306 research outputs found

    ANALYSIS AND VERIFICATION OF THE OPERATION OF THE STABILIZING ROBUST CONTROLLER'S ELECTRICAL CIRCUIT OF THE ROTOR FLUX-LINKAGE CONTROL SYSTEM

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    On the basis of the classical theory of robust control, the theory of stability and the theory of continued fractions, the linearized mathematical model, the procedure for calculating and designing an analog electrical circuit of the H∞-suboptimal robust controller of the flux-linkage control system of the rotor of an asynchronous electric drive, protected by Ukrainian Patent no.137157, were built. The circuit contains three operational amplifiers, several resistors and capacitors. The proposed mathematical model, the procedure for calculating and choosing the parameters of the resistors and capacitors of the circuit take into account the random variations of the object and the controller within the specified boundaries. An analytical relationship between the transfer function coefficients and the resistances of the resistors and the capacitances of the capacitors of the controller's electrical circuit was established. On a specific example, by calculation according to the developed algorithm, the limiting values of the tolerances of the circuit's resistances of the resistors and capacitances of the capacitors were identified and these values were selected with a margin from the standard series. Analysis of noise filtering by the electrical circuit of the controller in the Multisim package shows its insensitivity to noise spreads within fairly wide boundaries. На Π±Π°Π·Ρ– класичної Ρ‚Π΅ΠΎΡ€Ρ–Ρ— робастного управління, Ρ‚Π΅ΠΎΡ€Ρ–Ρ— стійкості Ρ– Ρ‚Π΅ΠΎΡ€Ρ–Ρ— Π»Π°Π½Ρ†ΡŽΠ³ΠΎΠ²ΠΈΡ… Π΄Ρ€ΠΎΠ±Ρ–Π² ΠΏΠΎΠ±ΡƒΠ΄ΠΎΠ²Π°Π½ΠΎ Π»Ρ–Π½Π΅Π°Ρ€ΠΈΠ·ΠΎΠ²Π°Π½Π° ΠΌΠ°Ρ‚Π΅ΠΌΠ°Ρ‚ΠΈΡ‡Π½Π° модСль, ΠΏΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Π° Ρ€ΠΎΠ·Ρ€Π°Ρ…ΡƒΠ½ΠΊΡƒ Ρ– проСктування Π°Π½Π°Π»ΠΎΠ³ΠΎΠ²ΠΎΡ— Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΈΡ‡Π½ΠΎΡ— схСми Н∞-ΡΡƒΠ±ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ робастного рСгулятора систСми управління потокозчСплСнням Ρ€ΠΎΡ‚ΠΎΡ€Π° асинхронного Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΎΠΏΡ€ΠΈΠ²ΠΎΠ΄Ρƒ, Ρ‰ΠΎ Π·Π°Ρ…ΠΈΡ‰Π΅Π½Π° ΠΏΠ°Ρ‚Π΅Π½Ρ‚ΠΎΠΌ Π£ΠΊΡ€Π°Ρ—Π½ΠΈ β„– 137157. Π‘Ρ…Π΅ΠΌΠ° ΠΌΡ–ΡΡ‚ΠΈΡ‚ΡŒ Ρ‚Ρ€ΠΈ ΠΎΠΏΠ΅Ρ€Π°Ρ†Ρ–ΠΉΠ½ΠΈΡ… ΠΏΡ–Π΄ΡΠΈΠ»ΡŽΠ²Π°Ρ‡Π°, ΠΊΡ–Π»ΡŒΠΊΠ° рСзисторів Ρ– кондСнсаторів. Π—Π°ΠΏΡ€ΠΎΠΏΠΎΠ½ΠΎΠ²Π°Π½Π° ΠΌΠ°Ρ‚Π΅ΠΌΠ°Ρ‚ΠΈΡ‡Π½Π° модСль, ΠΏΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Π° Ρ€ΠΎΠ·Ρ€Π°Ρ…ΡƒΠ½ΠΊΡƒ Ρ– Π²ΠΈΠ±ΠΎΡ€Ρƒ ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€Ρ–Π² рСзисторів Ρ– кондСнсаторів схСми Π²Ρ€Π°Ρ…ΠΎΠ²ΡƒΡŽΡ‚ΡŒ Π²ΠΈΠΏΠ°Π΄ΠΊΠΎΠ²Ρ– Π²Π°Ρ€Ρ–Π°Ρ†Ρ–Ρ— об’єкта Ρ– рСгулятора Π² Π·Π°Π΄Π°Π½ΠΈΡ… ΠΌΠ΅ΠΆΠ°Ρ…. ВстановлСно Π°Π½Π°Π»Ρ–Ρ‚ΠΈΡ‡Π½ΠΈΠΉ зв’язок ΠΌΡ–ΠΆ ΠΊΠΎΠ΅Ρ„Ρ–Ρ†Ρ–Ρ”Π½Ρ‚Π°ΠΌΠΈ ΠΏΠ΅Ρ€Π΅Π΄Π°Π²Π°Π»ΡŒΠ½ΠΎΡ— Ρ„ΡƒΠ½ΠΊΡ†Ρ–Ρ— Ρ– ΠΎΠΏΠΎΡ€Π°ΠΌΠΈ рСзисторів Ρ– ємностями кондСнсаторів Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΈΡ‡Π½ΠΎΡ— схСми рСгулятора. На ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½ΠΎΠΌΡƒ ΠΏΡ€ΠΈΠΊΠ»Π°Π΄Ρ– Ρ€ΠΎΠ·Ρ€Π°Ρ…ΡƒΠ½ΠΊΠΎΠ²ΠΈΠΌ ΡˆΠ»ΡΡ…ΠΎΠΌ Π·Π° Ρ€ΠΎΠ·Ρ€ΠΎΠ±Π»Π΅Π½ΠΈΠΌ Π°Π»Π³ΠΎΡ€ΠΈΡ‚ΠΌΠΎΠΌ виявлСні Π³Ρ€Π°Π½ΠΈΡ‡Π½Ρ– значСння допусків ΠΎΠΏΠΎΡ€Ρ–Π² рСзисторів Ρ– ємностСй кондСнсаторів схСми Ρ– здійснСний Ρ—Ρ… Π²ΠΈΠ±Ρ–Ρ€ Ρ–Π· запасом Π·Ρ– стандартних рядів. Аналіз Ρ„Ρ–Π»ΡŒΡ‚Ρ€Π°Ρ†Ρ–Ρ— Π·Π°Π²Π°Π΄ Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΈΡ‡Π½ΠΎΡŽ ΡΡ…Π΅ΠΌΠΎΡŽ рСгулятора Π² ΠΏΠ°ΠΊΠ΅Ρ‚Ρ– Multisim ΠΏΠΎΠΊΠ°Π·ΡƒΡ” Ρ—Ρ— Π½Π΅Ρ‡ΡƒΡ‚Π»ΠΈΠ²Ρ–ΡΡ‚ΡŒ Π΄ΠΎ Ρ€ΠΎΠ·ΠΌΠ°Ρ…Ρ–Π² Π·Π°Π²Π°Π΄ Ρƒ Π΄ΠΎΡΠΈΡ‚ΡŒ ΡˆΠΈΡ€ΠΎΠΊΠΈΡ… ΠΌΠ΅ΠΆΠ°Ρ…

