A conservation assessment of the amphibians and reptiles of the Forêt d’Ambre Special Reserve, north Madagascar

We surveyed the lowland rainforest of the Forêt d’Ambre Special Reserve in north Madagascar for amphibians and reptiles. We recorded a total of 20 amphibian and 39 reptile species via opportunistic searching and pitfall trapping in the first published survey to focus on this area. Consequently most of the species found were new records for the area. Approximately half of the species (51 %) were only found in relatively undisturbed areas of forest and 61 % appear to be restricted to lowland rainforest below 900 m elevation. The most vulnerable elements of this herpetofauna are the three species that appear to be locally endemic to Forêt d’Ambre (according to the current knowledge): Boophis baetkei, Brookesia sp. nov., and Rhombophryne sp. nov. An additional 25 species are considered regional endemics, 14 species are threatened according to the 2007 Red List of Threatened Species and 15 species are listed on the CITES appendices. This paper contributes to the current understanding of Malagasy patterns of biodiversity by documenting the composition, geographical and ecological distribution of the herpetofauna found at this site. Despite its protected status, currently the Reserve is not being managed sufficiently as it is subject to numerous human - induced environmental problems resulting in habitat destruction and should therefore be considered a high conservation management priority. Herein, we provide conservation and development recommendations for this highly diverse site of herpetological importance. Furthermore, we provide an updated and revised species list of the amphibians and reptiles of Montagne d’Ambre National Park and a species list for the private Fontenay Nature Park

Differences in time to patient access to innovative cancer medicines in six European countries

Patients across Europe face inequity regarding access to anticancer medicines. While access is typically evaluated through reimbursement status or sales data, patients can receive first access through early access programs (EAPs) or off-label use. This study aims to assess the time to patient access at the hospital level, considering different indications and countries. (Pre-)registered access to six innovative medicines (Olaparib, Niraparib, Ipilimumab, Osimeritinib, Nivolumab and Ibritunib) was measured using a cross-sectional survey. First patient access to medicines and indications were collected using the hospital databases. Nineteen hospitals from Hungary, Italy, the Netherlands, Belgium, Switzerland and France participated. Analysis showed that some hospitals achieved patient access before national reimbursement, primarily through EAPs. The average time from EMA-approval to patient access for these medicines was 2.1 years (Range: −0.9-7.1 years). Hospitals in Italy and France had faster access compared to Hungary and Belgium. Variation was also found within countries, with specialized hospitals (x̄: −0.9 years; SD: 2.0) more likely to provide patient access prior to national reimbursement than general hospitals (x̄: 0.4 years; SD: 2.9). Contextual differences were observed, with EAPs or off-label use being more prevalent in Switzerland than Hungary. Recent EMA-approved indications and drug combinations reached patients at a later stage. Substantial variation in patient access time was observed between and within countries. Improving pricing and reimbursement timelines, fostering collaboration between national health authorities and market authorization holders, and implementing nationally harmonized, data-generating EAPs can enhance timely and equitable patient access to innovative cancer treatments in Europe.</p

Squeezed light at sideband frequencies below 100 kHz from a single OPA

Quantum noise of the electromagnetic field is one of the limiting noise sources in interferometric gravitational wave detectors. Shifting the spectrum of squeezed vacuum states downwards into the acoustic band of gravitational wave detectors is therefore of challenging demand to quantum optics experiments. We demonstrate a system that produces nonclassical continuous variable states of light that are squeezed at sideband frequencies below 100 kHz. A single optical parametric amplifier (OPA) is used in an optical noise cancellation scheme providing squeezed vacuum states with coherent bright phase modulation sidebands at higher frequencies. The system has been stably locked for half an hour limited by thermal stability of our laboratory.Comment: 3 pages, 3 figure

Complete Primate Skeleton from the Middle Eocene of Messel in Germany: Morphology and Paleobiology

The best European locality for complete Eocene mammal skeletons is Grube Messel, near Darmstadt, Germany. Although the site was surrounded by a para-tropical rain forest in the Eocene, primates are remarkably rare there, and only eight fragmentary specimens were known until now. Messel has now yielded a full primate skeleton. The specimen has an unusual history: it was privately collected and sold in two parts, with only the lesser part previously known. The second part, which has just come to light, shows the skeleton to be the most complete primate known in the fossil record.We describe the morphology and investigate the paleobiology of the skeleton. The specimen is described as Darwinius masillae n.gen. n.sp. belonging to the Cercamoniinae. Because the skeleton is lightly crushed and bones cannot be handled individually, imaging studies are of particular importance. Skull radiography shows a host of teeth developing within the juvenile face. Investigation of growth and proportion suggest that the individual was a weaned and independent-feeding female that died in her first year of life, and might have attained a body weight of 650-900 g had she lived to adulthood. She was an agile, nail-bearing, generalized arboreal quadruped living above the floor of the Messel rain forest.Darwinius masillae represents the most complete fossil primate ever found, including both skeleton, soft body outline and contents of the digestive tract. Study of all these features allows a fairly complete reconstruction of life history, locomotion, and diet. Any future study of Eocene-Oligocene primates should benefit from information preserved in the Darwinius holotype. Of particular importance to phylogenetic studies, the absence of a toilet claw and a toothcomb demonstrates that Darwinius masillae is not simply a fossil lemur, but part of a larger group of primates, Adapoidea, representative of the early haplorhine diversification

