6,243 research outputs found
Frontostriatal Maturation Predicts Cognitive Control Failure to Appetitive Cues in Adolescents
Adolescent risk-taking is a public health issue that increases the odds of poor lifetime outcomes. One factor thought to influence adolescents' propensity for risk-taking is an enhanced sensitivity to appetitive cues, relative to an immature capacity to exert sufficient cognitive control. We tested this hypothesis by characterizing interactions among ventral striatal, dorsal striatal, and prefrontal cortical regions with varying appetitive load using fMRI scanning. Child, teen, and adult participants performed a go/no-go task with appetitive (happy faces) and neutral cues (calm faces). Impulse control to neutral cues showed linear improvement with age, whereas teens showed a nonlinear reduction in impulse control to appetitive cues. This performance decrement in teens was paralleled by enhanced activity in the ventral striatum. Prefrontal cortical recruitment correlated with overall accuracy and showed a linear response with age for no-go versus go trials. Connectivity analyses identified a ventral frontostriatal circuit including the inferior frontal gyrus and dorsal striatum during no-go versus go trials. Examining recruitment developmentally showed that teens had greater between-subject ventral-dorsal striatal coactivation relative to children and adults for happy no-go versus go trials. These findings implicate exaggerated ventral striatal representation of appetitive cues in adolescents relative to an intermediary cognitive control response. Connectivity and coactivity data suggest these systems communicate at the level of the dorsal striatum differentially across development. Biased responding in this system is one possible mechanism underlying heightened risk-taking during adolescence
Analysis of the Copenhagen Accord pledges and its global climatic impacts‚ a snapshot of dissonant ambitions
This analysis of the Copenhagen Accord evaluates emission reduction pledges by individual countries against the Accord's climate-related objectives. Probabilistic estimates of the climatic consequences for a set of resulting multi-gas scenarios over the 21st century are calculated with a reduced complexity climate model, yielding global temperature increase and atmospheric CO2 and CO2-equivalent concentrations. Provisions for banked surplus emission allowances and credits from land use, land-use change and forestry are assessed and are shown to have the potential to lead to significant deterioration of the ambition levels implied by the pledges in 2020. This analysis demonstrates that the Copenhagen Accord and the pledges made under it represent a set of dissonant ambitions. The ambition level of the current pledges for 2020 and the lack of commonly agreed goals for 2050 place in peril the Accord's own ambition: to limit global warming to below 2 °C, and even more so for 1.5 °C, which is referenced in the Accord in association with potentially strengthening the long-term temperature goal in 2015. Due to the limited level of ambition by 2020, the ability to limit emissions afterwards to pathways consistent with either the 2 or 1.5 °C goal is likely to become less feasibl
APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution
The APOBEC mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade. Many lessons learnt regarding APOBEC within virology are likely to be applicable to cancer. In this review, we explore the parallels between the role of APOBEC enzymes in HIV and cancer evolution. We discuss data supporting the role of APOBEC mutagenesis in creating HIV genome heterogeneity, drug resistance, and immune escape variants. We hypothesize similar functions of APOBEC will also hold true in cancer
Formation and Structure of a Current Sheet in Pulsed-Power Driven Magnetic Reconnection Experiments
We describe magnetic reconnection experiments using a new, pulsed-power
driven experimental platform in which the inflows are super-sonic but
sub-Alfv\'enic.The intrinsically magnetised plasma flows are long lasting,
producing a well-defined reconnection layer that persists over many
hydrodynamic time scales.The layer is diagnosed using a suite of high
resolution laser based diagnostics which provide measurements of the electron
density, reconnecting magnetic field, inflow and outflow velocities and the
electron and ion temperatures.Using these measurements we observe a balance
between the power flow into and out of the layer, and we find that the heating
rates for the electrons and ions are significantly in excess of the classical
predictions. The formation of plasmoids is observed in laser interferometry and
optical self-emission, and the magnetic O-point structure of these plasmoids is
confirmed using magnetic probes.Comment: 14 pages, 12 figures. Accepted for publication in Physics of Plasma
Open-domain topic identification of out-of-domain utterances using Wikipedia
Users of spoken dialogue systems (SDS) expect high quality interactions across a wide range of diverse topics. However, the implementation of SDS capable of responding to every conceivable user utterance in an informative way is a challenging problem. Multi-domain SDS must necessarily identify and deal with out-of-domain (OOD) utterances to generate appropriate responses as users do not always know in advance what domains the SDS can handle. To address this problem, we extend the current state-of-the-art in multi-domain SDS by estimating the topic of OOD utterances using external knowledge representation from Wikipedia. Experimental results on real human-to-human dialogues showed that our approach does not degrade domain prediction performance when compared to the base model. But more significantly, our joint training achieves more accurate predictions of the nearest Wikipedia article by up to about 30% when compared to the benchmarks
