Изменение офтальмотонуса на фоне эндовитреальных инъекций ингибиторов ангиогенеза

Neovascular macular degeneration treatment with repeated intravitreal injections may lead to both short-term and long-term elevations of intraocular pressure (IOP) level.PURPOSE: To evaluate intraocular pressure changes in patients who received different amounts of endovitreal antiVEGF injections for macular pathology treatment.METHODS: A retrospective analysis of 219 patients (219 eyes) with wet macular degeneration and persistent hypertension after intravitreal injections. All patients had injections performed only in one eye. The number of injections ranged from one to eight.RESULTS: Follow-up showed a persistent IOP elevation in 18 patients. A relation between hypertension and AMD clinical manifestations has been revealed.CONCLUSION: The retrospective analysis showed no significant correlation between the amount of hypertension cases and the number of injections.Систематическое лечение интравитреальными инъекциями неоваскулярных изменений в макуле может влиять на уровень офтальмотонуса. Повышение внутриглазного давления (ВГД) может быть не только сразу после инъекции, но и сохраняться более длительное время.ЦЕЛЬ. Оценить изменения ВГД на глазах пациентов, получавших различное количество эндовитреальных инъекций препарата с антиVEGF- активностью по поводу макулярной патологии.МЕТОДЫ. Ретроспективный анализ 219 пациентов (219 глаз) с влажной формой возрастной макулодистрофии (ВМД). Эндовитреальные инъекции проводились только в один глаз. Количество инъекций варьировало от одной до восьми. Оценивались только случаи персистирующей гипертензии.РЕЗУЛЬТАТЫ. У 18 пациентов при последующем наблюдении имело место повышенное ВГД персистирующего характера. Связи развития гипертензии и особенностей клинических проявлений ВМД выявлено не было.ЗАКЛЮЧЕНИЕ. Ретроспективный анализ не выявил четкой зависимости количества случаев гипертензии от числа проведенных инъекций

Molecular excitation in the Interstellar Medium: recent advances in collisional, radiative and chemical processes

We review the different excitation processes in the interstellar mediumComment: Accepted in Chem. Re

ЗНАЧЕНИЕ ВИРУСА ГЕРПЕСА 6-ГО ТИПА В ГЕНЕЗЕ СУДОРОЖНОГО СИНДРОМА У ДЕТЕЙ

The value of human herpes virus type 6 (HHV-6) in the structure of seizures in 114 children in three groups of patients: with neuroinfections, with epilepsy and febrile convulsions was studied. Determination of HHV-6 by polymerase chain reaction in the acute period of the disease is a reliable sign (p < 0.001), and most often diagnosed in children in the group with febrile seizures (53.8%). Recovery in children with seizures caused by HHV-6, was observed only in 28% of cases,38.8% of patients in the outcome of the disease expand the epilepsy.Изучено значение вируса герпеса человека 6-го типа (HHV-6) в структуре судорожного синдрома у 114 детей в трех группах больных: с нейроинфекциями, с эпилепсией и с фебрильными судорогами. Выявление генома HHV-6 методом полимеразной цепной реакции в остром периоде заболевания является достоверным признаком (р < 0,001) и наиболее часто обнаруживает-ся у детей в группе с фебрильными судорогами (53,8%). Выздоровление у детей с судорожным синдромом, обусловленным HHV-6, наблюдается лишь в 28% случаев, у 38,8% больных в исходе заболевания развивается эпилепсия.

