Invasive intrauterine Therapie

Zusammenfassung: Einige fetale Fehlbildungen führen bereits intrauterin zu Organschäden, die postpartal schwere bleibende Behinderungen zur Folge haben oder nicht mit dem Leben vereinbar sind. Fetale Eingriffe verlangen eine sichere pränatale Diagnosestellung, Ausschluss assoziierter Fehlbildungen, Reversibilität der schädlichen Krankheitseffekte und deutliche Verbesserung der Prognose durch den fetalen Eingriff an dafür spezialisierten multidisziplinären Therapiezentren. In der invasiven fetalen Therapie wird sowohl offen, wie bei der fetalen Myelomeningozelen(MMC)-Operation, als auch fetoskopisch operiert. Zu nennen sind z.B. die reversible fetoskopische Balloneinlage in die Trachea zur Stimulation des Lungenwachstums bei der kongenitalen Zwerchfellhernie des Feten mit schwerer Lungenhypoplasie oder die Laserkoagulation plazentarer Gefäßverbindungen zum Stopp eines unausgeglichenen Blutflusses beim fetofetalen Transfusionssyndrom (FFTS). Hauptkomplikation der fetalen Chirurgie ist der vorzeitige Blasensprun

Exchange Interactions and High-Energy Spin States in Mn_12-acetate

We perform inelastic neutron scattering measurements on the molecular nanomagnet Mn_12-acetate to measure the excitation spectrum up to 45meV (500K). We isolate magnetic excitations in two groups at 5-6.5meV (60-75K) and 8-10.5meV (95-120K), with higher levels appearing only at 27meV (310K) and 31meV (360K). From a detailed characterization of the transition peaks we show that all of the low-energy modes appear to be separate S = 9 excitations above the S = 10 ground state, with the peak at 27meV (310K) corresponding to the first S = 11 excitation. We consider a general model for the four exchange interaction parameters of the molecule. The static susceptibility is computed by high-temperature series expansion and the energy spectrum, matrix elements and ground-state spin configuration by exact diagonalization. The theoretical results are matched with experimental observation by inclusion of cluster anisotropy parameters, revealing strong constraints on possible parameter sets. We conclude that only a model with dominant exchange couplings J_1 ~ J_2 ~ 5.5meV (65K) and small couplings J_3 ~ J_4 ~ 0.6meV (7K) is consistent with the experimental data.Comment: 17 pages, 12 figure

Age and environment affect constitutive immune function in Red Knots (Calidris canutus)

We studied subspecies, age and environmental effects on constitutive immune function (natural antibody and complement titres, haptoglobin activity and leukocyte concentrations) in Red Knots (Calidris canutus). We compared C. c. islandica and C. c. canutus in the Wadden Sea and found no difference in immune function between subspecies. However, C. c. canutus on their wintering grounds in Banc d’Arguin had higher natural antibody and lower complement levels than C. c. canutus or C. c. islandica in the Wadden Sea. This suggests that immune function is determined more by the surrounding environment than by subspecies. We also compared age classes in the Wadden Sea and found that first year birds had significantly lower natural antibody levels than adults, but that second year birds no longer differed from adults. Finally, we examined the interaction of age and environment in Banc d’Arguin. We found that first year birds (but not adults) in a low quality habitat had higher leukocyte concentrations than first year birds or adults in a high quality habitat. Differences in available resources and defence needs between environments, and differences among individuals differentially distributed between sites, are likely important contributors to the variation in immune function we report. Future studies, which examine these factors on wild birds, will be important for our understanding of how animals function in their natural environment.

Multi-Conjugate Adaptive Optics images of the Trapezium Cluster

Multi-Conjugate Adaptive Optics (MCAO) combines the advantages of standard adaptive optics, which provides high contrast and high spatial resolution, and of wide field ~1' imaging. Up to recently, MCAO for astronomy was limited to laboratory experiments. In this paper, we present the first scientific results obtained with the first MCAO instrument put on the sky. We present a new study of the Trapezium cluster using deep MCAO images with a field of view of 1'x1' obtained at the VLT. We have used deep J, H and Ks images recently obtained with the prototype MCAO facility MAD at the VLT in order to search for new members and new multiple systems in the Trapezium cluster. On bright targets (Ks~9mag), these images allow us to reach DeltaKs~6mag as close as 0.4" We report the detection of 128 sources, including 10 new faint objects in the magnitude range between 16.1<Ks<17.9mag. In addition to all previously known multiple systems with separations greater than 0.1", we confirm the multiplicity of TCC-055. We also report the detection in J, H and Ks of a very red extended embedded protostellar object, HC419, previously detected in the thermal infrared only. The analysis of the first MCAO images obtained on the sky demonstrates not only the technical feasibility of MCAO but also its great potential and versatility in terms of scientific outputs.Comment: High resolution version available on http://arrakeen.free.fr/pub/madorion.pdf Accepted 25 Sep. 2007 for publication in A&A, 14 pages, 11 figure