Ultra-Slow Discharges That Precede Lightning Initiation
We report on ultra-slowly propagating discharge events with speeds in the range 1-13 km/s, much lower than any known lightning process. The propagation speeds of these discharges are orders of magnitude slower than leader or streamer speeds, but faster than the ion drift speed. For one particular event, a lightning leader forms about 40 ms later within 50 m of the discharge, likely within the same high field region. A second slow event forms 9 ms prior to the initiation, and leads into the negative leader. Most slow events appear to not be directly involved with lightning initiation. This suggests that the classic streamer cascade model of initiation is not always a definitive process. In this work we describe these discharge events displaying unique behavior, their relation to common lightning discharges, and their implications for lightning initiation
MMTF: The Maryland-Magellan Tunable Filter
This paper describes the Maryland-Magellan Tunable Filter (MMTF) on the
Magellan-Baade 6.5-meter telescope. MMTF is based on a 150-mm clear aperture
Fabry-Perot (FP) etalon that operates in low orders and provides transmission
bandpass and central wavelength adjustable from ~5 to ~15 A and from ~5000 to
over ~9200 A, respectively. It is installed in the Inamori Magellan Areal
Camera and Spectrograph (IMACS) and delivers an image quality of ~0.5" over a
field of view of 27' in diameter (monochromatic over ~10'). This versatile and
easy-to-operate instrument has been used over the past three years for a wide
variety of projects. This paper first reviews the basic principles of FP
tunable filters, then provides a detailed description of the hardware and
software associated with MMTF and the techniques developed to observe with this
instrument and reduce the data. The main lessons learned in the course of the
commissioning and implementation of MMTF are highlighted next, before
concluding with a brief outlook on the future of MMTF and of similar facilities
which are soon coming on line.Comment: 38 pages, 12 figures, 3 tables, now accepted for publication to the
Astronomical Journa
An Experimental Platform for Pulsed-Power Driven Magnetic Reconnection
We describe a versatile pulsed-power driven platform for magnetic
reconnection experiments, based on exploding wire arrays driven in parallel
[Suttle, L. G. et al. PRL, 116, 225001]. This platform produces inherently
magnetised plasma flows for the duration of the generator current pulse (250
ns), resulting in a long-lasting reconnection layer. The layer exists for long
enough to allow evolution of complex processes such as plasmoid formation and
movement to be diagnosed by a suite of high spatial and temporal resolution
laser-based diagnostics. We can access a wide range of magnetic reconnection
regimes by changing the wire material or moving the electrodes inside the wire
arrays. We present results with aluminium and carbon wires, in which the
parameters of the inflows and the layer which forms are significantly
different. By moving the electrodes inside the wire arrays, we change how
strongly the inflows are driven. This enables us to study both symmetric
reconnection in a range of different regimes, and asymmetric reconnection.Comment: 14 pages, 9 figures. Version revised to include referee's comments.
Submitted to Physics of Plasma
Charge injection instability in perfect insulators
We show that in a macroscopic perfect insulator, charge injection at a
field-enhancing defect is associated with an instability of the insulating
state or with bistability of the insulating and the charged state. The effect
of a nonlinear carrier mobility is emphasized. The formation of the charged
state is governed by two different processes with clearly separated time
scales. First, due to a fast growth of a charge-injection mode, a localized
charge cloud forms near the injecting defect (or contact). Charge injection
stops when the field enhancement is screened below criticality. Secondly, the
charge slowly redistributes in the bulk. The linear instability mechanism and
the final charged steady state are discussed for a simple model and for
cylindrical and spherical geometries. The theory explains an experimentally
observed increase of the critical electric field with decreasing size of the
injecting contact. Numerical results are presented for dc and ac biased
insulators.Comment: Revtex, 7pages, 4 ps figure
Overcoming the roadblocks to cardiac cell therapy using tissue engineering
Transplantations of various stem cells or their progeny have repeatedly improved cardiac performance in animal models of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent. Some of the recognized challenges are poor engraftment of implanted cells and, in the case of human cardiomyocytes, functional immaturity and lack of electrical integration, leading to limited contribution to the heart’s contractile activity and increased arrhythmogenic risks. Advances in tissue and genetic engineering techniques are expected to improve the survival and integration of transplanted cells, and to support structural, functional, and bioenergetic recovery of the recipient hearts. Specifically, application of a prefabricated cardiac tissue patch to prevent dilation and to improve pumping efficiency of the infarcted heart offers a promising strategy for making stem cell therapy a clinical reality.
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