Diagnostics and self-certification of specialists for increase of occupational mobility level

We suggested ways to improve occupational mobility in two directions, which worked on a number of enterprises. These areas are to improve quality management and self-assessmentПредложены пути повышения профессиональной мобильности по двум направлениям, которые отработаны на ряде предприятий. Такими направлениями являются совершенствование качеств менеджера и самоаттестаци

About some economic applications of cohort analysis

Nowadays, there is the problem of evaluating the return on advertising costs for industries with a delayed conversion. Cohort analysis is a series of studies which are conducted at certain time intervals. Using cohort analysis we can better assess the effectiveness of advertising channels for industries with a delayed conversion. Cohort analysis can be used to analyze following items: efficiency in the context of "traffic sources", usefulness of changes on the web site; assessment of effectiveness of marketing campaigns; assessment of impact of seasonality on the behavior of the user; the decision-making period. The article presents an overview of tools we can use to collect data for analysis. The article also describes the method of selection and the variants of the cohorts to construct the analysis. For demonstration of the proposed method and calculation variant, there is considered the practical example of building a cohort analysis. Using these method and the example of calculating, the companies with delayed conversion can analyze the effectiveness of Internet advertising for different advertising channels. © 2018 Author(s)

Statistical analysis of the use an internal capital adequacy assessment procedure in the monitoring of banks stability

To increase the stability of the banking system, it is necessary to use effective systems of risk management and monitoring of banks. One of these systems is the internal procedure for capital adequacy assessment (IPCAA). The purpose of this study is to assess, using a statistical analysis, the impact of the IPCAA procedure on changes in the value of banks' capital adequacy ratios. Some results of monitoring data are presented on risk-weighted assets, level 1 and 2 capitals, and capital adequacy ratios (CAR) for two foreign (2008 - 2018) and three Russian banks (2014 - 2018). The study showed the direct effect of increasing the risk-weighted assets on the level of capital adequacy (CAR). The results obtained allow concluding that there is a direct significant connection between the IPCAA procedure use and the stability of banks. This procedure provides a comprehensive assessment of the overall capital adequacy of banks, taking into account the existing risks in order to maintain an adequate and stable forecast level of capital. The study also revealed the needs of banks in creating adequate structures to ensure proper management of financial and operational risks, which will simplify the IPCAA process and ensure more effective capital planning and decision-making to provide the stability of both individual banks and the entire banking system. © 2020 American Institute of Physics Inc.. All rights reserved

Development of methods of physical modeling of high-temperature processes in microwave field

In the work discusses the basics of using the microwave field to simulate individual high-temperature processes. The work outlines the applications of the microwave field for the processing of technological waste. In the work the layout technological schemes on the basis of a household microwave oven are proposed.В работе рассмотрены аспекты использования микроволнового поля для моделирования отдельных высокотемпературных процессов. Изложены варианты применения СВЧ поля для переработки техногенных отходов. Предложены компоновочные технологические схемы на основе бытовой микроволновой печи

Analysis of failures of conservative treatment of clinical forms of male Infertility

In a survey of 1012 married couples, the male factor of infertility was detected in 54.7% (p≤0.05). For the reliability of evaluation of the results of spermatogenesis correction and the effectiveness of IVF (ICSI) procedures, 292 men (28.8%) were selected with an infertility factor and healthy wives. At the same time, in 196 people, the etiologic factor was known and in 96 patients idiopathic form of infertility was established (32,87%, р≤0,05). Patients were given 2 courses of stimulating therapy depending on the etiologic cause or empirical therapy in cases of the presence of an idiopathic form. In the absence of effect, couples were sent to IVF (ICSI). The effectiveness of the treatment, depending on the presence of 1, 2 or more 2 factors of infertility, was analysed in the SPSS® 17.0 (© SPSS Inc.) tables, the reliability was considered a program Biostat, 6.1. A direct correlation was found between the clinical variant of infertility and the frequency of pregnancy in the study group, and as well as a direct correlation between the number of external factors and the results of treatment.При обследовании 1012 супружеских пар мужской фактор инфертильности был выявлен в 54,7% (р≤0,05). для достоверности оценки результатов коррекции сперматогенеза и эффективности процедур ВРТ (ЭКО-ИКСИ), было отобрано 292 мужчин (28,8%) с фактором инфертильности и здоровыми женами. При этом у 196 человек этиологический фактор был известен и у 96 пациентов была установлена идиопатическая форма инфертильности (32,87%, р≤0,05). Пациентам было проведено 2 курса стимулирующей терапии в зависимости от этиологической причины или эмпирическая терапия в случаях наличия идиопатической формы. При отсутствии эффекта пары направлялись на ВРТ (ЭКО-ИКСИ). Результативность проводимого лечения в зависимости от наличия 1, 2 и более 2 факторов инфертильности, фиксировалась в таблицах SPSS® 17.0 (© SPSS Inc.), достоверность считалась программой Biostat, 6.1. Была выявлена прямая корреляция между клиническим вариантом инфертильности и частотой возникновения беременности в исследуемой группе, а также прямая корреляция между количеством внешних факторов и результатами лечения

