The Morphologically Divided Redshift Distribution of Faint Galaxies

We have constructed a morphologically divided redshift distribution of faint field galaxies using a statistically unbiased sample of 196 galaxies brighter than I = 21.5 for which detailed morphological information (from the Hubble Space Telescope) as well as ground-based spectroscopic redshifts are available. Galaxies are classified into 3 rough morphological types according to their visual appearance (E/S0s, Spirals, Sdm/dE/Irr/Pec's), and redshift distributions are constructed for each type. The most striking feature is the abundance of low to moderate redshift Sdm/dE/Irr/Pec's at I < 19.5. This confirms that the faint end slope of the luminosity function (LF) is steep (alpha < -1.4) for these objects. We also find that Sdm/dE/Irr/Pec's are fairly abundant at moderate redshifts, and this can be explained by strong luminosity evolution. However, the normalization factor (or the number density) of the LF of Sdm/dE/Irr/Pec's is not much higher than that of the local LF of Sdm/dE/Irr/Pec's. Furthermore, as we go to fainter magnitudes, the abundance of moderate to high redshift Irr/Pec's increases considerably. This cannot be explained by strong luminosity evolution of the dwarf galaxy populations alone: these Irr/Pec's are probably the progenitors of present day ellipticals and spiral galaxies which are undergoing rapid star formation or merging with their neighbors. On the other hand, the redshift distributions of E/S0s and spirals are fairly consistent those expected from passive luminosity evolution, and are only in slight disagreement with the non-evolving model.Comment: 11 pages, 4 figures (published in ApJ

Luminosity Functions of Elliptical Galaxies at z < 1.2

The luminosity functions of E/S0 galaxies are constructed in 3 different redshift bins (0.2 < z < 0.55, 0.55 < z < 0.8, 0.8 < z < 1.2), using the data from the Hubble Space Telescope Medium Deep Survey (HST MDS) and other HST surveys. These independent luminosity functions show the brightening in the luminosity of E/S0s by about 0.5~1.0 magnitude at z~1, and no sign of significant number evolution. This is the first direct measurement of the luminosity evolution of E/S0 galaxies, and our results support the hypothesis of a high redshift of formation (z > 1) for elliptical galaxies, together with weak evolution of the major merger rate at z < 1.Comment: To be published in ApJ Letters, 4 pages, AAS Latex, 4 figures, and 2 table

Anomalies in T cell function are associated with individuals at risk of mycobacterium abscessus complex infection

The increasing global incidence and prevalence of non-tuberculous mycobacteria (NTM) infection is of growing concern. New evidence of person-to-person transmission of multidrug-resistant NTM adds to the global concern. The reason why certain individuals are at risk of NTM infections is unknown. Using high definition flow cytometry, we studied the immune profiles of two groups that are at risk of Mycobacterium abscessus complex infection and matched controls. The first group was cystic fibrosis (CF) patients and the second group was elderly individuals. CF individuals with active M. abscessus complex infection or a history of M. abscessus complex infection exhibited a unique surface T cell phenotype with a marked global deficiency in TNFa production during mitogen stimulation. Importantly, immune-based signatures were identified that appeared to predict at baseline the subset of CF individuals who were at risk of M. abscessus complex infection. In contrast, elderly individuals with M. abscessus complex infection exhibited a separate T cell phenotype underlined by the presence of exhaustion markers and dysregulation in type 1 cytokine release during mitogen stimulation. Collectively, these data suggest an association between T cell signatures and individuals at risk of M. abscessus complex infection, however, validation of these immune anomalies as robust biomarkers will require analysis on larger patient cohorts

PHotometry Assisted Spectral Extraction (PHASE) and identification of SNLS supernovae

