A counter measure to Black hole attack on AODVbased Mobile Ad-Hoc Networks

Security is a major threat and essential requirement for mobile Ad Hoc network. Due to its inherent characteristics, it has many consequent challenges, which needs to be taken care of. In this paper we analyse the black hole attack in MANET using AODV as its routing protocol. Black hole is a type of routing attack where a malicious node impersonates a destination node by sending deceived route reply packet to a source node that initiates a route discovery process. By doing this, the malicious node can deprive the traffic from the source node. We propose a solution that makes a modification in existing AODV routing protoco

Natural treasures from Picrorhiza kurrooa: a computational exploration of drug-like properties and bioactivity of kutkin, cucurbitacin, apocynin and lupanine

Background: To analyse and predict the basic pharmacokinetic and toxicological properties of four compounds of interest found in Picrorhiza kurroa (Kutkin, cucurbitacin, apocynin and lupanine) using computational bioinformatics tools. Methods: The chemical structures and molecular properties of the compounds were obtained from authentic sources and processed for data profiling. 2D structures were converted to 3D structures using ChemSketch software and PHASE module. In silico screening of the 3D structures was performed using bioinformatics prediction software to assess drug-likeness, absorption, blood-brain barrier penetration, enzyme interaction potential, skin penetration, and acute oral toxicity. Results: Kutkin exhibited poor drug-likeness and low oral absorption, while the other three compounds showed promising drug-like properties and good oral absorption. Cucurbitacin and lupanine were predicted to cross the blood-brain barrier, while Kutkin and Apocynin were not. None of the compounds were substrates for P-glycoprotein, but Kutkin and cucurbitacin were substrates for CYP3A4. All four compounds had low skin penetration. Acute oral toxicity varied, with cucurbitacin classified as highly toxic and the others as slightly toxic. Conclusions: Cucurbitacin, apocynin, and lupanine have potential for further development as therapeutic agents due to their favorable drug-like properties and good absorption. Kutkin's poor drug-likeness and low absorption make it less suitable for oral drug development. This information provides valuable insights for further research on the medicinal properties of Picrorhiza kurroa and the development of new drugs based on its active compounds

Mechanistic insights into the analgesic and anti-inflammatory effects of alcoholic extracts from Curcuma longa

Background: Aim of the study was to scientifically validate the traditional Indian claims of Curcuma longa's (turmeric) antinociceptive (pain-relieving) and anti-inflammatory effects. Methods: The alcoholic extract of C. longa was tested in three rodent nociceptive models: acetic acid-induced writhing: examines visceral pain, formalin test: evaluates both acute and chronic neurogenic and inflammatory pain and tail immersion test to assess thermal pain. The extract's effects were compared to a control group and morphine (reference drug). Results: C. longa extract significantly reduced abdominal constrictions in the acetic acid test (59.36% inhibition). In the formalin test, the extract significantly decreased paw licking response time in both early (54.12% inhibition) and late phases (78.59% inhibition). C. longa extract significantly increased the tail flick reaction time in the immersion test, indicating pain relief. Conclusions: This study confirms the antinociceptive and anti-inflammatory activities of C. longa, providing scientific evidence for its traditional use in pain management

Low Power and Efficient Re-Configurable Multiplier for Accelerator

Deep learning is a rising topic at the edge of technology, with applications in many areas of our lives, including object detection, speech recognition, natural language processing, and more. Deep learning's advantages of high accuracy, speed, and flexibility are now being used in practically all major sciences and technologies. As a result, any efforts to improve the performance of related techniques are worthwhile. We always have a tendency to generate data faster than we can analyse, comprehend, transfer, and reconstruct it. Demanding data-intensive applications such as Big Data. Deep Learning, Machine Learning (ML), the Internet of Things (IoT), and high- speed computing are driving the demand for "accelerators" to offload work from general-purpose CPUs. An accelerator (a hardware device) works in tandem with the CPU server to improve data processing speed and performance. There are a variety of off-the-shelf accelerator architectures available, including GPU, ASIC, and FPGA architectures. So, this work focus on designing a multiplier unit for the accelerators. This increases the performance of DNN, reduced the area and increasing the training speed of the system

