580 research outputs found

    Investigation of changes in conductivity of juice during the evaporation process

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    The creation of this article was the necessity of experimental determination of the electric conductivity of juice depending on the concentration of solids, expressed by the empirical formula, in order to more precisely control specific power supplied to the machine and foaming. Authors of the article held staged experimental studies using apple juice, the juice of red mountain ash, buckthorn and black currant. Found that the relationship between the conductivity of the juice solids content corresponds to the empirical formula of Kohlrausch, however, this formula does not represent the contribution juice acidity value of conductivity, and allows to correlate the specific power input to the device with the concentration of solids. The empirical formulas for the distribution of electrical juice conductivity depending on the acidity and for calculation of the specific power depending on the concentration of dry matter, allows to keep the speed of the foam below its destruction speed in the zone of vigorous reflux

    Effect of Corbon Content on the Structure and Mechanical Properties of TI-10V-2Fe-3Al Alloy

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    The effect of carbon content on microstructure and mechanical properties of the transition (Ξ±+Ξ²)-titanium alloy Ti–10V–2Fe–3Al in a heat-strengthened state was studied. It was established that with the increase of carbon content in the alloy up to the limit of its solubility in a solid solution, the strength of the alloy increases, the plastic characteristics decrease. When the solubility limit of carbon in a solid solution in an alloy is exceeded, the appearance of titanium-based carbide particles was observed, while the strength of the alloy somewhat decreases, due to the decrease of the effect of solid-solution hardening from the elements present in the alloy, which are partially transferred from the solid solution to the titanium-based carbide particles.     Keywords: titanium alloys, titanium carbides, mechanical properties, hardening heat treatment

    Π’Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΡŒ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠΎΠ² Π³Π΅Π½ΠΎΠ² Ρ†ΠΈΡ‚ΠΎΠΊΠΈΠ½ΠΎΠ² TNF-Ξ±, IL-10, MBL2, IFN-Ξ³ ΠΈ IL-6 Π² Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠΈ ослоТнСнного тСчСния ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠΉ Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΉΠ½ΠΎΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΈ Ρƒ ΠΌΡƒΠΆΡ‡ΠΈΠ½

