25 research outputs found
Hypoxia Inducible Factor 1-Alpha (HIF-1 Alpha) Is Induced during Reperfusion after Renal Ischemia and Is Critical for Proximal Tubule Cell Survival
Acute tubular necrosis (ATN) caused by ischemia/reperfusion (I/R) during renal transplantation delays allograft function. Identification of factors that mediate protection and/or epithelium recovery could help to improve graft outcome. We studied the expression, regulation and role of hypoxia inducible factor 1-alpha (HIF-1 α), using in vitro and in vivo experimental models of I/R as well as human post-transplant renal biopsies. We found that HIF-1 α is stabilized in proximal tubule cells during ischemia and unexpectedly in late reperfusion, when oxygen tension is normal. Both inductions lead to gene expression in vitro and in vivo. In vitro interference of HIF-1 α promoted cell death and in vivo interference exacerbated tissue damage and renal dysfunction. In pos-transplant human biopsies, HIF-1 α was expressed only in proximal tubules which exhibited normal renal structure with a significant negative correlation with ATN grade. In summary, using experimental models and human biopsies, we identified a novel HIF-1 α induction during reperfusion with a potential critical role in renal transplant
Memorias del Primer Congreso Ecuatoriano de AntropologĂa. Volumen II
Este encuentro permitiĂł visualizar los campos fundamentales en los que la antropologĂa ecuatoriana ha incursionado y ha aportado como ciencia social. Se organizaron diez simposios que, de alguna manera, fueron un reflejo de las principales áreas de interĂ©s. Esa diversidad temática mostrĂł que la antropologĂa, a la vez que seguĂa preocupada por temáticas con larga trayectoria en el paĂs como la arqueologĂa, los estudios urbanos y rurales o la etnohistoria, tambiĂ©n habĂa incursionado en temáticas nuevas como son gĂ©nero, medio ambiente, identidad, entre otras
Relationship between lipoprotein lipase hindiii polymorphism and lipids in a group of colombian patients with obstructive coronary disease
HindIII polymorphism is the most common variant in the lipoprotein lipase gene, however, its association with cardiovascular disease is controversial. Objective: To establish the frequency of the HindIII polymorphism and its relationship with lipid profile and coronary arterial disease (CAD) in Colombian patients. Materials and Methods: The sample comprised patients attending a central hemodynamics of QuindĂo, by necessity of coronary angiography. HindIII polymorphism was evaluated by polymerase chain reaction and enzyme restriction. Results: 389 patients were divided into individuals with CAD = 50% (60.4%) and individuals with EOC <50% (39.6%). Low density lipoproteins cholesterol (LDL-C) was normal, but significantly higher in CAD = 50%. High density lipoprotein cholesterol (HDL-C) was low in both groups. Hind+/+ genotype and Hind+ allele frequency were 55% and 76%, respectively; for Hind+/- genotype was 41.1%, and for Hind-/- genotype and Hind- allele was 3.85% and 24%, respectively, without significant differences between groups. In CAD = 50%, total cholesterol (TC) and LDL-C were higher in allele Hind-, while HDL-C was lower in the Hind+ allele, with significant differences regarding CAD <50% and the same alleles. There were significant differences in triglyceride and very low density lipoprotein cholesterol) (VLDL-C) between genotypes in CAD <50% group. Conclusion: This work shows that even with a normal lipid profile, this population presents coronary obstructive disease, which does not seem to be associated with low levels of HDL-C or the LPL HindIII polymorphism alone, but may be related to the influence of these on lipids
Memorias del Primer Congreso Ecuatoriano de AntropologĂa. Volumen I
Los estudios de antropologĂa tomaron un particular impulso en el paĂs en la dĂ©cada de los setenta coincidencialmente con el inicio de la formaciĂłn de antropĂłlogos en la PUCE. Esta apertura se explica en parte por la coyuntura polĂtica de las ciencias sociales en el Ecuador en esa dĂ©cada y por el reconocimiento que hicieron algunos sectores de la sociedad ecuatoriana y del Estado de la existencia de un "problema" indĂgena y de un saber "andino" que traspasaba la realidad rural y la cultura nacional. De pronto la antropologĂa era la llamada a responder a una serie de preguntas a las cuales no habĂan llegado otras ciencias sociales, preguntas tales como Âżcuál es la diferencia entre lo indĂgena y lo campesino?, Âżcuál era la naturaleza de la cultura o las culturas indĂgenas que componĂan la diversidad Ă©tnica del paĂs?, ÂżcĂłmo implementar programas de ayuda y promociĂłn indĂgena?. Preguntas como Ă©stas afloraron en diversos sectores de la sociedad y todos coincidieron en la necesidad de un pensamiento y de una metodologĂa que oriente todo este conjunto de acciones. Esta ausencia era mucho más sentida en tanto en otras regiones de los Andes ya habĂan surgido estudios de esta naturaleza y se comenzaba a acuñar lo que se llamĂł una "teorĂa de lo andino". Esta fue la coyuntura en la que se comenzĂł, en la dĂ©cada de los setenta, a pensar en tĂ©rminos de la teorĂa antropolĂłgica. Los primeros caminos de la antropologĂa social ecuatoriana estuvieron influenciados sin duda por las corrientes teĂłricas de la sociologĂa rural y los estudios de campesinado, como resultado de los conflictos rurales que emergieron en la dĂ©cada de los sesenta ligados a la modernizaciĂłn del campo y a los proyectos de reforma agraria que se impulsaron en estas dĂ©cadas en AmĂ©rica Latina