Interleukin 2 and stimulator lymphoblastoid cells will induce human thymocytes to bind and kill K562 targets.

Human thymocytes cultured in the presence of IL-2 and an irradiated B cell line became cytotoxic to K562 target cells. Thymocytes cultured alone or with only IL-2 exhibited almost no killing, but thymocytes cultured in the presence of stimulator cells alone exhibited low levels of cytotoxic activity. Removal of Fc gamma receptor-bearing cells from the activated thymocyte population almost completely abolished the binding and lytic activity. Separation of thymocytes into Fc microns+ and Fc microns-cells before culturing with IL-2 and stimulator cells revealed that only the Fc microns+ subpopulation developed into K562 killer cells. These findings indicate that modulation of Fc microns to Fc gamma receptors on the thymocyte cell surface is part of the maturation process of this particular subset of cytotoxic cells. Morphologically, most of the activated Fc gamma+ K562-binding cells were large, granulated lymphocytes. Only very few of the round, nongranulated small thymocytes were bound to K562 target cells

Informality, Trade Policies And Smuggling In West Africa

In West Africa, recorded intra-regional trade is small but informal cross-border trade (ICBT) is pervasive, despite regional integration schemes intended to promote official trade. We argue that ICBT must be understood in light of two features of West African national boundaries: divergent economic policies between neighboring countries and the ease with which informal operators can ship goods across borders. We focus on two ICBT clusters: Senegal–The Gambia and Nigeria–Benin–Togo. Nigeria and Senegal have protected their domestic industries with high import barriers, whereas Benin, Togo and The Gambia have maintained lower import taxation. These differential trade policies, together with high mobility of goods and people across borders, lead to widespread smuggling, with goods imported legally in low-tax countries and re-exported unofficially to countries with higher import duties

Environmental Parameters of an Aborted Launch

Constituents of the pressure environment of an aborted launch include the unbalance of the atmospheric pressure caused by the blast and the pressure differentials developing across structures due to the rapid succession of overpressures and underpressures of the shockfront as it spreads through the launch complex. The main features of the thermal environment are the fireball, its heat output, and the values, distribution, and duration of the ambient temperatures. The knowledge of the behavior of the pressure and thermal environments of an aborted launch is a starting point for the engineering design or evaluation of materials, assemblies, or systems which might be exposed to the abort environment and are expected to survive. This paper describes the first known measurement and interpretation of abort data. The occasion was the accidental disintegration of the Atlas-Centaur vehicle at the Cape Kennedy Air Force Station, Florida, on 2 March 1965. Other applications of launch hazards instrumentation are discussed

Gravitationally enhanced depolarization of ultracold neutrons in magnetic-field gradients

Trapped ultracold neutrons (UCN) have for many years been the mainstay of experiments to search for the electric dipole moment (EDM) of the neutron, a critical parameter in constraining scenarios of new physics beyond the Standard Model. Because their energies are so low, UCN preferentially populate the lower region of their physical enclosure, and do not sample uniformly the ambient magnetic field throughout the storage volume. This leads to a substantial increase in the rate of depolarization, as well as to shifts in the measured frequency of the stored neutrons. Consequences for EDM measurements are discussed

Algorithms and literate programs for weighted low-rank approximation with missing data

Linear models identification from data with missing values is posed as a weighted low-rank approximation problem with weights related to the missing values equal to zero. Alternating projections and variable projections methods for solving the resulting problem are outlined and implemented in a literate programming style, using Matlab/Octave's scripting language. The methods are evaluated on synthetic data and real data from the MovieLens data sets

Fluctuation-induced interactions between dielectrics in general geometries

We study thermal Casimir and quantum non-retarded Lifshitz interactions between dielectrics in general geometries. We map the calculation of the classical partition function onto a determinant which we discretize and evaluate with the help of Cholesky factorization. The quantum partition function is treated by path integral quantization of a set of interacting dipoles and reduces to a product of determinants. We compare the approximations of pairwise additivity and proximity force with our numerical methods. We propose a ``factorization approximation'' which gives rather good numerical results in the geometries that we study

Сучасні підходи до питання ліквідації наслідків Чорнобильської катастрофи у віддалений період

У матеріалах наведено результати дослідження міграції радіонуклідів чорнобильського походження в біогеоценозах Волинського Полісся, зокрема лісових масивах, агроландшафтах, а також виявлення основних зон формування підвищеної радіоактивності на досліджуваних територіях

Circular photon drag effect in bulk tellurium

The circular photon drag effect is observed in a bulk semiconductor. The photocurrent caused by a transfer of both translational and angular momenta of light to charge carriers is detected in tellurium in the mid-infrared frequency range. Dependencies of the photocurrent on the light polarization and on the incidence angle agree with the symmetry analysis of the circular photon drag effect. Microscopic models of the effect are developed for both intra- and inter-subband optical absorption in the valence band of tellurium. The shift contribution to the circular photon drag current is calculated. An observed decrease of the circular photon drag current with increase of the photon energy is explained by the theory for inter-subband optical transitions. Theoretical estimates of the circular photon drag current agree with the experimental data.Comment: 8 pages, 4 figure