Metric connections in projective differential geometry

We search for Riemannian metrics whose Levi-Civita connection belongs to a given projective class. Following Sinjukov and Mikes, we show that such metrics correspond precisely to suitably positive solutions of a certain projectively invariant finite-type linear system of partial differential equations. Prolonging this system, we may reformulate these equations as defining covariant constant sections of a certain vector bundle with connection. This vector bundle and its connection are derived from the Cartan connection of the underlying projective structure.Comment: 10 page

The effects of music therapy on a group of institutionalised mentally retarded boys

A sample group of 9 profoundly or severely mentally retarded boys was chosen. Their  intelligence quotients were estimated at an average of 26, their mean chronological age at the beginning of the experiment was 11 years 10 months, and mean estimated mental age 2 years 4 months. The mean time they had spent in the institution was 4 years 10 months. The behaviour of the boys was such that they could be present in a group of 4 or 5 without disrupting the group. Music therapy in listening to music, participation by unpacking, playing and packing musical instruments away, and by walking to music, was given to small groups for half-an-hour per group, or to individuals for 7 to 10 minutes bi-weekly for 11 and a half weeks. Tests were conducted before and after the treatment, at an interval of exactly 3 calendar months apart. Significant improvements in social quotients, where social age was measured on the Vineland Social Maturity Scale, and in fine rr.otor control, were observed.S. Afr. Med. J., 48, 1723 (1974)

Dynamical coupling of pygmy and giant resonances in relativistic Coulomb excitation

We study the Coulomb excitation of pygmy dipole resonances (PDR) in heavy ion reactions at 100 MeV/nucleon and above. The reactions 68Ni+197Au and 68Ni+208Pb are taken as a practical examples. Our goal is to address the question of the influence of giant resonances on the PDR as the dynamics of the collision evolves. We show that the coupling to the giant resonances affects considerably the excitation probabilities of the PDR, a result that indicates the need of an improved theoretical treatment of the reaction dynamics at these bombarding energies.Comment: 6 pages, 4 figures, accepted for publication in Physics Letters

C-terminal extensions of ku70 and ku80 differentially influence dna end binding properties

The Ku70/80 heterodimer binds to DNA ends and attracts other proteins involved in the non-homologous end-joining (NHEJ) pathway of DNA double-strand break repair. We developed a novel assay to measure DNA binding and release kinetics using differences in Förster resonance

Creating patient value in glaucoma care

Purpose: The purpose of this paper is to explore in a specific hospital care process the applicability in practice of the theories of quality costing and value chains. Design/methodology/approach: In a retrospective case study an in-depth evaluation of the use of a quality cost mode

Balancing making a difference with making a living in the conservation sector

Goals play important roles in people's lives by focusing attention, mobilizing effort, and sustaining motivation. Understanding conservationists’ satisfaction with goal progress may provide insights into real-world environmental trends and flag risks to their well-being and motivation. We asked 2694 conservationists working globally how satisfied they were with progress towards goals important to them. We then explored how this satisfaction varied between groups. Finally, we looked at respondents' experiences associated with goal progress satisfaction. Many (94.0%) said “making a meaningful contribution to conservation” was an important goal for them, with over half being satisfied or very satisfied in this area (52.5%). However, respondents were generally dissatisfied with progress to collective conservation goals, such as stopping species loss, echoing formal assessments. Some groups were more likely to report dissatisfaction than others. For instance, those in conservation for longer tended to be less satisfied with collective goal progress (log-odds -0.21, 95% credibility interval (CI) -0.32 to -0.10), but practitioners reported greater satisfaction (log-odds 0.38, 95% CI 0.15-0.60). Likewise, those who are more optimistic in life (log-odds 0.24, 95% CI 0.17-0.32), male (log-odds 0.25, 95% CI 0.10-0.41), and working in conservation practice (log-odds 0.25, 95% CI 0.08-0.43) reported greater satisfaction with individual goal progress. Free-text responses suggested widespread dissatisfaction around livelihood goals, particularly related to job security and adequate compensation. While contributing to conservation appeared to be a source of satisfaction, slow goal progress in other areas – particularly around making a living – looked to be a source of distress and demotivation. Employers, funders, professional societies, and others should consider ways to help those in the sector make a difference whilst making a living, including by prioritizing conservationists' well-being when allocating funding. This support could include avoiding exploitative practices, fostering supportive work environments, and celebrating positive outcomes

Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance

Purpose Diagnosis of genetic disorders is hampered by large numbers of variants of uncertain significance (VUSs) identified through next-generation sequencing. Many such variants may disrupt normal RNA splicing. We examined effects on splicing of a large cohort of clinically identified variants and compared performance of bioinformatic splicing prediction tools commonly used in diagnostic laboratories. Methods Two hundred fifty-seven variants (coding and noncoding) were referred for analysis across three laboratories. Blood RNA samples underwent targeted reverse transcription polymerase chain reaction (RT-PCR) analysis with Sanger sequencing of PCR products and agarose gel electrophoresis. Seventeen samples also underwent transcriptome-wide RNA sequencing with targeted splicing analysis based on Sashimi plot visualization. Bioinformatic splicing predictions were obtained using Alamut, HSF 3.1, and SpliceAI software. Results Eighty-five variants (33%) were associated with abnormal splicing. The most frequent abnormality was upstream exon skipping (39/85 variants), which was most often associated with splice donor region variants. SpliceAI had greatest accuracy in predicting splicing abnormalities (0.91) and outperformed other tools in sensitivity and specificity. Conclusion Splicing analysis of blood RNA identifies diagnostically important splicing abnormalities and clarifies functional effects of a significant proportion of VUSs. Bioinformatic predictions are improving but still make significant errors. RNA analysis should therefore be routinely considered in genetic disease diagnostics