Sampling of environment and carcasses for the detection of Salmonella in swine abattoirs

The understanding of the epidemiology of Salmonella in slaughterhouses is a prerequisite for the establishment of control measures. In this study, 2841 samples were taken from the environment (before and during the operations), fecal material of incoming animals, different steps during the slaughter process and from carcasses to detect the presence of Salmonella in 4 abattoirs in the province of Quebec. Samples were processed using conventional enrichment and culture procedures and positive isolates were serotyped. Salmonella were found in 4.0% of the environment samples, including gloves and aprons. Despite an exceptionally high isolation rate of 21.3% in feces, probably the reflect of many clinical outbreaks of S. Typhimurium in the field, the percentage of positive isolates recovered from carcasses was 6.3%

TRIAD zoning in Quebec: Experiences and results after 5 years

The TRIAD approach to forest management involves dividing the forest into 3 zones, each with its own management\ud objectives, but with the overall goal of increasing the ecological and economic sustainability of the forest. For the past 5 years, we have been experimenting with TRIAD zoning in central Quebec, incorporating social interests into the original concept of TRIAD management. Results generally indicate that this approach is economically viable, socially acceptable, and preferable ecologically in this area. Although much remains to be done, thus far the consensus among the\ud various project participants is that this approach may be a good fit for the public forest of Canada

Segmental infantile hemangioma and concomitant hypertension in three African American neonates

We present three African American infants with segmental, ulcerated infantile hemangiomas and concomitant, persistent hypertension. When treated with beta-blocker therapy, the hemangiomas decreased in size and the ulcerations resolved, but there was no impact on the elevated blood pressure in one of our patients. We failed to identify any associations between infantile hemangioma and hypertension in the literature

Women and Alport syndrome

X-linked Alport syndrome (XLAS) is caused by mutations in type IV collagen causing sensorineural hearing loss, eye abnormalities, and progressive kidney dysfunction that results in near universal end-stage renal disease (ESRD) and the need for kidney transplantation in affected males. Until recent decades, the disease burden in heterozygous “carrier” females was largely minimized or ignored. Heterozygous females have widely variable disease outcomes, with some affected females exhibiting normal urinalysis and kidney function, while others develop ESRD and deafness. While the determinants of disease severity in females with XLAS are uncertain, skewing of X-chromosome inactivation has recently been found to play a role. This review will explore the natural history of heterozygous XLAS females, the determinants of disease severity, and the utility of using XLAS females as kidney donors

Digitization of the Canadian Parliamentary debates

This paper describes the digitization and enrichment of the Canadian House of Commons English Debates from 1901 to present. We start by laying out the general framework in which this project took place and then present the structure of the database and provide guidelines to prospective users. The paper concludes with the introduction of www.lipad.ca, an online platform designed as a hub for archiving Canadian political data, with the parliamentary proceedings at the centre of its architecture

Renal Survival in Children with Glomerulonephritis with Crescents: A Pediatric Nephrology Research Consortium Cohort Study

There is no evidence-based definition for diagnosing crescentic glomerulonephritis. The prognostic implications of crescentic lesions on kidney biopsy have not been quantified. Our objective was to determine risk factors for end-stage kidney disease (ESKD) in patients with glomerulonephritis and crescents on kidney biopsy. A query of the Pediatric Nephrology Research Consortium’s Pediatric Glomerulonephritis with Crescents registry identified 305 patients from 15 centers. A retrospective cohort study was performed with ESKD as the primary outcome. Median age at biopsy was 11 years (range 1–21). The percentage of crescents was 3–100% (median 20%). Etiologies included IgA nephropathy (23%), lupus (21%), IgA vasculitis (19%) and ANCA-associated GN (13%), post-infectious GN (5%), and anti-glomerular basement membrane disease (3%). The prevalence of ESKD was 12% at one year and 16% at last follow-up (median = 3 years, range 1–11). Median time to ESKD was 100 days. Risk factors for ESKD included %crescents, presence of fibrous crescents, estimated GFR, and hypertension at biopsy. For each 1% increase in %crescents, there was a 3% decrease in log odds of 1-year renal survival (p = 0.003) and a 2% decrease in log odds of renal survival at last follow-up (p \u3c 0.001). These findings provide an evidence base for enrollment criteria for crescentic glomerulonephritis in future clinical trials

The importance of clinician, patient and researcher collaborations in Alport syndrome

This is a post-peer-review, pre-copyedit version of an article published in Pediatric Nephrology. The final authenticated version is available online at: https://doi.org/10.1007/s00467-019-04241-7Alport syndrome (AS) is caused by mutations in the genes COL4A3, COL4A4 or COL4A5 and is characterised by progressive glomerular disease, sensorineural hearing loss and ocular defects. Occurring in less than 1:5000, AS is rare genetic disorder but still accounts for >1% of the prevalent population receiving renal replacement therapy. There is also increasing awareness about the risk of chronic kidney disease in individuals with heterozygous mutations in AS genes. The mainstay of current therapy is the use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers, yet potential new therapies are now entering clinical trials. The 2017 International Workshop on Alport Syndrome in Glasgow was a preconference workshop ahead of the 50th anniversary meeting of the European Society for Pediatric Nephrology. It focussed on updates in clinical practice, genetics, basic science and also incorporated patient perspectives. More than 80 international experts including clinicians, geneticists, researchers from academia and industry, and patient representatives took part in panel discussions and breakout groups. This report summarises the workshop proceedings and the relevant contemporary literature. It highlights the unique clinician, patient and researcher collaborations achieved by regular engagement between the groups

PreCam, a Precursor Observational Campaign for Calibration of the Dark Energy Survey

PreCam, a precursor observational campaign supporting the Dark Energy Survey (DES), is designed to produce a photometric and astrometric catalog of nearly a hundred thousand standard stars within the DES footprint, while the PreCam instrument also serves as a prototype testbed for the Dark Energy Camera (DECam)'s hardware and software. This catalog represents a potential 100-fold increase in Southern Hemisphere photometric standard stars, and therefore will be an important component in the calibration of the Dark Energy Survey. We provide details on the PreCam instrument's design, construction and testing, as well as results from a subset of the 51 nights of PreCam survey observations on the University of Michigan Department of Astronomy's Curtis-Schmidt telescope at Cerro Tololo Inter-American Observatory. We briefly describe the preliminary data processing pipeline that has been developed for PreCam data and the preliminary results of the instrument performance, as well as astrometry and photometry of a sample of stars previously included in other southern sky surveys.Comment: 21 pages, 15 figures, submitted to PAS