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    Goal. To develop a personified approach to the management of men with the urogenital chlamydia infection based on studying the molecular and genetic risk factors of the development of complications. Materials and methods. Patients with the urogenital chlamydia infection (20 men with the urogenital chlamydia infection of the lower urogenital tract and 20 men with complicated forms of the urogenital chlamydia infection) and men without any clinical or laboratory signs of STDs and inflammatory diseases of the urogenital tract. The following methods were used in the study: anamnestic, clinical, instrumental (transrectal ultrasonography) and laboratory (microscopic, bacteriological, molecular and biological (PCR, SNaPshot)). Results. According to the study results, the share of cases of ureteritis caused by C. trachomatis amounted to 10.5% of the total share of cases of ureteritis and 13.0% of cases of non-gonococcal ureteritis. The percentage of complicated urogenital diseases caused by C. trachomatis amounted to 34.5% of the total share of complicated forms and 35.7% of noncomplicated forms of the non-gonococcal origin. Subjective clinical signs of complicated forms of the chlamydia infection did not have any reliable distinctions from those observed in case of non-complicated forms of the disease; the infectious process caused by C. trachomatis was characterized by the absence of leukocytosis in the urethra in 30.0% of men with both non-complicated and complicated forms of the disease. The study of the polymorphism of cytokine genes revealed that the CC genotype of IL-6 gene at the -174 locus can serve as a molecular predictor of the complicated course of urogenital chlamydiosis in men while the GC genotype of IL-6 gene at the -174 locus can serve as a molecular predictor of the non-complicated course of urogenital chlamydiosis in men. Based on these results, the authors developed an algorithm for a differential approach to the management of patients suffering from chlamydia infection. Conclusion. A differential approach to the management of men with the urogenital chlamydia infection depending on the molecular predictor of the complicated course of the disease was developed.ЦСль. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° пСрсонализированного ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π° ΠΊ вСдСнию ΠΌΡƒΠΆΡ‡ΠΈΠ½ с ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠΉ Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΉΠ½ΠΎΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠ΅ΠΉ Π½Π° основании изучСния молСкулярно-гСнСтичСских Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠ² риска развития ослоТнСний заболСвания. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π‘ΠΎΠ»ΡŒΠ½Ρ‹Π΅ ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠΉ Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΉΠ½ΠΎΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠ΅ΠΉ (20 ΠΌΡƒΠΆΡ‡ΠΈΠ½ с ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠΉ Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΉΠ½ΠΎΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠ΅ΠΉ Π½ΠΈΠΆΠ½ΠΈΡ… ΠΎΡ‚Π΄Π΅Π»ΠΎΠ² ΠΌΠΎΡ‡Π΅ΠΏΠΎΠ»ΠΎΠ²ΠΎΠ³ΠΎ Ρ‚Ρ€Π°ΠΊΡ‚Π° ΠΈ 20 ΠΌΡƒΠΆΡ‡ΠΈΠ½ с ослоТнСнными Ρ„ΠΎΡ€ΠΌΠ°ΠΌΠΈ ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠΉ Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΉΠ½ΠΎΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΈ) ΠΈ 20 ΠΌΡƒΠΆΡ‡ΠΈΠ½, Π½Π΅ ΠΈΠΌΠ΅Π²ΡˆΠΈΡ… клиничСских ΠΈ Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Ρ… ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΎΠ² ИППП ΠΈ Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ‚Ρ€Π°ΠΊΡ‚Π°. Π’ исслСдовании ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ ΡΠ»Π΅Π΄ΡƒΡŽΡ‰ΠΈΠ΅ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹: анамнСстичСский, клиничСский, ΠΈΠ½ΡΡ‚Ρ€ΡƒΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹ΠΉ (Π’Π Π£Π—Π˜), Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Π΅ (микроскопичСский, бактСриологичСский, молСкулярнобиологичСскиС (ПЦР, SNaPshot)). Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. УстановлСно, Ρ‡Ρ‚ΠΎ доля ΡƒΡ€Π΅Ρ‚Ρ€ΠΈΡ‚ΠΎΠ², обусловлСнных C. trachomatis, составила 10,5% ΠΎΡ‚ ΠΎΠ±Ρ‰Π΅ΠΉ Π΄ΠΎΠ»ΠΈ ΡƒΡ€Π΅Ρ‚Ρ€ΠΈΡ‚ΠΎΠ² ΠΈ 13,0% ΠΎΡ‚ Π΄ΠΎΠ»ΠΈ Π½Π΅Π³ΠΎΠ½ΠΎΠΊΠΎΠΊΠΊΠΎΠ²Ρ‹Ρ… ΡƒΡ€Π΅Ρ‚Ρ€ΠΈΡ‚ΠΎΠ². Доля ослоТнСнных Ρ„ΠΎΡ€ΠΌ ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½Ρ‹Ρ… Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, обусловлСнных C. trachomatis, составила 34,5% ΠΎΡ‚ ΠΎΠ±Ρ‰Π΅ΠΉ Π΄ΠΎΠ»ΠΈ ослоТнСнных Ρ„ΠΎΡ€ΠΌ ΠΈ 35,7% ΠΎΡ‚ Π΄ΠΎΠ»ΠΈ ослоТнСнных Ρ„ΠΎΡ€ΠΌ Π½Π΅Π³ΠΎΠ½ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ этиологии. Π‘ΡƒΠ±ΡŠΠ΅ΠΊΡ‚ΠΈΠ²Π½Ρ‹Π΅ клиничСскиС ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΈ ослоТнСнных Ρ„ΠΎΡ€ΠΌ Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΉΠ½ΠΎΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΈ Π½Π΅ ΠΈΠΌΠ΅Π»ΠΈ достовСрных ΠΎΡ‚Π»ΠΈΡ‡ΠΈΠΉ ΠΎΡ‚ Ρ‚Π°ΠΊΠΎΠ²Ρ‹Ρ… ΠΏΡ€ΠΈ нСослоТнСнных Ρ„ΠΎΡ€ΠΌΠ°Ρ… заболСвания, ΠΏΡ€ΠΈ этом ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΎΠ½Π½Ρ‹ΠΉ процСсс, Π²Ρ‹Π·Π²Π°Π½Π½Ρ‹ΠΉ C. trachomatis, характСризовался отсутствиСм Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚ΠΎΠ·Π° Π² ΡƒΡ€Π΅Ρ‚Ρ€Π΅ Ρƒ 30,0% ΠΌΡƒΠΆΡ‡ΠΈΠ½ ΠΊΠ°ΠΊ с нСослоТнСнными, Ρ‚Π°ΠΊ ΠΈ с ослоТнСнными Ρ„ΠΎΡ€ΠΌΠ°ΠΌΠΈ заболСвания. ΠŸΡ€ΠΈ ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠΎΠ² Π³Π΅Π½ΠΎΠ² Ρ†ΠΈΡ‚ΠΎΠΊΠΈΠ½ΠΎΠ² установлСно, Ρ‡Ρ‚ΠΎ молСкулярным ΠΏΡ€Π΅Π΄ΠΈΠΊΡ‚ΠΎΡ€ΠΎΠΌ ослоТнСнного клиничСского тСчСния ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΎΠ·Π° Ρƒ ΠΌΡƒΠΆΡ‡ΠΈΠ½ ΠΌΠΎΠΆΠ΅Ρ‚ ΡΠ²Π»ΡΡ‚ΡŒΡΡ Π³Π΅Π½ΠΎΡ‚ΠΈΠΏ Π‘Π‘ Π³Π΅Π½Π° IL-6 Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ -174, молСкулярным ΠΏΡ€Π΅Π΄ΠΈΠΊΡ‚ΠΎΡ€ΠΎΠΌ нСослоТнСнного клиничСского тСчСния ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΎΠ·Π° Ρƒ ΠΌΡƒΠΆΡ‡ΠΈΠ½ β€” Π³Π΅Π½ΠΎΡ‚ΠΈΠΏ GC Π³Π΅Π½Π° IL-6 Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ -174. На основании ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… Π΄Π°Π½Π½Ρ‹Ρ… Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½ Π°Π»Π³ΠΎΡ€ΠΈΡ‚ΠΌ Π΄ΠΈΡ„Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ Ρ‚Π°ΠΊΡ‚ΠΈΠΊΠΈ вСдСния Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΉΠ½ΠΎΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠ΅ΠΉ. Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π° диффСрСнцированная Ρ‚Π°ΠΊΡ‚ΠΈΠΊΠ° вСдСния ΠΌΡƒΠΆΡ‡ΠΈΠ½, Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠΉ Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΉΠ½ΠΎΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠ΅ΠΉ, Π² зависимости ΠΎΡ‚ выявлСния молСкулярного ΠΏΡ€Π΅Π΄ΠΈΠΊΡ‚ΠΎΡ€Π° ослоТнСнного тСчСния заболСвания

