Aplikasi Simulasi Pengurutan Data Menggunakan Algoritma Heap Sort

Untuk memecahkan masalah pengurutan dalam membangun suatu program aplikasi, dibutuhkan algoritma pengurutan. Metode-metode pengurutan data pun ada berbagai jenis. Mulai dari binary sort, insertion sort, merge sort, Heap Sort dll. Heap Sort, algoritma pengurutan, merupakan salah satu metode pengurutan yang sering digunakan. Algoritma Heap Sort termasuk algoritma sorting yang susah dipahami karena banyak langkah-langkah dalam mengurutkan data. Dikembangkannya perangkat lunak simulasi Heap Sort, diharapkan dapat membantu dalam pemahaman algoritma ini. Dalam penelitian ini penulis mengembangkan sebuah program aplikasi simulasi pengurutan data menggunakan algoritma Heap Sort. Program aplikasi kompresi yang dibuat dapat digunakan pada sistem operasi Windows 7 dan XP, dengan menggunakan bahasa pemrograman Microsoft Visual Basic 6.0. Tujuan akhir dari implementasi perangkat lunak ini adalah diharapkan agar pembaca dan pengembang sistem dimasa yang akan datang dapat mengembangkan dan memperbaiki kekurangan serta keterbatasan yang terdapat pada perangkat lunak ini

Polygenic burden associated to oligodendrocyte precursor cells and radial glia influences the hippocampal volume changes induced by aerobic exercise in schizophrenia patients

Hippocampal volume decrease is a structural hallmark of schizophrenia (SCZ), and convergent evidence from postmortem and imaging studies suggests that it may be explained by changes in the cytoarchitecture of the cornu ammonis 4 (CA4) and dentate gyrus (DG) subfields. Increasing evidence indicates that aerobic exercise increases hippocampal volume in CA subfields and improves cognition in SCZ patients. Previous studies showed that the effects of exercise on the hippocampus might be connected to the polygenic burden of SCZ risk variants. However, little is known about cell type-specific genetic contributions to these structural changes. In this secondary analysis, we evaluated the modulatory role of cell type-specific SCZ polygenic risk scores (PRS) on volume changes in the CA1, CA2/3, and CA4/DG subfields over time. We studied 20 multi-episode SCZ patients and 23 healthy controls who performed aerobic exercise, and 21 multi-episode SCZ patients allocated to a control intervention (table soccer) for 3 months. Magnetic resonance imaging-based assessments were performed with FreeSurfer at baseline and after 3 months. The analyses showed that the polygenic burden associated with oligodendrocyte precursor cells (OPC) and radial glia (RG) significantly influenced the volume changes between baseline and 3 months in the CA4/DG subfield in SCZ patients performing aerobic exercise. A higher OPC- or RG-associated genetic risk burden was associated with a less pronounced volume increase or even a decrease in CA4/DG during the exercise intervention. We hypothesize that SCZ cell type-specific polygenic risk modulates the aerobic exercise-induced neuroplastic processes in the hippocampus