Anti-transglutaminase 6 antibodies in children and young adults with cerebral palsy.

Objectives. We have previously reported a high prevalence of gluten-related serological markers (GRSM) in children and young adults with cerebral palsy (CP). The majority had no enteropathy to suggest coeliac disease (CD). Antibodies against transglutaminase 6 (anti-TG6) represent a new marker associated with gluten-related neurological dysfunction. The aim of this study was to investigate the prevalence of anti-TG6 antibodies in this group of individuals with an early neurological injury resulting in CP. Materials and Methods. Sera from 96 patients with CP and 36 controls were analysed for IgA/IgG class anti-TG6 by ELISA. Results. Anti-TG6 antibodies were found in 12/96 (13%) of patients with CP compared to 2/36 (6%) in controls. The tetraplegic subgroup of CP had a significantly higher prevalence of anti-TG6 antibodies 6/17 (35%) compared to the other subgroups and controls. There was no correlation of anti-TG6 autoantibodies with seropositivity to food proteins including gliadin. Conclusions. An early brain insult and associated inflammation may predispose to future development of TG6 autoimmunity

Higher-order mesoscopic fluctuations in quantum wires: Conductance and current cumulants

We study conductance cumulants $>$ and current cumulants $C_j$ related to heat and electrical transport in coherent mesoscopic quantum wires near the diffusive regime. We consider the asymptotic behavior in the limit where the number of channels and the length of the wire in the units of the mean free path are large but the bare conductance is fixed. A recursion equation unifying the descriptions of the standard and Bogoliubov--de Gennes (BdG) symmetry classes is presented. We give values and come up with a novel scaling form for the higher-order conductance cumulants. In the BdG wires, in the presence of time-reversal symmetry, for the cumulants higher than the second it is found that there may be only contributions which depend nonanalytically on the wire length. This indicates that diagrammatic or semiclassical pictures do not adequately describe higher-order spectral correlations. Moreover, we obtain the weak-localization corrections to $C_j$ with $j\le 10$.Comment: 7 page

Transients in Power Systems

Power system engineering largely focuses on steady state analysis. The main areas of power system engineering are power flow studies and fault studies - both steady state technologies. But the world is largely transient, and power systems are always subject to time varying and short lived signals. This technical report concerns several important topics in transient analyses of power systems. The leading chapter deals with a new analytical tool-wavelets-for power system transients. Flicker and electric are furnace transients are discussed in Chapters I1 and IV. Chapter 111 deals with transients from shunt capacitor switching. The concluding chapters deal with transformer inrush current and non simultaneous pole closures of circuit breakers. This report was prepared by the students in EE532 at Purdue University. When I first came to Purdue in 1965, Professor El-Abiad was asking for student term projects which were turned into technical reports. I have \u27borrowed\u27 this idea and for many years we have produced technical reports from the power systems courses. The students get practice in writing reports, and the reader is able to get an idea of the coverage of our courses. I think that the students have done a good job on the subject of transients in power systems

Development of a cometosheath at comet 67P/Churuyumov-Gerasimenko: A case study comparison of Rosetta observations

Context: The ionosphere of a comet is known to deflect the solar wind through mass loading, but the interaction is dependent on cometary activity. We investigate the details of this process at comet 67P using the Rosetta Ion Composition Analyzer. Aims: This study aims to compare the interaction of the solar wind and cometary ions during two different time periods in the Rosetta mission. Methods: We compared both the integrated ion moments (density, velocity, and momentum flux) and the velocity distribution functions for two days, four months apart. The velocity distribution functions were projected into a coordinate system dependent on the magnetic field direction and averaged over three hours. Results: The first case shows highly scattered H+ in both ion moments and velocity distribution function. The He2+ ions are somewhat scattered, but less so, and appear more like those of H2O+ pickup ions. The second case shows characteristic evidence of mass-loading, where the solar wind species are deflected, but the velocity distribution function is not significantly changed. Conclusions: The distributions of H+ in the first case, when compared to He2+ and H2O+ pickup ions, are indicative of a narrow cometosheath on the scale of the H+ gyroradius. Thus, He2+ and H2O+, with larger gyroradii, are largely able to pass through this cometosheath. An examination of the momentum flux tensor suggests that all species in the first case have a significant non-gyrotropic momentum flux component that is higher than that of the second mass-loaded case. Mass loading is not a sufficient explanation for the distribution functions and momentum flux tensor in the first case, and so we assume this is evidence of bow shock formation.Comment: 14 pages, 9 figures, 3 tables, 2 video