    Operative Treatment of Patients with Pancreatic Pseudocysts

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    The article presents the results of surgical treatment of patients with pancreatic pseudocysts spent in hospital surgical clinic Siberian State Medical University from 2004 to 2016. 7 (17.5%) patients underwent conservative therapy. In the early postoperative period and in the long term (18 months) the analysis of the effectiveness of different methods of surgical treatment. According to the results of the research, the operations of the internal drainage along with resection and resection-draining interventions in assessing the quality of life showed similar long-term results. In turn, these interventions have provided significantly better quality of life (p> 0.05) than external drainage operation

    Unrepairable substrates of nucleotide excision repair and their application to suppress the activity of this repair system

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    In the previous studies, the DNA with the bulky Fap-dC derivative was demonstrated to be a difficult substrate for the nucleotide excision repair (NER), a system which is involved in the removal of bulky lesions from DNA. This type of compounds could be of particular interest as possible selective NER, considerably reducing the potency of DNA repair due to competitive immobilization of protein factors involved in this process. This approach can be potentially useful to increase the efficiency of chemotherapy. Aim. To identify DNA structures containing multiple bulky adducts that can efficiently inhibit the nucleotide excision repair. Methods. Enzymatic DNA synthesis, PCR, NER-competent cell extract preparation, in vitro NER assay, HPLC. Results. The conditions for the synthesis of extended DNA containing multiple unrepairable lesions were established. A wide range of DNA structures containing modified nucleotides was obtained. All modified DNAs were shown to inhibit the in vitro activity of the NER system. The DNA structure that inhibits the NER activity with the highest efficiency was selected. Conclusions. The model DNA structures effectively inhibiting the activity of NER were found. The new data obtained here can potentially be used for both basic and applied research.