BASECOL2023 scientific content

Context. The global context of making numerous data produced by researchers available requires collecting and organising the data, assigning meaningful metadata, and presenting the data in a meaningful and homogeneous way. The BASECOL database, which collects inelastic rate coefficients for application to the interstellar medium and to circumstellar and cometary atmospheres, meets those requirements. Aims. We aim to present the scientific content of the BASECOL2023 edition. Methods. While the previous versions relied on finding rate coefficients in the literature, the current version is populated with published results sent by the producers of data. The paper presents the database, the type of data that can be found, the type of metadata that are used, and the Virtual Atomic and Molecular Data Centre (VAMDC) standards that are used for the metadata. Finally, we present the different datasets species by species. Results. As the BASECOL database, interconnected with the VAMDC e-infrastructure, uses the VAMDC standards, the collisional data can be extracted with tools using VAMDC standards and can be associated with spectroscopic data extracted from other VAMDC connected databases such as the Cologne database for molecular spectroscopy (CDMS), the jet propulsion laboratory molecular spectroscopy database (JPL), and the high-resolution transmission molecular absorption database (HITRAN)

Prophylactic complexes of physiotherapy exerciseswhen planning Pregnancy

The relevance of a research of clinical manifestations and techniques of treatment and prevention of osteochondrosis when planning pregnancy is extremely high, in connection with influence on the patient, the course of pregnancy and the further result of childbirth. The physiology and pathology of bodies of the reproductive sphere, feature of a course of pregnancy and childbirth at women with dorsopatiya are insufficiently studied. Publications of the Russian and foreign authors showed that about 60% of pregnant women feel back pains on different terms of pregnancy. As during pregnancy in a female body there are various changes which can lead to complications during incubation of the child. Especially to physiological and specific changes the bone and articulate system softening not only joints, but also skeleton ligaments is subject. Articulate sheaves in lumbar department of a backbone are also exposed to influence of hormones, and in a complex with increase in weight and need of a deviation of a body can cause back pain back. Among the manifestations of vertebrogenny pathology bringing to pregnant women the greatest sufferings the pain syndrome which amplifies in process of increase in terms of a gestation is on the first place. In article complexes of physiotherapy exercises when planning pregnancy are described.Актуальность исследования клинических проявлений и методик лечения и профилактики остеохондроза при планировании беременности крайне высока, в связи с влиянием на пациента, течение беременности и дальнейший исход родов. Физиология и патология органов репродуктивной сферы, особенности течения беременности и родов у женщин с дорсопатиями недостаточно изучены. Публикации российских и зарубежных авторов показали, что около 60 % беременных женщин испытывают боли в спине на разных сроках беременности [1]. Так как в период беременности в женском организме происходят различные изменения, которые могут привести к осложнениям во время вынашивания ребенка. Особенно к физиологически-специфическим изменениям подвержена костно-суставная система размягчающая не только суставы, но и связки скелета. Суставные связки в поясничном отделе позвоночника также подвергаются влиянию гормонов, а в комплексе с увеличением веса и необходимостью отклонения тела назад может вызывать боль в спине. Среди проявлений вертеброгенной патологии, доставляющих беременным женщинам наибольшие страдания, на первом месте стоит болевой синдром, который усиливается по мере увеличения сроков гестации [5]. В статье описаны комплексы лечебной физкультуры при планировании беременности

Evaluation of hemostasis and severity of atherosclerosis in the peripheral arteries depending on the presence of insulin resistance

