Conceptual review of Aushadha Sevana Kaal

The knowledge of Aushadha Sevana Kaal or time of drug administration is very unique concept in our Ayurvedic science and it is very much essential for effective Ayurvedic managements. The different Aushadha Sevana Kaal are defined according to biological clocks. A proper Aushadha Sevana Kaal can be suggested to attain ultimate goal of equilibrium in Dosha, Dhatu and Mala which leads to Swasthya. Aushadha Sevana Kaal is mainly explained in relation with Rogabala, Rogibala, particular Dosha, Dhatu and other factors. Successful treatment can be achieved only when there is appropriate combination of Desha (region), Kaal (time), Pramana (dosage), Satmya (wholesomeness), Asatmya (unwholesomeness), Pathya (useful), Apathya (harmful). Amongst these seven factors, Kaal attains utmost importance in Chikitsa. Acharyas have mentioned different Aushadha Sevana Kaal in various Ayurvedic text. In this present article an attempt is made to review the references of Aushadha Sevana Kaal and understand the way they enhance therapeutic action of given medicine and can cure diseases easily

A Survey of Digital Watermarking Techniques

Volume 1 Issue 6 (August 2013

Constraining Unparticles from Top Physics at TeVatron

We study and analyze the recent observations of the top pair production $\sigma (p\bar p\to t \bar t)$ at TeVatron through flavor conserving and flavor violating channels ${\it via}$ vector and tensor unparticles. The unparticle sector is considered with the possibility of being a color singlet or octet. The modified unparticle propagator is used to investigate the contribution of these unparticles to the observed $A_{FB}^{t\bar t}$ (forward backward asymmetry in top pair production) and the spin correlation at TeVatron. We have also studied the impact of the flavor violating couplings of unparticles to the third generation quarks on (a) pair production of same sign tops/antitops $\sigma (p\bar p\to tt+\bar t \bar t)$ at TeVatron and (b) the partial top decay width for $\Gamma_{\cal U}(t\to u\,{\cal U}^V)$. We find that a large region of parameter space is consistent with the measurements of \tt production cross-section, \afbt and spin correlation coefficient at TeVatron and observe that the top decay width measurement constrains the flavor violating coupling of vector unparticles more severely than the same sign top/antitop production at TeVatron. We also predict the best point-set in the model parameter space for specific choices of \du corresponding to $\chi^2_{\rm min}$ evaluated using the \mttb spectrum of \afbt from the data set of Run II of TeVatron at the integrated luminosity 8.7 fb$^{-1}$. Our results and analysis are consistent even with unparticle theories having broken scale invariance as long as the infrared cut-off scale is much less than the top pair production threshold.Comment: 37 pages, 24 figures, 1 new figure and some discussions added, references updated, to appear in Physical Review

Biliary atresia with hyaline cartilage at the porta hepatis: a novel finding of undetermined significance: a case report

Biliary atresia is an important cause of liver disease and morbidity in infants with unknown etiology. To date, only five cases of biliary atresia with hyaline cartilage at the porta hepatis have been described. We present the case of a 65-day-old male child, with further insight and detailed discussion of this heterotopia of undetermined significance.Keywords: biliary atresia, hyaline cartilage, liver diseas

Petrographic investigation of selected natural cokes from Damodar Valley coalfields

The natural coke is a kind of fossil fuel and its reserves are scattered in almost coalfields covering approx. 2600 Km 2. In Indian coalfields, the igneous intrusion varies, causing regional in-situ burning of coal seams. The intrusion process itself is quite complex and does not follow any fixed trend everywhere. The chemical composition of the intrusion also varies from place to place. Petrographic, physical and chemical characterizations of some selected natural coke samples of Damodar Valley coalfields were done. The comprehensive study on above samples helped a lot in differentiation of natural cokes, slightly heat affected coal and normal coals obtained after washability at different specific gravities. The yield of the samples after washability varied from sample to sample. Through petrographic studies by microscopy, an effort has been made to decipher the new classification schemes for microtextures and microstructures of natural coke, which are generated through in-situ carbonisation of coal seams. Isotropic, anisotropic components and mineral matters were differentiated. Some selected natural coke fractions were explored for value addition in different studies. The study was helpful in establishing industrial use of natural coke in Power, Cement and Carbon Artifact industry