Phenomenological constraints on Lemaitre-Tolman-Bondi cosmological inhomogeneities from solar system dynamics

We, first, analytically work out the long-term, i.e. averaged over one orbital revolution, perturbations on the orbit of a test particle moving in a local Fermi frame induced therein by the cosmological tidal effects of the inhomogeneous Lemaitre-Tolman-Bondi (LTB) model. The LTB solution has recently attracted attention, among other things, as a possible explanation of the observed cosmic acceleration without resorting to dark energy. Then, we phenomenologically constrain both the parameters K_1 = -\ddot R/R and K_2 = -\ddot R^'/R^' of the LTB metric in the Fermi frame by using different kinds of solar system data. The corrections $\Delta\dot\varpi$ to the standard Newtonian/Einsteinian precessions of the perihelia of the inner planets recently estimated with the EPM ephemerides, compared to our predictions for them, yield K_1 = (4+8) 10^-26 s^-2, K_2 = (3+7) 10^-23 s^-2. The residuals of the Cassini-based Earth-Saturn range, compared with the numerically integrated LTB range signature, allow to obtain K_1/2 = 10^-27 s^-2. The LTB-induced distortions of the orbit of a typical object of the Oort cloud with respect to the commonly accepted Newtonian picture, based on the observations of the comet showers from that remote region of the solar system, point towards K_1/2 <= 10^-30-10^-32 s^-2. Such figures have to be compared with those inferred from cosmological data which are of the order of K1 \approx K2 = -4 10^-36 s^-2.Comment: LaTex2e, 18 pages, 3 tables, 3 figures. Minor changes. Reference added. Accepted by Journal of Cosmology and Astroparticle Physics (JCAP

Threshold concentration for H blistering in defect free W

Lattice distortion induced by high concentration of H is believed to be precursor of H blistering in single crystalline W (SCW) during H isotope irradiation. However, the critical H concentration needed to trigger bond-breaking of metal atoms presents a challenge to measure. Using density functional theory, we have calculated the formation energy of a vacancy and a self-interstitial atom (SIA) in supersaturated defect-free SCW with various H concentrations. When the ratio of H:W exceeds 1:2, the formation of both vacancies and self-interstitials becomes exothermic, meaning that spontaneous formation of micro-voids which can accommodate molecular H2 will occur. Molecular H2 is not allowed to form, and it is not needed either at the very initial stage of H blistering in SCW. With supersaturated H, the free volume at the vacancy or SIA is greatly smeared out with severe lattice distortion and more H can be trapped than in the dilute H case.Comment: 13 pages, 4 figure

Characterization of an outbreak of equine coronavirus infection in adult horses in Switzerland.

INTRODUCTION Outbreaks of equine coronavirus (ECoV) infections have been described in different parts of the world including Europe. The aim of this report was to describe clinical signs, diagnostic work-up and outcome of the first documented outbreak of ECoV in Switzerland in order to raise the awareness for the disease and its various clinical presentations. The outbreak occurred on a farm with 26 horses. Of these, seven horses developed clinical disease ranging from mild signs such as fever and anorexia to severe signs of acute colitis. One horse died due to severe endotoxemia and circulatory shock secondary to severe acute necrotizing enteritis and colitis. Out of the 26 horses, five horses tested positive for ECoV, including two ponies without any clinical signs of infection. The low number of positive cases should nevertheless be interpreted with caution as testing was only performed on one occasion, over a month after the onset of clinical signs in the first suspected case. This report highlights the importance of diagnostic testing and early implementation of biosecurity measures on a farm with an ECoV outbreak. It should furthermore raise the awareness for unspecific and mild clinical signs such as fever and anorexia in affected animals that are potentially able to spread the disease

Preparation of distilled and purified continuous variable entangled states

The distribution of entangled states of light over long distances is a major challenge in the field of quantum information. Optical losses, phase diffusion and mixing with thermal states lead to decoherence and destroy the non-classical states after some finite transmission-line length. Quantum repeater protocols, which combine quantum memory, entanglement distillation and entanglement swapping, were proposed to overcome this problem. Here we report on the experimental demonstration of entanglement distillation in the continuous-variable regime. Entangled states were first disturbed by random phase fluctuations and then distilled and purified using interference on beam splitters and homodyne detection. Measurements of covariance matrices clearly indicate a regained strength of entanglement and purity of the distilled states. In contrast to previous demonstrations of entanglement distillation in the complementary discrete-variable regime, our scheme achieved the actual preparation of the distilled states, which might therefore be used to improve the quality of downstream applications such as quantum teleportation

Catheter-based intervention for symptomatic patient with severe mitral regurgitation and very poor left ventricular systolic function - Safe but no room for complacency

Many patients with left ventricular systolic dysfunction have concomitant mitral regurgitation (MR). Their symptoms and prognosis worsen with increasing severity of MR. Percutaneous MitraClip((R)) can be used safely to reduce the severity of MR even in patients with advanced heart failure and is associated with improved symptoms, quality of life and exercise tolerance. However, a few patients with very poor left ventricular systolic function may experience significant haemodynamic disturbance in the peri-procedural period. We present three such patients, highlighting some of the potential problems encountered and discuss their possible pathophysiological mechanisms and safety measures.published_or_final_versio