Discovery of optically faint obscured quasars with Virtual Observatory tools

We use Virtual Observatory (VO) tools to identify optically faint, obscured (i.e., type 2) active galactic nuclei (AGN) in the two Great Observatories Origins Deep Survey (GOODS) fields. By employing publicly available X-ray and optical data and catalogues we discover 68 type 2 AGN candidates. The X-ray powers of these sources are estimated by using a previously known correlation between X-ray luminosity and X-ray-to-optical flux ratio. Thirty-one of our candidates have high estimated powers (Lx > 10^44 erg/s) and therefore qualify as optically obscured quasars, the so-called ``QSO 2''. Based on the derived X-ray powers, our candidates are likely to be at relatively high redshifts, z ~ 3, with the QSO 2 at z ~ 4. By going ~ 3 magnitudes fainter than previously known type 2 AGN in the two GOODS fields we are sampling a region of redshift - power space which was previously unreachable with classical methods. Our method brings to 40 the number of QSO 2 in the GOODS fields, an improvement of a factor ~ 4 when compared to the only 9 such sources previously known. We derive a QSO 2 surface density down to 10^-15 erg/cm^2/s in the 0.5 - 8 keV band of >~ 330/deg^2, ~ 30% of which is made up of previously known sources. This is larger than current estimates and some predictions and suggests that the surface density of QSO 2 at faint flux limits has been underestimated. This work demonstrates that VO tools are mature enough to produce cutting-edge science results by exploiting astronomical data beyond ``classical'' identification limits (R <~ 25) with interoperable tools for statistical identification of sources using multiwavelength information.Comment: 16 pages, 6 figures, accepted for publication in Astronomy & Astrophysics. PDF file with higher resolution figures available at http://www.eso.org/~ppadovan/AVO-paper.pd

RATAN-600 7.6-cm Deep Sky Strip Surveys at the Declination of the SS433 Source During the 1980-1999 Period. Data Reduction and the Catalog of Radio Sources in the Right-Ascension Interval 7h < R.A. < 17h

We use two independent methods to reduce the data of the surveys made with RATAN-600 radio telescope at 7.6 cm in 1988-1999 at the declination of the SS433 source. We also reprocess the data of the "Cold" survey (1980-1981). The resulting RCR (RATAN COLD REFINED) catalog contains the right ascensions and fluxes of objects identified with those of the NVSS catalog in the right-ascension interval 7h < R.A. < 17h. We obtain the spectra of the radio sources and determine their spectral indices at 3.94 and 0.5 GHz. The spectra are based on the data from all known catalogs available from the CATS, Vizier, and NED databases, and the flux estimates inferred from the maps of the VLSS and GB6 surveys. For 245 of the 550 objects of the RCR catalog the fluxes are known at two frequencies only: 3.94 GHz (RCR) and 1.4 GHz (NVSS). These are mostly sources with fluxes smaller than 30 mJy. About 65% of these sources have flat or inverse spectra (alpha > -0.5). We analyze the reliability of the results obtained for the entire list of objects and construct the histograms of the spectral indices and fluxes of the sources. Our main conclusion is that all 10-15 mJy objects found in the considered right-ascension interval were already included in the decimeter-wave catalogs.Comment: 26 pages, 18 figure

A mid-infrared study of very low mass stars and brown dwarfs in Upper Scorpius

We report the results of mid-IR observations with VISIR at the VLT of 10 ultracool dwarfs members of the nearby Upper Scorpius OB association in four filters ranging between 8.59 (PAH1) to 12.8 $\mu$m (Ne II), and one brown dwarf with Spitzer between 3.6 and 24 $\mu$m. Seven of our targets are detected in at least one of the bands, and we derive upper limits on the fluxes of the remaining 4. These results combined with previous studies from the literature lead to an improved disk frequency of 50$\pm$12%. This frequency is significantly higher than that of accretors (16.3%$\pm$6.2%). Only one object showing mid-IR excess also has H$\alpha$ emission at a level indicating that it must be accreting. Four of the detected targets are multiple system candidates. The observed disk frequency for sub-stellar objects in the Upper Scorpius association is similar to that of stars, consistent with a common formation scenario. It is also similar to the disk fractions observed in younger clusters, suggesting that the disk lifetimes might be longer for ultracool dwarfs than for higher-mass stars.Comment: 10 pages, 4 figures, accepted for A&

