Изменения гемоциркуляторных и респираторных функций при бронхиальной астме у детей

One hundred and fifty bronchial asthma patients aged 6 to 14 yrs were complexly examined for haemodynamic parameters in correlation with the lung function and the diaphragm activity in different stages of the disease. The respiratory dysfunction based on the bronchial obstruction, irregular lung ventilation and reduction in the diaphragm functional activity was shown to be accompanied by changes in the regional and central blood circulation. A consistency of these disorders depended on the basic therapyУ 150 больных бронхиальной астмой в возрасте от 6 до 14 лет проведено комплексное исследование параметров гемодинамики во взаимосвязи с оценкой функции внешнего дыхания и активности диафрагмы в различные периоды заболевания. Показано, что респираторная дисфункция, в основе которой лежат бронхиальная обструкция, неравномерная вентиляция легких и снижение функциональной активности диафрагмы, сочетается с изменениями регионарной и центральной гемоциркуляции. Причем стойкость отмеченных отклонений зависит от применения базисной терапии

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

: Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10(-11)) in 4,380 cases and 310,238 controls. This locus is near the FLT1 gene encoding Fms-like tyrosine kinase 1, providing biological support, as a placental isoform of this protein (sFlt-1) is implicated in the pathology of preeclampsia. The association was strongest in offspring from pregnancies in which preeclampsia developed during late gestation and offspring birth weights exceeded the tenth centile. An additional nearby variant, rs12050029, associated with preeclampsia independently of rs4769613. The newly discovered locus may enhance understanding of the pathophysiology of preeclampsia and its subtypes.<br/

Relationship of brachial artery responsiveness parameters to left ventricular diastolic dysfunction in patients with rheumatoid arthritis

Objective: to study vascular responsiveness parameters in rheumatoid arthritis (RA) patients with and without left ventricular diastolic dysfunction (DD) and to identify the predictors of DD among the characteristics of vascular responsiveness in RA patients having no cardiovascular diseases. Subjects and methods. The investigation enrolled 61 RA patients (mean age 47.1 years; 87% of females) without cardiovascular comorbidity. All the patients underwent standard echocardiographic study with diastolic function assessment in accordance with the 2005 European Society of Cardiology guidelines. Vascular responsiveness was studied using brachial artery Doppler ultrasonography in a 5-minute compression test. Associations between vascular responsiveness parameters and DD were studied using logistic regression models and adjusting for patient gender and age. Results and discussion. DD was found in 35 (57%) patients. The parameters of vascular responsiveness in RA patients with DD differed from those in RA patients without DD. The decrement in blood flow volumetric velocity in the brachial artery 10 sec (odds ratio [OR] 0.8; 95% confidence interval [CI] 0.7-0.97), and 1 min (OR 0.7; 95% CI 0.5-0.96) after decompression and the relative increment in blood flow volumetric velocity within the first minute after decompression (OR = 0.9; 95% CI 0.9-0.99) were associated with the presence of DD. There were no statistically significant associations of the changes in brachial artery diameter with DD. Conclusion. The decrement in blood flow volumetric velocity in the brachial artery, as evidenced by the compression test, is associated with DD in RA patients without cardiovascular diseases. The association of impairments in vasomotor and diastolic functions in RA shows the commonness of pathogenic mechanisms for the development of these changes and opens considerable scope for the earlier diagnosis of DD according to the results of the study of vascular responsiveness

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10(-11)) in 4,380 cases and 310,238 controls. This locus is near the FLT1 gene encoding Fms-like tyrosine kinase 1, providing biological support, as a placental isoform of this protein (sFlt-1) is implicated in the pathology of preeclampsia. The association was strongest in offspring from pregnancies in which preeclampsia developed during late gestation and offspring birth weights exceeded the tenth centile. An additional nearby variant, rs12050029, associated with preeclampsia independently of rs4769613. The newly discovered locus may enhance understanding of the pathophysiology of preeclampsia and its subtypes

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Abstract Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia. Studies to identify maternal variants associated with preeclampsia have been limited by sample size. Here, the authors meta-analyze eight GWAS of 9,515 preeclamptic women, identifying five variants associated with preeclampsia and showing that genetic predisposition to hypertension is a major risk factor for preeclampsia