    Π‘ΠΈΠ½Ρ‚Π΅Π· Π½ΠΎΠ²ΠΈΡ… спіроциклічних N-Π°Ρ€ΠΈΠ»Π·Π°ΠΌΡ–Ρ‰Π΅Π½ΠΈΡ… 2-Ρ‚Ρ–ΠΎΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½-4,6-Π΄Ρ–ΠΎΠ½Ρ–Π²

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    A convenient and efficient method for the synthesis of new unsaturated spiro-annulated N-aryl-4,6-dioxopyrimidine-2-thione derivatives has been developed. The resulting compounds can be potential biological active molecules or precursors for further chemical modification.Aim. To develop the methods for the synthesis of new unsaturated spiro-annulated 2-thiopyrimidine-4,6-dione derivatives, which can be used as potentially biological active molecules or precursors for their formation.Results and discussion. By condensation of N-aryl-substituted thioureas and allylmalonic acid using acetic anhydride or acetyl chloride the series of 5-allyl-substituted 2-thiopyrimidinediones has been synthesized. Their further alkylation with allyl bromide or metallyl chloride led to formation of 5,5-dialkenyl derivatives, which were converted to the corresponding unsaturated spirocyclic dioxopyrimidine-2-thiones by ring-closing metathesis.Β Experimental part. The synthesis of the starting compounds and title products was performed by preparative chemical methods, TLC and column chromatography, elemental analysis, NMR-spectroscopy.Conclusions. The efficient three-step synthetic route of new unsaturated spiro-annulated N-aryl-4,6-dioxopyrimidine-2-thione derivatives from the starting N-arylsubstituted thioureas and allylmalonic acid has been developed. The spiro-annulated products obtained can find application in biological and pharmaceutical science or as starting substrates for further chemical modification.Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½ ΡƒΠ΄ΠΎΠ±Π½Ρ‹ΠΉ ΠΈ эффСктивный ΠΌΠ΅Ρ‚ΠΎΠ΄ синтСза Π½ΠΎΠ²Ρ‹Ρ… нСнасыщСнных спиро-Π°Π½Π½Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… N-Π°Ρ€ΠΈΠ»Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Ρ… 2-Ρ‚ΠΈΠΎΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½-4,6-Π΄ΠΈΠΎΠ½ΠΎΠ². ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ соСдинСния ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹ΠΌΠΈ Π±ΠΈΠΎΠ°ΠΊΡ‚ΠΈΠ²Π½Ρ‹ΠΌΠΈ ΠΌΠΎΠ»Π΅ΠΊΡƒΠ»Π°ΠΌΠΈ ΠΈΠ»ΠΈ исходными вСщСствами для дальнСйшСй химичСской ΠΌΠΎΠ΄ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ.ЦСль Ρ€Π°Π±ΠΎΡ‚Ρ‹ – Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² получСния Π½ΠΎΠ²Ρ‹Ρ… нСнасыщСнных спиро-Π°Π½Π½Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄Π½Ρ‹Ρ… 2-Ρ‚ΠΈΠΎΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½-4,6-Π΄ΠΈΠΎΠ½Π° ΠΊΠ°ΠΊ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… биологичСски Π°ΠΊΡ‚ΠΈΠ²Π½Ρ‹Ρ… соСдинСний ΠΈΠ»ΠΈ ΠΏΠΎΠ»ΡƒΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΎΠ² для ΠΈΡ… получСния.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ ΠΈΡ… обсуТдСниС. ΠšΠΎΠ½Π΄Π΅Π½ΡΠ°Ρ†ΠΈΠ΅ΠΉ N-Π°Ρ€ΠΈΠ»Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Ρ… Ρ‚ΠΈΠΎΠΌΠΎΡ‡Π΅Π²ΠΈΠ½ ΠΈ Π°Π»Π»ΠΈΠ»ΠΌΠ°Π»ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты с использованиСм уксусного Π°Π½Π³ΠΈΠ΄Ρ€ΠΈΠ΄Π° ΠΈΠ»ΠΈ Π°Ρ†Π΅Ρ‚ΠΈΠ»Ρ…Π»ΠΎΡ€ΠΈΠ΄Π° синтСзирован ряд 5-Π°Π»Π»ΠΈΠ»Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Ρ… 2-Ρ‚ΠΈΠΎΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½Π΄ΠΈΠΎΠ½ΠΎΠ². ΠŸΡ€ΠΈ ΠΈΡ… ΠΏΠΎΡΠ»Π΅Π΄ΡƒΡŽΡ‰Π΅ΠΌ Π°Π»ΠΊΠΈΠ»ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ Π°Π»Π»ΠΈΠ»Π±Ρ€ΠΎΠΌΠΈΠ΄ΠΎΠΌ ΠΈΠ»ΠΈ ΠΌΠ΅Ρ‚Π°Π»Π»ΠΈΠ»Ρ…Π»ΠΎΡ€ΠΈΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Ρ‹ 5,5-Π΄ΠΈΠ°Π»ΠΊΠ΅Π½ΠΈΠ»ΡŒΠ½Ρ‹Π΅ ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄Π½Ρ‹Π΅, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ рСакциями мСтатСзиса с Π·Π°ΠΊΡ€Ρ‹Ρ‚ΠΈΠ΅ΠΌ Ρ†ΠΈΠΊΠ»Π° Π±Ρ‹Π»ΠΈ ΠΊΠΎΠ½Π²Π΅Ρ€Ρ‚ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ Π² ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠ΅ Π½Π΅ΠΏΡ€Π΅Π΄Π΅Π»ΡŒΠ½Ρ‹Π΅ спироцикличСскиС диоксопиримидин-2-Ρ‚ΠΈΠΎΠ½Ρ‹.Β  Β Π­ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Π°Ρ Ρ‡Π°ΡΡ‚ΡŒ. Π‘ΠΈΠ½Ρ‚Π΅Π· исходных соСдинСний ΠΈ Ρ†Π΅Π»Π΅Π²Ρ‹Ρ… ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΎΠ² классичСскими ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌΠΈ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΈΠ²Π½ΠΎΠΉ Ρ…ΠΈΠΌΠΈΠΈ; очистка ΠΈ идСнтификация ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… соСдинСний ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡŒ ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌΠΈ тонкослойной ΠΈ ΠΊΠΎΠ»ΠΎΠ½ΠΎΡ‡Π½ΠΎΠΉ Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ, ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ элСмСнтного Π°Π½Π°Π»ΠΈΠ·Π°, спСктроскопиСй ЯМР.Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½ эффСктивный трСхстадийный ΠΏΡƒΡ‚ΡŒ получСния ΠΈΠ· исходных Ρ‚ΠΈΠΎΠΌΠΎΡ‡Π΅Π²ΠΈΠ½ ΠΈ Π°Π»Π»ΠΈΠ»ΠΌΠ°Π»ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты Π½ΠΎΠ²Ρ‹Ρ… нСнасыщСнных спиро-Π°Π½Π½Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄Π½Ρ‹Ρ… N-Π°Ρ€ΠΈΠ»-4,6-диоксопиримидин-2-Ρ‚ΠΈΠΎΠ½Π°. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ спироцикличСскиС ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Ρ‹ ΠΌΠΎΠ³ΡƒΡ‚ Π½Π°ΠΉΡ‚ΠΈ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π² Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ фармацСвтичСской Π½Π°ΡƒΠΊΠ΅, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚ΡŒΡΡ ΠΊΠ°ΠΊ исходныС соСдинСния для дальнСйшСй химичСской ΠΌΠΎΠ΄ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ.Π ΠΎΠ·Ρ€ΠΎΠ±Π»Π΅Π½ΠΎ Π·Ρ€ΡƒΡ‡Π½ΠΈΠΉ Ρ‚Π° Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΈΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄ синтСзу Π½ΠΎΠ²ΠΈΡ… нСнасичСних спіро-Π°Π½Π΅Π»ΡŒΠΎΠ²Π°Π½ΠΈΡ… N-Π°Ρ€ΠΈΠ»Π·Π°ΠΌΡ–Ρ‰Π΅Π½ΠΈΡ… 2-Ρ‚Ρ–ΠΎΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½-4,6-Π΄Ρ–ΠΎΠ½Ρ–Π². ΠžΠ΄Π΅Ρ€ΠΆΠ°Π½Ρ– сполуки ΠΌΠΎΠΆΡƒΡ‚ΡŒ Π±ΡƒΡ‚ΠΈ ΠΏΠΎΡ‚Π΅Π½Ρ†Ρ–ΠΉΠ½ΠΈΠΌΠΈ Π±Ρ–ΠΎΠ°ΠΊΡ‚ΠΈΠ²Π½ΠΈΠΌΠΈ ΠΌΠΎΠ»Π΅ΠΊΡƒΠ»Π°ΠΌΠΈ Π°Π±ΠΎ прСкурсорами для ΠΏΠΎΠ΄Π°Π»ΡŒΡˆΠΎΡ— Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΎΡ— ΠΌΠΎΠ΄ΠΈΡ„Ρ–ΠΊΠ°Ρ†Ρ–Ρ—. ΠœΠ΅Ρ‚Π° Ρ€ΠΎΠ±ΠΎΡ‚ΠΈ – Ρ€ΠΎΠ·Ρ€ΠΎΠ±ΠΊΠ° ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ–Π² одСрТання Π½ΠΎΠ²ΠΈΡ… нСнасичСних спіро-Π°Π½Π΅Π»ΡŒΠΎΠ²Π°Π½ΠΈΡ… ΠΏΠΎΡ…Ρ–Π΄Π½ΠΈΡ… 2-Ρ‚Ρ–ΠΎΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½-4,6-Π΄Ρ–ΠΎΠ½Ρƒ як ΠΏΠΎΡ‚Π΅Π½Ρ†Ρ–ΠΉΠ½ΠΈΡ… Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΎ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΈΡ… сполук Π°Π±ΠΎ Π½Π°ΠΏΡ–Π²ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Ρ–Π² для Ρ—Ρ… отримання. