Mapping Sex Offender Addresses: The Utility of the Alaska Sex Offender Registry as a Research Data Base

The registration of sex offenders was part of a national effort to enhance public safety by permitting law enforcement officials to track the location of convicted sex offenders after their release. All fifty states have enacted legislation requiring persons convicted of various sex-related offenses to register with law enforcement agencies; many states also grant public access to all or a portion of their registries. This document reports on the Alaska Statistical Analysis Center's efforts to improve data accuracy in the Alaska Sex Offender Registry, maintained by the Alaska State Troopers, and to assess the registry's utility as a research tool.Bureau of Justice Statistics, Grant No. 1999-RU-RX-K006Background of the Project / Research Methodology / Results / Utility: Spatial Justice Research / APPENDICES / A. Alaska’s Sex Offender Registration Law / B. Establishment of a Central Registry of Sex Offenders in Alaska / C. Definitions of Offenses for which Convicted Persons Must Register as Sex Offenders in Alask

Dietary elimination of children with food protein induced gastrointestinal allergy – micronutrient adequacy with and without a hypoallergenic formula?

Background: The cornerstone for management of Food protein-induced gastrointestinal allergy (FPGIA) is dietary exclusion; however the micronutrient intake of this population has been poorly studied. We set out to determine the dietary intake of children on an elimination diet for this food allergy and hypothesised that the type of elimination diet and the presence of a hypoallergenic formula (HF) significantly impacts on micronutrient intake. Method: A prospective observational study was conducted on children diagnosed with FPIGA on an exclusion diet who completed a 3 day semi-quantitative food diary 4 weeks after commencing the diet. Nutritional intake where HF was used was compared to those without HF, with or without a vitamin and mineral supplement (VMS). Results: One-hundred-and-five food diaries were included in the data analysis: 70 boys (66.7%) with median age of 21.8 months [IQR: 10 - 67.7]. Fifty-three children (50.5%) consumed a HF and the volume of consumption was correlated to micronutrient intake. Significantly (p <0.05) more children reached their micronutrient requirements if a HF was consumed. In those without a HF, some continued not to achieve requirements in particular for vitamin D and zinc, in spite of VMS. Conclusion: This study points towards the important micronutrient contribution of a HF in children with FPIGA. Children, who are not on a HF and without a VMS, are at increased risk of low intakes in particular vitamin D and zinc. Further studies need to be performed, to assess whether dietary intake translates into actual biological deficiencies

Mid-Infrared Emission from E+A Galaxies in the Coma Cluster

We have used ISO to observe at 12$\mu$m seven E+A galaxies plus an additional emission line galaxy, all in the Coma cluster. E+A galaxies lacking narrow emission lines have 2.2$\mu$m to 12$\mu$m flux density ratios or limits similar to old stellar populations (typical of early-type galaxies). Only galaxies with emission lines have enhanced 12$\mu$m flux density. Excess 12$\mu$m emission is therefore correlated with the presence of on-going star formation or an active galactic nucleus (AGN). By comparing the current star formation rates with previous rates estimated from the Balmer absorption features, we divide the galaxies into two groups: those for which star formation has declined significantly following a dramatic peak $\sim$ 1 Gyr ago; and those with a significant level of ongoing star formation or/and an AGN. There is no strong difference in the spatial distribution on the sky between these two groups. However, the first group has systemic velocities above the mean cluster value and the second group below that value. This suggests that the two groups differ kinematically. Based on surveys of the Coma cluster in the radio, the IRAS sources, and galaxies detected in H$\alpha$ emission, we sum the far infrared luminosity function of galaxies in the cluster. We find that star formation in late type galaxies is probably the dominant component of the Coma cluster far infrared luminosity. The presence of significant emission from intracluster dust is not yet firmly established. The member galaxies also account for most of the far infrared output from nearby rich clusters in general.Comment: AAS Latex, accepted for publication in Ap

Dissecting the luminosity function of the Coma cluster of galaxies using CFHT wide field images