The role of inducing factors in the formation of Rendall plaques and the development of urolithiasis

In this article, we present the main information about some promising markers of urolithiasis-substances formed on the surface of the transitional cell epithelium and involved in the inhibition or induction of crystal formation. The reason for their formation is still not fully understood. There is a hypothesis that they are inducers of calculus formation in the renal calyceal system and are directly related to Randall's plaques, whose role in the pathogenesis of ICdd remains a subject of discussion. In this regard, the study of the relationship of certain markers of urolithiasis with dysfunction of urothelium in the zone of formation of Randalla plaques is important for understanding the pathogenesis of this disease, for which an attempt has been made to thoroughly study Russian and English literature in databases (MEdlINE, PubMed, Medscape). A total of 126 sources were studied (all studies for the period 2000 - 2017), of which 15 publications of the most significant and relevant studies were selected for this review.В данной работе представлены основные сведения о некоторых перспективных маркерах мочекаменной болезни – субстанциях, образующихся на поверхности переходно-клеточного эпителия и участвующих в ингибировании или индукции кристаллообразования. Причина их образования является сих пор до конца не ясна. Существует гипотеза о том, что они являются индукторами образования конкрементов в чашечно-лоханочной системах почек и напрямую связаны с бляшками рэндалла, роль которых в патогенезе МКБдо сих пор остается предметом дискуссии. В связи с этим, изучение связи некоторых маркеров мочекаменной болезни с дисфункцией уротелия в зоне формирования бляшек рендалла имеет важное значение для понимания патогенеза этого заболевания, для чего предпринята попытка всестороннего изучения русской и англоязычной литературы в базах данных (MEdlINE, PubMed, Medscape). Всего изучено 126 источников (все исследования за период 2000 – 2017 гг.), из них в настоящий обзор отобрано 15 публикаций наиболее значимых и релевантных исследований

Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

Background and purpose: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions: Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013

Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry

Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007

循环经济中的区域产业参与者的创新解决方法

Received July 5, 2022; accepted December 28, 2022.Дата поступления 5 июля 2022 г.; дата принятия к печати 6 сентября 2022 г.Relevance. Recent practice has convincingly tested the fact that the transition to a circular economy is an important goal for society and individual companies, especially in resource-intensive manufacturing industries. Research objective. The purpose of the study is to develop a theoretical and methodological basis for the creation of innovative solvates in regional industry, based on the concept of circular economy. Data and methods. The research methodology is represented by the convergence of system-synergetic, resource-efficient and cluster approaches, which makes it possible to identify regions where integrating industrial enterprises and related fields of activity form conditions and produce values in the concept of the circular economy. Results. The theoretical and methodological basis for the creation of new structures for the innovative development of regional industry on the platform of circularity, principles of inclusiveness, resilience and environmental friendliness has been formed; a new concept - innovative solvates has been introduced into scientific circulation. Based on the cluster analysis, the zones of localization of innovative solvates in the regions of Russia were identified. This made it possible to single out a cluster group with a high scientific and innovative potential, as well as a cluster of regions with the potential to localize innovative solvates, which included regions of industrial and resource specialization. Conclusions. The article presents the directions of solving the problem of achieving the conditions imposed by the circular economy in the innovative solvates of the industrial sector of the region. The study is motivated by several considerations. The first is the formation of an integral conceptual and terminological apparatus, theoretical and methodological basis of research. The second is the establishment of partnerships necessary for the implementation of circularity conditions in an innovative solvate, and the analysis of ways in which a solvate can switch to a circular economy.Актуальность. Практикой последнего времени убедительно тестируется тот факт, что переход к экономике замкнутого цикла является важной целью для общества и отдельных компаний, особенно в ресурсоемких отраслях обрабатывающей промышленности, поскольку парадигма циркулярности базируется на принципах рационального распределения и безотходного использования ресурсов. Цель исследования. Цель исследования - разработка теоретико-методологического базиса создания инновационных сольватов (объединения инновационного типа, характеризующиеся единым замкнутым техноло-гическим циклом) в региональной промышленности, основанных на концепции циркулярной экономики, а также инструментария определения локалитетов сольватации. Данные и методы. Методология исследования представлена конвергенцией системно-синергетического, ресурсно-результативного и кластерного подходов, что позволяет выявить регионы, в которых интегрирующиеся предприятия промышленности и смежных сфер деятельности формируют условия и продуцируют ценности в концепте принципов и критериев экономики замкнутого цикла. Результаты. Сформирован теоретико-методологический базис создания новых структур инновационного развития региональной промышленности на платформе циркулярности, принципов инклюзивности, резильентности и экологичности; введено в научный оборот новое понятиеинновационные сольваты. На основании проведения кластерного анализа выявлены зоны локализации инновационных сольватов в регионах России. Это позволило выделить кластерную группу с высоким научным и инновационным потенциалом, а также кластер регионов с потенциалом локализации инновационных сольватов, в который вошли регионы промышленно-ресурсной специализации. Выводы. В статье представлены направления решения проблемы достижения условий, которые налагает циркулярная экономика в инновационных сольватах промышленного сектора региона. Исследование мотивировано несколькими соображениями. Первое - формирование целостного понятийно-терминологического аппарата, теоретико-методологического базиса исследования, а также концепции выявления локалитетов инновационных сольватаций в региональной промышленности. Второе – установление партнерских отношений, необходимых для реализации условий циркулярности в инновационном сольвате, и анализ способов, с помощью которых сольват может перейти на экономику замкнутого цикла, нацеленную на рациональное использование ресурсов всеми его участниками.现实性：最近的案例有力地证明，向循环经济过渡是社会和公司的重要 目标，特别是在资源密集型的制造业。因为循环模式是基于资源合理分 配和无废物利用的原则。 研究目标：在理论和方法学基础上为区域工业创造创新型联合体，这是 在循环经济概念的基础上创建的。另外，文章研究了联合体的工具。 数据与方法：研究方法以系统协同、资源高效和集群方法的融合为代 表。它可以确定在哪些地区形成了整合工业和相关企业的条件，并可在 闭环经济原则和标准概念中产生价值。 研究结果：形成了在循环性平台上创建区域工业创新发展新结构的理论 和方法基础。这是以循环性、包容性、韧性和环境友好性为原则的。一 个新的概念被引入——创新型联合体。文章在集群分析的基础上，确定 了创新型联合体在俄罗斯各地区的定位。这使得我们能够选出高科学和 创新潜力的集群组，以及具有本地化创新型联合体潜力的区域集群，其 中包括工业和资源专业化区域。 结论：本文提出了在实现循环经济中，地区工业部门的创新型联合体所 遇到问题的解决办法。这项研究的动机有几个方面。首先是形成整体概 念和术语，提出研究理论和方法基础，以及识别区域工业中创新型联合 体地点的概念。其次，是建立必要的伙伴关系，以便在创新联合体中实 施循环性。并分析联合体走向闭环经济的方式，旨在使其所有参与者合 理利用资源。The research was supported by the grant from the Russian Science Foundation № 22- 28-00050, https://rscf.ru/project/22-28-00050, and was conducted at the Southern Federal University