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ Ρ‚Π° Ρ—Ρ… обговорСння. ΠšΠΎΠ½Π΄Π΅Π½ΡΠ°Ρ†Ρ–Ρ”ΡŽN-Π°Ρ€ΠΈΠ»Π·Π°ΠΌΡ–Ρ‰Π΅Π½ΠΈΡ… тіосСчовин Ρ‚Π° Π°Π»Ρ–Π»ΠΌΠ°Π»ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти Ρ–Π· застосуванням ΠΎΡ†Ρ‚ΠΎΠ²ΠΎΠ³ΠΎ Π°Π½Π³Ρ–Π΄Ρ€ΠΈΠ΄Ρƒ Π°Π±ΠΎ Π°Ρ†Π΅Ρ‚ΠΈΠ»Ρ…Π»ΠΎΡ€ΠΈΠ΄Ρƒ синтСзовано ΡΠ΅Ρ€Ρ–ΡŽ 5-Π°Π»Ρ–Π»Π·Π°ΠΌΡ–Ρ‰Π΅Π½ΠΈΡ… 2-Ρ‚Ρ–ΠΎΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½Π΄Ρ–ΠΎΠ½Ρ–Π². ΠŸΡ€ΠΈ ΠΏΠΎΠ΄Π°Π»ΡŒΡˆΠΎΠΌΡƒ Ρ—Ρ… Π°Π»ΠΊΡ–Π»ΡƒΠ²Π°Π½Π½Ρ– Π°Π»Ρ–Π»Π±Ρ€ΠΎΠΌΡ–Π΄ΠΎΠΌ Π°Π±ΠΎ ΠΌΠ΅Ρ‚Π°Π»Ρ–Π»Ρ…Π»ΠΎΡ€ΠΈΠ΄ΠΎΠΌ ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΎ 5,5-Π΄Ρ–Π°Π»ΠΊΠ΅Π½Ρ–Π»ΡŒΠ½Ρ– ΠΏΠΎΡ…Ρ–Π΄Π½Ρ–, які рСакціями мСтатСзису Ρ–Π· закриттям Ρ†ΠΈΠΊΠ»Ρƒ Π±ΡƒΠ»ΠΎ ΠΏΠ΅Ρ€Π΅Ρ‚Π²ΠΎΡ€Π΅Π½ΠΎ Π½Π° Π²Ρ–Π΄ΠΏΠΎΠ²Ρ–Π΄Π½Ρ– нСнасичСні спіроциклічні діоксопіримідин-2-Ρ‚Ρ–ΠΎΠ½ΠΈ.Π•ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Π° частина. Π‘ΠΈΠ½Ρ‚Π΅Π· Π²ΠΈΡ…Ρ–Π΄Π½ΠΈΡ… сполук Ρ‚Π° Ρ†Ρ–Π»ΡŒΠΎΠ²ΠΈΡ… ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Ρ–Π² класичними ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌΠΈ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΈΠ²Π½ΠΎΡ— Ρ…Ρ–ΠΌΡ–Ρ—; очистку Ρ‚Π° Ρ–Π΄Π΅Π½Ρ‚ΠΈΡ„Ρ–ΠΊΠ°Ρ†Ρ–ΡŽ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΈΡ… сполук здійснСно ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌΠΈ Ρ‚ΠΎΠ½ΠΊΠΎΡˆΠ°Ρ€ΠΎΠ²ΠΎΡ— Ρ‚Π° ΠΊΠΎΠ»ΠΎΠ½ΠΊΠΎΠ²ΠΎΡ— Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„Ρ–Ρ—, Π΅Π»Π΅ΠΌΠ΅Π½Ρ‚Π½ΠΈΠΌ Π°Π½Π°Π»Ρ–Π·ΠΎΠΌ, ЯМР-ΡΠΏΠ΅ΠΊΡ‚Ρ€ΠΎΡΠΊΠΎΠΏΡ–Ρ”ΡŽ.Висновки. Π ΠΎΠ·Ρ€ΠΎΠ±Π»Π΅Π½ΠΎ Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΈΠΉ тристадійний ΡˆΠ»ΡΡ… отримання Π· Π²ΠΈΡ…Ρ–Π΄Π½ΠΈΡ… тіосСчовин Ρ‚Π° Π°Π»Ρ–Π»ΠΌΠ°Π»ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти Π½ΠΎΠ²ΠΈΡ… нСнасичСних спіро-Π°Π½Π΅Π»ΡŒΠΎΠ²Π°Π½ΠΈΡ… ΠΏΠΎΡ…Ρ–Π΄Π½ΠΈΡ… N-Π°Ρ€ΠΈΠ»-4,6-діоксопіримідин-2-Ρ‚Ρ–ΠΎΠ½Ρƒ. ΠžΠ΄Π΅Ρ€ΠΆΠ°Π½Ρ– спіроциклічні ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΈ ΠΌΠΎΠΆΡƒΡ‚ΡŒ Π·Π½Π°ΠΉΡ‚ΠΈ застосування Π² Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ— Ρ‚Π° Ρ„Π°Ρ€ΠΌΠ°Ρ†Π΅Π²Ρ‚ΠΈΡ‡Π½Ρ–ΠΉ Π½Π°ΡƒΡ†Ρ–, Π°Π±ΠΎ Π²ΠΈΠΊΠΎΡ€ΠΈΡΡ‚ΠΎΠ²ΡƒΠ²Π°Ρ‚ΠΈΡΡŒ як Π²ΠΈΡ…Ρ–Π΄Π½Ρ– сполуки для ΠΏΠΎΠ΄Π°Π»ΡŒΡˆΠΎΡ— Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΎΡ— ΠΌΠΎΠ΄ΠΈΡ„Ρ–ΠΊΠ°Ρ†Ρ–Ρ—