Urine analysis in KUB calculi in a tertiary care hospital

Background: This study was conducted to study the complete urine examination in patients presented with stones in kidney ureter and bladder.Methods: A retrospective study was done in patients with KUB stones who are attended OP or admitted in Saveetha Medical College and Hospital from January 2019 to December 2019. The data was collected from the Department of Urology, Radiology and Clinical pathology and entered in excel sheet, analysed descriptively. In our study 1000 cases were found to be CT-KUB and their urine samples are examined by dipstick method, microscopic examination and computed tomography (kidney ureter bladder) remain the most accurate imaging modality to detect kidney stones and to direct management.Results: A cross-sectional study was conducted in 1000 patients with KUB stones and their urine examination was done. CT-KUB stones are found in the kidney of 540 patients, ureter- 440 patients, bladder- 20 patients respectively. In our study 17-70 years age group of patients were presented with stones and their urine examination showed RBC (30%), protein (21%), pus cells and leukocytes (26%).Conclusions: The present study found abnormal components are present in urine of KUB stone patients such as Red blood cells, Protein, Pus cells and leukocytes present. Hence it is mandatory to check the urine examination in-KUB Stone patients to prevent the further consequences in kidney, ureter and bladder

Operative management of tibial plateau fractures: an assessment of functional and radiological outcomes with Rasmusssens scoring system

Background: Fractures of the proximal tibia involve a major weight bearing joint and are intra-articular injuries which frequently result in functional impairment. They require an accurate reduction of the articular surface with stable internal fixation. If these fractures are not managed appropriately, they often result in high rates of morbidity in the form of knee stiffness and arthritis. This study was done to assess the functional and radiological outcomes following various surgical modalities and to compare them with other studies as available in literature.Methods: 30 patients with tibial plateau fractures treated by various surgical modalities at Saveetha Medical College and Hospital were studied from January 2013 to February 2015 and were followed up for a minimum period of 6 months. Functional and radiological outcomes were assessed by the Rasmussens scoring system.Results: All 30 patients fulfilling the inclusion criteria were thoroughly evaluated and were taken up for surgery with various modalities of fixation which included cannulated cancellous screws, T and L buttress plates and locking compression plates. Articular surface elevation with bone grafting was done in depressed fractures. Early knee mobilization was started and strict non-weight bearing walking was advocated. We had a 90% acceptable functional result which was comparable with other studies.Conclusions: In our study, we conclude that accurate reduction of the articular surface with stable internal fixation and early mobilization with bone grafting in depressed fractures with protracted weight bearing till fracture union gives good functional results. Also radiological values often do not often correlate well with functional outcomes.

Scale Filtering Analysis of Kinetic Reconnection and its Associated Turbulence

Previously, using an incompressible von K\'arm\'an-Howarth formalism, the behavior of cross-scale energy transfer in magnetic reconnection and turbulence was found to be essentially identical to each other, independent of an external magnetic (guide) field, in the inertial and energy-containing ranges (Adhikari et al., Phys. Plasmas 30, 082904, 2023). However, this description did not account for the energy transfer in the dissipation range for kinetic plasmas. In this letter, we adopt a scale-filtering approach to investigate this previously unaccounted-for energy transfer channel in reconnection. Using kinetic particle-in-cell (PIC) simulations of antiparallel and component reconnection, we show that the pressure-strain (PS) interaction becomes important at scales smaller than the ion inertial length, where the nonlinear energy transfer term drops off. Also, the presence of a guide field makes a significant difference in the morphology of the scale-filtered energy transfer. These results are consistent with kinetic turbulence simulations, suggesting that the pressure strain interaction is the dominant energy transfer channel between electron scales and ion scales