162 research outputs found
Recovering quantum information through partial access to the environment
We investigate the possibility of correcting errors occurring on a
multipartite system through a feedback mechanism that acquires information from
partial access to the environment. A partial control scheme of this kind might
be useful when dealing with correlated errors. In fact, in such a case, it
could be enough to gather local information to decide what kind of global
recovery to perform. Then, we apply this scheme to the depolarizing and
correlated errors, and quantify its performance by means of the entanglement
fidelity
Determination of set-membership identifiability sets
International audienceThis paper concerns the concept of set-membership identifiability introduced in \cite{jauberthie}. Given a model, a set-membership identifiable set is a connected set in the parameter domain of the model such that its corresponding trajectories are distinct to trajectories arising from its complementary. For obtaining the so-called set-membership identifiable sets, we propose an algorithm based on interval analysis tools. The proposed algorithm is decomposed into three parts namely {\it mincing}, {\it evaluating} and {\it regularization} (\cite{jaulin2}). The latter step has been modified in order to obtain guaranteed set-membership identifiable sets. Our algorithm will be tested on two examples
The GstLAL Search Analysis Methods for Compact Binary Mergers in Advanced LIGO's Second and Advanced Virgo's First Observing Runs
After their successful first observing run (September 12, 2015 - January 12,
2016), the Advanced LIGO detectors were upgraded to increase their sensitivity
for the second observing run (November 30, 2016 - August 26, 2017). The
Advanced Virgo detector joined the second observing run on August 1, 2017. We
discuss the updates that happened during this period in the GstLAL-based
inspiral pipeline, which is used to detect gravitational waves from the
coalescence of compact binaries both in low latency and an offline
configuration. These updates include deployment of a zero-latency whitening
filter to reduce the over-all latency of the pipeline by up to 32 seconds,
incorporation of the Virgo data stream in the analysis, introduction of a
single-detector search to analyze data from the periods when only one of the
detectors is running, addition of new parameters to the likelihood ratio
ranking statistic, increase in the parameter space of the search, and
introduction of a template mass-dependent glitch-excision thresholding method.Comment: 12 pages, 7 figures, to be submitted to Phys. Rev. D, comments
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The GstLAL template bank for spinning compact binary mergers in the second observation run of Advanced LIGO and Virgo
We describe the methods used to construct the aligned-spin template bank of
gravitational waveforms used by the GstLAL-based inspiral pipeline to analyze
data from the second observing run of Advanced LIGO and Virgo. The bank expands
upon the parameter space covered during the first observing run, including
coverage for merging compact binary systems with total mass between 2
and 400 and mass ratios between 1 and
97.989. Thus the systems targeted include merging neutron star-neutron star
systems, neutron star-black hole binaries, and black hole-black hole binaries
expanding into the intermediate-mass range. Component masses less than 2
have allowed (anti-)aligned spins between while
component masses greater than 2 have allowed
(anti-)aligned between . The bank placement technique combines a
stochastic method with a new grid-bank method to better isolate noisy
templates, resulting in a total of 677,000 templates.Comment: 9 pages, 13 figure
Coupling of CFD and semiempirical methods for designing three-phase condensate separator: case study and experimental validation
This study presents an approach to determine the dimensions of three-phase separators. First, we designed different vessel configurations based on the fluid properties of an Iranian gas condensate field. We then used a comprehensive computational fluid dynamic (CFD) method for analyzing the three-phase separation phenomena. For simulation purposes, the combined volume of fluid–discrete particle method (DPM) approach was used. The discrete random walk (DRW) model was used to include the effect of arbitrary particle movement due to variations caused by turbulence. In addition, the comparison of experimental and simulated results was generated using different turbulence models, i.e., standard k–ε, standard k–ω, and Reynolds stress model. The results of numerical calculations in terms of fluid profiles, separation performance and DPM particle behavior were used to choose the optimum vessel configuration. No difference between the dimensions of the optimum vessel and the existing separator was found. Also, simulation data were compared with experimental data pertaining to a similar existing separator. A reasonable agreement between the results of numerical calculation and experimental data was observed. These results showed that the used CFD model is well capable of investigating the performance of a three-phase separator
Effect of Satureja hortensis extracted oil on Aspergillus flavusin fish feed
In a preliminary study, the antifungal properties of essential oil of Satureja hortensis at different tenderness were tested on potato – dextrose agar (PDA). The fungus Aspergillus flavus PTCC 5006 was isolated from pistachio nut obtained from Rafsanjan area, Iran. Among the essential oil compounds, 500 ppm concentration was completely inhibited Aspergillus flavus growth. After determination of the most effective concentration, it was added to fish feeds compound which inhibited fungal growth and production of aflatoxin. Its concentration was determined as 500 ppm and over of essential oil of Satureja hortensis. The essential oil of Satureja hortensis was analyzed by means of GC-MS and their effective factors were evaluated for fish feeds and their results are shown in tables
Izolacija i sposobnost hvatanja slobodnih radikala cijanidin 3-O-glikozida iz plodova Ribes biebersteinii Berl.