    Kinky Behavior in Josephson Junctions

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    We analyze nonperturbatively the behavior of a Josephson junction in which two BCS superconductors are coupled through an Anderson impurity. We recover earlier perturbative results which found that a Ξ΄=Ο€\delta=\pi phase difference is preferred when the impurity is singly occupied and the on-site Coulomb interaction is large. We find a novel intermediate phase in which one of Ξ΄=0\delta=0 and Ξ΄=Ο€\delta=\pi is stable while the other is metastable, with the energy E(Ξ΄)E(\delta) having a kink somewhere in between. As a consequence of the kink, the Iβˆ’VI-V characteristics of the junction are modified at low voltages.Comment: 7 pages, 7 encapsulated PostScript figures; figure 3 correcte

    STABILITY AND ACCURACY OF THE ROBUST SYSTEM FOR STABILIZING THE ROTOR FLUX-LINKAGE OF AN ASYNCHRONOUS ELECTRIC DRIVE AT RANDOM VARIATIONS OF THE UNCERTAIN PARAMETERS WITHIN THE SPECIFIED BOUNDARIES

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    Purpose. The aim is to investigate the stability and the accuracy of a robust system for stabilizing the rotor flux-linkage of an asynchronous electric drive at random variations of the uncertain parameters of the object and the regulator within the specified boundaries. Methodology. To make the research, the mathematical model of the rotor flux-linkage channel of the vector control system of an asynchronous electric drive with parametric uncertainty was applied. The transfer function of the Н∞-suboptimal regulator was calculated using the mixed sensitivity method. This transfer function was used to construct the regulator structural scheme in the form of a connection of proportional and integrating links and several adders. Analytical dependences of the coefficients of the regulator's transfer function on the parameters of links of such a connection are determined. These dependences served to researching the influence of uncertain parameters of the regulator links and the object on the stability of the robust system and the accuracy of flux-linkage stabilization. Results. Investigations of the robust system stability and the accuracy of flux-linkage stabilization in the Robust Control Toolbox are done. The curves of the flux-linkage transient processes and the Bode diagram for the open system at random variations of the indeterminate parameters of the object and the regulator links within the specified boundaries are constructed. A choice of variable parameters was carried out by the Monte Carlo method. By the scatter of the obtained curves of the transient processes, the accuracy of flux-linkage stabilization was determined, and according to the Bode diagram, stability reserves in the amplitude and the phase of the robust system were determined. A high accuracy of flux-linkage stabilization (deviation less than 1 %) in fairly wide ranges of changing the uncertain parameters of the object and the regulator, while maintaining the stability of the system with permissible reserves in amplitude and phase, is established. Originality. For the first time, analytical dependences of the coefficients of the transfer function of the Н∞-suboptimal regulator on the parameters of its structural scheme, which represented in the form of a connection of proportional and integrating links, are obtained. The method for calculating the stability of a robust flux-linkage control system and the accuracy of its stabilization at random variations of the uncertain parameters of the object and the regulator links within the specified boundaries is developed. Practical value. The use of the proposed method allows, during the design of the regulator, to ensure the selection of its elements from standard series

    Study Of Mass Losses Of Cauliflower At Storage Depending On A Packing Way

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    Tissues of fresh vegetables are characterized by the high quantity of moisture (80…96 %), active metabolism, low resistance to mechanical lesions, are spoiled fast. Metabolism in cells of tissues, so mass losses, depends on the content of water and dry substances.It is impossible to manage abiotic factors under conditions of open soil. So, there appears a necessity to study the influence of abiotic factors on the process of mass decrease at cauliflower storage that gives a possibility to prognosticate its mass losses and aptitude to storage.The aim of the study was to analyze the influence of weather conditions of the vegetation period of cauliflower, volume, specific mass and porosity of heads and packing methods on the intensity of natural mass losses of cauliflower at storage. The research gives a possibility to decrease natural losses of cauliflower heads and to prolong the storage duration of it. Cauliflower mass losses at the expanse of water evaporation depend on weather conditions of the vegetation period of the plant. It has been established, that there is a middle force reverse connection with the coefficient correlation r=–0,465 between the intensity of water evaporation at cauliflower heads storage and GTC, middle force connection with the coefficient correlation r=0,437 – with the average day temperature, and strong reverse connection r=–0,776 with the relative air humidity. There was elaborated the regression equation that gives an understanding about mass losses of cauliflower heads, packed in PF, at the expanse of water evaporation.The intensity of water evaporation of cauliflower at storage depends on package method. At packing in a stretch-film (SF), the intensity of moisture decrease, % a day, was the least, equal to 0,30–0,31. The ratio between moisture losses to ones of dry substances was 0,45–0,68. At packing in a performed stretch-film (PSF), the intensity of moisture decrease, % a day, was higher a little – 0,37–0,43.The more storage duration of cauliflower of late ripeness was provided by individual packing of heads in a polyethylene stretch-film. This packing type provided less total natural losses of products: in Skywoker F1– 6,0 %, in Kasper F1 and Santamaria F1 – 6,3 %. Natural losses for a day in variants with using a stretch-film were within 0,05–0,06 % depending on hybrid

    Feasibility of a Small, Rapid Optical-to-IR Response, Next Generation Gamma Ray Burst Mission

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    We present motivations for and study feasibility of a small, rapid optical to IR response gamma ray burst (GRB) space observatory. By analyzing existing GRB data, we give realistic detection rates for X-ray and optical/IR instruments of modest size under actual flight conditions. Given new capabilities of fast optical/IR response (about 1 s to target) and simultaneous multi-band imaging, such an observatory can have a reasonable event rate, likely leading to new science. Requiring a Swift-like orbit, duty cycle, and observing constraints, a Swift-BAT scaled down to 190 square cm of detector area would still detect and locate about 27 GRB per yr. for a trigger threshold of 6.5 sigma. About 23 percent of X-ray located GRB would be detected optically for a 10 cm diameter instrument (about 6 per yr. for the 6.5 sigma X-ray trigger).Comment: Elaborated text version of a poster presented at 2012 Malaga/Marbella symposiu