Hybridization and Postprocessing Techniques for Mixed Eigenfunctions

We introduce hybridization and postprocessing techniques for the Raviart–Thomas approximation of second-order elliptic eigenvalue problems. Hybridization reduces the Raviart–Thomas approximation to a condensed eigenproblem. The condensed eigenproblem is nonlinear, but smaller than the original mixed approximation. We derive multiple iterative algorithms for solving the condensed eigenproblem and examine their interrelationships and convergence rates. An element-by-element postprocessing technique to improve accuracy of computed eigenfunctions is also presented. We prove that a projection of the error in the eigenspace approximation by the mixed method (of any order) superconverges and that the postprocessed eigenfunction approximations converge faster for smooth eigenfunctions. Numerical experiments using a square and an L-shaped domain illustrate the theoretical results

Microservice Transition and its Granularity Problem: A Systematic Mapping Study

Microservices have gained wide recognition and acceptance in software industries as an emerging architectural style for autonomic, scalable, and more reliable computing. The transition to microservices has been highly motivated by the need for better alignment of technical design decisions with improving value potentials of architectures. Despite microservices' popularity, research still lacks disciplined understanding of transition and consensus on the principles and activities underlying "micro-ing" architectures. In this paper, we report on a systematic mapping study that consolidates various views, approaches and activities that commonly assist in the transition to microservices. The study aims to provide a better understanding of the transition; it also contributes a working definition of the transition and technical activities underlying it. We term the transition and technical activities leading to microservice architectures as microservitization. We then shed light on a fundamental problem of microservitization: microservice granularity and reasoning about its adaptation as first-class entities. This study reviews state-of-the-art and -practice related to reasoning about microservice granularity; it reviews modelling approaches, aspects considered, guidelines and processes used to reason about microservice granularity. This study identifies opportunities for future research and development related to reasoning about microservice granularity.Comment: 36 pages including references, 6 figures, and 3 table

Nonreciprocal Directional Dichroism and Toroidalmagnons in Helical Magnets

We investigate a dynamical magnetoelectric effect due to a magnetic resonance in helical spin structures through the coupling between magnetization and electric polarization via a spin current mechanism. We show that the magnon has both the dynamical magnetic moment $\Delta M^\omega$ and the electric moment $\Delta P^\omega$ ($\perp \Delta M^\omega$), i.e., a dynamical toroidal moment, under external magnetic fields, and thus it is named the {\em toroidalmagnon}. The toroidalmagnon exists in most conical spin structures owing to the generality of the spin current mechanism. In the absorption of electromagnetic waves, the toroidalmagnon excitation process generally induces a nonreciprocal directional dichroism as a consequence of an interference of the magnetic and electric responses.Comment: 5 pages, 2 figure

Financing Maternal and Child Health—What Are the Limitations in Estimating Donor Flows and Resource Needs?

Marco Schäferhoff and colleagues critique funding estimates for the maternal and child health Millennium Development Goals, and make recommendations for improving the tracking of financing flows and estimating the costs of scaling up interventions for mothers and children

Spatial distribution of low-energy plasma around 2 comet 67P/CG from Rosetta measurements

International audienceWe use measurements from the Rosetta plasma consortium (RPC) Langmuir probe (LAP) and mutual impedance probe (MIP) to study the spatial distribution of low-energy plasma in the near-nucleus coma of comet 67P/Churyumov-Gerasimenko. The spatial distribution is highly structured with the highest density in the summer hemisphere and above the region connecting the two main lobes of the comet, i.e. the neck region. There is a clear correlation with the neutral density and the plasma to neutral density ratio is found to be ∼1-2·10 −6 , at a cometocentric distance of 10 km and at 3.1 AU from the sun. A clear 6.2 h modulation of the plasma is seen as the neck is exposed twice per rotation. The electron density of the collisonless plasma within 260 km from the nucleus falls of with radial distance as ∼1/r. The spatial structure indicates that local ionization of neutral gas is the dominant source of low-energy plasma around the comet

Faire l’Union. La refondation des parties de droite après les élections de 2002

Un nouveau parti de droite, pour le moment dénommé UMP, a été mis en place entre des deux tours de l'élection présidentielle. Cet article se donne pour objectif d'analyser les enjeux de cette transformation. La genèse de l'UMP permet de saisir dans quelle mesure un parti poli-tique peut être conçu comme la connexion d'un ensemble de systèmes de coopération organisés autour de postes à conquérir. En effet, l'impératif d'unification de la droite française est lié au décalage persistant existant entre les systèmes de coopération législatif et présidentiel. Mais les questions soulevées par cette fusion partisane (l'UMP inclut le RPR, DL et une majeure partie de l'UDF) montrent que cette vision ne peut suffire et que les partis ne sont pas seulement des systèmes de coopération mais aussi des systèmes de production. Dès lors, leurs logiques d'organisation internes pèsent sur ce travail de transformation du social en politique, de la plu-ralité en homogénéité. Dans le cas de l'UMP, il s'agit d'abord de mettre en commun des modes de fonctionnement, en particulier de définir la place et la légitimité accordées respectivement aux adhérents et aux élus, mais aussi d'organiser l'expression de la pluralité idéologique par la mise en place de courants