEEG cortical sources.ResultAs a confirmation of previous studies, compared to the Nold subjects, the AD, LBD, and PD patients showed higher widespread delta source activities and lower posterior alpha source activities. Specifically, posterior alpha source activities were more abnormal in the AD than the LBD and PD groups, while widespread delta source activities were more abnormal in the PD and DLB than the AD group. As novel results, in relation to the LBD and PD patients without visual hallucinations and the control groups (Nold, AD), those with visual hallucinations were characterized by higher parietal delta source activities (LBD, Figure 1) and parieto‐occipital alpha sources activities (PD, Figure 2).ConclusionThese novel results suggest that in LBD and PD patients resting in the quiet wakefulness, abnormalities in cortical neural synchronization at delta and alpha frequencies in parietal cortex are differently related to visual hallucinations despite the essence of alpha‐synucleinopathy

Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases

Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70-0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved