Contextuality-by-Default: A Brief Overview of Ideas, Concepts, and Terminology

This paper is a brief overview of the concepts involved in measuring the degree of contextuality and detecting contextuality in systems of binary measurements of a finite number of objects. We discuss and clarify the main concepts and terminology of the theory called "contextuality-by-default," and then discuss a possible generalization of the theory from binary to arbitrary measurements.Comment: Lecture Notes in Computer Science 9535 (with the corrected list of authors) (2016

SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice

Huntingtons disease (HD) is a neurodegenerative disorder for which there are no disease-modifying treatments. SIRT1 is a NAD+-dependent protein deacetylase that is implicated in maintaining neuronal health during development, differentiation and ageing. Previous studies suggested that the modulation of SIRT1 activity is neuroprotective in HD mouse models, however, the mechanisms controlling SIRT1 activity are unknown. We have identified a striatum-specific phosphorylation-dependent regulatory mechanism of SIRT1 induction under normal physiological conditions, which is impaired in HD. We demonstrate that SIRT1 activity is down-regulated in the brains of two complementary HD mouse models, which correlated with altered SIRT1 phosphorylation levels. This SIRT1 impairment could not be rescued by the ablation of DBC1, a negative regulator of SIRT1, but was linked to changes in the sub-cellular distribution of AMPK-α1, a positive regulator of SIRT1 function. This work provides insights into the regulation of SIRT1 activity with the potential for the development of novel therapeutic strategies

Does the national program of prevention of mother to child transmission of HIV (PMTCT) reach its target in Ouagadougou, Burkina Faso?

Background: In the context of universal access to prevention, treatment, care and support, each country has to ensure that 80% of women and children in need have access to PMTCT interventions.Objective: To assess the PMTCT program achievement in Ouagadougou, the capital city of Burkina Faso.Methods: Between August and October 2008, a cross sectional study was carried out in the five health districts of the Centre Health Region. We reviewed weekly statistics from all health care centres (HCC) to compute the coverage of PMTCT program. In 38 HCC with functional PMTCT program, we extracted data of interest from HCC registers and made direct observations of PMTCT services.Results: The PMTCT program was implemented in 49% of HCC (target for the national program: 70%). Fifteen to 31% of these centers were often in shortage for PMTCT consumables. Patients’ privacy was not observed in 67% of Voluntary Counselling & HIV Testing wards. Care providers were not qualified enough to deliver PMTCT services. Vitamin A supplementation was not implemented. None of the facilities offered the whole package of PMTCT program interventions. HCC providing HIV testing in labour or in postnatal ward were consistently lacking. Only 86% of antenatal care new attendants benefited from pre-test counselling; 2.4% of pretested women were HIV-positive and 39% of positive mothers received antiretroviral prophylaxis.Conclusion: Coverage and quality of PMTCT programme in the Centre Health Region in Burkina Faso are still limited. Particular support is needed for training, supervision and infrastructures upgrading.Key words: vertical transmission, HIV infection, program, implementation

Medieval Novgorod in its Wider Context

Studies in centre/periphery relations

Frey Syndrome Complicating Parotidectomy: A Case Report And Review Of Literature

The parotid gland is one of the major salivary glands located on the face. It is commonly affected by diseases necessitating its surgical removal. The facial nerve is in intimate contact with this structure and can easily be damaged during operation on this gland. Parotidectomy is the surgical operation done to remove part or the whole of the parotid gland. There are several types of parotidectomies. These may be superficial, total, total conservative, radical or extended radical. A number of complications may ensue following this procedure. Frey syndrome is one of such complications but uncommon. It is therefore the aim of this paper to present this index case with a review of literature. Key words: Frey syndrome, Parotidectomy, Complication

A Comprehensive Analysis of Swift/XRT Data: III. Jet Break Candidates in X-ray and Optical Afterglow Lightcurves

The Swift/XRT data of 179 GRBs (from 050124 to 070129) and the optical afterglow data of 57 pre- and post-Swift GRBs are analyzed, in order to systematically investigate the jet-like breaks in the X-ray and optical afterglow lightcurves. We find that not a single burst can be included in the ``Platinum'' sample, in which the data satisfy all the criteria of a jet break. By releasing one or more requirements to define a jet break, some candidates of various degrees could be identified. In the X-ray band, 42 out of the 103 well-sampled X-ray lightcurves have a decay slope of the post-break segment >1.5 (``Bronze'' sample), and 27 of them also satisfy the closure relations of the forward models (``Silver'' sample). The numbers of the ``Bronze'' and ``Silver'' candidates in the optical lightcurves are 27 and 23, respectively. Thirteen bursts have well-sampled optical and X-ray lightcurves, but only seven cases are consistent with an achromatic break, but even in these cases only one band satisfies the closure relations (``Gold'' sample). The observed break time in the XRT lightcurves is systematically earlier than that in the optical bands. All these raise great concerns in interpreting the jet-like breaks as jet breaks and further inferring GRB energetics from these breaks. By assuming that these breaks are jet breaks, we perform a similar analysis as previous work to calculate the jet opening angle (theta_j) and energetics (E_k) with the ``Silver'' and ``Gold'' jet break candidates. The derived E_K distribution reveals a much larger scatter than the pre-Swift sample. A tentative anti-correlation between theta_j and E_{K,iso} is found for both the pre-Swift and Swift GRBs, indicating that the E_K could still be quasi-universal, if the breaks in discussion are indeed jet breaks(abridge).Comment: 48 pages, including 5 tables and 8 figures. Accepted for publication in ApJ. This is the third paper of a series. Paper I and II see astro-ph/0612246 (ApJ, 2007, 666,1002) and arXiv:0705.1373 (ApJ, 2007, 669, n2,in press

A network-oriented adaptive agent model for learning regulation of a highly sensitive person’s response

Inspired by the work of Elaine Aron, in this paper a human-like adaptive computational agent model of the internal processes of a highly sensitive person (HSP) is presented. This agent model was used to get a better understanding of what goes wrong in these internal processes once this person gets upset. A scenario is addressed where a highly sensitive person will get upset by an external stimulus and will not be able to calm down by herself. Yet in a social context the interaction with a second person (without high sensitivity) will calm the HSP down, thus contributing to regulation. To obtain an adaptive model a Hebbian learning connection was integrated. During interaction with a second person this Hebbian learning link will become stronger, which makes it possible for a HSP to become independent after some time and be able to regulate upsetting external stimuli all by herself

Precautionary labelling of foods for allergen content: are we ready for a global framework?

© 2014 Allen et al.; licensee BioMed Central Ltd.Food allergy appears to be on the rise with the current mainstay of treatment centred on allergen avoidance. Mandatory allergen labelling has improved the safety of food for allergic consumers. However an additional form of voluntary labelling (termed precautionary allergen labelling) has evolved on a wide range of packaged goods, in a bid by manufacturers to minimise risk to customers, and the negative impact on business that might result from exposure to trace amounts of food allergen present during cross-contamination during production. This has resulted in near ubiquitous utilisation of a multitude of different precautionary allergen labels with subsequent confusion amongst many consumers as to their significance. The global nature of food production and manufacturing makes harmonisation of allergen labelling regulations across the world a matter of increasing importance. Addressing inconsistencies across countries with regards to labelling legislation, as well as improvement or even banning of precautionary allergy labelling are both likely to be significant steps forward in improved food safety for allergic families. This article outlines the current status of allergen labelling legislation around the world and reviews the value of current existing precautionary allergen labelling for the allergic consumer. We strongly urge for an international framework to be considered to help roadmap a solution to the weaknesses of the current systems, and discuss the role of legislation in facilitating this