[Abridged] We determined the luminosity function (LF) of the Coma cluster galaxies selected by luminosity, and the LF bi-variate in central brightness. The Coma cluster and control fields were imaged using the CFH12K (42x28 arcmin) and UH8K (28x28 arcmin) wide-field cameras at the CFHT. Selected HST images were used for testing. Quantities were derived from measurements in at least two colors, which have the following features: (1) Galaxies as faint as three times the luminosity of the brightest globular clusters are in the completeness region of our data. (2) We have a complete census (in the explored region) of low surface brightness galaxies with central surface brightness galaxies almost as low as the faintest so far cataloged ones. (3) The explored area is among the largest ever sampled with CCDs at comparable depth for any cluster of galaxies. (4) The error budget includes all sources of errors known to date. Using HST images we also discovered that blends of globular clusters, not resolved in individual components due to seeing, look like dwarf galaxies when observed from the ground and are numerous and bright. The derived Coma LF is relatively steep (alpha=-1.4) over the 11 magnitudes sampled, but the slope and shape depend on color. A large population of faint low surface brightness galaxies was discovered, representing the largest contributor (in number) to the LF at faint magnitudes. We found a clear progression for a faintening of the LF from high surface brightness galaxies (mu~20 mag/arcsec2) to galaxies of very faint central brightnesses (mu~24.5 mag/arcsec2), and some evidence for a steepening. Compact galaxies, usually classified as stars and therefore not included in the LF, are found to be a minor population in Coma.Comment: ApJ, in pres

The stellar population histories of early-type galaxies. III. The Coma Cluster

We present stellar population parameters of twelve early-type galaxies (ETGs) in the Coma Cluster based on spectra obtained using the Low Resolution Imaging Spectrograph on the Keck II Telescope. Our data allow us to examine in detail the zero-point and scatter in their stellar population properties. Our ETGs have SSP-equivalent ages of on average 5-8 Gyr with the models used here, with the oldest galaxies having ages of ~10 Gyr old. This average age is identical to the mean age of field ETGs. Our ETGs span a large range in velocity dispersion but are consistent with being drawn from a population with a single age. Specifically, ten of the twelve ETGs are consistent within their formal errors of having the same age, 5.2+/-0.2 Gyr, over a factor of more than 750 in mass. We therefore find no evidence for downsizing of the stellar populations of ETGs in the core of the Coma Cluster. We suggest that Coma Cluster ETGs may have formed the majority of their mass at high redshifts but suffered small but detectable star formation events at z~0.1-0.3. Previous detections of 'downsizing' from stellar populations of local ETGs may not reflect the same downsizing seen in lookback studies of RSGs, as the young ages of the local ETGs represent only a small fraction of their total masses. (abridged)Comment: 49 pages, 20 figures (19 EPS, 1 JPEG). MNRAS, in press. For version with full resolution of Fig. 1 see http://www.astro.rug.nl/~sctrager/coma.pdf; for Table 2, see http://www.astro.rug.nl/~sctrager/coma_table2.pdf; for Table B3, see http://www.astro.rug.nl/~sctrager/coma_tableB3.pd

Development of a new real-time PCR for the detection of pilchard orthomyxovirus (POMV) in apparently healthy fish

Pilchard orthomyxovirus (POMV) is a virus of concern to the Atlantic salmon aquaculture industry in Tasmania. First isolated from wild pilchards in southern Australia in 1998, the virus is now a recognised pathogen of farmed Atlantic salmon (Salmo salar) in Tasmania. While the current real-time PCR for POMV targets segment 5 of the viral genome, recent viral gene expression data suggests that other segments of the POMV genome presented higher transcription levels and thus may be better candidates for the early detection of the virus. This study aimed to design and begin validating a more sensitive reverse transcriptase real-time PCR (RT-qPCR) assay to detect POMV. Primers and probes were developed targeting two independent viral genes derived from segments 7 and 8, which presented higher transcription levels than segment 5 in both cell culture and infected fish. These were compared with the current POMV RT-qPCR. The POMV segment 8 assay had a higher analytical sensitivity than segment 7, detecting at least 1 plasmid copy μl−1, and was 10-fold more sensitive than both POMV segment 7 and 5 assays when analysing nucleic acid from a positive field sample. Both new assays also had high analytical specificity, detecting the 11 POMV isolates tested (inclusivity testing) and not amplifying nucleic acids from other viruses, including ISAV, a related orthomyxovirus. In the latent class model analysis, the diagnostic sensitivity of the segment 8 and 7 assays were higher than segment 5 in 93% and 92% of simulations, respectively. Seven samples (18.4%), all from subclinical fish infected with POMV, returned a positive result only with the segment 8 assay. Both new assays showed reproducible results when applied to aliquots of the same samples tested in three different laboratories. The new POMV segment 8 assay shows promising results as a surveillance tool for detecting POMV in fish without any symptoms.publishedVersio

