5,557 research outputs found
Grievance Procedures and the Democratization of American Life
[Excerpt] No institution in the nation\u27s history has struggled so long and so valiantly for the democratization of American life as the organized labor movement. Decade after decade, trade unionists have fought for human rights and dignity against almost insuperable forces of wealth, privilege, and partisan government, including the country\u27s courts, soldiery, and police. They have battled against poverty of means, mind, and spirit in the teeth of bayonets, massacre, assault, injunctions, imprisonment, dismissal from jobs, blacklisting, and legislative and judicial defeat of vital measures
Preface
[Excerpt] The six short essays in this modest publication assess the impact upon industrial relations of the accelerating democratization of American life
Preface
[Excerpt] The six short essays in this modest publication assess the impact upon industrial relations of the accelerating democratization of American life
Lyman alpha radiation in external galaxies
The Ly alpha line of atomic hydrogen is often a luminous component of the radiation emitted by distant galaxies. Except for those galaxies which have a substantial central source of non-stellar ionizing radiation, most of the Ly alpha radiation emitted by galaxies is generated within regions of the interstellar medium which are photoionized by starlight. Conversely, much of the energy radiated by photoionized regions is carried by the Ly alpha line. Only hot, massive stars are capable of ionizing hydrogen in the interstellar medium which surrounds them, and because such stars are necessarily short-lived, Ly alpha emission traces regions of active star formation. Researchers argue that the strength of the Ly alpha emission observed from external galaxies may be used to estimate quantitatively the dust content of the emitting region, while the Ly alpha line profile is sensitive to the presence of shock waves. Interstellar dust particles and shock waves are intimately associated with the process of star formation in two senses. First, both dust particles and shock waves owe their existence to stellar activity; second, they may both serve as agents which facilitate the formation of stars, shocks by triggering gravitational instabilities in the interstellar gas that they compress, and dust by shielding star-forming molecular clouds from the ionizing and dissociative effects of external UV radiation. By using Ly alpha observations as a probe of the dust content in diffuse gas at high redshift, we might hope to learn about the earliest epochs of star formation
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.
Sanfilippo syndrome type B (MPS IIIB) is characterized by profound mental retardation in childhood, dementia and death in late adolescence; it is caused by deficiency of α-N-acetylglucosaminidase and resulting lysosomal storage of heparan sulfate. A mouse model, generated by homologous recombination of the Naglu gene, was used to study pathological changes in the brain. We found earlier that neurons in the medial entorhinal cortex (MEC) and the dentate gyrus showed a number of secondary defects, including the presence of hyperphosphorylated tau (Ptau) detected with antibodies raised against Ptau in Alzheimer disease brain. By further use of immunohistochemistry, we now show staining in neurons of the same area for beta amyloid, extending the resemblance to Alzheimer disease. Ptau inclusions in the dentate gyrus of MPS IIIB mice were reduced in number when the mice were administered LiCl, a specific inhibitor of Gsk3β. Additional proteins found elevated in MEC include proteins involved in autophagy and the heparan sulfate proteoglycans, glypicans 1 and 5, the latter closely related to the primary defect. The level of secondary accumulations was associated with elevation of glypican, as seen by comparing brains of mice at different ages or with different mucopolysaccharide storage diseases. The MEC of an MPS IIIA mouse had the same intense immunostaining for glypican 1 and other markers as MPS IIIB, while MEC of MPS I and MPS II mice had weak staining, and MEC of an MPS VI mouse had no staining at all for the same proteins. A considerable amount of glypican was found in MEC of MPS IIIB mice outside of lysosomes. We propose that it is the extralysosomal glypican that would be harmful to neurons, because its heparan sulfate branches could potentiate the formation of Ptau and beta amyloid aggregates, which would be toxic as well as difficult to degrade
Interstellar water chemistry: from laboratory to observations
Water is observed throughout the universe, from diffuse interstellar clouds
to protoplanetary disks around young stars, and from comets in our own solar
system and exoplanetary atmospheres to galaxies at high redshifts. This review
summarizes the spectroscopy and excitation of water in interstellar space as
well as the basic chemical processes that form and destroy water under
interstellar conditions. Three major routes to water formation are identified:
low temperature ion-molecule chemistry, high-temperature neutral-neutral
chemistry and gas-ice chemistry. The rate coefficients of several important
processes entering the networks are discussed in detail; several of them have
been determined only in the last decade through laboratory experiments and
theoretical calculations. Astronomical examples of each of the different
chemical routes are presented using data from powerful new telescopes, in
particular the Herschel Space Observatory. Basic chemical physics studies
remain critically important to analyze astronomical data.Comment: Authors' manuscript 138 pages, 34 figures, 4 tables, published in a
