Effect of the green-emitting CaF2:Ce3+,Tb3+ phosphor particles’ size on color rendering index and color quality scale of the in-cup packaging multichip white LEDs

In this paper, we investigate the effect of the green-emitting CaF2:Ce (3+), Tb (3+) phosphor particle's size on the color rendering index (CRI) and the color quality scale (CQS) of the in-cup packaging multichip white LEDs (MCW-LEDs). For this purpose, 7000K and 8500K in-cup packaging MCW-LEDs is simulated by the commercial software Light Tools. Moreover, scattering process in the phosphor layers is investigated by using Mie Theory with Mat Lab software. Finally, the research results show that the green-emitting CaF2: Ce (3+), Tb (3+) phosphor's size crucially influences on the CRI and CQS. From that point of view, CaF2: Ce (3+), Tb (3+) can be proposed as a potential practical direction for manufacturing the in-cup packaging phosphor WLEDs.Web of Science13235134

Catalytic Performance of La-Ni/Al2O3 Catalyst for CO2 Reforming of Ethanol

Bio-derived ethanol has been considered as an attractive and alternative feedstock for dry or steam reforming reactions to generate renewable hydrogen, which may be used for replacement of conventional fossil fuels. Ethanol dry reforming (EDR) is an environmentally-friendly process since it transforms greenhouse gas, CO2 to value-added products and ethanol can be easily obtained from biomass which is free of catalyst poisons (i.e. sulphur-containing compounds). However, there are currently limited studies regarding syngas production from EDR [1, 2]. Ni-based catalysts are commonly used for reforming reactions due to its capability of C-C bond rupture, relatively low cost and high availability compared to precious metals [2]. Nevertheless, carbonaceous deposition may considerably deteriorate catalytic activity and stability of Ni-based catalysts. La promoter reportedly hindered carbon deposition and improved catalytic activity [3]. Hence, the objective of this research was to investigate the effect of La promotion on 10%Ni/Al2O3 catalyst for EDR

Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension.

Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimics events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset of genes that encode multiple proteins collectively referred to as the senescence-associated secretory phenotype (SASP). Emerging evidence suggests that the presence of these proinflammatory and matrix-degrading molecules has deleterious effects in a variety of tissues. In the current study, we demonstrated in a transgenic mouse model that early removal of senescent cells induced upon elevated intraocular pressure (IOP) protects unaffected RGCs from senescence and apoptosis. Visual evoked potential (VEP) analysis demonstrated that remaining RGCs are functional and that the treatment protected visual functions. Finally, removal of endogenous senescent retinal cells after IOP elevation by a treatment with senolytic drug dasatinib prevented loss of retinal functions and cellular structure. Senolytic drugs may have the potential to mitigate the deleterious impact of elevated IOP on RGC survival in glaucoma and other optic neuropathies

Co-doping green-emitting CaF2:Ce3+,Tb3+ and yellow-emitting phosphor particles for improving the cct deviation and luminous efficacy of the in-cup phosphor packaging WLEDs

In last few decades, Light emitting diodes (LEDs) with a series of excellence advantages is considered as the next generational light source. In this research, by co-doping the Green-emitting CaF2:Ce3+,Tb3+ phosphor to yellow-emitting YAG: Ce phosphor compound of the 7000K and 8500 K in-cup packaging white LED lamps (WLEDs), an innovative solution for improving color uniformity and luminous efficiency is proposed, investigated, and demonstrated. By using Mie Theory with Mat Lab and Light Tool software, the obtained results show that the CCT Deviation and luminous efficacy of the 7000 K and 8500 K in-cup phosphor packaging WLEDs crucial are influenced by the Green-emitting CaF2:Ce3+,Tb3+ phosphor's concentration. The results show that the green-emitting phosphor can beconsider as a potential practical solution for manufacturing the in-cup packaging phosphor WLEDs in the near future.Web of Science12389889

Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency.

Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events. We tested urocortin 2 gene transfer as single-agent therapy for insulin deficiency using two mouse models. Urocortin 2 gene transfer reduced blood glucose for months after a single intravenous injection, through increased skeletal muscle insulin sensitivity, increased insulin release in response to glucose stimulation, and increased plasma insulin levels before and during euglycemic clamp. The combined increases in both insulin availability and sensitivity resulted in improved glycemic indices-events that were not anticipated in these insulin-deficient models. In addition, urocortin 2 gene transfer reduced ocular manifestations of long-standing insulin deficiency such as vascular leak and improved retinal function. Finally, mortality was reduced by urocortin 2 gene transfer. The mechanisms for these beneficial effects included increased activities of AMP-activated protein kinase and Akt (protein kinase B) in skeletal muscle, increased skeletal muscle glucose uptake, and increased insulin release. These data suggest that urocortin 2 gene transfer may be a viable therapy for new onset type 1 diabetes and might reduce insulin needs in later stage disease

Synbiotic Agents and Their Active Components for Sustainable Aquaculture: Concepts, Action Mechanisms, and Applications

peer reviewedAquaculture is a fast-emerging food-producing sector in which fishery production plays an imperative socio-economic role, providing ample resources and tremendous potential worldwide. However, aquatic animals are exposed to the deterioration of the ecological environment and infection outbreaks, which represent significant issues nowadays. One of the reasons for these threats is the excessive use of antibiotics and synthetic drugs that have harmful impacts on the aquatic atmosphere. It is not surprising that functional and nature-based feed ingredients such as probiotics, prebiotics, postbiotics, and synbiotics have been developed as natural alternatives to sustain a healthy microbial environment in aquaculture. These functional feed additives possess several beneficial characteristics, including gut microbiota modulation, immune response reinforcement, resistance to pathogenic organisms, improved growth performance, and enhanced feed utilization in aquatic animals. Nevertheless, their mechanisms in modulating the immune system and gut microbiota in aquatic animals are largely unclear. This review discusses basic and current research advancements to fill research gaps and promote effective and healthy aquaculture production.2. Zero hunger3. Good health and well-being6. Clean water and sanitation9. Industry, innovation and infrastructure12. Responsible consumption and productio

Ultra-wide Spectral Bandwidth and Enhanced Absorption in a Metallic Compound Grating Covered by Graphene Monolayer

Graphene, a two-dimensional monatomic layer of carbon material, has demonstrated as a good candidate for applications of ultrafast photodetectors, transistors, transparent electrodes, and biosensing. Recently, many studies have shown that using metallic deep gratings could enhance the absorptance of graphene of 2.3% up to 80% in the near infrared region for applications in photon detection. This paper presents utilizing a nanograting structure, namely, a compound metallic grating could greatly enhance the absorptance of graphene to 100% and widen its spectral bandwidth to 600 nm, which are greater than those of previous work. The study also showed that the absorptance spectrum is insensitive to angles of incidence. Furthermore, the proposed graphene-covered compound grating might bring a lot of benefits for graphene designs-based optical and optoelectronic devices

Sr2Si5N8:Eu2+ phosphor: a novel recommendation for improving the lighting performance of the 7000 K remote-packaging white LEDs

In the last few years, white LED lamps (WLEDs) have been popularly used in general lighting because of some excellent properties, such as fast response time, environment friendliness, small size, long lifetime, and high efficiency. In this research, we propose a novel recommendation for improving the lighting performance (in terms of the colour rending index, colour quality scale, and luminous efficiency) of the 7000 K remote-packaging WLEDs by adding the red-emitting Sr2Si5N8:Eu2+ phosphor to the yellow-emitting YAG:Ce phosphor compound. In the first stage, we use MATLAB to investigate the light scattering process based on Mie Theory. After that, we use the Light Tool software to simulate and demonstrate this process. Finally, the simulation results are verified with analytical analysis, which clearly shows that the lighting performance of the 7000 K remote-packaging WLEDs significantly depended on the Sr2Si5N8:Eu2+ concentration. The results provided a potential practical solution for manufacturing remote phosphor WLEDs in the near future.Web of Science67434133

¹H NMR based metabolomics of CSF and blood serum: a metabolic profile for a transgenic rat model of Huntington disease

AbstractHuntington disease (HD) is a hereditary brain disease. Although the causative gene has been found, the exact mechanisms of the pathogenesis are still unknown. Recent investigations point to metabolic and energetic dysfunctions in HD neurons.Both univariate and multivariate analyses were used to compare proton nuclear magnetic resonance spectra of serum and cerebrospinal fluid (CSF) taken from presymptomatic HD transgenic rats and their wild-type littermates. N-acetylaspartate (NAA), was found to be significantly decreased in the serum of HD rats compared to wild-type littermates. Moreover, in the serum their levels of glutamine, succinic acid, glucose and lactate are significantly increased as well. An increased concentration of lactate and glucose is also found in CSF. There is a 1:1 stoichiometry coupling glucose utilization and glutamate cycling. The observed increase in the glutamine concentration, which indicates a shutdown in the neuronal-glial glutamate-glutamine cycling, results therefore in an increased glucose concentration. The elevated succinic acid concentration might be due to an inhibition of succinate dehydrogenase, an enzyme linked to the mitochondrial respiratory chain and TCA cycle. Moreover, reduced levels of NAA may reflect an impairment of mitochondrial energy production. In addition, the observed difference in lactate supports a deficiency of oxidative energy metabolism in rats transgenic for HD as well.The observed metabolic alterations seem to be more profound in serum than in CSF in presymptomatic rats. All findings suggest that even in presymptomatic rats, a defect in energy metabolism is already apparent. These results support the hypothesis of mitochondrial energy dysfunction in HD

A facile synthesis and properties of bismuth vanadate (BiVO4) photocatalyst by hydrothermal method

In this study, BiVO4 photocatalysts were synthesized by hydrothermal method using Bi(NO3)3 5H2O and NH4VO3 as raw materials followed by calcination at different temperatures in the range from 350 °C to 600 °C. The as-synthesized BiVO4 samples were characterized by a number of physicochemical techniques including X-ray diffraction (XRD), Raman analysis, Scanning Electron Microscopy (SEM), and UV-Visible (UV-Vis) light diffuse reflectance spectrophotometry. The effect of temperatures calcination on structure, surface morphology, visible-light photocatalytic activity and light absorption performance of BiVO4 was discussed in details