Aim: We present new extraction and identification techniques for supernova (SN) spectra developed within the Supernova Legacy Survey (SNLS) collaboration. Method: The new spectral extraction method takes full advantage of photometric information from the Canada-France-Hawai telescope (CFHT) discovery and reference images by tracing the exact position of the supernova and the host signals on the spectrogram. When present, the host spatial profile is measured on deep multi-band reference images and is used to model the host contribution to the full (supernova + host) signal. The supernova is modelled as a Gaussian function of width equal to the seeing. A chi-square minimisation provides the flux of each component in each pixel of the 2D spectrogram. For a host-supernova separation greater than <~ 1 pixel, the two components are recovered separately and we do not use a spectral template in contrast to more standard analyses. This new procedure permits a clean extraction of the supernova separately from the host in about 70% of the 3rd year ESO/VLT spectra of the SNLS. A new supernova identification method is also proposed. It uses the SALT2 spectrophotometric template to combine the photometric and spectral data. A galaxy template is allowed for spectra for which a separate extraction of the supernova and the host was not possible. Result: These new techniques have been tested against more standard extraction and identification procedures. They permit a secure type and redshift determination in about 80% of cases. The present paper illustrates their performances on a few sample spectra.Comment: 27 pages, 18 Figures, 1 Table. Accepted for publication in A&

Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) web-server

Genomics Data Miner (GMine) is a user-friendly online software that allows non-experts to mine, cluster and compare multidimensional biomolecular datasets. Various powerful visualization techniques are provided, generating high quality figures that can be directly incorporated into scientific publications. Robust and comprehensive analyses are provided via a broad range of data-mining techniques, including univariate and multivariate statistical analysis, supervised learning, correlation networks, clustering and multivariable regression. The software has a focus on multivariate techniques, which can attribute variance in the measurements to multiple explanatory variables and confounders. Various normalization methods are provided. Extensive help pages and a tutorial are available via a wiki server. Using GMine we reanalyzed proteome microarray data of host antibody response against Plasmodium falciparum. Our results support the hypothesis that immunity to malaria is a higher-order phenomenon related to a pattern of responses and not attributable to any single antigen. We also analyzed gene expression across resting and activated T cells, identifying many immune-related genes with differential expression. This highlights both the plasticity of T cells and the operation of a hardwired activation program. These application examples demonstrate that GMine facilitates an accurate and in-depth analysis of complex molecular datasets, including genomics, transcriptomics and proteomics data

CD161 expression defines new human γδ T cell subsets

γδ T cells are a highly versatile immune lineage involved in host defense and homeostasis, but questions remain around their heterogeneity, precise function and role during health and disease. We used multi−parametric flow cytometry, dimensionality reduction, unsupervised clustering, and self-organizing maps (SOM) to identify novel γδ T cell naïve/memory subsets chiefly defined by CD161 expression levels, a surface membrane receptor that can be activating or suppressive. We used middle-to-old age individuals given immune blockade is commonly used in this population. Whilst most Vδ1+subset cells exhibited a terminal differentiation phenotype, Vδ1− subset cells showed an early memory phenotype. Dimensionality reduction revealed eight γδ T cell clusters chiefly diverging through CD161 expression with CD4 and CD8 expression limited to specific subpopulations. Comparison of matched healthy elderly individuals to bronchiectasis patients revealed elevated Vδ1+ terminally differentiated effector memory cells in patients potentially linking this population with chronic proinflammatory disease