Thematic Issue "Astrochemistry" in Chemical Reviews (December 2013), volume
113, 9043-9085 following peer review by the American Chemical Society. The
published paper is available as open access at
http://pubs.acs.org/doi/abs/10.1021/cr400317
Introduction to \u3ci\u3eIndustrial Relations at the Dawn of the New Millenium\u3c/i\u3e
[Excerpt] The essays assembled in the volume focus upn the state of the art of industrial relations at the dawn of the new millennium. The authors of these essays are members of the faculty of the School of Industrial and Labor Relations at Cornell University, or were formerly closely associated with the school. They have found, to their delight, that in creating the essays presented here, they released an enchantment of scholarly memory that illuminates the past and present states of the scholarly disciplines they cultivate and encourages speculation about the future of these disciplines
Excitable media in open and closed chaotic flows
We investigate the response of an excitable medium to a localized
perturbation in the presence of a two-dimensional smooth chaotic flow. Two
distinct types of flows are numerically considered: open and closed. For both
of them three distinct regimes are found, depending on the relative strengths
of the stirring and the rate of the excitable reaction. In order to clarify and
understand the role of the many competing mechanisms present, simplified models
of the process are introduced. They are one-dimensional baker-map models for
the flow and a one-dimensional approximation for the transverse profile of the
filaments.Comment: 14 pages, 16 figure
Recommended from our members
Constraints on asteroid magnetic field evolution and the radii of meteorite parent bodies from thermal modelling
Paleomagnetic measurements of ancient terrestrial and extraterrestrial samples indicate that numerous planetary bodies generated magnetic fields through core dynamo activity during the early solar system. The existence, timing, intensity and stability of these fields are governed by the internal transfer of heat throughout their parent bodies. Thus, paleomagnetic records preserved in natural samples can contain key information regarding the accretion and thermochemical history of the rocky bodies in our solar system. However, models capable of predicting these field properties across the entire active lifetime of a planetary core that could relate the processes occurring within these bodies to features in these records and provide such information are limited. Here, we perform asteroid thermal evolution models across suites of radii, accretion times and thermal diffusivities with the aim of predicting when fully and partially differentiated asteroids generated magnetic fields. We find that dynamo activity in both types of asteroid is delayed until ∼4.5-5.5 Myr after calcium-aluminium-rich inclusion formation due to the partitioning of 26Al into the silicate portion of the body during differentiation and large early surface heat fluxes, followed by a brief period (<12.5 Myr for bodies with radii <500 km) of thermally-driven dynamo activity as heat is convected from the core across a partially-molten magma ocean. We also expect that gradual core solidification produced compositionally-driven dynamo activity in these bodies, the timing of which could vary by tens to hundreds of millions of years depending on the S concentration of the core and the radius of the body. There was likely a pause in core cooling and dynamo activity following the cessation of convection in the magma ocean. Our predicted periods of magnetic field generation and quiescence match eras of high and low paleointensities in the asteroid magnetic field record compiled from paleomagnetic measurements of multiple meteorites, providing the possible origins of the remanent magnetisations carried by these samples. We also compare our predictions to paleomagnetic results from different meteorite groups to constrain the radii of the angrite, CV chondrite, H chondrite, IIE iron meteorite and Bjürbole (L/LL chondrite) parent bodies and identify a likely nebula origin for the remanent magnetisation carried by the CM chondrites.St John's College, University of Cambridge
The Royal Societ
ISO observations of far-infrared rotational emission lines of water vapor toward the supergiant star VY Canis Majoris
We report the detection of numerous far-infrared emission lines of water
vapor toward the supergiant star VY Canis Majoris. A 29.5 - 45 micron grating
scan of VY CMa, obtained using the Short Wavelength Spectrometer (SWS) of the
Infrared Space Observatory (ISO) at a spectral resolving power of approximately
2000, reveals at least 41 spectral features due to water vapor that together
radiate a total luminosity ~ 25 solar luminosities. In addition to pure
rotational transitions within the ground vibrational state, these features
include rotational transitions within the (010) excited vibrational state. The
spectrum also shows the doublet Pi 1/2 (J=5/2) <-- doublet Pi 3/2 (J=3/2) OH
feature near 34.6 micron in absorption. Additional SWS observations of VY CMa
were carried out in the instrument's Fabry-Perot mode for three water
transitions: the 7(25)-6(16) line at 29.8367 micron, the 4(41)-3(12) line
31.7721 micron, and the 4(32)-3(03) line at 40.6909 micron. The higher spectral
resolving power of approximately 30,000 thereby obtained permits the line
profiles to be resolved spectrally for the first time and reveals the "P Cygni"
profiles that are characteristic of emission from an outflowing envelope.Comment: 11 pages (inc. 2 figures), LaTeX, uses aaspp4.sty, accepted for
publication in ApJ Letter
- …