    The use of an antibacterial implant in the treatment of periprosthetic infection in an HIV-positive patient

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    Background: The frequency of occurrence of infectious complications after hip arthroplasty in HIV-infected patients is extremely high. Revision arthroplasty for periprosthetic infection is the leader (64%) among the causes of early revision interventions. The search for ways to increase the efficiency of the sanitizing stage of treatment due to antibacterial coatings of the endoprosthesis components continues.Objective: Demonstration of a clinical case of treatment of periprosthetic infection in an HIV-positive patient using a spacer and a femoral component of a hip joint endoprosthesis coated with linear Sp1 carbon chains and silver. 123 months after hip arthroplasty for stage 3 dysplastic coxarthrosis in HIV-positive patient of 42 years old developed an instability of the acetabular component with the growth of Staphylococcus aureus in punctates. A revision was performed with the removal of the endoprosthesis and the installation of an articulating spacer with the addition of antibiotics. 12 weeks later, a recurrence of periprosthetic infection occurred, and Enterococcus faecalis was detected in punctates. During re-endoprosthetics, there was an installation of an articulating spacer covered with a two-dimensionally ordered linear-chain carbon doped with silver, based on the Zimmer CPT femoral component and bone cement with antibiotics addition. After 3 months, the second stage of revision arthroplasty was performed with implantation of an individual acetabular component and a femoral component coated with two-dimensionally ordered linear-chain carbon doped with silver.Conclusion: 4 months after the operation the patient returned to work, 12 months later the functional results were satisfactory. The use of components coated with two-dimensionally ordered linear-chain carbon doped with silver in an HIV-positive patient with recurrent periprosthetic infection made it possible to stop the infectious process, improve limb function and the quality of life

    Simple Bosonization Solution of the 2-channel Kondo Model: I. Analytical Calculation of Finite-Size Crossover Spectrum

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    We present in detail a simple, exact solution of the anisotropic 2-channel Kondo (2CK) model at its Toulouse point. We reduce the model to a quadratic resonant-level model by generalizing the bosonization-refermionization approach of Emery and Kivelson to finite system size, but improve their method in two ways: firstly, we construct all boson fields and Klein factors explicitly in terms of the model's original fermion operators ckσjc_{k \sigma j}, and secondly we clarify explicitly how the Klein factors needed when refermionizing act on the original Fock space. This enables us to explicitly follow the adiabatic evolution of the 2CK model's free-fermion states to its exact eigenstates, found by simply diagonalizing the resonant-level model for arbitrary magnetic fields and spin-flip coupling strengths. In this way we obtain an {\em analytic} description of the cross-over from the free to the non-Fermi-liquid fixed point. At the latter, it is remarkably simple to recover the conformal field theory results for the finite-size spectrum (implying a direct proof of Affleck and Ludwig's fusion hypothesis). By analyzing the finite-size spectrum, we directly obtain the operator content of the 2CK fixed point and the dimension of various relevant and irrelevant perturbations. Our method can easily be generalized to include various symmetry-breaking perturbations. Furthermore it establishes instructive connections between different renormalization group schemes such as poor man's scaling, Anderson-Yuval type scaling, the numerical renormalization group and finite-size scaling.Comment: 35 pages Revtex, 7 figures, submitted to Phys. Rev.

    Results of Application of the New Nutrient Media Set for Cholera Diagnostics within the Frames of the Special Tactical Training Exercises for Specialized Anti-Epidemic Team

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    Carried out is approbation of the new nutrient media set for cholera diagnostics on the basis of bakers' yeast pancreatic digest within the frames of the special tactical training exercises for specialized anti-epidemic team (SAET). It is demonstrated that the developed nutrient media set compare favourably with its analogues, commonly used for practical procedures; and its constituent media have a potential to be included into the SAET mobilization reserve
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