2D QSAR STUDIES ON THE DIFFERENTIAL INHIBITION OF ALDOSE REDUCTASE BY FLAVONIODS COMPOUNDS:A COMPARATIVE STUDY

A quantitative structure activity relationship study of  66 molecules was performed using MLR(Multiple Linear Regression) and PCR (Principal component Analysis) of aldose reductase by flavonoids compounds.Various descriptors, topological indices were used to characterize flavonoids molecules.In the developed model MLR is giving vary significant results wheras PCR  has revealed some important information. Keywords: Flavonoids, aldose reuctase, QSAR, Multiple Linear Regression, Principle Component Regressio

Clinical evaluation of Kasisadi Ghrita local application in Parikartika (Fissure-in-ano)

Background: Parikartika is characterized by sharp cutting pain in anal regionIn Parikartika, Teevrashoola, bleeding is seen, similarly severe pain and slimy blood discharge are seen in Fissure-inano. Objective: To assess the efficiency of Kasisadi Ghruta local application in the management of fissure-in-ano. Methods: The patient having classical signs and symptoms of Parikartika (fissure in ano) having Age group 20 to 60 years were recruited for the study. Trial group was treated with Kasisadi Ghruta twice a day local application for 28 days. Results: Average relief observed was 62.5% in most of symptoms. Kasisadi Ghruta is having Shothahara, Vedanasthapana and Ropana properties due to which it helps in healing of fissure in ano. Conclusion: Kasisadi Ghruta local application is having better results in fissure-in-ano

Retrospective record based study of maternal and fetal outcome in induction of labour at 40 and 41 weeks of gestation in uncomplicated primigravida women

Background: The objective of the study was to compare maternal and foetal outcome after induction in two groups: women who were induced at 40-weeks and at 41-weeks.Methods: This was a retrospective study conducted over period of one year from 1 January 2018 to 31 December 2018 in the obstetrics and gynaecology department. A total of 200 uncomplicated primigravida women were included in the study. The data was collected and comparative analysis was done between two groups: control group (group A), women with induction at 40 weeks; study group (group B), women with induction at 41 weeks. The outcome was then analysed in terms of mode of delivery, oligohydramnios, meconium-stained liquor, Apgar score, need of NICU, perinatal death. The data was collected, analysed and statistical analysis was done using the Chi square test.Results: Out of total 200 women, 104 women were of 40 weeks and 96 women had completed 41 weeks. The LSCS rate was reduced from 25.96% to 17.7%, when the labour was induced at 41 weeks, the instrumental delivery rate was low in the study group compared to the control group. Even though the meconium staining of liquor was high but NICU admission and perinatal mortality was comparatively lower in the study group.Conclusions: Induction of labour done at 41weeks is associated with reduced maternal morbidity and no adverse effect on the perinatal outcome as compare to induction at 40 weeks

Performance of Repetitive Tasks Induces Decreased Grip Strength and Increased Fibrogenic Proteins in Skeletal Muscle: Role of Force and Inflammation

Background This study elucidates exposure-response relationships between performance of repetitive tasks, grip strength declines, and fibrogenic-related protein changes in muscles, and their link to inflammation. Specifically, we examined forearm flexor digitorum muscles for changes in connective tissue growth factor (CTGF; a matrix protein associated with fibrosis), collagen type I (Col1; a matrix component), and transforming growth factor beta 1 (TGFB1; an upstream modulator of CTGF and collagen), in rats performing one of two repetitive tasks, with or without anti-inflammatory drugs. Methodology/Results To examine the roles of force versus repetition, rats performed either a high repetition negligible force food retrieval task (HRNF), or a high repetition high force handle-pulling task (HRHF), for up to 9 weeks, with results compared to trained only (TR-NF or TR-HF) and normal control rats. Grip strength declined with both tasks, with the greatest declines in 9-week HRHF rats. Quantitative PCR (qPCR) analyses of HRNF muscles showed increased expression of Col1 in weeks 3–9, and CTGF in weeks 6 and 9. Immunohistochemistry confirmed PCR results, and also showed greater increases of CTGF and collagen matrix in 9-week HRHF rats than 9-week HRNF rats. ELISA, and immunohistochemistry revealed greater increases of TGFB1 in TR-HF and 6-week HRHF, compared to 6-week HRNF rats. To examine the role of inflammation, results from 6-week HRHF rats were compared to rats receiving ibuprofen or anti-TNF-α treatment in HRHF weeks 4–6. Both treatments attenuated HRHF-induced increases in CTGF and fibrosis by 6 weeks of task performance. Ibuprofen attenuated TGFB1 increases and grip strength declines, matching our prior results with anti-TNFα. Conclusions/Significance Performance of highly repetitive tasks was associated with force-dependent declines in grip strength and increased fibrogenic-related proteins in flexor digitorum muscles. These changes were attenuated, at least short-term, by anti-inflammatory treatments