Spectroscopy of high proper motion stars in the ground--based UV

Based on high quality spectral data (spectral resolution R>60000) within the wavelength range of 3550-5000 AA we determined main parameters (effective temperature, surface gravity, microturbulent velocity, and chemical element abundances including heavy metals from Sr to Dy) for 14 metal-deficient G-K stars with large proper motions. The stars we studied have a wide range of metallicity: [Fe/H]=-0.3 \div -2.9. Abundances of Mg, Al, Sr and Ba were calculated with non-LTE line-formation effects accounted for. Abundances both of the radioactive element Th and r-process element Eu were determined using synthetic spectrum calculations. We selected stars that belong to different galactic populations according to the kinematical criterion and parameters determined by us. We found that the studied stars with large proper motions refer to different components of the Galaxy: thin, thick disks and halo. The chemical composition of the star BD+80 245 located far from the galactic plane agrees with its belonging to the accreted halo. For the giant HD115444 we obtained [Fe/H]=-2.91, underabundance of Mn, overabundance of heavy metals from Ba to Dy, and, especially high excess of the r-process element Europium: [Eu/Fe]=+1.26. Contrary to its chemical composition typical for halo stars, HD115444 belongs to the disc population according to its kinematic parameters.Comment: 16 pages, 4 figures, 5 tables, "UV Universe-2010 (2nd NUVA Symposium) conference

Birth and early evolution of a planetary nebula

The final expulsion of gas by a star as it forms a planetary nebula --- the ionized shell of gas often observed surrounding a young white dwarf --- is one of the most poorly understood stages of stellar evolution. Such nebulae form extremely rapidly (about 100 years for the ionization) and so the formation process is inherently difficult to observe. Particularly puzzling is how a spherical star can produce a highly asymmetric nebula with collimated outflows. Here we report optical observations of the Stingray Nebula which has become an ionized planetary nebula within the past few decades. We find that the collimated outflows are already evident, and we have identified the nebular structure that focuses the outflows. We have also found a companion star, reinforcing previous suspicions that binary companions play an important role in shaping planetary nebulae and changing the direction of successive outflows.Comment: 9 pages + 3 figures. To appear in Nature, 2 April 199

The Young Stellar Population of IC1613. I. A New Catalogue of OB Associations

Context: Determining the parameters of massive stars is crucial to understand many processes in galaxies and the Universe, since these objects are important sources of ionization, chemical enrichment and momentum. 10m class telescopes enable us to perform detailed quantitative spectroscopic analyses of massive stars in other galaxies, sampling areas of different metallicity. Relating the stars to their environment is crucial to understand the physical processes ruling their formation and evolution. Aims: In preparation for the GTC, our goal is to build a catalogue of massive star candidates in the metal-poor irregular galaxy IC1613 with high astrometric accuracy, apt for the current generation of multi-object spectrographs. A census of OB associations in this galaxy is also needed, to provide important additional information about age and environment of the candidate OB stars. Methods: From INT-WFC observations, we have built an astrometric and photometric catalogue of stars in IC1613. Candidate blue massive stars are preselected from their colors. A friends-of-friends algorithm is developed to find their clustering in the galaxy. While a common physical origin for all the members of the associations cannot be ensured, this is a necessary first step to place candidate OB stars in a population context. Results: We have produced a deep catalogue of targets in IC1613 that covers a large field of view. To achieve high astrometric accuracy a new astrometric procedure is developed for the INT-WFC data. We have also built a catalogue of OB associations in IC1613. We have found that they concentrate in the central regions, specially in the HII bubbles. The study of extinction confirms that it is patchy, with local values of color-excess above the foreground value.Comment: Accepted for publication in Astronomy and Astrophysics. 16 pages + appendix (14 pages); 20 figure

Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells

A decline in the prevalence of parasites such as hookworms appears to be correlated with the rise in non-communicable inflammatory conditions in people from high- and middle-income countries. This correlation has led to studies that have identified proteins produced by hookworms that can suppress inflammatory bowel disease (IBD) and asthma in animal models. Hookworms secrete a family of abundant netrin-domain containing proteins referred to as AIPs (Anti-Inflammatory Proteins), but there is no information on the structure-function relationships. Here we have applied a downsizing approach to the hookworm AIPs to derive peptides of 20 residues or less, some of which display anti-inflammatory effects when co-cultured with human peripheral blood mononuclear cells and oral therapeutic activity in a chemically induced mouse model of acute colitis. Our results indicate that a conserved helical region is responsible, at least in part, for the anti-inflammatory effects. This helical region has potential in the design of improved leads for treating IBD and possibly other inflammatory conditions