COVID-19-ассоциированный ангиит: обзор литературы и описание клинического случая

The article systematizes information about various dermatological signs of a novel coronavirus infection – COVID-19. Special attention is paid to the phenomenon of COVID-19-associated angiitis. A clinical case of acroischemia associated with COVID-19 is described: on the 34th day after the onset of infection, a patient developed skin cyanosis of the distal parts of the fingers, which resolved spontaneously after a few days. The need for further research on the skin manifestations of COVID-19 and the development of an effective strategy for managing patients, as well as monitoring the condition of convalescents, is emphasized.В статье систематизированы сведения о различных дерматологических признаках новой коронавирусной инфекции – COVID-19. Особое внимание уделено феномену COVID-19-ассоциированного ангиита. Описан клинический случай акроишемии, связанной с COVID-19: у пациента на 34-й день после дебюта инфекции развился цианоз кожи дистальных отделов пальцев кистей, разрешившийся самостоятельно через несколько дней. Подчеркивается необходимость дальнейших исследований кожных проявлений COVID-19 и разработки эффективной стратегии ведения пациентов, а также мониторинга состояния реконвалесцентов

Structure impact in antenna effect of novel upper rim substituted tetra-1,3-diketone calix[4]arenes on Tb(III) green and Yb(III) NIR-luminescence

© 2016 Elsevier Ltd.Two novel calix[4]arene macrocyclic ligands functionalized with four 1,3-diketone groups at the upper and hydroxyl (3) or propyloxy-groups (6) at the lower rims were synthesized and characterized using NMR, IR spectroscopy, mass spectrometry, and elemental analysis. UV-vis spectrophotometry and ESI mass spectrometry studies indicate 1:1 complex formation of ligands 3 and 6 with Ln(III) (Ln=Tb, Yb) in alkaline DMF solutions resulted from coordination of Ln(III) with 1,3-diketonate groups. Luminescence study of Ln(III) complexes with 3 and 6 reveals significant difference in antenna effects of their deprotonated forms on both Tb(III)- and Yb(III)-centered luminescence. Comparison of ligand-centered emission for ligands 3 and 6 points to the latter as more efficient antenna for Tb(III) and Yb(III). Different conformational behavior of ligands 3 and 6 in alkaline media is assumed as a reason for the experimentally observed difference in sensitization pathways in Ln(III) complexes with 3 and 6

Electrophysiological, morphological, and ultrastructural features of the injured spinal cord tissue after transplantation of human umbilical cord blood mononuclear cells genetically modified with the VEGF and GDNF genes

© 2017 Y. O. Mukhamedshina et al.In this study, we examined the efficacy of human umbilical cord blood mononuclear cells (hUCB-MCs), genetically modified with the VEGF and GDNF genes using adenoviral vectors, on posttraumatic regeneration after transplantation into the site of spinal cord injury (SCI) in rats. Thirty days after SCI, followed by transplantation of nontransduced hUCB-MCs, we observed an improvement in H (latency period, LP) and M(Amax) waves, compared to the group without therapy after SCI. For genetically modified hUCB-MCs, there was improvement in Amax of M wave and LP of both the M and H waves. The ratio between Amax of the H and M waves (Hmax/Mmax) demonstrated that transplantation into the area of SCI of genetically modified hUCB-MCs was more effective than nontransduced hUCB-MCs. Spared tissue and myelinated fibers were increased at day 30 after SCI and transplantation of hUCB-MCs in the lateral and ventral funiculi 2.5 mm from the lesion epicenter. Transplantation of hUCB-MCs genetically modified with the VEGF and GNDF genes significantly increased the number of spared myelinated fibers (22-fold, P>0.01) in the main corticospinal tract compared to the nontransduced ones. HNA+ cells with the morphology of phagocytes and microglia-like cells were found as compact clusters or cell bridges within the traumatic cavities that were lined by GFAP+ host astrocytes. Our results show that hUCB-MCs transplanted into the site of SCI improved regeneration and that hUCB-MCs genetically modified with the VEGF and GNDF genes were more effective than nontransduced hUCB-MCs

High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones

© The Author(s) 2017.Polyelectrolyte-coated nanoparticles consisting of terbium and gadolinium complexes with calix[4]arene tetra-diketone ligand were first synthesized. The antenna effect of the ligand on Tb(III) green luminescence and the presence of water molecules in the coordination sphere of Gd(III) bring strong luminescent and magnetic performance to the core-shell nanoparticles. The size and the core-shell morphology of the colloids were studied using transmission electron microscopy and dynamic light scattering. The correlation between photophysical and magnetic properties of the nanoparticles and their core composition was highlighted. The core composition was optimized for the longitudinal relaxivity to be greater than that of the commercial magnetic resonance imaging (MRI) contrast agents together with high level of Tb(III)-centered luminescence. The tuning of both magnetic and luminescent output of nanoparticles is obtained via the simple variation of lanthanide chelates concentrations in the initial synthetic solution. The exposure of the pheochromocytoma 12 (PC 12) tumor cells and periphery human blood lymphocytes to nanoparticles results in negligible effect on cell viability, decreased platelet aggregation and bright coloring, indicating the nanoparticles as promising candidates for dual magneto-fluorescent bioimaging

A facile synthetic route to convert Tb(III) complexes of novel tetra-1,3-diketone calix[4]resorcinarene into hydrophilic luminescent colloids

The work presents the synthesis of a novel calix[4]resorcinarene cavitand bearing four 1,3-diketone groups at the upper rim and its complex formation with Tb(iii) ions in DMF and DMSO solutions. Electrospray ionization mass spectra, 1H NMR, UV-Vis and luminescence spectra indicate a long (three hours at least) equilibration time for the complex formation between the cavitand and Tb(iii) in alkaline DMF and DMSO solutions. These results are explained by the restricted keto-enol conversion, resulting from the steric hindrance effect of the methylenedioxy-groups linking the benzene rings within the cavitand framework. A facile synthetic route to convert luminescent Tb(iii) complexes of various stoichiometries into luminescent hydrophilic colloids is disclosed in this work. The route is based on the reprecipitation of the Tb(iii) complexes from DMF to aqueous solutions with further polyelectrolyte deposition without prior separation of the luminescent complexes. The luminescent colloids exhibit high stability over time and in buffer systems, which is a prerequisite for their applicability in analysis and biolabeling. © the Partner Organisations 2014

High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones

Polyelectrolyte-coated nanoparticles consisting of terbium and gadolinium complexes with calix[4]arene tetra-diketone ligand were first synthesized. The antenna effect of the ligand on Tb(III) green luminescence and the presence of water molecules in the coordination sphere of Gd(III) bring strong luminescent and magnetic performance to the core-shell nanoparticles. The size and the core-shell morphology of the colloids were studied using transmission electron microscopy and dynamic light scattering. The correlation between photophysical and magnetic properties of the nanoparticles and their core composition was highlighted. The core composition was optimized for the longitudinal relaxivity to be greater than that of the commercial magnetic resonance imaging (MRI) contrast agents together with high level of Tb(III)-centered luminescence. The tuning of both magnetic and luminescent output of nanoparticles is obtained via the simple variation of lanthanide chelates concentrations in the initial synthetic solution. The exposure of the pheochromocytoma 12 (PC 12) tumor cells and periphery human blood lymphocytes to nanoparticles results in negligible effect on cell viability, decreased platelet aggregation and bright coloring, indicating the nanoparticles as promising candidates for dual magneto-fluorescent bioimaging

STRUKTURA IZMENENIY MINERAL'NOY PLOTNOSTI LUChEVOY KOSTI PO DANNYM REVMATOLOGIChESKOGO TsENTRA G.KAZANI

Цель: выявить распространенность снижения минеральной плотности костной ткани у жителей города Казани. Материалы и методы: Обследовано 4770 человек, на базе ревматологического центра ГКБ №1, на рентгенологическом двухабсорбционном остеоденситометре DTX 200 по лучевой кости. Проводился опрос больных по разработанной анкете, в которую было включено 30 вопросов, касающихся выявления клинических симптомов и факторов риска остеопороза. Результаты: Показано, что снижение минеральной плотности костной ткани представлено у значительной части населения, также широко представлены различные факторы риска снижения минеральной плотности костной ткани, клинические симптомы остеопороза Факторы риска, клинические симптомы достоверно чаще представлены в группе пациенток с остеопорозом, чем в группахс остеопенией и нормальной плотностью кости. Заключение: Снижение минеральной плотности костной ткани разной степени выраженности и факторы риска широко распространены у населения г. Казани

