Using Webqual 4.0 in the evaluation of the Russian B2C Cosmetic websites

The rapid development of Russian e-commerce has involved the emergence of different Web sites. The latest tendencies showed that there is an upward trend in online purchases in the country. This paper examines the results of a quality survey of three different types of cosmetic Web sites in Russia. This industry sector is of particular interest because of its rapid growth and a wide range of organizations involved in this business. The Web sites are examined in terms of design, usability, and information quality. The findings show strengths and weaknesses of the sites and demonstrate user impressions over the interaction with the Web sites

Specific flatures of the tailings’ recultivation

Дана химико-минералогическая характеристика хвостовых отложений обогатительных фабрик Казахстана и Средней Азии, рассмотрены экологические условия произрастания на них растений и вопросы химической стабилизации пылящей поверхности хвостохранилищ, эксплуатация которых еще не закончилась. Установлено, что хвостохранилища предприятий цветной металлургии представляют интерес с точки зрения использования растений со шлама как микроэлементной добавки к корму сельскохозяйственных животных, а сами отложения как дешевые микроэлементные удобрения.The paper presents the chemicomineralogical characteristics of the tailings of the concentration factory of the Kazakhstan and the Central Asia. Ecological conditions for the plant’s growth on the tailings are discussed, as well as the problems of the chemical stabilization of the dusting surfaces of the tailings yet being exploitated. It was established, that the plant from tailings of the coloured metallurgical enterprizes may be used as a microelement addition to the cattle food, while the tailing itself may be used as a sourse of cheap microelement fertilizers

Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen

Autoantibody-mediated tissue destruction is among the main features of organ-specific autoimmunity. This report describes “an antibody enzyme” (abzyme) contribution to the site-specific degradation of a neural antigen. We detected proteolytic activity toward myelin basic protein (MBP) in the fraction of antibodies purified from the sera of humans with multiple sclerosis (MS) and mice with induced experimental allergic encephalomyelitis. Chromatography and zymography data demonstrated that the proteolytic activity of this preparation was exclusively associated with the antibodies. No activity was found in the IgG fraction of healthy donors. The human and murine abzymes efficiently cleaved MBP but not other protein substrates tested. The sites of MBP cleavage determined by mass spectrometry were localized within immunodominant regions of MBP. The abzymes could also cleave recombinant substrates containing encephalytogenic MBP(85-101) peptide. An established MS therapeutic Copaxone appeared to be a specific abzyme inhibitor. Thus, the discovered epitope-specific antibody-mediated degradation of MBP suggests a mechanistic explanation of the slow development of neurodegeneration associated with MS