Comparison of in-situ delay monitors for use in Adaptive Voltage Scaling

In Adaptive Voltage Scaling (AVS) the supply voltage of digital circuits is tuned according to the circuit's actual operating condition, which enables dynamic compensation to PVTA variations. By exploiting the excessive safety margins added in state-of-the-art worst-case designs considerable power saving is achieved. In our approach, the operating condition of the circuit is monitored by in-situ delay monitors. This paper presents different designs to implement the in-situ delay monitors capable of detecting late but still non-erroneous transitions, called Pre-Errors. The developed Pre-Error monitors are integrated in a 16 bit multiplier test circuit and the resulting Pre-Error AVS system is modeled by a Markov chain in order to determine the power saving potential of each Pre-Error detection approach

Recent observations of peculiar Gamma-ray bursts using 3.6 m Devasthal Optical Telescope (DOT)

India has been actively involved in the follow-up observations of optical afterglows of gamma-ray bursts (GRBs) for more than two decades, using the country's meter-class facilities such as the 1.04 m Sampurnanand Telescope, 1.3 m Devasthal Fast Optical Telescope, 2.01 m Himalayan Chandra Telescope along with many others in the country, utilizing the longitudinal advantage of the place. However, since 2016, Indian astronomers have embarked on a new era of exploration by utilizing the country's largest optical telescope, the 3.6 m Devasthal Optical Telescope (DOT) at the Devasthal Observatory of ARIES Nainital. This unique telescope has opened up exciting opportunities for transient study. Starting from the installation itself, the DOT has been actively performing the target of opportunity (ToO) observations, leading to many interesting discoveries. Notable achievements include the contributions towards the discovery of long GRB 211211A arising from a binary merger, the discovery of the most delayed optical flare from GRB 210204A along with the very faint optical afterglow (fainter than 25 mag in g-band) of GRB 200412B. We also successfully observed the optical counterpart of the very-high-energy (VHE) detected burst GRB 201015A using DOT. Additionally, DOT has been used for follow-up observations of dark and orphan afterglows, along with the observations of host galaxies associated with peculiar GRBs. More recently, DOT's near-IR follow-up capabilities helped us to detect the first near-IR counterpart (GRB 230409B) using an Indian telescope. In this work, we summarise the recent discoveries and observations of GRBs using the 3.6 m DOT, highlighting the significant contributions in revealing the mysteries of these cosmic transients.Comment: 16 pages, 2 figures, 1 table, accepted for publication in the Bulletin of Li\`ege Royal Society of Sciences as a part of 3$^{rd}$ Belgo-Indian Network for Astronomy and Astrophysics (BINA) workshop, 22-24 March 202

MHC class II deficiency: Report of a novel mutation and special review

The MHC II deficiency is a rare autosomal recessive primary immunodeficiency syndrome with increased susceptibility to respiratory and gastrointestinal infections, failure to thrive and early mortality. This syndrome is caused by mutations in transcription regulators of the MHC II gene and results in development of blind lymphocytes due to the lack of indicatory MHC II molecules. Despite homogeneity of clinical manifestations of patients with MHC II deficiency, the genetic defects underlying this disease are heterogeneous. Herein, we report an Iranian patient with MHC II deficiency harbouring a novel mutation in RFXANK and novel misleading clinical features. He had ataxic gait and dysarthria from 30 months of age. Epidemiology, clinical and immunological features, therapeutic options and prognosis of patients with MHC II are reviewed in this paper. © 2017 SEICAP. Published by Elsevier Espana, ˜ S.L.U. All rights reserved

Potential of Mycobacterium tuberculosis resuscitation-promoting factors as antigens in novel tuberculosis sub-unit vaccines

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Diagnostic and prognostic significance of exercise-induced premature ventricular complexes in men and women: A four year follow-up