Π£ Π½Π°ΡˆΠΈΡ… ΠΏΠΎΠΏΠ΅Ρ€Π΅Π΄Π½Ρ–Ρ… дослідТСннях Π±ΡƒΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‰ΠΎ Π”ΠΠš Π· ΠΎΠ±'Ρ”ΠΌΠ½ΠΈΠΌ ΠΏΠΎΡ…Ρ–Π΄Π½ΠΈΠΌ Fap-dC Ρ” складнорСпарованим субстратом для систСми Сксцизійної Ρ€Π΅ΠΏΠ°Ρ€Π°Ρ†Ρ–Ρ— Π½ΡƒΠΊΠ»Π΅ΠΎΡ‚ΠΈΠ΄Ρ–Π² (Π•Ρ€Π½). Π—'єднання Ρ‚Π°ΠΊΠΎΠ³ΠΎ Ρ‚ΠΈΠΏΡƒ ΠΌΠΎΠΆΡƒΡ‚ΡŒ становити особливий інтСрСс як ΠΌΠΎΠΆΠ»ΠΈΠ²Ρ– сСлСктивні Ρ–Π½Π³Ρ–Π±Ρ–Ρ‚ΠΎΡ€ΠΈ систСми Π•Ρ€Π½, Π·Π½Π°Ρ‡Π½ΠΎ Π·Π½ΠΈΠΆΡƒΡŽΡ‡ΠΈ Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ Ρ€Π΅ΠΏΠ°Ρ€Π°Ρ†Ρ–Ρ— Π”ΠΠš ΡˆΠ»ΡΡ…ΠΎΠΌ Π·Π²'язування Π±Ρ–Π»ΠΊΠΎΠ²ΠΈΡ… Ρ‡ΠΈΠ½Π½ΠΈΠΊΡ–Π², Π·Π°Π»ΡƒΡ‡Π΅Π½ΠΈΡ… Π΄ΠΎ Π΄Π°Π½ΠΎΠ³ΠΎ процСсу. Π¦Π΅ΠΉ ΠΏΡ–Π΄Ρ…Ρ–Π΄ ΠΌΠΎΠΆΠ΅ Π±ΡƒΡ‚ΠΈ ΠΏΠΎΡ‚Π΅Π½Ρ†Ρ–ΠΉΠ½ΠΎ корисний для підвищСння СфСктивності Ρ…Ρ–ΠΌΡ–ΠΎΡ‚Π΅Ρ€Π°ΠΏΡ–Ρ—. ΠœΠ΅Ρ‚Π°. Π”Π°Π½Π΅ дослідТСння спрямованС Π½Π° ΠΏΠΎΡˆΡƒΠΊ Π”ΠΠš-структур, Ρ‰ΠΎ ΠΌΡ–ΡΡ‚ΡΡ‚ΡŒ ΠΌΠ½ΠΎΠΆΠΈΠ½Π½Ρ– ΠΎΠ±'Ρ”ΠΌΠ½Ρ– Π°Π΄Π΄ΡƒΠΊΡ‚ΠΈ, які Π· Π½Π°ΠΉΠ±Ρ–Π»ΡŒΡˆΠΎΡŽ Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŽ ΠΌΠΎΠΆΡƒΡ‚ΡŒ ΠΏΡ€ΠΈΠ³Π½Ρ–Ρ‡ΡƒΠ²Π°Ρ‚ΠΈ Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ систСми. ΠœΠ΅Ρ‚ΠΎΠ΄ΠΈ. Π€Π΅Ρ€ΠΌΠ΅Π½Ρ‚Π°Ρ‚ΠΈΠ²Π½ΠΈΠΉ синтСз Π”ΠΠš, ΠŸΠ›Π , приготування Π•Ρ€Π½-ΠΊΠΎΠΌΠΏΠ΅Ρ‚Π΅Π½Ρ‚Π½ΠΈΡ… ΠΊΠ»Ρ–Ρ‚ΠΈΠ½Π½ΠΈΡ… Скстрактів, рСакція вирізання, Ρ‰ΠΎ ΠΊΠ°Ρ‚Π°Π»Ρ–Π·ΡƒΡ”Ρ‚ΡŒΡΡ Π±Ρ–Π»ΠΊΠ°ΠΌΠΈ Π•Ρ€Π½ in vitro, Π’Π•Π Π₯. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΏΡ–Π΄Π±Ρ–Ρ€ ΡƒΠΌΠΎΠ² синтСзу протяТних ΠΌΠΎΠ΄Π΅Π»ΡŒΠ½ΠΈΡ… Π”ΠΠš Π· ΠΌΠ½ΠΎΠΆΠΈΠ½Π½ΠΈΠΌ Π²ΠΊΠ»ΡŽΡ‡Π΅Π½Π½ΡΠΌ Π½Π΅Ρ€Π΅ΠΏΠ°Ρ€ΠΎΠ²Π°Π½ΠΎΠ³ΠΎ пошкодТСння Fap-dC. ΠžΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΎ ряд Π”ΠΠš-структур, Ρ‰ΠΎ ΠΌΡ–ΡΡ‚ΠΈΡ‚ΡŒ Π² своєму складі Ρ€Ρ–Π·Π½Ρƒ ΠΊΡ–Π»ΡŒΠΊΡ–ΡΡ‚ΡŒ ΠΌΠΎΠ΄ΠΈΡ„Ρ–ΠΊΠΎΠ²Π°Π½ΠΈΡ… Π»Π°Π½ΠΎΠΊ. Показано, Ρ‰ΠΎ всі ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½Ρ– Π”ΠΠš ΠΏΡ€ΠΈΠ³Π½Ρ–Ρ‡ΡƒΡŽΡ‚ΡŒ Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ систСми Π•Ρ€Π½ in vitro. ΠžΠ±Ρ€Π°Π½Π° Π”ΠΠš-структура, яка ΠΏΡ€ΠΈΠ³Π½Ρ–Ρ‡ΡƒΡ” NER Π½Π°ΠΉΠ±Ρ–Π»ΡŒΡˆ високою Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŽ. Висновки. ΠœΠΎΠ΄Π΅Π»ΡŒΠ½Ρ– Π”ΠΠš Π· Π½Π΅Ρ€Π΅ΠΏΠ°Ρ€ΠΎΠ²Π°Π½ΠΈΠΌΠΈ ΡƒΡˆΠΊΠΎΠ΄ΠΆΠ΅Π½Π½ΡΠΌΠΈ, Π·Π΄Π°Ρ‚Π½Ρ– високою Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŽ ΠΏΡ€ΠΈΠ³Π½Ρ–Ρ‡ΡƒΠ²Π°Ρ‚ΠΈ NER, ΠΌΠΎΠΆΡƒΡ‚ΡŒ розглядатися Π² якості Ρ–Π½Π³Ρ–Π±Ρ–Ρ‚ΠΎΡ€Ρ–Π² систСми Π•Ρ€Π½. ВиявлСні Π² Π΄Π°Π½Ρ–ΠΉ Ρ€ΠΎΠ±ΠΎΡ‚Ρ– закономірності ΠΏΠΎΡ‚Π΅Π½Ρ†Ρ–ΠΉΠ½ΠΎ ΠΌΠΎΠΆΡƒΡ‚ΡŒ Π±ΡƒΡ‚ΠΈ використані для провСдСння як Ρ„ΡƒΠ½Π΄Π°ΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½ΠΈΡ…, Ρ‚Π°ΠΊ Ρ– ΠΏΡ€ΠΈΠΊΠ»Π°Π΄Π½ΠΈΡ… Π΄ΠΎΡΠ»Ρ–Π΄ΠΆΠ΅Π½ΡŒ.Π’ Π½Π°ΡˆΠΈΡ… ΠΏΡ€Π΅Π΄Ρ‹Π΄ΡƒΡ‰ΠΈΡ… исслСдованиях Π±Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ Π”ΠΠš с ΠΎΠ±ΡŠΠ΅ΠΌΠ½Ρ‹ΠΌ ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄Π½Ρ‹ΠΌ Fap-dC являСтся Ρ‚Ρ€ΡƒΠ΄Π½ΠΎΡ€Π΅ΠΏΠ°Ρ€ΠΈΡ€ΡƒΠ΅ΠΌΡ‹ΠΌ субстратом для систСмы эксцизионной Ρ€Π΅ΠΏΠ°Ρ€Π°Ρ†ΠΈΠΈ Π½ΡƒΠΊΠ»Π΅ΠΎΡ‚ΠΈΠ΄ΠΎΠ² (ЭРН). БоСдинСния Ρ‚Π°ΠΊΠΎΠ³ΠΎ Ρ‚ΠΈΠΏΠ° ΠΌΠΎΠ³ΡƒΡ‚ ΠΏΡ€Π΅Π΄ΡΡ‚Π°Π²Π»ΡΡ‚ΡŒ особый интСрСс ΠΊΠ°ΠΊ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½Ρ‹Π΅ сСлСктивныС ΠΈΠ½Π³ΠΈΠ±ΠΈΡ‚ΠΎΡ€Ρ‹ систСмы ЭРН, Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ сниТая ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Ρ€Π΅ΠΏΠ°Ρ€Π°Ρ†ΠΈΠΈ Π”ΠΠš ΠΏΡƒΡ‚Π΅ΠΌ связывания Π±Π΅Π»ΠΊΠΎΠ²Ρ‹Ρ… Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠ², Π²ΠΎΠ²Π»Π΅Ρ‡Π΅Π½Π½Ρ‹Ρ… Π² этот процСсс. Π­Ρ‚ΠΎΡ‚ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎ ΠΏΠΎΠ»Π΅Π·Π΅Π½ для ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΡ эффСктивности Ρ…ΠΈΠΌΠΈΠΎΡ‚Π΅Ρ€Π°ΠΏΠΈΠΈ. ЦСль.Π’Π΅ΠΊΡƒΡ‰Π΅Π΅ исслСдованиС Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½ΠΎ Π½Π° поиск Π”ΠΠš-структур, содСрТащих мноТСствСнныС ΠΎΠ±ΡŠΠ΅ΠΌΠ½Ρ‹Π΅ Π°Π΄Π΄ΡƒΠΊΡ‚Ρ‹, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ с наибольшСй ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ ΠΌΠΎΠ³ΡƒΡ‚ ΠΏΠΎΠ΄Π°Π²Π»ΡΡ‚ΡŒ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ систСмы. ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π€Π΅Ρ€ΠΌΠ΅Π½Ρ‚Π°Ρ‚ΠΈΠ²Π½Ρ‹ΠΉ синтСз Π”ΠΠš, ПЦР, ΠΏΡ€ΠΈΠ³ΠΎΡ‚ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ЭРН-ΠΊΠΎΠΌΠΏΠ΅Ρ‚Π΅Π½Ρ‚Π½Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… экстрактов, рСакция вырСзания, катализируСмая Π±Π΅Π»ΠΊΠ°ΠΌΠΈ ЭРН in vitro, Π’Π­Π–Π₯. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ ΠΏΠΎΠ΄Π±ΠΎΡ€ условий синтСза протяТСнных ΠΌΠΎΠ΄Π΅Π»ΡŒΠ½Ρ‹Ρ… Π”ΠΠš с мноТСствСнным Π²ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅ΠΌ Π½Π΅Ρ€Π΅ΠΏΠ°Ρ€ΠΈΡ€ΡƒΠ΅ΠΌΠΎΠ³ΠΎ поврСТдСния Fap-dC. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½ ряд Π”ΠΠš-структур, содСрТащий Π² своСм составС Ρ€Π°Π·Π»ΠΈΡ‡Π½ΠΎΠ΅ количСство ΠΌΠΎΠ΄ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… звСньСв. Показано, Ρ‡Ρ‚ΠΎ всС ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ Π”ΠΠš ΠΏΠΎΠ΄Π°Π²Π»ΡΡŽΡ‚ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ систСмы ЭРН in vitro. Π’Ρ‹Π±Ρ€Π°Π½Π° Π”ΠΠš-структура, которая ΠΈΠ½Π³ΠΈΠ±ΠΈΡ€ΡƒΠ΅Ρ‚ NER Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ высокой ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ. Π’Ρ‹Π²ΠΎΠ΄Ρ‹. ΠœΠΎΠ΄Π΅Π»ΡŒΠ½Ρ‹Π΅ Π”ΠΠš с Π½Π΅Ρ€Π΅ΠΏΠ°Ρ€ΠΈΡ€ΡƒΠ΅ΠΌΡ‹ΠΌΠΈ поврСТдСниями, способныС высокой ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ ΠΏΠΎΠ΄Π°Π²Π»ΡΡ‚ΡŒ NER, ΠΌΠΎΠ³ΡƒΡ‚ Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°Ρ‚ΡŒΡΡ Π² качСствС ΠΈΠ½Π³ΠΈΠ±ΠΈΡ‚ΠΎΡ€ΠΎΠ² систСмы ЭРН. ΠžΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Π½Ρ‹Π΅ Π² настоящСй Ρ€Π°Π±ΠΎΡ‚Π΅ закономСрности ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎ ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ для провСдСния Π½Π΅ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ Ρ„ΡƒΠ½Π΄Π°ΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹Ρ…, Π½ΠΎ ΠΈ ΠΏΡ€ΠΈΠΊΠ»Π°Π΄Π½Ρ‹Ρ… исслСдований

