The knowledge of Aushadha Sevana Kaal or time of drug administration is very unique concept in our Ayurvedic science and it is very much essential for effective Ayurvedic managements. The different Aushadha Sevana Kaal are defined according to biological clocks. A proper Aushadha Sevana Kaal can be suggested to attain ultimate goal of equilibrium in Dosha, Dhatu and Mala which leads to Swasthya. Aushadha Sevana Kaal is mainly explained in relation with Rogabala, Rogibala, particular Dosha, Dhatu and other factors. Successful treatment can be achieved only when there is appropriate combination of Desha (region), Kaal (time), Pramana (dosage), Satmya (wholesomeness), Asatmya (unwholesomeness), Pathya (useful), Apathya (harmful). Amongst these seven factors, Kaal attains utmost importance in Chikitsa. Acharyas have mentioned different Aushadha Sevana Kaal in various Ayurvedic text. In this present article an attempt is made to review the references of Aushadha Sevana Kaal and understand the way they enhance therapeutic action of given medicine and can cure diseases easily