Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin, New Zealand, for the generous gifts of MitoE and MitoQ, without which this work would not have been possible.Peer reviewedPublisher PD

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis

Funding The study was funded entirely by institutional funds.Peer reviewedPostprin

A nonlinear scalar model of extreme mass ratio inspirals in effective field theory II. Scalar perturbations and a master source

The motion of a small compact object (SCO) in a background spacetime is investigated further in a class of model nonlinear scalar field theories having a perturbative structure analogous to the General Relativistic description of extreme mass ratio inspirals (EMRIs). We derive regular expressions for the scalar perturbations generated by the SCO's motion valid through third order in $\epsilon$, the size of the SCO to the background curvature length scale. Our expressions are compared to those calculated through second order in $\epsilon$ by Rosenthal in [E. Rosenthal, CQG 22, S859 (2005)] and found to agree but our procedure for regularizing the scalar perturbations is considerably simpler. Following the Detweiler-Whiting (DW) scheme, we use our regular expressions for the field and derive the regular self-force corrections through third order. We find agreement with our previous derivation based on a variational principle of an effective action for the worldline associated with the SCO thus demonstrating the internal consistency of our formalism. This also explicitly demonstrates that the DW decomposition of Green's functions is a valid and practical method of self force computation at higher orders in perturbation theory and, as we show in an appendix, at all orders in perturbation theory. Finally, we identify a master source from which all other physically relevant quantities are derivable. Knowing the master source perturbatively allows one to construct the waveform measured by an observer, the regular part of the field on the worldline, the regular part of the self force, and orbital quantities such as shifts of the innermost stable circular orbit, etc. The existence of a master source together with the regularization methods implemented in this series should be indispensable for derivations of higher-order gravitational self force corrections.Comment: For Part 1 of this series, see arXiv:1012.4488. 20 pages, 7 figure

Sea ice <i>p</i>CO₂ dynamics and air-ice CO₂ fluxes during the Sea Ice Mass Balance in the Antarctic (SIMBA) experiment - Bellingshausen Sea, Antarctica

Temporal evolution of pCO2 profiles in sea ice in the Bellingshausen Sea, Antarctica, in October 2007 shows physical and thermodynamic processes controls the CO2 system in the ice. During the survey, cyclical warming and cooling strongly influenced the physical, chemical, and thermodynamic properties of the ice cover. Two sampling sites with contrasting characteristics of ice and snow thickness were sampled: one had little snow accumulation (from 8 to 25 cm) and larger temperature and salinity variations than the second site, where the snow cover was up to 38 cm thick and therefore better insulated the underlying sea ice. We show that each cooling/warming event was associated with an increase/decrease in the brine salinity, total alkalinity (TA), total dissolved inorganic carbon (TCO2), and in situ brine and bulk ice CO2 partial pressures (pCO2). Thicker snow covers reduced the amplitude of these changes: snow cover influences the sea ice carbonate system by modulating the temperature and therefore the salinity of the sea ice cover. Results indicate that pCO2 was undersaturated with respect to the atmosphere both in the in situ bulk ice (from 10 to 193 µatm) and brine (from 65 to 293 µatm), causing the sea ice to act as a sink for atmospheric CO2 (up to 2.9 mmol m-2 d-1), despite supersaturation of the underlying seawater (up to 462 µatm)

Inorganic carbon dynamics of melt-pond-covered first-year sea ice in the Canadian Arctic

Melt pond formation is a common feature of spring and summer Arctic sea ice, but the role and impact of sea ice melt and pond formation on both the direction and size of CO2 fluxes between air and sea is still unknown. Here we report on the CO2-carbonate chemistry of melting sea ice, melt ponds and the underlying seawater as well as CO2 fluxes at the surface of first-year landfast sea ice in the Resolute Passage, Nunavut, in June 2012. Early in the melt season, the increase in ice temperature and the subsequent decrease in bulk ice salinity promote a strong decrease of the total alkalinity (TA), total dissolved inorganic carbon (T CO2) and partial pressure of CO2 (pCO2) within the bulk sea ice and the brine. As sea ice melt progresses, melt ponds form, mainly from melted snow, leading to a low in situ melt pond pCO2 (36 μatm). The percolation of this low salinity and low pCO2 meltwater into the sea ice matrix decreased the brine salinity, TA and T CO2, and lowered the in situ brine pCO2 (to 20 μatm). This initial low in situ pCO2 observed in brine and melt ponds results in air-ice CO2 fluxes ranging between -0.04 and -5.4 mmolm-2 day-1 (negative sign for fluxes from the atmosphere into the ocean). As melt ponds strive to reach pCO2 equilibrium with the atmosphere, their in situ pCO2 increases (up to 380 μatm) with time and the percolation of this relatively high concentration pCO2 meltwater increases the in situ brine pCO2 within the sea ice matrix as the melt season progresses. As the melt pond pCO2 increases, the uptake of atmospheric CO2 becomes less significant. However, since melt ponds are continuously supplied by meltwater, their in situ pCO2 remains undersaturated with respect to the atmosphere, promoting a continuous but moderate uptake of CO2 (∼-1 mmolm-2 day-1) into the ocean. Considering the Arctic seasonal sea ice extent during the melt period (90 days), we estimate an uptake of atmospheric CO2 of -10.4 Tg of Cyr-1. This represents an additional uptake of CO2 associated with Arctic sea ice that needs to be further explored and considered in the estimation of the Arctic Ocean's overall CO2 budget

Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats

Background The neuropathy of type II diabetes mellitus (DM) is increasing in prevalence worldwide. We aimed to test the hypothesis that in a rodent model of type II DM, neuropathy would lead to increased neurotoxicity and block duration after lidocaine-induced sciatic nerve block when compared with control animals. Methods Experiments were carried out in Zucker diabetic fatty rats aged 10 weeks (early diabetic) or 18 weeks (late diabetic, with or without insulin 3 units per day), and age-matched healthy controls. Left sciatic nerve block was performed using 0.2 ml lidocaine 2%. Nerve conduction velocity (NCV) and F-wave latency were used to quantify nerve function before, and 1 week after nerve block, after which sciatic nerves were used for neurohistopathology. Results Early diabetic animals did not show increased signs of nerve dysfunction after nerve block. In late diabetic animals without insulin vs control animals, NCV was 34.8 (5.0) vs 41.1 (4.1) ms s−1 (P<0.01), and F-wave latency was 7.7 (0.5) vs 7.0 (0.2) ms (P<0.01), respectively. Motor nerve block duration was prolonged in late diabetic animals, but neurotoxicity was not. Late diabetic animals receiving insulin showed intermediate results. Conclusions In a rodent type II DM model, nerves have increased sensitivity for short-acting local anaesthetics without adjuvants in vivo, as evidenced by prolonged block duration. This sensitivity appears to increase with the progression of neuropathy. Our results do not support the hypothesis that neuropathy due to type II DM increases the risk of nerve injury after nerve bloc

Properties of the ferrimagnetic double-perovskite A_{2}FeReO_{6} (A=Ba and Ca)

Ceramics of A_{2}FeReO_{6} double-perovskite have been prepared and studied for A=Ba and Ca. Ba_{2}FeReO_{6} has a cubic structure (Fm3m) with $a\approx$8.0854(1) \AA whereas Ca_{2}FeReO_{6} has a distorted monoclinic symmetry with $a\approx 5.396(1) \AA, b\approx 5.522(1) \AA, c\approx 7.688(2) \AA$ and $\beta =90.4^{\circ} (P21/n)$. The barium compound is metallic from 5 K to 385 K, i.e. no metal-insulator transition has been seen up to 385 K, and the calcium compound is semiconducting from 5 K to 385 K. Magnetization measurements show a ferrimagnetic behavior for both materials, with T_{c}=315 K for Ba_{2}FeReO_{6} and above 385 K for Ca_{2}FeReO_{6}. A specific heat measurement on the barium compound gave an electron density of states at the Fermi level, N(E_{F}) equal to 6.1$\times 10^{24} eV^{-1}mole^{-1}$. At 5 K, we observed a negative magnetoresistance of 10 % in a magnetic field of 5 T, but only for Ba_{2}FeReO_{6}. Electrical, thermal and magnetic properties are discussed and compared to the analogous compounds Sr_{2}Fe(Mo,Re)O_{6}.Comment: 5 pages REVTeX, 7 figures included, submitted to PR

Theory of optomechanics: Oscillator-field model of moving mirrors

In this paper we present a model for the kinematics and dynamics of optomechanics which describe the coupling between an optical field, here modeled by a massless scalar field, and the internal (e.g., determining its reflectivity) and mechanical (e.g., displacement) degrees of freedom of a moveable mirror. As opposed to implementing boundary conditions on the field we highlight the internal dynamics of the mirror which provides added flexibility to describe a variety of setups relevant to current experiments. The inclusion of the internal degrees of freedom in this model allows for a variety of optical activities of mirrors from those exhibiting broadband reflective properties to the cases where reflection is suppressed except for a narrow band centered around the characteristic frequency associated with the mirror's internal dynamics. After establishing the model and the reflective properties of the mirror we show how appropriate parameter choices lead to useful optomechanical models such as the well known Barton-Calogeracos model [G. Barton and A. Calogeracos, Ann. Phys. 238, 227 (1995)] and the important yet lesser explored nonlinear models (e.g., $Nx$ coupling) for small photon numbers $N$, which present models based on side-band approximations [H. Kimble et al., Phys. Rev. D 65, 022002 (2001)] cannot cope with. As a simple illustrative application we consider classical radiation pressure cooling with this model. To expound its theoretical structure and physical meanings we connect our model to field-theoretical models using auxiliary fields and the ubiquitous Brownian motion model of quantum open systems. Finally we describe the range of applications of this model, from a full quantum mechanical treatment of radiation pressure cooling, quantum entanglement between macroscopic mirrors, to the backreaction of Hawking radiation on black hole evaporation in a moving mirror analog.Comment: 27 pages, 3 figure

Replacement of multiyear sea ice and changes in the open water season duration in the Beaufort Sea since 2004

The last decade has witnessed the nine lowest Arctic September sea ice extents in the observational record. It also forms the most recent third of the long-term trend in that record, which reached -13.4% decade-1 in 2015. While hemispheric analyses paint a compelling picture of sea ice loss across the Arctic, the situation with multiyear ice in the Beaufort Sea is particularly dire. This study was undertaken in light of substantial changes that have occurred in the extent of summer multiyear sea ice in the Arctic inferred from the passive microwave record. To better elucidate these changes at a sub-regional scale, we use data from the Canadian Ice Service archive, the most direct observations of sea ice stage-of-development available. We also build upon the only previous sea ice climatological analysis for Canada's western Arctic region by sea ice stage-of-development that ended in 2004. The annual evolution of sea ice by stage of development in Canada's western Arctic changed dramatically between 1983 and 2014. The rate of these changes and their spatial prevalence were most prominent in the last decade. In summer, total sea ice loss occurred via reductions in old and first-year sea ice over increasingly large areas and over more months per year. Resultant delay of thermodynamic freeze up has increased the annual open water duration in the study region. The winter sea ice cover was increasingly composed of first-year sea ice at the expense of old ice. Breakup timing has not significantly changed in the region