Supplementary Material for: Combined Treatment of an Amyotrophic Lateral Sclerosis Rat Model with Recombinant GOT1 and Oxaloacetic Acid: A Novel Neuroprotective Treatment

<b><i>Background/Aim:</i></b> The sporadic form of the disease affects the majority of amyotrophic lateral sclerosis (ALS) patients. The role of glutamate (Glu) excitotoxicity in ALS has been extensively documented and remains one of the prominent hypotheses of ALS pathogenesis. In light of this evidence, the availability of a method to remove excess Glu from brain and spinal cord extracellular fluids without the need to deliver drugs across the blood-brain barrier and with minimal or no adverse effects may provide a major therapeutic asset, which is the primary aim of this study. <b><i>Methods:</i></b> The therapeutic efficacy of the combined treatment with recombinant Glu-oxaloacetate-transaminase (rGOT) and its co-factor oxaloacetic acid (OxAc) has been tested in an animal model of sporadic ALS. <b><i>Results:</i></b> We found that OxAc/rGOT treatment provides significant neuroprotection to spinal cord motor neurons. It also slows down the development of motor weakness and prolongs survival. <b><i>Conclusion:</i></b> In this study we bring evidence that the administration of Glu scavengers to rats with sporadic ALS inhibited the massive death of spinal cord motor neurons, slowed the onset of motor weakness and prolonged survival. This treatment may be of high clinical significance for the future treatment of chronic neurodegenerative diseases

Millimetron - a large Russian-European submillimeter space observatory

Millimetron is a Russian-led 12 m diameter submillimeter and far-infrared space observatory which is included in the Space Plan of the Russian Federation for launch around 2017. With its large collecting area and state-of-the-art receivers, it will enable unique science and allow at least one order of magnitude improvement with respect to the Herschel Space Observatory. Millimetron will be operated in two basic observing modes: as a single-dish observatory, and as an element of a ground-space very long baseline interferometry (VLBI) system. As single-dish, angular resolutions on the order of 3 to 12 arc sec will be achieved and spectral resolutions of up to a million employing heterodyne techniques. As VLBI antenna, the chosen elliptical orbit will provide extremely large VLBI baselines (beyond 300,000 km) resulting in micro-arc second angular resolution

'RadioAstron'-A telescope with a size of 300 000 km: Main parameters and first observational results

The Russian Academy of Sciences and Federal Space Agency, together with the participation of many international organizations, worked toward the launch of the RadioAstron orbiting space observatory with its onboard 10-m reflector radio telescope from the Baikonur cosmodrome on July 18, 2011. Together with some of the largest ground-based radio telescopes and a set of stations for tracking, collecting, and reducing the data obtained, this space radio telescope forms a multi-antenna ground-space radio interferometer with extremely long baselines, making it possible for the first time to study various objects in the Universe with angular resolutions a million times better than is possible with the human eye. The project is targeted at systematic studies of compact radio-emitting sources and their dynamics. Objects to be studied include supermassive black holes, accretion disks, and relativistic jets in active galactic nuclei, stellar-mass black holes, neutron stars and hypothetical quark stars, regions of formation of stars and planetary systems in our and other galaxies, interplanetary and interstellar plasma, and the gravitational field of the Earth. The results of ground-based and inflight tests of the space radio telescope carried out in both autonomous and ground-space interferometric regimes are reported. The derived characteristics are in agreement with the main requirements of the project. The astrophysical science program has begun. © 2013 Pleiades Publishing, Ltd