Two hundred eighty patients (197 men and 83 women) with normal rest electrocardiograms and no history of prior myocardial infarction were referred for evaluation of chest pain. It was found that exercise-induced premature ventricular complexes had a lower sensitivity, specificity, positive predictive value and negative predictive value in predicting significant coronary artery disease than exercise-induced ST segment depression greater than or equal to 1 mm. The incidence of exercise-induced premature ventricular complexes was not significantly different in patients with no significant coronary artery disease, single vessel disease or multivessel disease. The site of origin of exercise-induced premature ventricular complexes was not helpful in predicting the presence or severity of coronary artery disease. At a mean follow-up period of 47.1 months, exercise-induced premature ventricular complexes did not predict coronary events (cardiac death or nonfatal myocardial infarction) in men or women

Impact of Moderate to Severe Renal Impairment on Mortality and Appropriate Shocks in Patients with Implantable Cardioverter Defibrillators

Background. Due to underrepresentation of patients with chronic kidney disease (CKD) in large Implantable-Cardioverter Defibrillator (ICD) clinical trials, the impact of ICD remains uncertain in this population. Methods. Consecutive patients who received ICD at Creighton university medical center between years 2000–2004 were included in a retrospective cohort after excluding those on maintenance dialysis. Based on baseline Glomerular filtration rate (GFR), patients were classified as severe CKD: GFR < 30 mL/min; moderate CKD: GFR: 30–59 mL/min; and mild or no CKD: GFR ≥ 60 mL/min. The impact of GFR on appropriate shocks and survival was assessed using Kaplan-Meier method and Generalized Linear Models (GLM) with log-link function. Results. There were 509 patients with a mean follow-up of 3.0 + 1.3 years. Mortality risk was inversely proportional to the estimated GFR: 2 fold higher risk with GFR between 30–59 mL/min and 5 fold higher risk with GFR < 30 mL/min. One hundred and seventy-seven patients received appropriate shock(s); appropriate shock-free survival was lower in patients with severe CKD (GFR < 30) compared to mild or no CKD group (2.8 versus 4.2 yrs). Conclusion. Even moderate renal dysfunction increases all cause mortality in CKD patients with ICD. Severe but not moderate CKD is an independent predictor for time to first appropriate shock

Verification of a rigorous 2D model of rough surface scattering

A rigorous two-dimensional (2D) model of electromagnetic surface scatter has been developed, based on a boundary element method (BEM) established by Simonsen [1]. Simulated far-field scatter is compared to that measured from a laser scatterometer for a sinusoidal grating, with a mean difference of 3% of the peak intensity

Phytochemical analysis and evaluation of antibacterial activity of Moringa oleifera extracts against gram-negative bacteria: an in vitro and molecular docking studies

Moringa oleifera seed and leaf are used traditionally for the treatment of various healthproblems (among others, hypertension, scrapes, skin infection, diabetes, genitourinaryillnesses), and to boost the immune system, as well as to act as a contraceptive. Inthis study, the antibacterial activity of seed and leaf M. oleifera extracts on three-gramnegative bacteria was investigated, and phytochemical analysis for the association ofantibacterial activity with the active constituents in the plant was determined. Moreover,understanding of the mechanism of action was achieved by applying the Auto DockVina technique. The phytochemical screening of M. oleifera seed and leaf extractsexhibited the presence of alkaloids, carbohydrates, cardioactive glycosides, flavonoids,tannins, phenols, steroids and terpenoids. In silico results revealed that compounds(4-O-caffeoyl quinic acid, 4-(α-L-rhamnopyranosyloxyl)-benzylisothiocyanate);(Isoquercitrin, 4-(α-L-rhamnopyranosyloxy) benzyl glucosinolate); and (Astragalin,4-(α-L-rhamnopyranosyloxy) benzyl glucosinolate) from leaf and seed have the highestbinding affinity and very good interactions with Transcriptional Activator Protein (LasR),Klebsiella pneumoniae carbapenemase (KPC), and Malonyl-CoA-acyl carrier proteintransacylase (FabD), respectively