On numerical modeling of couple heat, air and moisture transfer through multilayered walls

This paper reports on numerical modeling of heat, air, and moisture transfer through multilayered walls. Building materials are often subjected to temporal climatic variations, which can induce a transfer of heat and moisture through the walls of the building and the foundation soil. These materials are generally considered as porous media. The coupled heat, air and moisture transfer in building materials is of paramount importance in the construction area. In this way, a mathematical model has been elaborated and validated using a benchmark example. Here, we aim to determine the energy losses. The capillary pressure is considered as potential moisture which represents both the transport of vapor and liquid phases of the water. Basing on basic functions of partial differential equations, one can convert certain measurable properties of porous media as coefficients depending on the temperature and the capillary pressure. The results obtained compare favorably with other available in the literature

On numerical modeling of couple heat, air and moisture transfer through multilayered walls

This paper reports on numerical modeling of heat, air, and moisture transfer through multilayered walls. Building materials are often subjected to temporal climatic variations, which can induce a transfer of heat and moisture through the walls of the building and the foundation soil. These materials are generally considered as porous media. The coupled heat, air and moisture transfer in building materials is of paramount importance in the construction area. In this way, a mathematical model has been elaborated and validated using a benchmark example. Here, we aim to determine the energy losses. The capillary pressure is considered as potential moisture which represents both the transport of vapor and liquid phases of the water. Basing on basic functions of partial differential equations, one can convert certain measurable properties of porous media as coefficients depending on the temperature and the capillary pressure. The results obtained compare favorably with other available in the literature

Adeno-Associated Virus Activates an Innate Immune Response in Normal Human Cells but Not in Osteosarcoma Cells▿

Adeno-associated virus (AAV) is a small, DNA-containing dependovirus with promising potential as a gene delivery vehicle. Given the variety of applications of AAV-based vectors in the treatment of genetic disorders, numerous studies have focused on the immunogenicity of recombinant AAV. In general, AAV vectors appear not to induce strong inflammatory responses. We have found that AAV2, when it infects the osteosarcoma cells U2OS, can initiate part of its replicative cycle in the absence of helper virus. This does not occur in untransformed cells. We set out to test whether the cellular innate antiviral defenses control this susceptibility and found that, in nonimmune normal human fibroblasts, AAV2 induces type I interferon production and release and the accumulation of nuclear promyelocytic leukemia bodies. AAV fails to mobilize this defense pathway in the U2OS cells. This permissiveness is in large part due to impairment of the viral sensing machinery in these cells. Our investigations point to Toll-like receptor 9 as a potential intracellular sensor that detects AAV2 and triggers the antiviral state in AAV-infected untransformed cells. Efficient sensing of the AAV genome and the ensuing activation of an innate antiviral response are thus crucial cellular events dictating the parvovirus infectivity in host cells

Ancient human genomes suggest three ancestral populations for present-day Europeans

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages