Analysis and application of digital spectral warping in analog and mixed-signal testing

Spectral warping is a digital signal processing transform which shifts the frequencies contained within a signal along the frequency axis. The Fourier transform coefficients of a warped signal correspond to frequency-domain 'samples' of the original signal which are unevenly spaced along the frequency axis. This property allows the technique to be efficiently used for DSP-based analog and mixed-signal testing. The analysis and application of spectral warping for test signal generation, response analysis, filter design, frequency response evaluation, etc. are discussed in this paper along with examples of the software and hardware implementation

A low-cost sensing system for quality monitoring of dairy products

The dairy industry is in need of a cost-effective, highly reliable, very accurate, and fast measurement system to monitor the quality of dairy products. This paper describes the design and fabrication works undertaken to develop such a system. The techniques used center around planar electromagnetic sensors operating with radio frequency excitation. Computer-aided computation, being fast, facilitates on-line monitoring of the quality. The sensor technology proposed has the ability to perform volumetric penetrative measurements to measure properties throughout the bulk of the product

Recent discoveries in the cycling, growing and aging of the p53 field

The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a mediator of the therapeutic effect of anticancer drugs. Still during recent few years even more amazing discoveries have been done. Here we review such topics as suppression of epigenetic silencing of a large number of non-coding RNAs, role of p53 in suppression of the senescence phenotype, inhibition of oncogenic metabolism, protection of normal cells from chemotherapy and even tumor suppression without apoptosis and cell cycle arrest

Specifity of central character’s image creation in L. Sterne’s work ‘The life and opinions of Tristram Shandy, gentleman’

The article deals with specifity of central character’s image creation in L. Sterne’s novel ‘The Life and Opinions of Tristram Shandy, Gentleman’

Recent progress in targeting cancer

In recent years, numerous new targets have been identified and new experimental therapeutics have been developed. Importantly, existing non-cancer drugs found novel use in cancer therapy. And even more importantly, new original therapeutic strategies to increase potency, selectivity and decrease detrimental side effects have been evaluated. Here we review some recent advances in targeting cancer

Complementation of two mutant p53: Implications for loss of heterozygosity in cancer

AbstractRemarkably, a cancer cell rarely possesses two mutant p53 proteins. Instead, mutation of one allele is usually associated with loss of the second p53 allele. Why do not two mutant p53 co-exist? We hypothesize that two different p53 may complement each other, when expressed at equal levels. By titrating trans-deficient and DNA-binding-deficient p53 in cells with mutant p53 and by co-transfecting distinct mutant p53 in p53-null cells, we demonstrated activation of p53-dependent transcription. We suggest that, due to complementation of two mutant p53, cancer cells need to delete the second p53 allele rather than mutate it

Electron-phonon interaction via Pekar mechanism in nanostructures

We consider an electron-acoustic phonon coupling mechanism associated with the dependence of crystal dielectric permittivity on the strain (the so-called Pekar mechanism) in nanostructures characterized by strong confining electric fields. The efficiency of Pekar coupling is a function of both the absolute value and the spatial distribution of the electric field. It is demonstrated that this mechanism exhibits a phonon wavevector dependence similar to that of piezoelectricity and must be taken into account for electron transport calculations in an extended field distribution. In particular, we analyze the role of Pekar coupling in energy relaxation in silicon inversion layers. Comparison with the recent experimental results is provided to illustrate its potential significance

BIST Design for CCD Based Digital Imaging System

This paper presents a BIST design for CCD-based digital imaging system. Pixels on a CCD are not free from defective or faulty pixels due to numerous causes such as imperfect fabrication, excessive exposure to light, radiation, sensing element aging, and excessive mechanical shock, to mention a few. Today\u27s high demand for high resolution CCDs is dictating defect/fault-tolerance in such devices. Especially, traditional on-device BIST cannot be readily employed on the imaging devices such as CCD due to the unique requirement that no pixel can be utilized to repair or bypass a defect on any other pixels. Therefore, the BIST technique designed and simulated in this paper is a technique to test and repair the defects on pixels off the device, referred to as off-device tolerance. The basic idea was proposed in our previous work in [2] where the off-device defect/fault tolerance was investigated and a soft-test/repair technique was theoretically proposed in order to demonstrate the efficiency and effectiveness in terms ofreliability, referred to as virtual yield. A Verilog-based design and simulation is provided to demonstrate the validity of the off-device soft-test/repair in terms of reliability (or virtual yield) enhancement and performance

Elimination of Proliferating Cells Unmasks the Shift from Senescence to Quiescence Caused by Rapamycin

Background: Depending on cellular context, p53-inducing agents (such as nutlin-3a) cause different outcomes including reversible quiescence and irreversible senescence. Inhibition of mTOR shifts the balance from senescence to quiescence. In cell lines with incomplete responses to p53, this shift may be difficult to document because of a high proportion of proliferating cells contaminating arrested (quiescent and senescent) cells. This problem also complicates the study of senescence caused by minimal levels of p21 that are capable to arrest a few cells. Methodology: During induction of senescence by low levels of endogenous p53 and ectopic p21, cells were co-treated with nocodazole, which eliminated proliferating cells. As a result, only senescent and quiescent cells remained. Results and Discussion: This approach revealed that rapamycin efficiently converted nutlin-induced-senescence into quiescence. In the presence of rapamycin, nutlin-arrested MCF-7 cells retained the proliferative potential and small/lean morphology. Using this approach, we also unmasked senescence in cells arrested by low levels of ectopic p21, capable to arrest only a small proportion of HT1080-p21-9 cells. When p21 did cause arrest, mTOR caused senescent phenotype. Rapamycin and high concentrations of nutlin-3a, which inhibit the mTOR pathway in these particular cells, suppressed senescence, ensuring quiescence instead. Thus, p21 causes senescence passively, just by causing arrest, while still activ