Aim. Research of peripheral arterial atherosclerosis and condition of inflammation and hemostasis in addiction of insulin resistance measured with TG / HDL-C ratio. Materials and Methods. In the research were included 50 patients of both sexes 30-75 years old. First group consisted of 21 persons with TG I HDL-C >3. The second group included 29 persons with TG / HDL-C 3 values of C-reactive protein were authentically high: 4,03+3,16 and 2,81+3,72 in first and second groups accordingly (p=0,033). Members of first group had lower activity of antithrombin III: 97,6+19,6 in first group, 110,4+11,0 in second one (p=0,009). In group of patients with insulin resistance platelet aggregation inducted by adrenaline and A D P 10 mcm was authentically low (p3 had higher percent of artery stenosis of femoropopliteal segment than patients of the second group (47,7+35,9% and 10,7±17,5%, p=0,01). Conclusion. Patients with the indirect marker TG / HDL-C>3 had low activity of antithrombin III and high level of C-reactive protein. Patients with insulin resistance had changes of platelet link of hemostasis characterized with high sensitivity to aggregation inductors and with low aggregation activity measured by light transmission. Patients of first group had more valuable peripheral arterial atherosclerosis of low extremities mainly in femoropopliteal segment.Цель. Изучение особенностей атеросклеротического поражения периферических артерий, состояния воспаления и гемостаза в зависимости от инсулинорезистентности, оцениваемой по величине коэффициента ТГ7ХСЛВП. Материалы и методы. В исследование включены 50 пациентов обоего пола 30-75 лет. Первую группу составляли 21 человек с ТГ/ХСЛВП >3. Во вторую группу вошли 29 человек с ТГ/ХСЛВП 3 значения С-реактивного белка были достоверно выше - 4,03+3,16 и 2,81 ±3,72, в первой и второй группах соответсвенно (р=0,033). Лица первой группы имели более низкую активность антитромбина III - 97,6+19,6 в первой группе, 110,4+11,0 - во второй (р=0,009). В группе больных с инсулинорезистентностью агрегация тромбоцитов, индуцируемая адреналином и А Д Ф 10 мкМ, была достоверно ниже (р3 имели достоверно больший процент стенозирования артерий бедренно-подколенного сегмента в сравнении с пациентами второй группы (47,7+35,9% и 10,7+17,5%, р=0,01). Выводы. Пациенты со значениями косвенного маркера инсулинорезистентности ТГ/ХСЛВП >3 имели достоверно меньшую активность антитромбина III и больший уровень С-реактивного белка. Изменения тромбоцитарного звена гемостаза у этих больных характеризовалось повышенной сенситивностью к индукторам агрегации и меньшей агрегационной активности, оцениваемой по светопропусканию. Больные первой группы имели более значительное атеросклеротическое поражение артерий нижних конечностей

Changes to the Fossil Record of Insects through Fifteen Years of Discovery

The first and last occurrences of hexapod families in the fossil record are compiled from publications up to end-2009. The major features of these data are compared with those of previous datasets (1993 and 1994). About a third of families (>400) are new to the fossil record since 1994, over half of the earlier, existing families have experienced changes in their known stratigraphic range and only about ten percent have unchanged ranges. Despite these significant additions to knowledge, the broad pattern of described richness through time remains similar, with described richness increasing steadily through geological history and a shift in dominant taxa, from Palaeoptera and Polyneoptera to Paraneoptera and Holometabola, after the Palaeozoic. However, after detrending, described richness is not well correlated with the earlier datasets, indicating significant changes in shorter-term patterns. There is reduced Palaeozoic richness, peaking at a different time, and a less pronounced Permian decline. A pronounced Triassic peak and decline is shown, and the plateau from the mid Early Cretaceous to the end of the period remains, albeit at substantially higher richness compared to earlier datasets. Origination and extinction rates are broadly similar to before, with a broad decline in both through time but episodic peaks, including end-Permian turnover. Origination more consistently exceeds extinction compared to previous datasets and exceptions are mainly in the Palaeozoic. These changes suggest that some inferences about causal mechanisms in insect macroevolution are likely to differ as well

ADDITIONAL PROFESSIONAL EDUCATION IN THE CONTEXT OF A NEW INDUSTRIAL REVOLUTION

Twenty-first century is called the century of human capital, which is rapidly becoming obsolete and requires systematic updating and accumulation. Additional professional education system is one of the most effective forms of human development. The article presents the results of the next stage of the research problems of additional vocational training system in staffing modernizing the economy of Siberia. These problems are considered from the perspective of demand and supply of educational services. The authors' conclusions are based on data from a poll of listeners APE and in-depth interviews with heads of educational centers. On the basis of their conclusions about the motives, expectations and results of additional professional education from the perspective of consumers and customers APE. The paper also presents the strategy centers APE regarding interactions with employees and employers, as well as competitors in the market for educational services