Experimental tissue engineering of fetal skin

Purpose: In some human fetuses undergoing prenatal spina bifida repair, the skin defect is too large for primary closure. The aim of this study was to engineer an autologous fetal skin analogue suitable for in utero skin reconstruction during spina bifida repair. Methods: Keratinocytes (KC) and fibroblasts (FB) isolated from skin biopsies of 90-day-old sheep fetuses were cultured. Thereafter, plastically compressed collagen hydrogels and fibrin gels containing FB were prepared. KC were seeded onto these dermal constructs and allowed to proliferate using different culture media. Constructs were analyzed histologically and by immunohistochemistry and compared to normal ovine fetal skin. Results: Development of a stratified epidermis covering the entire surface of the collagen gel was observed. The number of KC layers and degree of organization was dependent on the cell culture media used. The collagen hydrogels exhibited a strong tendency to shrink after eight to ten days of culture in vitro. On fibrin gels, we did not observe the formation of a physiologically organized epidermis. Conclusion: Collagen-gel-based ovine fetal cell-derived skin analogues with near normal anatomy can be engineered in vitro and may be suitable for autologous fetal transplantation

Detection of Extended Red Emisson in the Diffuse Interstellar Medium

Extended Red Emission (ERE) has been detected in many dusty astrophysical objects and this raises the question: Is ERE present only in discrete objects or is it an observational feature of all dust, i.e. present in the diffuse interstellar medium? In order to answer this question, we determined the blue and red intensities of the radiation from the diffuse interstellar medium (ISM) and examined the red intensity for the presence of an excess above that expected for scattered light. The diffuse ISM blue and red intensities were obtained by subtracting the integrated star and galaxy intensities from the blue and red measurements made by the Imaging Photopolarimeter (IPP) aboard the Pioneer 10 and 11 spacecraft. The color of the diffuse ISM was found to be redder than the Pioneer intensities, contrary to that expected for scattered light (Diffuse Galactic Light [DGL]). The red DGL was calculated using the blue diffuse ISM intensities and the approximately invariant color of the DGL calculated with the DGL model. Subtracting the calculated red DGL from the red diffuse ISM intensities resulted in the detection of an excess red intensity. This represents the likely detection of ERE in the diffuse ISM since H-alpha emission cannot account for the strength of this excess and the only other known emission process applicable to the diffuse ISM is ERE. Thus, ERE appears to be a general characteristic of dust. From the correlation between N_HI and ERE intensity the ERE photon conversion efficiency was estimated at 10 +/- 3%.Comment: 44 pages (41 figures included), to be published in the ApJ, new version corrected for small error in fig. 2

Hot subdwarfs from the ESO Supernova Ia Progenitor Survey: II. Atmospheric parameters of subdwarf O stars

We address the origin and evolutionary status of hot subdwarf stars by studying the optical spectral properties of 58 subdwarf O (sdO) stars. Combining them with the results of our previously studied subdwarf B (sdB) stars, we aim at investigating possible evolutionary links. We analyze high-resolution ESO VLT UVES spectra from the ESO Supernova Ia Progenitor Survey (SPY). Effective temperatures, gravities, and helium abundances are determined simultaneously by fitting the profiles of H and He lines using dedicated synthetic spectra in NLTE. Evidence for cool companions to 8 sdOs as well as a binary consisting of two sdO stars is found. A correlation between He abundances and the presence of carbon and/or nitrogen lines emerges: below solar He abundance, no sdO shows C or N lines. In contrast, C and/or N lines are present in ALL sdOs with super- solar He abundance. We thus use the solar He abundance to divide our sample into He-deficient and He-enriched sdOs. While He-deficient sdOs are scattered in a wide range of the Teff-log(g)-diagram, most of the He-enriched sdOs cluster in a narrow region at Teff = 40,000 ... 50,000K and log(g)=5.5 ... 6.0. An evolu- tionary link between sdBs and sdOs appears plausible only for the He-deficient sdOs indicating that they are the likely successors to sdBs. The properties of He-enriched sdOs cannot be explained with canonical single star evolutionary models. Alternative scenarios (late hot flasher) as well as for binary evolution (white dwarf merger; post-RGB evolution) are tested. While we regard the post-RGB scenario as inappropriate, the white dwarf merger and the late hot flasher scenarios remain viable to explain the origin of He-enriched sdOs.Comment: 14 pages, 10 figures, Astronomy & Astrophysics accepte