The reversed-phase preparative high performance liquid chromatographic purification of the methanol extract of the fruits of Ribes biebersteinii Berl. (Grossulariaceae) afforded five cyanidin glycosides, 3-O-sambubiosyl-5-O-glucosyl cyanidin (1), cyanidin 3-O-sambubioside (2), cyanidin 3-O-glucoside (3), cyanidin 3-O-(2G-xylosyl)-rutinoside (4) and cyanidin 3-O-rutinoside (5). They showed considerable free-radical-scavenging properties in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay with the RC50 values of 9.29 × 106, 9.33 × 106, 8.31 × 106, 8.96 × 106 and 9.55 × 106 mol L1, respectively. The structures of these compounds were elucidated by various chemical hydrolyses and spectroscopic means. The total anthocyanin content was 1.9 g per 100 g dried fruits on cyanidin 3-glucoside basis.Pet cijanidin glikozida, 3-O-sambubiozil-5-O-glukozil cijanidin (1), cijanidin 3-O-sambubiozid (2), cijanidin 3-O-glukozid (3), cijanidin 3-O-(2G-ksilozil)-rutinozid (4) i cijanidin 3-O-rutinosid (5) izolirani su iz metanolnog ekstrakta plodova Ribes biebersteinii Berl. (Grossulariaceae) koristeći reverzno-faznu preparativnu tekućinsku kromatografiju visoke učinkovitosti. Cijanidin glikozidi pokazali su sposobnost hvatanja slobodnih radikala u pokusu s 2,2-difenil-1-pikrilhidrazilom (DPPH). Dobivene su sljedeće RC50 vrijednosti: 9,29 × 106, 9,33 × 106, 8,31 × 106, 8,96 × 106, odnosno 9,55 × 106 mol L1. Strukture glikozida određene su kemijskom hidrolizom i spektroskopijom masa. Ukupni sadržaj antocijanina bio je 1,9 g na 100 g suhih plodova preračunato na cijanidin 3-glukozid
Artificial intelligence for detection of microsatellite instability in colorectal cancer-a multicentric analysis of a pre-screening tool for clinical application.
BACKGROUND
Microsatellite instability (MSI)/mismatch repair deficiency (dMMR) is a key genetic feature which should be tested in every patient with colorectal cancer (CRC) according to medical guidelines. Artificial intelligence (AI) methods can detect MSI/dMMR directly in routine pathology slides, but the test performance has not been systematically investigated with predefined test thresholds.
METHOD
We trained and validated AI-based MSI/dMMR detectors and evaluated predefined performance metrics using nine patient cohorts of 8343 patients across different countries and ethnicities.
RESULTS
Classifiers achieved clinical-grade performance, yielding an area under the receiver operating curve (AUROC) of up to 0.96 without using any manual annotations. Subsequently, we show that the AI system can be applied as a rule-out test: by using cohort-specific thresholds, on average 52.73% of tumors in each surgical cohort [total number of MSI/dMMRÂ = 1020, microsatellite stable (MSS)/ proficient mismatch repair (pMMR)Â = 7323 patients] could be identified as MSS/pMMR with a fixed sensitivity at 95%. In an additional cohort of NÂ = 1530 (MSI/dMMRÂ = 211, MSS/pMMRÂ = 1319) endoscopy biopsy samples, the system achieved an AUROC of 0.89, and the cohort-specific threshold ruled out 44.12% of tumors with a fixed sensitivity at 95%. As a more robust alternative to cohort-specific thresholds, we showed that with a fixed threshold of 0.25 for all the cohorts, we can rule-out 25.51% in surgical specimens and 6.10% in biopsies.
INTERPRETATION
When applied in a clinical setting, this means that the AI system can rule out MSI/dMMR in a quarter (with global thresholds) or half of all CRC patients (with local fine-tuning), thereby reducing cost and turnaround time for molecular profiling
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