The level of neurotrophic factor of the brain during hypoxic-ischemic encephalopathy in infants

In work changes of level of serumal biomarkers at children are defined. The established changes can explain to some extent disturbances of adaptic and recovery processes in nervous tissue in response to its hypoxemic damage.В работе определены изменения уровня сывороточных биомаркеров у детей. Установленные изменения могут в определенной степени объяснить нарушения адаптационных и восстановительных процессов в нервной ткани в ответ на ее гипоксическое повреждение

Micromechanical Properties of Injection-Molded Starch–Wood Particle Composites

The micromechanical properties of injection molded starch–wood particle composites were investigated as a function of particle content and humidity conditions. The composite materials were characterized by scanning electron microscopy and X-ray diffraction methods. The microhardness of the composites was shown to increase notably with the concentration of the wood particles. In addition,creep behavior under the indenter and temperature dependence were evaluated in terms of the independent contribution of the starch matrix and the wood microparticles to the hardness value. The influence of drying time on the density and weight uptake of the injection-molded composites was highlighted. The results revealed the role of the mechanism of water evaporation, showing that the dependence of water uptake and temperature was greater for the starch–wood composites than for the pure starch sample. Experiments performed during the drying process at 70°C indicated that the wood in the starch composites did not prevent water loss from the samples.Peer reviewe

Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes

Aim. To study such circulating angiogenesis factors as vascular endothelial growth factor (VEGF-A), hepatocyte growth factor (HGF), insulin-like growth factor (IGF-1), as well as the cytokine profile (IL-1β, TNF-α, IL-6, IL-8, IL-23) and their soluble receptors (SRp55 TNF-α, SR IL-6) in the blood serum of gout patients having various obesity phenotypes.Material and methods. The study included 112 male patients with intercritical gout. The patients were divided into 2 study groups: the 1st group consisted of 39 patients with a metabolically healthy obesity (MHO) phenotype and body mass index (BMI) ≥25 kg/m2; the 2nd group included 73 people having metabolically unhealthy obesity (MUO) with impaired immune status, hypertension (HTN) and class 1 abdominal obesity. The control group consisted of 25 metabolically healthy subjects with normal body weight. Serum concentration of uric acid, CRP, insulin, leptin, insulin resistance index (HOMA-IR), cytokine status, plasma levels of VEGF-A, HGF, IGF-1 were studied. To assess the left ventricular (LV) diastolic function, tissue Doppler imaging of the mitral annulus was used.Results. In the group of patients with MUO, an increase of pro-inflammatory cytokines (IL-1β, IL-6, IL-23, TNF-α, SRp55 TNF-α) was revealed, while the level of TNF-α and IL-1β exceeds the control values in 4,7 and 6,8 times, respectively (p <0,05), and in the group of patients with MHO, 1,4 and 1,6 times, respectively (p<0,05). Correlations between VEGF-A and TNF-α (r=0,59, p<0,0001), IL-6 (r=0,68, p<0,001), CRP (r=0,59, p<0,0001), serum uric acid level (r=0,47, p<0,0001), decrease in high-density lipoprotein cholesterol (HDL-C) (r=-0,28, p<0,05) and diastolic blood pressure (r=0,51, p<0,0001) were determined. The concentration of HGF and VEGF-A correlated with BMI (p<0,001). Associations of IGF-1 and HGF with hyperuricemia, carbohydrate metabolism and diastolic remodeling were established.Conclusion. The relationship between circulating levels of VEGF-A, HGF and IGF-1 with indicators of cytokine status, carbohydrate metabolism and Doppler imaging criteria for LV diastolic dysfunction allows to consider them as additional predictors of unfavorable cardiovascular risk

Transparent polymer sensor for visual and photometrical detection of thiocyanate in oilfield water

A novel colorimetric sensor has been proposed for sensitive and accurate visual and spectrophotometric detection of thiocyanate using polymethacrylate matrix, which also has the potential for use with samples without pretreatment. The determination method is based on shaping of a Fe3+-thiocyanate colored complex into a transparent polymer matrix, followed by measurement of absorbance at 490 nm. The principle of this colorimetric sensor is not ordinary colorimetry, but a new colorimetric strategy that combines solid phase extraction and spectrophotometric determination of thiocyanate following completion of the color change processes. The method ensures determination of 0.8–30.0 mg L−1 of thiocyanate with the detection limit of 0.3 mg L−1. The proposed simple method makes it possible to determine visually in the concentration above 6.0 mg L−1 using a color scale. The test results show that the polymethacrylate matrix can be used for determination of thiocyanate in oilfield water

Rapid colorimetric determination of ascorbic acid by solid phase extraction of iodine into a polymethacrylate matrix

The proposed iodometric solid-phase spectrophotometry method is based on interaction of ascorbic acid with molecular iodine in a solution with further extraction of the unreacted iodine into a polymethacrylate matrix followed by its spectrophotometric measurement in the solid phase. The amount of iodine extracted by the matrix is in inverse linear dependence on the concentration of ascorbic acid in the solution. The method can be employed for the range of ascorbic acid concentrations 1.0-9.0 mg dm-3, while its detection limit is 0.8 mg dm-3