In vivo transplantation of fetal human gut-derived enteric neural crest cells

The prospect of using neural cell replacement for the treatment of severe enteric neuropathies has seen significant progress in the last decade. The ability to harvest and transplant enteric neural crest cells (ENCCs) that functionally integrate within recipient intestine has recently been confirmed by in vivo murine studies. Although similar cells can be harvested from human fetal and postnatal gut, no studies have as yet verified their functional viability upon in vivo transplantation. We sought to determine whether ENCCs harvested from human fetal bowel are capable of engraftment and functional integration within recipient intestine following in vivo transplantation into postnatal murine colon. Enteric neural crest cells selected and harvested from fetal human gut using the neurotrophin receptor p75NTR were lentivirally labeled with either GFP or calcium-sensitive GCaMP and transplanted into the hindgut of Rag2−/γc−/C5−-immunodeficient mice at postnatal day 21. Transplanted intestines were assessed immunohistochemically for engraftment and differentiation of donor cells. Functional viability and integration with host neuromusculature was assessed using calcium imaging. Transplanted human fetal gut-derived ENCC showed engraftment within the recipient postnatal colon in 8/15 mice (53.3%). At 4 weeks posttransplantation, donor cells had spread from the site of transplantation and extended projections over distances of 1.2 ± 0.6 mm (n = 5), and differentiated into enteric nervous system (ENS) appropriate neurons and glia. These cells formed branching networks located with the myenteric plexus. Calcium transients (change in intensity F/F0 = 1.25 ± 0.03; 15 cells) were recorded in transplanted cells upon stimulation of the recipient endogenous ENS demonstrating their viability and establishment of functional connections

In vivo transplantation of fetal human gut-derived enteric neural crest cells

The prospect of using neural cell replacement for the treatment of severe enteric neuropathies has seen significant progress in the last decade. The ability to harvest and transplant enteric neural crest cells (ENCCs) that functionally integrate within recipient intestine has recently been confirmed by in vivo murine studies. Although similar cells can be harvested from human fetal and postnatal gut, no studies have as yet verified their functional viability upon in vivo transplantation. We sought to determine whether ENCCs harvested from human fetal bowel are capable of engraftment and functional integration within recipient intestine following in vivo transplantation into postnatal murine colon. Enteric neural crest cells selected and harvested from fetal human gut using the neurotrophin receptor p75NTR were lentivirally labeled with either GFP or calcium-sensitive GCaMP and transplanted into the hindgut of Rag2−/γc−/C5−-immunodeficient mice at postnatal day 21. Transplanted intestines were assessed immunohistochemically for engraftment and differentiation of donor cells. Functional viability and integration with host neuromusculature was assessed using calcium imaging. Transplanted human fetal gut-derived ENCC showed engraftment within the recipient postnatal colon in 8/15 mice (53.3%). At 4 weeks posttransplantation, donor cells had spread from the site of transplantation and extended projections over distances of 1.2 ± 0.6 mm (n = 5), and differentiated into enteric nervous system (ENS) appropriate neurons and glia. These cells formed branching networks located with the myenteric plexus. Calcium transients (change in intensity F/F0 = 1.25 ± 0.03; 15 cells) were recorded in transplanted cells upon stimulation of the recipient endogenous ENS demonstrating their viability and establishment of functional connections

Structural Parameters of Dwarf Galaxies in the Coma Cluster: On the Origin of dS0 Galaxies

In this paper we analyze the structural parameters of the dwarf galaxies in the Coma cluster with $-18 \le M_{B} \le -16$ and classify them in two types: those with surface brightness profiles well fitted by a single Sersic law were called dwarf ellipticals (dEs), and those fitted with Sersic-plus-exponential profiles were classified as dwarf lenticulars (dS0s). The comparison of the structural parameters of the dwarf galaxies in the Coma and Virgo clusters shows that they are analogous. Photometrically, the dE and dS0 galaxies in Coma are equivalent, having similar colors and global scales. However, the scale of the innermost parts (bulges) of dS0 galaxies is similar to the bulges of late-type spiral galaxies. In contrast, dEs have larger scales than the bulges of bright galaxies. This may indicate that dS0 and dE galaxies have different origins. While dE galaxies can come from dwarf irregulars (dIs) or from similar processes as bright Es, the origin of dS0 galaxies can be harassed bright late-type spiral galaxies.Comment: 48 pages, 14 figure, 4 tables. Accepted for publication in A