Results of screening and diagnostic stages of epidemiological study of rheumatic diseases social and economic consequences in Tatarstan republic

Results of screening and diagnostic stages of epidemiological study performed in Tatarstan republic in the context of inter-regional program “Social and economic consequences of rheumatic diseases” (RD) are presented. Objective. To study structure and prevalence of rheumatic diseases. Material and methods. 3272 rural (58,5% female) and 3043 urban (54,6% female) inhabitants were questionnaired. All respondents reported joint swelling and a random part of pts with joint pain were selected and examined. Results. RD were diagnosed in 81,1% (812 persons), non rheumatic diseases – in 8,4% (84 persons), low back pain syndrome – in 6,9% (69 persons), and in 3,7 (37 persons) diseases were not revealed. 498 rural and 504 urban inhabitants with previously revealed osteoarthritis, rheumatoid arthritis or other bone-joint diseases were further examined. Conclusion. Information about structure and prevalence of RD among adult inhabitants of Tatarstan republic with joint complaints was obtained

Representations of Non-Profit Organizations of the Republic of Bashkortostan on the Priorities of Family Policy at the Regional Level: the Results of the Empirical Study

Актуальность работы связана с необходимостью совершенствования механизмов реализации семейной и демографической политики Российской Федерации и ее субъектов, в том числе Республики Башкортостан, с участием некоммерческих организаций (НКО) как одного из активных субъектов данной деятельности. В статье представлена оценка приоритетных задач семейной политики на региональном уровне руководителями некоммерческих организаций Республики Башкортостан, непосредственно ориентирующихся на поддержку семьи и семейных ценностей, оценен потенциал участия некоммерческого сектора в их реализации. Эмпирической основой исследования являются результаты проведенного Центром изучения человеческого потенциала ГАНУ «Институт стратегических исследований Республики Башкортостан» в 2017 г. экспертного опроса руководителей некоммерческих организаций по целевой выборке, с общим объемом выборки 96 экспертов. Показано, что ведущими задачами государственной семейной политики на региональном уровне респонденты считают повышение уровня жизни семей с детьми, однако значительная доля экспертных оценок приходится также на подчеркивание актуальности и важности решения проблем, связанных с изменением традиционной семейных ценностей. Эксперты считают, что НКО оказывают более качественные услуги семьям с детьми, а также отличаются от государственных исполнительных органов власти большей оперативностью и гибкостью. В связи с этим НКО видятся как основные партнеры органов власти в реализации задач семейной политики в данном направлении. В то же время эффективность и потенциал НКО, характер и степень влияния на укрепление ценностей семьи и детства требует дальнейших исследований.The urgency of the work is the need to improve the mechanisms for implementing the family and demographic policy of the Russian Federation and its subjects, including the Republic of Bashkortostan, with the participation of non-profit organizations (NPOs) as one of the active subjects of this activity. The article presents an assessment of the priority tasks of the family policy at the regional level by the leaders of the non-commercial organizations of the Republic of Bashkortostan who directly focus on supporting the family and family values, and the potential for participation of the non-profit sector in their implementation. The empirical basis of the study is the results of an expert survey of managers of non-profit organizations on target selection conducted by the Center for Human Resource Research of the Institute of Strategic Studies of the Republic of Bashkortostan in 2017, with a total sample size of 96 experts. It is shown that the respondents consider the leading tasks of the state family policy at the regional level in raising the standard of living of families with children, but a significant share of expert assessments also has to emphasize the relevance and importance of addressing the problems associated with changing traditional family values. Experts believe that NPOs provide higher-quality services to families with children, and differ from government executive authorities with greater speed and flexibility. In this regard, NPOs are seen as the main partners of the authorities in the implementation of the objectives of family policy in this direction. At the same time, the effectiveness and potential of NPOs, the nature and extent of the impact on strengthening the values of the family and childhood requires further research.Статья подготовлена в рамках выполнения государственного задания Центра изучения человеческого потенциала ГАНУ ИСИ РБ за 2018 г