    Nanostructured metal-fullerene field emission cathode

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    One of the important properties of carbon nanostructures is their cold electron emission ability. Carbon nanotubes and other nanostructures are capable of emitting high currents at relatively low electrical fields. They are already used in functional devices such as field emitters. The conventional method of carbon nanostructured cathodes manufacturing is thin film nanocarbon deposition using CVD process on electrically conducting substrate like metal or doped silicon plates. The alternative way of manufacturing of carbon field emission cathodes is based on a special processing of carbon microfibers or composite materials in metal holders. We used the similar approach to produce composite metal-nanocarbon material which may be easily processed and shaped to produce an effective field emission cathode which can be easily fixed an any environment. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/2058

    THERMAL STEAM PLASMA DECOMPOSITION OF ORGANOCHLORINE COMPOUNDS

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    The report considers the decomposition of carbon tetrachloride and chlorobenzene by the plasma obtained in an AC plasma torch with separate supply of shielding gas and reaction components.171-17

    Harnessing the capabilities of spray granulation in the food industry for the production of functional foods

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    The article is the literature review of a current state of production technologies of powdery foodstuff, concentrates and multicomponent mixes. The need of the food industry for qualitative methods of processing of raw materials of different physical and chemical structure is noted. The authors give the reasons about need and possibility of a choice of granulation as a method of data processing of products. Physical and chemical features of granulation methods of disperse environments of various aggregate states based on the studied regularities and works of other authors are considered. The authors made the assumption of the application prospects of the method of liquid dispersion on the surface of particles in a suspended state for a granulation of foodstuff and they offered the alternative option. The possibility to use whey as binding element is considered. At the end of article authors draw the conclusion about the prospects of use of a method of dispersion of liquid on the surface of particles in a suspended state for a granulation of foodstuff

    USAGE OF AC PLASMA TORCH FOR PRODUCTION OF OXIDE POWDERS

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    The report deals with the synthesis of oxide materials in a plasma torch with separate injection of plasma-forming gas and solid aerosol of precursors. Thus, it is possible to provide a stability of the plasma torch operation and high degree of mixing of thermal plasma and precursors.188-18

    ΠœΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡ исслСдования молСкулярныхмаркСров ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ гСнСтичСскогориска развития ослоТнСний ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠΉΡ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΉΠ½ΠΎΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΈ

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    The authors present the results of the first four stages of research conducted under Government Contract No. 02.740.11.0774: Development of a Technology for Molecular Diagnostics of the Individual Genetic Risk of Development of Reproductive Function Disorders Associated with Human Urogenital Chlamydial Infection.ΠŸΡ€Π΅Π΄ΡΡ‚Π°Π²Π»Π΅Π½Ρ‹ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΏΠ΅Ρ€Π²Ρ‹Ρ… Ρ‡Π΅Ρ‚Ρ‹Ρ€Π΅Ρ… этапов Π½Π°ΡƒΡ‡Π½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΡΠΊΠΎΠΉ Ρ€Π°Π±ΠΎΡ‚Ρ‹, выполняСмой Π² Ρ€Π°ΠΌΠΊΠ°Ρ… ГосударствСнного ΠΊΠΎΠ½Ρ‚Ρ€Π°ΠΊΡ‚Π° β„– 02.740.11.0774 Β«Π Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ молСкулярной диагностики ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ гСнСтичСского риска развития Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΠΉ Ρ€Π΅ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΈ, ассоциированных с ΡƒΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠΉ Ρ…Π»Π°ΠΌΠΈΠ΄ΠΈΠΉΠ½ΠΎΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠ΅ΠΉ Ρƒ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°Β»
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