Induction of labour with titrated oral Misoprostol suspension: a comparative study with vaginal Misoprostol

A CAJM journal article comparing the effectiveness of titrated orally and vaginally administered misoprostol for induction of labour administered at the University of Zimbabwe Teaching Hospital..Objective: To compare the effectiveness of titrated orally and vaginally administered misoprostol for induction of labour. Study Design: Unmasked randomized controlled trial. Setting: Department of Obstetrics and Gynaecology University of Zimbabwe, Harare. Subjects: Pregnant women with singleton foetus in cephalic presentation booked for induction of labour, were randomized to receive titrated orally or vaginally administered misoprostol. Main Outcome Measures: The main outcomes were the duration of labour and induction to delivery interval. The secondary outcomes were neonatal and maternal complications. Methods: 134 women were recruited into the study; 69 and 65 were randomized into orally and vaginally administered misoprostol respectively. Results: The baseline characteristics in the two groups were similar. Women induced with titrated oral misoprostol suspension had a shorter interval from administration of the drug to initiation of uterine contractions (OR = 0.94 .95% Cl 0.42 to 2.12 ) and a longer duration of labour (OR = 0.36; 95% Cl 0.16 to 0.79). Labour was augmented with oxytocin in the oral group. The mean drug dose was 28mcg in the oral group. There was no difference in the mode of delivery between the two groups. Hypertonic uterine contractions were not detected. Ruptured uterus did not occur in the study population. There were more neonatal admissions in the vaginal than the oral group (OR = 1.03 .95% Cl 0.29 to 1.39). Conclusion: Titrated oral misoprostol suspension is as effective and safe as vaginal misoprostol for induction of labour even in poor resource countries where intrapartum monitoring is inadequate

Induction of labour with titrated oral Misoprostol suspension. A comparative study with vaginal Misoprostol

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High-performance multifunctional Graphene yarns: Toward wearable all-carbon energy storage textiles

The successful commercialization of smart wearable garments is hindered by the lack of fully integrated carbon-based energy storage devices into smart wearables. Since electrodes are the active components that determine the performance of energy storage systems, it is important to rationally design and engineer hierarchical architectures atboth the nano- and macroscale that can enjoy all of the necessary requirements for a perfect electrode. Here we demonstrate a large-scale flexible fabrication of highly porous high-performance multifunctional graphene oxide (GO) and rGO fibers and yarns by taking advantage of the intrinsic soft self-assembly behavior of ultralarge graphene oxide liquid crystalline dispersions. The produced yarns, which are the only practical form of these architectures for real-life device applications, were found to be mechanically robust (Young’s modulus in excess of 29 GPa) and exhibited high native electrical conductivity (2508 ± 632 S m–1) and exceptionally high specific surface area (2605 m2 g–1 before reduction and 2210 m2 g–1 after reduction). Furthermore, the highly porous nature of these architectures enabled us to translate the superior electrochemical properties of individual graphene sheets into practical everyday use devices with complex geometrical architectures. The as-prepared final architectures exhibited an open network structure with a continuous ion transport network, resulting in unrivaled charge storage capacity (409 F g–1 at 1 A g–1) and rate capability (56 F g–1 at 100 A g–1) while maintaining their strong flexible nature