The CH fraction of Carbon stars at high Galactic latitudes

CH stars form a distinct class of objects with characteristic properties like iron deficiency, enrichment of carbon and overabundance in heavy elements. These properties can provide strong observational constraints for theoretical computation of nucleosynthesis at low-metallicity. An important question is the relative surface density of CH stars which can provide valuable inputs to our understanding on the role of low to intermediate-mass stars in the early Galactic chemical evolution. Spectroscopic characterization provides an effective way of identifying CH stars. The present analysis is aimed at a quantitative assessment of the fraction of CH stars in a sample of stars using a set of spectral classification criteria. The sample consists of 92 objects selected from a collection of candidate Faint High Latitude Carbon stars from the Hamburg/ESO survey. Medium resolution (R ~ 1300) spectra for these objects were obtained using OMR at VBO, Kavalur and HFOSC at HCT, IAO, Hanle, during 2007 - 2009 spanning a wavelength range 3800 - 6800 A. Spectral analysis shows 36 of the 92 objects to be potential CH stars; combined with our earlier studies (Goswami 2005, Goswami et al. 2007) this implies ~ 37% (of 243) objects as the CH fraction. We present spectral descriptions of the newly identified CH star candidates. Estimated effective temperatures, 12C/13C isotopic ratios and their locations on the two colour J-H vs H-K plot are used to support their identification.Comment: 18 pages, 8 figures,Accepted for publication in MNRA

Exploring pre-main sequence variables of ONC: The new variables

Since 2004, we have been engaged in a long-term observing program to monitor young stellar objects in the Orion Nebula Cluster. We have collected about two thousands frames in V, R, and I broad-band filters on more than two hundred nights distributed over five consecutive observing seasons. The high-quality and time-extended photometric data give us an opportunity to address various phenomena associated with young stars. The prime motivations of this project are i) to explore various manifestations of stellar magnetic activity in very young low-mass stars; ii) to search for new pre-main sequence eclipsing binaries; and iii) to look for any EXor and FUor like transient activities associated with YSOs. Since this is the first paper on this program, we give a detailed description of the science drivers, the observation and the data reduction strategies as well. In addition to these, we also present a large number of new periodic variables detected from our first five years of time-series photometric data. Our study reveals that about 72% of CTTS in our FoV are periodic, whereas, the percentage of periodic WTTS is just 32%. This indicates that inhomogeneities patterns on the surface of CTTS of the ONC stars are much more stable than on WTTS. From our multi-year monitoring campaign we found that the photometric surveys based on single-season are incapable of identifying all periodic variables. And any study on evolution of angular momentum based on single-season surveys must be carried out with caution.Comment: Accepted for publication by MNRAS, 26 pages, 17 figures, 6 table

Pharmacology as a foreign language: A preliminary evaluation of podcasting as a supplementary learning tool for non-medical prescribing students

<p>Abstract</p> <p>Background</p> <p>Nurses and other health professionals in the U.K. can gain similar prescribing rights to doctors by undertaking a non-medical prescribing course. Non-medical prescribing students must have a thorough understanding of the pharmacology of prescribing to ensure safe practice. Pharmacology education at this level is complicated by the variation in students' prior subject knowledge of, and anxiety about, the subject. The recent advances in technology, particularly the potential for mobile learning, provide increased opportunities for students to familiarise themselves with lecture materials and hence promote understanding. The objective of this study was therefore to evaluate both the subjective (student perception) and objective (student use and exam results) usefulness of podcasts of pharmacology lectures which were provided as an extra learning tool to two cohorts (n = 69) of non-medical prescribing students.</p> <p>Methods</p> <p>The podcasts were made available to students through the virtual learning environment WebCT. Use of podcasts by two successive cohorts of nurse prescribing students (n = 69) was tracked through WebCT. Survey data, which was collected from 44 of these students, investigated patterns of/reasons for podcast use and perceived usefulness of podcasts as a learning tool. Of these 69 students, 64 completed the pharmacology exam. In order to examine any impact of podcasts on student knowledge, their exam results were compared with those of two historical cohorts who did not have access to podcasts (n = 70).</p> <p>Results</p> <p>WebCT tracking showed that 91% of students accessed at least one podcast. 93% of students used the podcasts to revisit a lecture, 85% used podcasts for revision, and 61% used the podcasts when they had a specific question. Only 22% used the podcasts because they had missed a pharmacology session. Most students (81%) generally listened to the entire podcast rather than specific sections and most (73%) used them while referring to their lecture handouts. The majority of students found the podcasts helpful as a learning tool, as a revision aid and in promoting their understanding of the subject. Evaluation of the range of marks obtained, mode mark and mean mark suggested improved knowledge in students with access to podcasts compared to historical cohorts of students who did not have access to pharmacology podcasts.</p> <p>Conclusions</p> <p>The results of this study suggest that non-medical prescribing students utilised podcasts of pharmacology lectures, and have found the availability of these podcasts helpful for their learning. Exam results indicate that the availability of podcasts was also associated with improved exam performance.</p

Circulating microRNAs as novel biomarkers for diabetes mellitus.

