A method to determine spatial access to specialized palliative care services using GIS

This is the final version of the article. Available from BioMed Central via the DOI in this record.BACKGROUND: Providing palliative care is a growing priority for health service administrators worldwide as the populations of many nations continue to age rapidly. In many countries, palliative care services are presently inadequate and this problem will be exacerbated in the coming years. The provision of palliative care, moreover, has been piecemeal in many jurisdictions and there is little distinction made at present between levels of service provision. There is a pressing need to determine which populations do not enjoy access to specialized palliative care services in particular. METHODS: Catchments around existing specialized palliative care services in the Canadian province of British Columbia were calculated based on real road travel time. Census block face population counts were linked to postal codes associated with road segments in order to determine the percentage of the total population more than one hour road travel time from specialized palliative care. RESULTS: Whilst 81% of the province's population resides within one hour from at least one specialized palliative care service, spatial access varies greatly by regional health authority. Based on the definition of specialized palliative care adopted for the study, the Northern Health Authority has, for instance, just two such service locations, and well over half of its population do not have reasonable spatial access to such care. CONCLUSION: Strategic location analysis methods must be developed and used to accurately locate future palliative services in order to provide spatial access to the greatest number of people, and to ensure that limited health resources are allocated wisely. Improved spatial access has the potential to reduce travel-times for patients, for palliative care workers making home visits, and for travelling practitioners. These methods are particularly useful for health service planners - and provide a means to rationalize their decision-making. Moreover, they are extendable to a number of health service allocation problems.Funding for this research was provided by the British Columbia Medical Services Foundation and British Columbia Rural and Remote Health Research Network. NS is funded by a Michael Smith Foundation for Health Research Scholar Award and a Canadian Institutes of Health Research New Investigator Award

Non-equilibrium Relations for Spin Glasses with Gauge Symmetry

We study the applications of non-equilibrium relations such as the Jarzynski equality and fluctuation theorem to spin glasses with gauge symmetry. It is shown that the exponentiated free-energy difference appearing in the Jarzynski equality reduces to a simple analytic function written explicitly in terms of the initial and final temperatures if the temperature satisfies a certain condition related to gauge symmetry. This result is used to derive a lower bound on the work done during the non-equilibrium process of temperature change. We also prove identities relating equilibrium and non-equilibrium quantities. These identities suggest a method to evaluate equilibrium quantities from non-equilibrium computations, which may be useful to avoid the problem of slow relaxation in spin glasses.Comment: 8 pages, 2 figures, submitted to JPS

Place-Based Simulation Modeling: Agent-Based Modeling and Virtual Environments

Since the earliest geographical explorations of criminal phenomena, scientists have come to the realization that crime occurrences can often be best explained by analysis at local scales. For example, the works of Guerry and Quetelet—which are often credited as being the first spatial studies of crime—analyzed data that had been aggregated to regions approximately similar to US states. The next major seminal work on spatial crime patterns was from the Chicago School in the 20th century and increased the spatial resolution of analysis to the census tract (an American administrative area that is designed to contain approximately 4,000 individual inhabitants). With the availability of higher-quality spatial data, as well as improvements in the computing infrastructure (particularly with respect to spatial analysis and mapping), more recent empirical spatial criminology work can operate at even higher resolutions; the “crime at places” literature regularly highlights the importance of analyzing crime at the street segment or at even finer scales. These empirical realizations—that crime patterns vary substantially at micro places—are well grounded in the core environmental criminology theories of routine activity theory, the geometric theory of crime, and the rational choice perspective. Each theory focuses on the individual-level nature of crime, the behavior and motivations of individual people, and the importance of the immediate surroundings. For example, routine activities theory stipulates that a crime is possible when an offender and a potential victim meet at the same time and place in the absence of a capable guardian. The geometric theory of crime suggests that individuals build up an awareness of their surroundings as they undertake their routine activities, and it is where these areas overlap with crime opportunities that crimes are most likely to occur. Finally, the rational choice perspective suggests that the decision to commit a crime is partially a cost-benefit analysis of the risks and rewards. To properly understand or model these three decisions it is important to capture the motivations, awareness, rationality, immediate surroundings, etc., of the individual and include a highly disaggregate representation of space (i.e. “micro-places”). Unfortunately one of the most common methods for modeling crime, regression, is somewhat poorly suited capturing these dynamics. As with most traditional modeling approaches, regression models represent the underlying system through mathematical aggregations. The resulting models are therefore well suited to systems that behave in a linear fashion (e.g., where a change in model input leads to a predictable change in the model output) and where low-level heterogeneity is not important (i.e., we can assume that everyone in a particular group of people will behave in the same way). However, as alluded to earlier, the crime system does not necessarily meet these assumptions. To really understand the dynamics of crime patterns, and to be able to properly represent the underlying theories, it is necessary to represent the behavior of the individual system components (i.e. people) directly. For this reason, many scientists from a variety of different disciplines are turning to individual-level modeling techniques such as agent-based modeling

Relic Neutrinos and Z-Resonance Mechanism for Highest-Energy Cosmic Rays

The origin of the highest-energy cosmic rays remains elusive. The decay of a superheavy particle (X) into an ultra-energetic neutrino which scatters from a relic (anti-)neutrino at the Z-resonance has attractive features. Given the necessary X mass of $10^{14\sim15}$ GeV, the required lifetime, $10^{15\sim16}$ y, renders model-building a serious challenge but three logical possibilities are considered: (i) X is a Higgs scalar in SU(15) belonging to high-rank representation, leading to {\it power}-enhanced lifetime; (ii) a global X quantum number has {\it exponentially}-suppressed symmetry-breaking by instantons; and (iii) with additional space dimension(s) localisation of X within the real-world brane leads to {\it gaussian} decay suppression, the most efficient of the suppression mechanisms considered.Comment: 10 page LaTeX and one postscript figure. References adde

On the work distribution for the adiabatic compression of a dilute classical gas

We consider the adiabatic and quasi-static compression of a dilute classical gas, confined in a piston and initially equilibrated with a heat bath. We find that the work performed during this process is described statistically by a gamma distribution. We use this result to show that the model satisfies the non-equilibrium work and fluctuation theorems, but not the flucutation-dissipation relation. We discuss the rare but dominant realizations that contribute most to the exponential average of the work, and relate our results to potentially universal work distributions.Comment: 4 page

3-Ethyl-2-methyl-5-methyl­ene-6,7-di­hydroindol-4(5H)-one

The title compound, C12H15NO, a degradation product of molindone hydro­chloride, was prepared by the reaction of molindone with methyl iodide and subsequent reaction of the resulting quaternary ammonium salt with 2N aqueous sodium hydroxide. The newly formed double bond is exocyclic in nature and the carbonyl group is conjugated with the π-electrons of the pyrrole ring. The six-membered ring is in the half-chair conformation. The H atom attached to the N atom is involved in an inter­molecular hydrogen bond with the O atom of a screw-related mol­ecule, thus forming a continuous chain

Membraneless seawater desalination

Disclosed are microfluidic devices and systems for the desalination of water. The devices and systems can include an electrode configured to generate an electric field gradient in proximity to an intersection formed by the divergence of two microfluidic channels from an inlet channel. Under an applied bias and in the presence of a pressure driven flow of saltwater, the electric field gradient can preferentially direct ions in saltwater into one of the diverging microfluidic channels, while desalted water flows into second diverging channel. Also provided are methods of using the devices and systems described herein to decrease the salinity of water.Board of Regents, University of Texas Syste