Diabetes mellitus is characterized by insulin secretion from pancreatic β cells that is insufficient to maintain blood glucose homeostasis. Autoimmune destruction of β cells results in type 1 diabetes mellitus, whereas conditions that reduce insulin sensitivity and negatively affect β-cell activities result in type 2 diabetes mellitus. Without proper management, patients with diabetes mellitus develop serious complications that reduce their quality of life and life expectancy. Biomarkers for early detection of the disease and identification of individuals at risk of developing complications would greatly improve the care of these patients. Small non-coding RNAs called microRNAs (miRNAs) control gene expression and participate in many physiopathological processes. Hundreds of miRNAs are actively or passively released in the circulation and can be used to evaluate health status and disease progression. Both type 1 diabetes mellitus and type 2 diabetes mellitus are associated with distinct modifications in the profile of miRNAs in the blood, which are sometimes detectable several years before the disease manifests. Moreover, circulating levels of certain miRNAs seem to be predictive of long-term complications. Technical and scientific obstacles still exist that need to be overcome, but circulating miRNAs might soon become part of the diagnostic arsenal to identify individuals at risk of developing diabetes mellitus and its devastating complications

Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stroke in young adults although relatively uncommon in the general population (incidence of 2.6/100,000 per year). Minor cervical traumas, infection, migraine and hypertension are putative risk factors, and inverse associations with obesity and hypercholesterolemia are described. No confirmed genetic susceptibility factors have been identified using candidate gene approaches. We performed genome-wide association studies (GWAS) in 1,393 CeAD cases and 14,416 controls. The rs9349379[G] allele (PHACTR1) was associated with lower CeAD risk (odds ratio (OR) = 0.75, 95% confidence interval (CI) = 0.69-0.82; P = 4.46 × 10(-10)), with confirmation in independent follow-up samples (659 CeAD cases and 2,648 controls; P = 3.91 × 10(-3); combined P = 1.00 × 10(-11)). The rs9349379[G] allele was previously shown to be associated with lower risk of migraine and increased risk of myocardial infarction. Deciphering the mechanisms underlying this pleiotropy might provide important information on the biological underpinnings of these disabling conditions

Pioglitazone: A review of analytical methods

Pioglitazone is an oral anti-hyperglycemic agent. It is used for the treatment of diabetes mellitus type 2. It selectively stimulates nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma). It was the tenth-best-selling drug in the U.S. in 2008. This article examines published analytical methods reported so far in the literature for the determination of pioglitazone in biological samples and pharmaceutical formulations. They include various techniques like electrochemical methods, spectrophotometry, capillary electrophoresis, high-performance liquid chromatography, liquid chromatographyâelectrospray ionization-tandem mass spectrometry and high-performance thin layer chromatography. Keywords: Pioglitazone, Analytical methods, Diabetes mellitus type

All spray pyrolysis-coated CdTe–TiO2 heterogeneous films for photo-electrochemical solar cells

Abstract Cadmium telluride (CdTe) thin films of different thicknesses deposited onto titanium dioxide (TiO2) nanoparticle layer by spray pyrolysis deposition (SPD) are demonstrated as major photo-active semiconductor in photo-electrochemical solar cell configuration using iodide/triiodide (I−/I3 −) redox couple as a hole transport layer. The CdTe–TiO2 heterogeneous films were characterized by X-ray photoelectron spectroscopy which identified doublet split of Cd 3d and Ti 2p which confirms CdTe and TiO2. Optical absorbance and transmittance of CdTe and TiO2 films which were examined by UV–Vis spectroscopy confirm that the optical bandgap of CdTe is 1.5 eV with a dominant photo-absorption in the spectral window of 350–800 nm, while TiO2 showed a bandgap of 3.1 eV and is optically transparent in the visible spectral window. The present work examined photo-anodes comprising 1, 3, 5, and 10 SPD cycles of CdTe coated on TiO2 nanoparticle layer. The solar cell with 5 SPD cycles of CdTe resulting in 0.4% efficiency. Results can be articulated to the CdTe deposited by 5 SPD cycles provided an optimum surface coverage in the bulk of TiO2, while the higher SPD cycles leads to agglomeration which blocks the porosity of the heterogeneous films